Review
Critical Care Medicine
Jan Gunst, Michael. P. P. Casaer, Jean-Charles Preiser, Jean Reignier, Greet van den Berghe
Summary: Recent randomized controlled trials have shown that early full nutritional support does not benefit critically ill patients and may cause harm. The absence of benefit may not be due to low nutritional risk patients or low amino acid doses, as previously hypothesized. Mechanistic studies suggest that the lack of benefit is due to anabolic resistance and suppression of recovery-enhancing pathways induced by feeding. Large randomized controlled trials have not investigated the impact of different feeding strategies initiated after the acute phase in patients recovering from critical illness.
Article
Pediatrics
Ying Lin, Xiaomin Wang, Lingyan Li, Yun Gou, Liping Zhang, Lijing Wang, Junhong Yang
Summary: This study aimed to understand the characteristics of children with feed intolerance (FI) and identify the factors predicting FI in critically ill children. The study found that higher PIM3 score, mechanical ventilation (MV), sepsis, hypokalemia, and lower PaO2 were independent risk factors for FI, whereas higher albumin was an independent protective factor for FI.
EUROPEAN JOURNAL OF PEDIATRICS
(2023)
Article
Nutrition & Dietetics
Dimitrios Karayiannis, Sotirios Kakavas, Aikaterini Sarri, Vassiliki Giannopoulou, Christina Liakopoulou, Edison Jahaj, Aggeliki Kanavou, Thodoris Pitsolis, Sotirios Malachias, George Adamos, Athina Mantelou, Avra Almperti, Konstantina Morogianni, Olga Kampouropoulou, Anastasia Kotanidou, Zafeiria Mastora
Summary: This study describes the feeding practices of intubated COVID-19 patients during their second week of hospitalization and finds that enteral feeding may be associated with a shorter duration of hospitalization and mechanical ventilation support.
Article
Health Care Sciences & Services
Yisong Cheng, Chaoyue Chen, Hao Yang, Min Fu, Xi Zhong, Bo Wang, Zhi Hu, Min He, Zhongwei Zhang, Xiaodong Jin, Yan Kang, Qin Wu
Summary: This study compared the efficacy and safety of domperidone administered via the feeding tube versus intravenous metoclopramide in critically ill patients with EFI. The findings suggest that tube feeding domperidone was more effective in improving enteral nutrition delivery performance in these patients.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Nutrition & Dietetics
Guangxuan Lv, Tao Zhang, Luping Wang, Xin Fu, Yucong Wang, Hua Yao, Huang Fang, Xiaoxiao Xia, Jing Yang, Bo Wang, Zhongwei Zhang, Xiaodong Jin, Yan Kang, Yisong Cheng, Qin Wu
Summary: This study developed a technique to assess the feasibility of predicting the efficacy of prokinetic agents in critically ill patients. The results showed that gastric antrum echodensity can predict the effectiveness of prokinetic agents. The findings of this study can assist clinicians in deciding whether to use prokinetic agents when feeding intolerance occurs in critically ill patients.
FRONTIERS IN NUTRITION
(2023)
Article
Nutrition & Dietetics
Hong-Yeul Lee, Jung-Kyu Lee, Hye-Jin Kim, Dal-Lae Ju, Sang-Min Lee, Jinwoo Lee
Summary: Continuous enteral feeding has been shown to be more effective in achieving target nutrition, especially in patients receiving mechanical ventilation.
Article
Nutrition & Dietetics
R. D. Eveleens, J. M. Hulst, B. A. E. de Koning, J. van Brakel, D. Rizopoulos, G. Garcia Guerra, I Vanhorebeek, G. Van den Berghe, K. F. M. Joosten, S. C. A. T. Verbruggen
Summary: This study evaluated the associations between enteral nutrition (EN) intake in critically ill children during the first week and patient characteristics, clinical characteristics, and clinical outcomes. The results showed that various patient and clinical characteristics were related to EN intake, but there were no independent associations found between EN intake and clinical outcomes such as mortality, new acquired infection, and duration of stay.
