Review
Pharmacology & Pharmacy
Tao Sheng, Bowen Luo, Wentao Zhang, Xinyang Ge, Jicheng Yu, Yuqi Zhang, Zhen Gu
Summary: The application of microneedles for vaccine delivery has gained widespread interests due to its high compliance, minimal invasiveness, and convenience. Recent advances in the development and application of microneedles for vaccination based on different delivery strategies have been introduced. The prospects for its application including opportunities and challenges are further discussed.
ADVANCED DRUG DELIVERY REVIEWS
(2021)
Article
Multidisciplinary Sciences
Song Li, Youngeun Kim, Jeong Woo Lee, Mark R. Prausnitz
Summary: Single-use microneedle patches have been developed for painless and bloodless tattooing, which can provide medical information, respond to physiological changes, and encode personal health information. These patches offer increased safety and access to medical tattoos for improved cosmetic outcomes.
Article
Multidisciplinary Sciences
Guang Yao, Lei Kang, Cuicui Li, Sihong Chen, Qian Wang, Junzhe Yang, Yin Long, Jun Li, Kangning Zhao, Weina Xu, Weibo Cai, Yuan Lin, Xudong Wang
Summary: The study introduced a self-powered implantable fracture therapy device, which can accelerate bone fracture healing, improve bone density, and flexural strength. The device is characterized by self-responsiveness, battery-free operation, and no surgical removal after biomedical intervention.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Pharmacology & Pharmacy
Lukas C. Lammerding, Joerg Breitkreutz
Summary: The study investigated the use of inkjet printing as a manufacturing technology for dissolvable microneedle array patches. It was found that using printing method could precisely control the dosage and reduce drug waste. This study demonstrated the potential of inkjet printing technology in the manufacturing of personalized microneedle array patches.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Chemistry, Multidisciplinary
Ziqi Gao, Tao Sheng, Wentao Zhang, Huiheng Feng, Jicheng Yu, Zhen Gu, Yuqi Zhang
Summary: Microneedles have emerged as a promising platform for transdermal drug delivery. Recent research has shown the potential of using microneedles in combination with cell therapy to address localized conditions and improve treatment efficacy. This study provides an overview of the recent advances, applications, challenges, and future prospects of microneedle-assisted cell delivery.
Review
Biotechnology & Applied Microbiology
Xue Jiang, Huanhuan Zhao, Wei Li
Summary: This paper discusses the importance of drug-carrying nanoparticles in disease treatments and the advantages of microneedle-mediated delivery of nanoparticles. It provides an overview of several methods for nanoparticle delivery and the potential clinical applications.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Pharmacology & Pharmacy
Hiep X. Nguyen, Chien N. Nguyen
Summary: Transdermal delivery has limitations due to the barrier function of the stratum corneum layer, but microneedle technology provides a promising platform for delivering macromolecules by creating microchannels in the skin. This review article summarizes the recent research on microneedle-mediated delivery of macromolecules, covering various topics such as skin introduction, transdermal delivery, microneedles, biopharmaceuticals, safety, manufacturing, and the future of microneedle technology.
Article
Biochemistry & Molecular Biology
Ze Qiang Zhao, Ling Liang, Liu Fu Hu, Yu Ting He, Li Yue Jing, Yue Liu, Bo Zhi Chen, Xin Dong Guo
Summary: To address the issue of drug administration in Alzheimer's disease patients, a new drug delivery system using subcutaneously implanted microneedles was developed. The microneedles release the drug over an extended period and offer advantages such as faster onset of effect and longer duration compared to oral administration.
Article
Chemistry, Multidisciplinary
Long Lin, Yuqiong Wang, Minkun Cai, Xinran Jiang, Yongyan Hu, Zaizai Dong, Dedong Yin, Yilin Liu, Shaohua Yang, Zhiguang Liu, Jian Zhuang, Ye Xu, Chuan Fei Guo, Lingqian Chang
Summary: The multimicrochannel microneedle microporation (4M) platform proposed in this work achieves high efficiency, safety, and uniformity for in vivo intracellular delivery. It utilizes internal microchannels implemented through the microneedle to provide a concentrated, safe electric field that accelerates cargo movement under electrophoresis and triggers cell electroporation for enhanced transport across cell membranes. This platform has shown significant improvements in anticancer effects and reduced systemic toxicity, making it a general-purpose delivery tool for emerging drugs in vivo.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Review
Pharmacology & Pharmacy
Lalitkumar K. Vora, Akmal H. Sabri, Yara Naser, Achmad Himawan, Aaron R. J. Hutton, Qonita Kurnia Anjani, Fabiana Volpe-Zanutto, Deepakkumar Mishra, Mingshan Li, Aoife M. Rodgers, Alejandro J. Paredes, Eneko Larran, Raghu Raj Singh Thakur, Ryan F. Donnelly
Summary: The minimally-invasive and painless nature of microneedle (MN) application has enabled the technology to obviate many issues with injectable drug delivery. MNs not only administer therapeutics directly into the dermal and ocular space, but they can also control the release profile of the active compound over a desired period. This review discusses various MN formulations loaded with different therapeutics, the design aspects such as polymer selection and MN geometry, as well as manufacturing and regulatory hurdles that need to be overcome to bring MN technology to the market.
