Journal
MOLECULES
Volume 27, Issue 15, Pages -Publisher
MDPI
DOI: 10.3390/molecules27154723
Keywords
multicomponent reactions (MCRs); pyrazole derivatives; biological activity; medicinal chemistry; drug discovery
Funding
- Direccion de Investigaciones at the Universidad Pedagogica y Tecnologica de Colombia [SGI 3312]
- Universidad del Valle
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This review summarizes the recent developments in the synthesis of biologically active molecules containing the pyrazole moiety using multicomponent reactions. The review provides analytical and activity data, synthetic mechanisms, and molecular docking simulations for these molecules, in order to facilitate further research in this area.
Pyrazole and its derivatives are considered a privileged N-heterocycle with immense therapeutic potential. Over the last few decades, the pot, atom, and step economy (PASE) synthesis of pyrazole derivatives by multicomponent reactions (MCRs) has gained increasing popularity in pharmaceutical and medicinal chemistry. The present review summarizes the recent developments of multicomponent reactions for the synthesis of biologically active molecules containing the pyrazole moiety. Particularly, it covers the articles published from 2015 to date related to antibacterial, anticancer, antifungal, antioxidant, alpha-glucosidase and alpha-amylase inhibitory, anti-inflammatory, antimycobacterial, antimalarial, and miscellaneous activities of pyrazole derivatives obtained exclusively via an MCR. The reported analytical and activity data, plausible synthetic mechanisms, and molecular docking simulations are organized in concise tables, schemes, and figures to facilitate comparison and underscore the key points of this review. We hope that this review will be helpful in the quest for developing more biologically active molecules and marketed drugs containing the pyrazole moiety.
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