CLINICAL NUTRITION
(2021)
Article
Critical Care Medicine
Daren K. Heyland, Alfonso Ortiz, Christian Stoppe, Jayshil J. Patel, D. Dante Yeh, George Dukes, Yaozhu J. Chen, Cristina Almansa, Andrew G. Day
Summary: This study found that enteral feed intolerance is common in critically ill patients and is associated with more severe illnesses and worse clinical outcomes.
CRITICAL CARE MEDICINE
(2021)
Article
Nutrition & Dietetics
Montserrat Sierra-Colomina, Nagam Anna Yehia, Farhan Mahmood, Christopher Parshuram, Haifa Mtaweh
Summary: The utilization of noninvasive ventilation (NIV) in pediatric intensive care units (PICUs) to support children with respiratory failure has increased, but there is variation in the practice of initiating enteral nutrition (EN) due to safety concerns. This retrospective study found that early enteral feeding in children on NIV was associated with a lower rate of respiratory complications and shorter ICU stays.
Article
Nutrition & Dietetics
Orit Raphaeli, Liran Statlender, Chen Hajaj, Itai Bendavid, Anat Goldstein, Eyal Robinson, Pierre Singer
Summary: This study assessed the association between gastrointestinal intolerance and adverse clinical outcomes in critically ill patients using machine learning algorithms. It found that gastric residual volume was an important predictor for both poor outcomes and early enteral nutrition failure. Early recognition of at-risk patients is essential.
Review
Critical Care Medicine
Aaron J. Heffernan, C. Talekar, M. Henain, L. Purcell, M. Palmer, H. White
Summary: This meta-analysis compares continuous enteral feeding with intermittent or bolus administration methods and finds no clinically relevant differences in most outcome measures relevant to the care of critically ill patients. However, there is a lack of high-quality randomized controlled clinical trials to guide this decision.
Article
Critical Care Medicine
Ichiro Osawa, Norihiko Tsuboi, Hisataka Nozawa, Nao Nishimura, Satoshi Nakagawa
Summary: This study evaluated the effect of ultrasound-guided postpyloric feeding tube placement in critically ill children and found a significantly higher first-pass success rate and shorter median insertion time with no complications. Further investigation with a larger pool of operators and randomized controlled patient assignment is needed.
PEDIATRIC CRITICAL CARE MEDICINE
(2021)
Article
Medicine, General & Internal
Chang-Jie Ren, Bo Yao, Miao Tuo, Hui Lin, Xiang-Yu Wan, Xu-Feng Pang
Summary: In this non-inferiority study, the average blood glucose in SF was not inferior to that in CF. The incidence of hyperglycemia was higher in the CF group than in the SF group. There was no significant difference in feeding intolerance between SF and CF.
CHINESE MEDICAL JOURNAL
(2021)
Review
Nursing
Fang Peng, Huaqin Wang, Jianzhi Li, Mengqi Ma, Xuemeng Jiang, Han Run, Qingting Li, Juanjuan Leng, Luwei Xiao, Li Tang
Summary: This study evaluates and summarizes the evidence for prevention and management of enteral feeding intolerance in critically ill patients, providing reference for clinical practice.
JOURNAL OF CLINICAL NURSING
(2023)
Review
Nursing
Ting Liu, Ping Feng, Can Wang, Omorogieva Ojo, Yu-yu Wang, Xiao-hua Wang
Summary: This study aimed to explore the effects of dietary fibre on enteral feeding intolerance and clinical outcomes in critically ill patients. The results showed that the dietary fibre group had a significantly decreased risk of diarrhea, regurgitation, vomiting, constipation, and mortality, as well as shorter time to reach full enteral nutrition, duration of intensive care unit stay, and hospital stay.