ADVANCED DRUG DELIVERY REVIEWS
(2023)
Article
Chemistry, Multidisciplinary
Lijun Cai, Zhiqiang Luo, Hanxu Chen, Yuanjin Zhao
Summary: Microneedle-motors (MNMs) for active drug delivery are developed using a flexible multimodal microfluidic lithographic approach. The MNMs, with sharp tips and spherical fuel-loading cavities, are continuously obtained from microfluidics with the assistance of flow lithography. The structural parameters of the MNMs can be precisely tailored by adjusting the flow speed or the shape of the photomask. These MNMs demonstrate efficient penetration of tissue-like substrates, indicating their potential in overcoming physiological barriers for cargo release. These findings highlight the value of multimodal microfluidic lithographic MNMs in biomedical and other relevant areas.
Article
Engineering, Biomedical
Jungho Lee, Sebin Park, Phuong Thao Le, Geunho Lee, Hyoun Wook Lee, Gaeun Yun, Juhyeong Jeon, Jeongwoo Park, Duy Tho Pham, Young Sook Park, Hoon Lim, Chulhong Kim, Tae Sik Hwang, Seung Whan Kim, Geunbae Lim
Summary: In this study, a shelf-stable dissolving microneedle (MN) patch is developed to prevent rebleeding during an emergency treatment. A minimally invasive hemostatic drug delivery system is established using a peripheral MN (p-MN) patch that enables topical drug absorption in the damaged capillaries. The invasiveness of MNs is examined through histological examination and the skin penetration force is quantified to demonstrate the milder administration of the p-MN patch compared to conventional MN patches. Hemostatic performance is studied systematically and the superior performance of the p-MN patch is demonstrated in an in vivo rat model.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Engineering, Biomedical
Jeongyun You, Seorin Juhng, Jieun Song, Jihyun Park, Mingyu Jang, Geonwoo Kang, Huisuk Yang, Hye Su Min, Jiwoo Shin, Seri Lee, Hyuk Wan Ko, Hyungil Jung
Summary: Liraglutide is a promising option for the treatment of type 2 diabetes mellitus (T2DM), as it reduces the risk of hypoglycemia compared to insulin. However, concerns related to injection prevent regular use. Dissolving microneedles (DMNs) are a potential substitute for injection, but have limitations in drug delivery and maintaining drug activity. This study introduces egg microneedles (EMNs) with functional layered structures that successfully deliver liraglutide with maximum drug activity, making it a good alternative to injections in T2DM treatment.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Pharmacology & Pharmacy
Huizhi Kang, Zhuo Zuo, Ru Lin, Muzi Yao, Yang Han, Jing Han
Summary: Microneedle patch (MNP) is an alternative drug delivery method with unique advantages, and hyaluronic acid microneedle patch (HA MNP) is a prominent strategy with various applications. In this review, the benefits and applications of HA MNP are summarized, highlighting its potential in drug delivery and disease treatment.
Review
Chemistry, Multidisciplinary
Rong Li, Li Zhang, Xuebing Jiang, Li Li, Shanshan Wu, Xin Yuan, Hao Cheng, Xian Jiang, Maling Gou
Summary: This review article provides an overview of the art, advantages, and considerations of 3D printing in the manufacturing of microneedle arrays.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Materials Science, Multidisciplinary
Yuyu Gao, Binbin Zhang, Yiming Liu, Kuanming Yao, Xingcan Huang, Jian Li, Tsz Hung Wong, Ya Huang, Jiyu Li, Jingkun Zhou, Mengge Wu, Hu Li, Zhan Gao, Wooyoung Park, Chun Ki Yiu, Huiling Jia, Rui Shi, Dengfeng Li, Xinge Yu
Summary: This study introduces an intelligent tactile sensor that mimics the multi-mechanoreceptor synergistic effect in human skin. The sensor exhibits excellent performance and decoding capability for multimodal tactile information, enabling 3D force refactoring and accurate direction tracking.
