Article
Multidisciplinary Sciences
David R. Maestas, Liam Chung, Jin Han, Xiaokun Wang, Sven D. Sommerfeld, Sean H. Kelly, Erika Moore, Helen Hieu Nguyen, Joscelyn C. Mejias, Alexis N. Pena, Hong Zhang, Joshua S. T. Hooks, Alexander F. Chin, James I. Andorko, Cynthia A. Berlinicke, Kavita Krishnan, Younghwan Choi, Amy E. Anderson, Ronak Mahatme, Christopher Mejia, Marie Eric, JiWon Woo, Sudipto Ganguly, Donald J. Zack, Liang Zhao, Edward J. Pearce, Franck Housseau, Drew M. Pardoll, Jennifer H. Elisseeff
Summary: The immune system plays an important role in tissue repair. A regenerative immunotherapy using the helminth Schistosoma mansoni soluble egg antigen (SEA) was developed, which stimulates the production of IL-4 and other type 2-associated cytokines. The application of regenerative SEA (rSEA) promotes accumulation of IL-4-expressing T helper cells, eosinophils, and regulatory T cells, leading to improved repair and reduced fibrosis. Encapsulation and controlled release of rSEA in a hydrogel further enhance tissue repair.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Chemistry, Multidisciplinary
Michaela Petaroudi, Aleixandre Rodrigo-Navarro, Oana Dobre, Matthew J. Dalby, Manuel Salmeron-Sanchez
Summary: Living interfaces are a novel class of active materials that allow precise control over cell behavior. This study presents a biointerface between engineered bacteria and mammalian cells, which successfully regulates the stemness markers of human mesenchymal stem cells.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Review
Cell Biology
Yan-Ruide Li, Zachary Spencer Dunn, Yang Zhou, Derek Lee, Lili Yang
Summary: Cell-based cancer immunotherapy has revolutionized the treatment of hematological malignancies, with CAR-T cell therapies achieving unprecedented clinical response rates. The autologous nature of current CAR-T cell products poses challenges, while allogeneic cell products face concerns such as GvHD and allorejection. Advances in developing stem cell-engineered allogeneic cell therapies aim to overcome these limitations.
Review
Biology
Ines E. Dias, Carlos A. Viegas, Joao F. Requicha, Maria J. Saavedra, Jorge M. Azevedo, Pedro P. Carvalho, Isabel R. Dias
Summary: This review article compiles the research conducted over the last two decades on the use of goats as an animal model in preclinical studies involving stem cells for the treatment of injuries or diseases in various organ systems. The findings suggest that the caprine model is particularly suited for studying stem cells in the musculoskeletal system and has limited but significant applications in other fields such as dermatology, ophthalmology, dentistry, pneumology, cardiology, and urology. Mesenchymal stem cells (MSCs) show promise in tissue engineering and regenerative medicine due to their ability to differentiate into different cell types and their immunomodulatory and regenerative properties. Appropriate animal models, such as goats, are essential for the development and evaluation of regenerative medicine treatments and future clinical trials in humans.
Article
Engineering, Biomedical
Michaela Petaroudi, Aleixandre Rodrigo-Navarro, Oana Dobre, Matthew J. Dalby, Manuel Salmeron-Sanchez
Summary: Living biointerfaces are a new type of biomaterials that combine living cells and polymeric matrices to act as instructive materials for surrounding cells. In this study, living biomaterials based on Lactococcus lactis expressing specific genes were used to control hematopoietic stem cells in both 2D and 3D environments. The results showed that these living biomaterials can direct the interaction between stem cells and bacteria, and can significantly expand the population of specific stem cells in 3D hydrogels. The findings suggest the potential of using genetically engineered bacteria-based living materials for ex-vivo expansion of stem cells and clinical applications in hematological disorders.
ADVANCED HEALTHCARE MATERIALS
(2022)
Editorial Material
Multidisciplinary Sciences
Alexander Goedel, Fredrik Lanner
Summary: The molecular mechanisms involved in human gastrulation, a crucial stage in early embryonic development, have been largely elusive, but gene-expression data from a gastrulating human embryo shed light on this process.
Editorial Material
Multidisciplinary Sciences
Leonid A. Mirny
Summary: The study reveals that loop extrusion, essential for chromosome folding and function, also plays a crucial part in repairing double-strand DNA breaks.
Article
Biotechnology & Applied Microbiology
Qiulin He, Junxin Lin, Fanghao Zhou, Dandan Cai, Yiyang Yan, Yejie Shan, Shufang Zhang, Tiefeng Li, Xudong Yao, Hongwei Ouyang
Summary: Nonuniform microstretching (NUMS), a natural phenomenon in bone tissues, promotes osteogenic differentiation and has potential positive effects on bone healing.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2022)
Review
Engineering, Biomedical
Yaron Bram, Duc-Huy T. Nguyen, Vikas Gupta, Jiwoon Park, Chanel Richardson, Vasuretha Chandar, Robert E. Schwartz
Summary: Liver disease is a significant clinical issue affecting 600 million people worldwide. Liver transplantation, although the gold standard treatment for liver failure, currently meets less than 10% of the global demand due to a shortage of available organs. Cell- and tissue-based therapies offer a promising alternative to organ transplantation.