INTENSIVE AND CRITICAL CARE NURSING
(2023)
Article
Biotechnology & Applied Microbiology
Komathi Perumal, Kein Seong Mun, Ning Yi Yap, Azad Hassan Abdul Razack, Glenda Carolyn Gobe, Teng Aik Ong, Shanggar Kuppusamy, Retnagowri Rajandram
BIOMED RESEARCH INTERNATIONAL
(2020)
Article
Multidisciplinary Sciences
Christudas Morais, Retnagowri Rajandram, Jade S. Blakeney, Abishek Iyer, Jacky Y. Suen, David W. Johnson, Glenda C. Gobe, David P. Fairlie, David A. Vesey
Summary: The expression of PAR2 is decreased in renal cell carcinoma compared with normal kidney tissue, suggesting that PAR2 may not be a promising target for the treatment of this type of cancer.
Article
Surgery
Jun Kit Koong, Retnagowri Rajandram, Naveendran Sidambram, Vairavan Narayanan
Summary: This study aimed to assess the effectiveness of handouts in improving postoperative consent understanding and recall compared to standard verbal consent. The results showed no significant difference in understanding between the two groups, but there was a significant decline in recall of specific consent items over time in both groups. Handouts may have increased patient satisfaction, but did not improve recall.
SURGEON-JOURNAL OF THE ROYAL COLLEGES OF SURGEONS OF EDINBURGH AND IRELAND
(2022)
Article
Surgery
C. A. Chai, W. S. Yeoh, R. Rajandram, K. P. Aung, T. A. Ong, S. Kuppusamy, A. Nazran, K. Kumaran, A. H. A. Razack, J. Y. Teoh
Summary: The study found that CxBladder had high negative predictive value (NPV) and sensitivity in predicting suspicious cystoscopy findings, indicating its potential as an adjunct to cystoscopy for monitoring NMIBC.
FRONTIERS IN SURGERY
(2021)
Review
Critical Care Medicine
Lingwei Wong, Retnagowri Rajandram, Nikki Allorto
Summary: This study aimed to compare the timing of early excision in burn surgery and associated outcomes in low income countries (LICs) and high income countries (HICs). The findings show that early excision leads to shorter length of stay (LOS) for patients, while late excision has lower mortality rates in both LICs and HICs. Additionally, early excision reduces the occurrence of sepsis.
Article
Public, Environmental & Occupational Health
Chee Ken Chan, Thian Yin Lam, Kanesh Kumaran Seevalingam, Retnagowri Rajandram, Shanggar Kuppusamy
ASIA-PACIFIC JOURNAL OF PUBLIC HEALTH
(2022)
Article
Endocrinology & Metabolism
Retnagowri Rajandram, Jun K. Koong, Kia F. Quek, Eng G. Lee, Azad H. A. Razack, Shanggar Kuppusamy
Summary: This study investigated factors contributing towards differences in testosterone concentration in multiethnic Malaysian men with multiple comorbidities. The results showed that Malaysian men of Malay origin had lower testosterone concentration compared with Indian and Chinese men. Waist circumference and low high-density lipoprotein levels were also associated with lower testosterone concentrations.
CLINICAL ENDOCRINOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Ruth Naomi, Hasnah Bahari, Zhi Yi Ong, Yong Yoke Keong, Hashim Embong, Retnagowri Rajandram, Soo Huat Teoh, Fezah Othman, Rosnani Hasham, Khoo Boon Yin, Priyatharisni Kaniappan, Muhammad Dain Yazid, Zainul Amiruddin Zakaria
Summary: This article provides an overview of the medicinal chemistry and pharmacology of Andrographis paniculata and its active compounds in terms of anti-cancer activity, primary mechanism of action, and cellular targets, particularly in the lipid-dependent cancer pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Ruth Naomi, Muhammad Dain Yazid, Hasnah Bahari, Yong Yoke Keong, Retnagowri Rajandram, Hashim Embong, Soo Huat Teoh, Shariff Halim, Fezah Othman
Summary: This review paper explores the impact of BPA on obesity and potential cardiovascular complications. By analyzing relevant studies, it is found that BPA exposure may lead to obesity and potentially affect lipid profile and genes associated with lipolysis in in vivo trials.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Surgery
Shu Yu Lim, Retnagowri Rajandram, April Camilla Roslani
Summary: This study investigated the effectiveness of hemorrhoidal artery ligation supplementation in reducing post-operative bleeding in patients undergoing laser hemorrhoidoplasty. The results showed that the supplementation did not reduce the incidence of post-operative bleeding, indicating that laser hemorrhoidoplasty alone is sufficient for treating hemorrhoids.