ADVANCED MATERIALS TECHNOLOGIES
(2023)
Article
Multidisciplinary Sciences
Yiming Liu, Chun Ki Yiu, Zhao Zhao, Wooyoung Park, Rui Shi, Xingcan Huang, Yuyang Zeng, Kuan Wang, Tsz Hung Wong, Shengxin Jia, Jingkun Zhou, Zhan Gao, Ling Zhao, Kuanming Yao, Jian Li, Chuanlu Sha, Yuyu Gao, Guangyao Zhao, Ya Huang, Dengfeng Li, Qinglei Guo, Yuhang Li, Xinge Yu
Summary: Recent advancements in virtual reality (VR) technologies have led to the creation of a flawless 3D virtual world, providing a cutting-edge social platform for humans. In addition to visual, auditory, and tactile sensations, the sense of smell, or olfaction, has both physiological and psychological influences on humans. This study introduces a concept of skin-interfaced olfactory feedback systems utilizing flexible and miniaturized odor generators (OGs) that are wirelessly programmable for olfactory VR applications.
NATURE COMMUNICATIONS
(2023)
Article
Chemistry, Physical
Daquan Zhang, Yudong Zhu, Rui Jiao, Jinming Zhou, Qianpeng Zhang, Swapnadeep Poddar, Beitao Ren, Xiao Qiu, Bryan Cao, Yu Zhou, Chen Wang, Ke-Fan Wang, Yunlong Zi, Haibo Zeng, Mitch Guijun Li, Hongyu Yu, Qingfeng Zhou, Zhiyong Fan
Summary: In this study, a novel metal seeding growth method was used to obtain three-dimensional perovskite nanowire forests with excellent mechanical stretchability. Stretchable photodetectors based on these perovskite nanowire forests were demonstrated to exhibit superior photodetection performance.
Article
Multidisciplinary Sciences
Jiyu Li, Yang Fu, Jingkun Zhou, Kuanming Yao, Xue Ma, Shouwei Gao, Zuankai Wang, Jian-Guo Dai, Dangyuan Lei, Xinge Yu
Summary: Thermal management is crucial for electronics, especially wearable and skin electronics, as it determines the level of integration and miniaturization. In this study, a thermal management strategy using a thin, soft, radiative-cooling interface (USRI) is reported, which can achieve temperature reduction greater than 56 degrees C by both radiative and nonradiative heat transfer. The USRI can be easily integrated with skin electronics and used as a conformable sealing layer. Demonstrations showed improved performance for flexible circuits, epidermal electronics, and skin-interfaced wireless photoplethysmography sensors. This offers a new approach for effective thermal management in advanced skin-interfaced electronics for health care monitoring.
Article
Materials Science, Multidisciplinary
Zhan Gao, Liang Mei, Jingkun Zhou, Yang Fu, Li Zhai, Zhiyuan Li, Ruijie Yang, Dengfeng Li, Qiang Zhang, Jiahui He, Jian Li, Xingcan Huang, Hu Li, Yiming Liu, Kuanming Yao, Yuyu Gao, Long Zheng, Ye Chen, Dangyuan Lei, Hua Zhang, Zhiyuan Zeng, Xinge Yu
Summary: This study presents an electronic eye system with a fully transparent artificial retina that can perceive light from all directions without weakening the photo-response. Demonstrations of different shaped electronic eye prototypes show the possibility for double sided imaging in a single device configuration.
Review
Nanoscience & Nanotechnology
Genjie Yang, Jiyu Li, Mengge Wu, Xinge Yu, Junsheng Yu
Summary: Flexible photodetectors (FPDs) have attracted great interest in wearable healthcare monitoring, imaging sensors, and portable optical communication due to their wearability, portability, and even implantability. Organic and perovskite-based materials are promising candidates for FPDs due to their high optoelectronic performance, mechanical flexibility, low-temperature solution processability, and cost-effectiveness. This review summarizes the progress of organic, perovskite, and organic-perovskite hybrid-based FPDs and their applications in artificial intelligence, providing a roadmap for next-generation sensing technologies.
