Journal
NANOTECHNOLOGY
Volume 33, Issue 38, Pages -Publisher
IOP Publishing Ltd
DOI: 10.1088/1361-6528/ac7810
Keywords
amentoflavone; nanoparticles; doxorubicin; synergistic therapy
Funding
- Scientific projects research platform of Suzhou University [2020ykf19, 2020ykf24, 2021xhx051]
- Key research projects of Anhui Provincial Education Department [KJ2021A1109]
- Provincial natural science foundation of Anhui [1808085MH256, 1908085MC100]
- International Cooperation projects of Anhui Province [202104b11020017]
- Suzhou Science-Technology Plan Projects [2019071]
- Anhui Province Engineering project political course [2020szsfkc1001]
- Scientific research platform of Suzhou University [2021XJPT33, 2021XJPT36ZC, 2021XJPT37ZC]
- Provincial college students innovation and entrepreneurship training program [S202110379108]
- Natural Science Foundation of Suzhou University [2021BSK048]
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This study developed a self-assembling nanoplatform that can be combined with anticancer drugs for synergistic therapy, with good drug delivery efficiency and stability.
Therapeutic nanoparticles can be combined with different anticancer drugs to achieve a synergistic therapy and avoid the limitations of traditional medicine and thus have clinical prospects for cancer. Herein, an effective nanoplatform was developed for self-assembling AMF@DOX-Fe3+-PEG nanoparticles (ADPF NPs) via the coordination of ferric ions (Fe3+), amentoflavone (AMF), doxorubicin (DOX), and PEG-polyphenol. The ADPF NPs possessed high drug loading efficiency, good stability and dispersion in water, prolonged blood circulation, and pH-dependent release, which leading to targeted drug transport and enhanced drug accumulation in the tumor. The AMF from the ADPF NPs could inhibit the expression of the Aldo-keto reductase family 1B10 (AKR1B10) and nuclear factor-kappa B p65 (NF-kappa B p65), which reduced the cardiotoxicity induced by DOX and enhanced the chemotherapy efficacy. This study established a new strategy of combining drug therapy with a nanoplatform. This new strategy has a wide application prospect in clinical tumor therapy.
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