Article
Biotechnology & Applied Microbiology
Ning Yi Yap, Teng Aik Ong, Jayalakshmi Pailoor, Glenda Gobe, Retnagowri Rajandram
Summary: CD14 nuclear immunostaining in the RCC kidney and serum sCD14 are significantly associated with RCC stage and adverse survival prognosis, indicating their potential role in tumor progression and prognosis.
Article
Oncology
Thinisha Sathis Kumar, Wan Muhammad Afnan, Chet-Ying Chan, Christine Audrey, Si-Lei Fong, Retnagowri Rajandram, Kheng-Seang Lim, Vairavan Narayanan
Summary: This study retrospectively analyzed the incidence of seizures and the impact of anti-seizure medication on survival in patients with glioma. The results showed that pre-operative seizures indicated a better overall prognosis, and the use of medications like levetiracetam significantly improved survival rates in glioma patients.
JOURNAL OF NEURO-ONCOLOGY
(2022)
Review
Medicine, General & Internal
Sugania Malar Chinapayan, Shanggar Kuppusamy, Ning Yi Yap, Komathi Perumal, Glenda Gobe, Retnagowri Rajandram
Summary: Renal cell carcinoma is the most lethal genitourinary malignancy, and obesity is a risk factor for its development. This systematic review and meta-analysis found that visfatin and nesfatin-1 showed significant associations with RCC, indicating their potential role in the development and progression of the disease, as well as their potential diagnostic and prognostic capabilities.
Article
Medicine, General & Internal
Vethunan Tamalvanan, Retnagowri Rajandram, Shanggar Kuppusamy
Summary: Pain control plays a crucial role in the successful clearance of stones during extracorporeal shockwave lithotripsy (ESWL) for urolithiasis. Patient factors, such as gender, age, body habitus, and anxiety level, as well as stone-related factors like size, laterality, and location, can influence pain perception during ESWL. This study investigates the impact of patient and stone factors on pain perception during ESWL, with a focus on procedural anxiety in the first and subsequent sessions. It was found that pre-procedural anxiety significantly affects pain scores during the first ESWL session, and anxiety-reducing methods should be explored to minimize unnecessary analgesic use.
Review
Pathology
Snehlata Samberkar, Retnagowri Rajandram, Kein-Seong Mun, Prashant Samberkar, Mahmoud Danaee, Intan Suhana Binti Zulkafli
MALAYSIAN JOURNAL OF PATHOLOGY
(2019)
Article
Critical Care Medicine
Christina Boncyk, Kimberly Rengel, Joanna Stollings, Matt Marshall, Xiaoke Feng, Matthew Shotwell, Pratik P. Pandharipande, Christopher G. Hughes
Summary: This study describes the incidence and factors associated with recurrent delirium in the intensive care unit (ICU). The researchers found that over 10% of delirious ICU patients experienced recurrent symptoms, and factors such as age, duration of mechanical ventilation, and medication exposure were associated with recurrence.
JOURNAL OF CRITICAL CARE
(2024)
Article
Critical Care Medicine
Thomas C. Rollinson, Luke A. McDonald, Joleen Rose, Glenn Eastwood, Rahul Costa-Pinto, Lucy Modra, Akinori Maeda, Zoe Bacolas, James Anstey, Samantha Bates, Scott Bradley, Jodi Dumbrell, Craig French, Angaj Ghosh, Kimberley Haines, Tim Haydon, Carol L. Hodgson, Jennifer Holmes, Nina Leggett, Forbes McGain, Cara Moore, Kathleen Nelson, Jeffrey Presneill, Hannah Rotherham, Simone Said, Meredith Young, Peinan Zhao, Andrew Udy, Ary Serpa Neto, Anis Chaba, Rinaldo Bellomo
Summary: Neuromuscular blockers (NMBs) used during prone positioning in COVID-19 ARDS patients can improve oxygenation and have a sustained effect upon returning to supine position.