ADVANCED ELECTRONIC MATERIALS
(2023)
Article
Multidisciplinary Sciences
Jian Li, Yiming Liu, Mengge Wu, Kuanming Yao, Zhan Gao, Yuyu Gao, Xingcan Huang, Tsz Hung Wong, Jingkun Zhou, Dengfeng Li, Hu Li, Jiyu Li, Ya Huang, Rui Shi, Junsheng Yu, Xinge Yu
Summary: In this study, a wearable 3D printed TENG sensor array with 100 sensing units was developed. Each unit showed good sensitivity and a wide range of pressure detection. The crosstalk effect between adjacent units was greatly reduced by using independent sensing.
FUNDAMENTAL RESEARCH
(2023)
Article
Nanoscience & Nanotechnology
Kuanming Yao, Yawen Yang, Pengcheng Wu, Guangyao Zhao, Lidai Wang, Xinge Yu
Summary: With the advancement of technology, the emergence of skin electronics, a new approach to electronic devices that are thin, soft, and even stretchable for wear and attachment to the skin, has attracted much attention. Researchers have made efforts in materials science, design strategies, and novel applications to achieve compliance, stretchability, comfortability, and maximize the potential of skin electronics. This article summarizes recent advances in functional materials, conductive materials, design strategies, and practical applications in the fields of smart healthcare and human-machine interface, contributing to the development of skin electronics for ubiquitous use in daily life.
IEEE OPEN JOURNAL OF NANOTECHNOLOGY
(2023)
Article
Automation & Control Systems
Yifan Liu, Meng Chen, Chishing Chan, Ho-yin Chnnan, Jianping Wang, Xinge Yu, Xinyue Li, Wen Jung Li
Summary: This article introduces a wireless IoT motion sensor weighing only 2g, which can be attached to mice to collect continuous motion data for multiple days. It also presents a combined segmentation method and imbalanced learning process for recognizing common and random mouse behaviors in cages, achieving a macro-recall rate of 94.55%.
ADVANCED INTELLIGENT SYSTEMS
(2023)
Article
Engineering, Electrical & Electronic
Ya Huang, Jingkun Zhou, Pingchuan Ke, Xu Guo, Chun Ki Yiu, Kuanming Yao, Shaoyu Cai, Dengfeng Li, Yu Zhou, Jian Li, Tsz Hung Wong, Yiming Liu, Lei Li, Yuyu Gao, Xingcan Huang, Hu Li, Jiyu Li, Binbin Zhang, Zhenlin Chen, Huanxi Zheng, Xingyu Yang, Haichen Gao, Zichen Zhao, Enming Song, Hui Wu, Zuankai Wang, Zhaoqian Xie, Kening Zhu, Xinge Yu
Summary: This study reports a skin-integrated wireless haptic interface based on actuator arrays, which offers multimodal and complex feedback mechanisms. The interface utilizes different feedback modes to selectively activate different cutaneous receptors, providing users with diverse haptic sensations.
NATURE ELECTRONICS
(2023)
Proceedings Paper
Engineering, Electrical & Electronic
Pengcheng Wu, Xinge Yu
Summary: Wearable flexible electronics have the potential to enrich and facilitate people's daily life, but high costs have hindered their commercialization and application in everyday life. In this study, a low-cost and rapid fabrication approach for wearable flexible electronics was reported, where liquid metal coating material was used to create soft and stretchable patterns on commonly used substrate materials, enabling the manufacturing of low-cost disposable wearable electronics.
2023 IEEE 23RD INTERNATIONAL CONFERENCE ON NANOTECHNOLOGY, NANO
(2023)
Article
Materials Science, Multidisciplinary
Xingcan Huang, Yiming Liu, Wooyoung Park, Zhao Zhao, Jiyu Li, Chee Kent Lim, Tsz Hung Wong, Chun Ki Yiu, Yuyu Gao, Jingkun Zhou, Hu Li, Ling Zhao, Jian Li, Binbin Zhang, Ya Huang, Rui Shi, Dengfeng Li, Jiaying Mo, Jinpei Wang, Chao Zhang, Yuhang Li, Zuankai Wang, Xinge Yu
Summary: This article reports a fully stretchable magnesium-air battery based on dual-ions-conducting hydrogels, which exhibits high performance and stable electrical outputs, showing great potential for applications in flexible and bio-integrated electronics. Additionally, the battery's good biocompatibility offers opportunities for biomedical applications.
