UGT1A1 and UGT1A9 Are Responsible for Phase II Metabolism of Tectorigenin and Irigenin In Vitro

Identification of the metabolites produced following Iris tectorum Maxim oral administration and a network pharmacology-based analysis of their potential pharmacological properties

(2021) Jie Liu et al.   XENOBIOTICA

Metabolite identification of iridin in rats by using UHPLC-MS/MS and pharmacokinetic study of its metabolite irigenin

(2021) Tao Hu et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Tectorigenin protects against unilateral ureteral obstruction by inhibiting Smad3‐mediated ferroptosis and fibrosis

(2021) Jianchun Li et al.   PHYTOTHERAPY RESEARCH

Irigenin treatment alleviates doxorubicin (DOX)-induced cardiotoxicity by suppressing apoptosis, inflammation and oxidative stress via the increase of miR-425

(2020) Langtao Guo et al.   BIOMEDICINE & PHARMACOTHERAPY

Tectorigenin Alleviates Inflammation, Apoptosis, and Ossification in Rat Tendon-Derived Stem Cells via Modulating NF-Kappa B and MAPK Pathways

(2020) Safwat Adel Abdo Moqbel et al.   Frontiers in Cell and Developmental Biology

Tectorigenin protects against experimental fulminant hepatic failure by regulating the TLR4/mitogen-activated protein kinase and TLR4/nuclear factor-κB pathways and autophagy

(2019) Lingjian Zhang et al.   PHYTOTHERAPY RESEARCH

Glucosylation and Glutathione Conjugation of Chlorpyrifos and Fluopyram Metabolites Using Electrochemistry/Mass Spectrometry

(2019) Tessema Mekonnen et al.   MOLECULES

Predicting and Understanding the Human Microbiome’s Impact on Pharmacology

(2019) Reese Hitchings et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Current trends in drug metabolism and pharmacokinetics

(2019) Yuhua Li et al.   Acta Pharmaceutica Sinica B

Tectorigenin, an isoflavone aglycone from the rhizome of Belamcanda chinensis , induces neuronal expression of erythropoietin via accumulation of hypoxia‐inducible factor‐1α

(2019) Etta Y. Liu et al.   PHYTOTHERAPY RESEARCH

Human UGT2B7 is the major isoform responsible for the glucuronidation of clopidogrel carboxylate

(2018) Jin-Zi Ji et al.   BIOPHARMACEUTICS & DRUG DISPOSITION

Uridine 5'‑diphospho‑glucronosyltrasferase: Its role in pharmacogenomics and human disease (Review)

(2018) Celia Sanchez‑Dominguez et al.   Experimental and Therapeutic Medicine

Glucuronidation of icaritin by human liver microsomes, human intestine microsomes and expressed UDP-glucuronosyltransferase enzymes: identification of UGT1A3, 1A9 and 2B7 as the main contributing enzymes

(2017) Li Wang et al.   XENOBIOTICA

Belamcanda chinensis (L.) DC-An ethnopharmacological, phytochemical and pharmacological review

(2016) Le Zhang et al.   JOURNAL OF ETHNOPHARMACOLOGY

Irigenin, a novel lead from Western Himalayan chemiome inhibits Fibronectin-Extra Domain A induced metastasis in Lung cancer cells

(2016) Asif Amin et al.   Scientific Reports

Species- and gender-dependent differences in the glucuronidation of a flavonoid glucoside and its aglycone determined using expressed UGT enzymes and microsomes

(2015) Peimin Dai et al.   BIOPHARMACEUTICS & DRUG DISPOSITION

Inhibition screening method of microsomal UGTs using the cocktail approach

(2015) Julieta Gradinaru et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Belamcandae chinensis rhizoma – a review of phytochemistry and bioactivity

(2015) Dorota Woźniak et al.   FITOTERAPIA

Excretion of tectorigenin in rat urine orally administrated at different dosages by ultra-performance liquid chromatography coupled to quadrupole time-of-flight mass spectrometry

(2014) Ziming Shi et al.   EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS

Excretion of tectoridin metabolites in rat urine and bile orally administrated at different dosages and their inhibitory activity against aldose reductase

(2014) Jialin Qu et al.   FITOTERAPIA

Dynamic Changes of Flavonoids Contents in the Different Parts of Rhizome of Belamcanda chinensis During the Thermal Drying Process

(2014) Yan Zhu et al.   MOLECULES

CYP450 1A2 and multiple UGT1A isoforms are responsible for jatrorrhizine metabolism in human liver microsomes

(2013) Hui Zhou et al.   BIOPHARMACEUTICS & DRUG DISPOSITION

The UDP-glucuronosyltransferases: Their role in drug metabolism and detoxification

(2013) Andrew Rowland et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Simultaneous determination of tectorigenin and its metabolites in rat plasma by ultra performance liquid chromatography/quadrupole time-of-flight mass spectrometry

(2013) Shen Wang et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

UDP-glucuronosyltransferase 1A1 is the principal enzyme responsible for puerarin metabolism in human liver microsomes

(2012) Cheng-Feng Luo et al.   ARCHIVES OF TOXICOLOGY

Pharmacokinetics and metabolism of jatrorrhizine, a gastric prokinetic drug candidate

(2012) Rong Shi et al.   BIOPHARMACEUTICS & DRUG DISPOSITION

Effect of Efavirenz on UDP-Glucuronosyltransferase 1A1, 1A4, 1A6, and 1A9 Activities in Human Liver Microsomes

(2012) Hye Young Ji et al.   MOLECULES

Identification of the Human UDP-Glucuronosyltransferases Involved in the Glucuronidation of Combretastatin A-4

(2010) S. Aprile et al.   DRUG METABOLISM AND DISPOSITION

Regioselective Glucuronidation of Tanshinone IIa after Quinone Reduction: Identification of Human UDP-Glucuronosyltransferases, Species Differences, and Interaction Potential

(2010) Q. Wang et al.   DRUG METABOLISM AND DISPOSITION