JOURNAL OF CRITICAL CARE
(2024)
Article
Critical Care Medicine
Kyung Hun Nam, Jason Phua, Bin Du, Shinichiro Ohshimo, Hwa Jung Kim, Chae-Man Lim, Sheila Nainan Myatra, Nik Azman Bin Nik Adib, Yaseen M. Arabi, Ming-Cheng Chan, Mohammad Omar Faruq, Ike Sri Redjeki, Do Ngoc Son, Khalid Mahmood Khan Nafees, Dilshan Priyankara, Boonsong Patjanasoontorn, Jose Emmanuel Palo, Aidos Konkayev, Gentle Sunder Shrestha, Younsuck Koh
Summary: This study investigated the current practices of mechanical ventilation in Asian intensive care units. The results showed that low tidal volume ventilation and sufficient PEEP were underused in patients with ARDS, while intermediate tidal volumes were commonly used in patients without ARDS. Country income, age, and severity of illness were associated with mortality.
JOURNAL OF CRITICAL CARE
(2024)
Article
Critical Care Medicine
Rudolf Likar, Ilia Aroyo, Katrin Bangert, Bjorn Degen, Rainer Dziewas, Oliver Galvan, Michaela Trapl Grundschober, Markus Kostenberger, Paul Muhle, Joerg C. Schefold, Patrick Zuercher
Summary: This article presents expert opinions on the diagnosis and management of dysphagia in ICU patients. The panel suggests adopting clinical algorithms to promote standardized and high-quality care, and proposes two clinical management algorithms to improve early detection and effective treatment of dysphagia in ICU patients.
JOURNAL OF CRITICAL CARE
(2024)
Article
Critical Care Medicine
Pawel Pasieka, Anna Surowka, Jakub Fronczek, Evan Skwara, Miroslaw Czuczwar, Michal Borys, Pawel Krawczyk, Miroslaw Zietkiewicz, Lukasz R. Nowak, Maciej Zukowski, Katarzyna Kotfis, Katarzyna Cwyl, Jacek Skowronek, Joanna Solek-Pastuszka, Jowita Biernawska, Pawel Grudzien, Pawel Nasilowski, Natalia Popek, Waldemar Cyrankiewicz, Katarzyna Sierakowska, Wojciech Mudyna, Szymon Bialka, Dorota Studzinska, Szymon Bernas, Mariusz Piechota, Waldemar Machala, Lukasz Sadowski, Jan Stefaniak, Radoslaw Owczuk, Malgorzata Szymkowiak, Ryszard Gawda, Natalia Kozera, Barbara Adamik, Waldemar Gozdzik, Agnieszka Wieczorek, Jaroslaw Janc, Anna Kluzik, Janusz Trzebicki, Pawel Zatorski, Wojciech Gola, Hubert Hymczak, Lukasz J. Krzych, Szymon Czajka, Urszula Kosciuczuk, Bartosz Kudlinski, Hans Flaatten, Wojciech Szczeklik
Summary: The study aims to evaluate whether there is an increased propensity to limit life-sustaining treatment (LST) among elderly patients in Poland from 2018-2019 compared to 2016-2017. The results show that clinicians in Poland have become more proactive in limiting LST in critically ill patients aged 80 and above during the studied period, although the prevalence of LST limitations in Poland remains low.
JOURNAL OF CRITICAL CARE
(2024)
Article
Critical Care Medicine
Jihad Mallat, Malcolm Lemyze, Marc-Olivier Fischer
Summary: In mechanically ventilated patients with acute circulatory failure, changes in PVI induced by PLR accurately predict fluid responsiveness.
