Transcriptome-Wide Mapping of Small-Molecule RNA-Binding Sites in Cells Informs an Isoform-Specific Degrader of QSOX1 mRNA

Reimagining Druggability Using Chemoproteomic Platforms

(2021) Jessica N. Spradlin et al.   ACCOUNTS OF CHEMICAL RESEARCH

Reprogramming of Protein-Targeted Small-Molecule Medicines to RNA by Ribonuclease Recruitment

(2021) Peiyuan Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Chemical profiling of DNA G-quadruplex-interacting proteins in live cells

(2021) Xiaoyun Zhang et al.   Nature Chemistry

A chemical probe based on the PreQ1 metabolite enables transcriptome-wide mapping of binding sites

(2021) Sumirtha Balaratnam et al.   Nature Communications

Small-molecule targeted recruitment of a nuclease to cleave an oncogenic RNA in a mouse model of metastatic cancer

(2020) Matthew G. Costales et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Translation of the intrinsically disordered protein α-synuclein is inhibited by a small molecule targeting its structured mRNA

(2020) Peiyuan Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PEARL-seq: A Photoaffinity Platform for the Analysis of Small Molecule-RNA Interactions

(2020) Herschel Mukherjee et al.   ACS Chemical Biology

Perspectives on targeting RNA with small molecules to capture opportunities at the intersection of chemistry, biology, and medicine

(2019) Matthew D. Disney   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A cross-linking approach to map small molecule-RNA binding sites in cells

(2019) Sai Pradeep Velagapudi et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Molecular Inhibitor of QSOX1 Suppresses Tumor Growth in vivo

(2019) Amber L Fifield et al.   MOLECULAR CANCER THERAPEUTICS

R-BIND: An Interactive Database for Exploring and Developing RNA-Targeted Chemical Probes

(2019) Brittany S. Morgan et al.   ACS Chemical Biology

Expedited mapping of the ligandable proteome using fully functionalized enantiomeric probe pairs

(2019) Yujia Wang et al.   Nature Chemistry

High expression of QSOX1 is associated with tumor invasiveness and high grades groups in prostate cancer

(2018) Jin A. Baek et al.   PATHOLOGY RESEARCH AND PRACTICE

Mechanistic studies of a small-molecule modulator of SMN2 splicing

(2018) Jingxin Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Discovery of Risdiplam, a Selective Survival of Motor Neuron-2 (SMN2) Gene Splicing Modifier for the Treatment of Spinal Muscular Atrophy (SMA)

(2018) Hasane Ratni et al.   JOURNAL OF MEDICINAL CHEMISTRY

High-throughput determination of RNA structures

(2018) Eric J. Strobel et al.   NATURE REVIEWS GENETICS

ScanFold: an approach for genome-wide discovery of local RNA structural elements—applications to Zika virus and HIV

(2018) Ryan J. Andrews et al.   PeerJ

Inforna 2.0: A Platform for the Sequence-Based Design of Small Molecules Targeting Structured RNAs

(2016) Matthew D. Disney et al.   ACS Chemical Biology

Small-molecule approaches toward the targeting of oncogenic miRNAs: roadmap for the discovery of RNA modulators

(2016) Audrey Di Giorgio et al.   Future Medicinal Chemistry

Structural imprints in vivo decode RNA regulatory mechanisms

(2015) Robert C. Spitale et al.   NATURE

Single-nucleotide-resolution mapping of m6A and m6Am throughout the transcriptome

(2015) Bastian Linder et al.   NATURE METHODS

Reprogramming the Mechanism of Action of Chlorambucil by Coupling to a G-Quadruplex Ligand

(2014) Marco Di Antonio et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structure of Human RNase L Reveals the Basis for Regulated RNA Decay in the IFN Response

(2014) Y. Han et al.   SCIENCE

Covalent Small-Molecule-RNA Complex Formation Enables Cellular Profiling of Small-Molecule-RNA Interactions

(2013) Lirui Guan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

In vivo genome-wide profiling of RNA secondary structure reveals novel regulatory features

(2013) Yiliang Ding et al.   NATURE

Understanding the transcriptome through RNA structure

(2011) Yue Wan et al.   NATURE REVIEWS GENETICS

A Modular Approach to Synthetic RNA Binders of the Hepatitis C Virus Internal Ribosome Entry Site

(2010) Maia Carnevali et al.   CHEMBIOCHEM