ANNUAL REVIEW OF BIOMEDICAL ENGINEERING, VOL 23, 2021
(2021)
Editorial Material
Multidisciplinary Sciences
Alison Abbott
Summary: Researchers are interested in understanding the reasons behind cell secretion of vesicles and the functions of these vesicles during delivery.
Review
Veterinary Sciences
Hussein M. M. El-Husseiny, Eman A. A. Mady, Mahmoud A. Y. Helal, Ryou Tanaka
Summary: The use of stem cells in veterinary practice is rapidly evolving, with significant research efforts focused on both experimental animals and clinical cases. Stem cells, particularly mesenchymal stem cells (MSCs), are promising for therapeutic applications due to their immunomodulatory capabilities and ease of isolation. However, challenges remain in their clinical implementation for treating various animal diseases, driving further advancements in stem cell therapies.
VETERINARY SCIENCES
(2022)
Review
Cell Biology
Daria D. Linkova, Yulia P. Rubtsova, Marfa N. Egorikhina
Summary: The review summarizes the development of cryopreservation techniques for mesenchymal stem cells (MSCs), revealing a wide variety of protocols for different types of MSCs and tissue-engineered structures. While there is extensive research on cryopreserving cell suspensions, there is limited literature on freezing intact tissues or tissue-engineered structures.
Review
Immunology
Lea Rimailho, Carla Faria, Marcin Domagala, Camille Laurent, Christine Bezombes, Mary Poupot
Summary: Despite advancements in therapy and increased survival rates, B cell malignancies often lead to relapse. Immune cell-based therapies, particularly γδ T cells, show promising results for cancer immunotherapy. Manipulating γδ T cells through immunotherapeutic approaches provides potential treatment strategies for B cell malignancies.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Biotechnology & Applied Microbiology
Yun-Feng Zhou, Di Zhang, Wan-Ting Yan, Kai Lian, Zheng-Zheng Zhang
Summary: This article reviews the therapeutic potential of multipotent stromal cells (MSCs) in repairing meniscal injuries and discusses the avenues for utilizing these cells. The current progress on biomaterial implants is also reviewed.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Cell & Tissue Engineering
Christofer Baldwin, Johntaehwan Kim, Srikanth Sivaraman, Raj R. Rao
Summary: Skeletal muscle tissue engineering has been a focus in developing regenerative strategies for injured or degenerative skeletal muscle tissue. Stem cells have gained attention as potential sources for developing skeletal muscle tissue. Understanding the molecular pathways that govern skeletal muscle formation in development is key to advancing stem cell differentiation.
JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Rebecca M. Tashiro, Joshua G. Philips, Christopher S. Winefield
MOLECULAR GENETICS AND GENOMICS
(2016)
Article
Multidisciplinary Sciences
Joshua G. Philips, Fatima Naim, Michal T. Lorenc, Kevin J. Dudley, Roger P. Hellens, Peter M. Waterhouse
Review
Plant Sciences
Julia Bally, Hyungtaek Jung, Cara Mortimer, Fatima Naim, Joshua G. Philips, Roger Hellens, Aureliano Bombarely, Michael M. Goodin, Peter M. Waterhouse
ANNUAL REVIEW OF PHYTOPATHOLOGY, VOL 56
(2018)
Article
Plant Sciences
Joshua G. Philips, Kevin J. Dudley, Peter M. Waterhouse, Roger P. Hellens
FRONTIERS IN PLANT SCIENCE
(2019)
Article
Plant Sciences
Ronan C. Broad, Julien P. Bonneau, Jesse T. Beasley, Sally Roden, Joshua G. Philips, Ute Baumann, Roger P. Hellens, Alexander A. T. Johnson
Article
Plant Sciences
Joshua G. Philips, Walftor Dumin, Christopher Winefield
FRONTIERS IN PLANT SCIENCE
(2019)
Review
Medicine, General & Internal
Gabrielle M. O'Sullivan, Joshua G. Philips, Heidi J. Mitchell, Michael Dornbusch, John E. J. Rasko
Summary: Since 2001, gene technology in Australia has been regulated under a legislated national Gene Technology Regulatory Scheme, which aims to assess the potential risks of gene technology to human health and the environment. This scheme works alongside the Australian Therapeutic Goods Administration to ensure the safety and efficacy of therapeutic products. Recent reforms to the scheme aim to facilitate the safe development and delivery of gene-based human therapeutics in Australia, serving as a model for other jurisdictions.
FRONTIERS IN MEDICINE
(2022)
Article
Biotechnology & Applied Microbiology
Joshua G. Philips, Elena Martin-Avila, Andrea V. Robold
Summary: This review provides updated evidence on the likelihood, factors, and barriers for horizontal gene transfer in genetically modified plants, and presents the legislation and frameworks followed by the Australian Gene Technology Regulator in considering the risks posed by horizontal gene transfer.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