JOURNAL OF CRITICAL CARE
(2024)
Article
Critical Care Medicine
Jingyuan Xu, Yanjie Zhang, Jie Jiang, Yi Yang, Fengmei Guo
Summary: This meta-analysis examined the effect of milrinone on prognosis in adult critically ill patients and found a significant decrease in the incidence of ventricular arrhythmia in patients with cardiac surgery. However, there was no significant reduction in all-cause mortality or the incidence of myocardial infarction. More research is needed to determine the reliable and conclusive evidence for the effects of milrinone.
JOURNAL OF CRITICAL CARE
(2024)
Article
Critical Care Medicine
Zhi-Tao Li, Da-Bing Huang, Jian-Feng Zhao, Hui Li, Shui-Qiao Fu, Wei Wang
Summary: Venous congestion is associated with AKI after cardiac surgery, but not necessarily with CRRT. Among the markers tested, IRVF exhibits the strongest correlation with AKI.
JOURNAL OF CRITICAL CARE
(2024)
Article
Critical Care Medicine
Sarah E. Nelson, Spyridoula Tsetsou, John Liang
Summary: This article discusses a range of issues associated with tracking CLABSI and CAUTI metrics, including lack of evidence, moral distress, and definition problems. It recommends forming a task force consisting of key stakeholders to improve the use of these metrics.
JOURNAL OF CRITICAL CARE
(2024)
Article
Critical Care Medicine
Ross Prager, Eric Walser, Kaan Y. Balta, Anton Nikouline, William R. Leeper, Kelly Vogt, Neil Parry, Robert Arntfield
Summary: Resuscitative TEE has been shown to be a valuable diagnostic tool in trauma care, with the potential to impact treatment strategies and diagnostic approaches for patients in the trauma bay.
JOURNAL OF CRITICAL CARE
(2024)
Article
Critical Care Medicine
Jaeyun Sung, Sanu S. Rajendraprasad, Kemuel L. Philbrick, Brent A. Bauer, Ognjen Gajic, Aditya Shah, Krzysztof Laudanski, Johan S. Bakken, Joseph Skalski, Lioudmila V. Karnatovskaia
Summary: With a large number of cells and genes, the human gut microbiome is crucial for health and disease. Modern living disrupts the balance between the host and its microbiome, leading to adverse impacts on critical illness and patient outcomes. Restoring the gut microbiome shows promise for preventing and treating critical illnesses.
JOURNAL OF CRITICAL CARE
(2024)
Article
Critical Care Medicine
Claire Chaignat, Laurent Lagrost, Karena Moretto, Jean-Paul Pais de Barros, Hadrien Winiszewski, Jacques Grober, Philippe Saas, Gael Piton
Summary: The aim of this study was to investigate the correlation between plasma citrulline levels and plasma lipopolysaccharide (LPS) concentration, as well as the impact of sepsis on gut function in critically ill patients. The results showed no correlation between plasma citrulline concentration and plasma LPS concentration or activity. However, septic patients had significantly lower plasma citrulline levels. Additionally, abdominal sepsis was associated with higher plasma LPS activity compared to extra-abdominal sepsis.
JOURNAL OF CRITICAL CARE
(2024)
Article
Critical Care Medicine
Pyoung Jik Lee, Thomas Hampton
Summary: This study found that smartphone applications with low-cost external microphones can reliably measure average noise levels in both laboratory and field settings, but show significant differences compared to professional equipment when measuring maximum noise levels.
JOURNAL OF CRITICAL CARE
(2024)
Article
Critical Care Medicine
Greg Roberts, James S. Krinsley, Jean-Charles Preiser, Stephen Quinn, Peter R. Rule, Michael Brownlee, Guillermo E. Umpierrez, Irl B. Hirsch
Summary: Relative hypoglycemia was commonly seen in patients with HbA1c ≥ 8% and was independently associated with mortality. Absolute hypoglycemia was associated with mortality regardless of HbA1c.
JOURNAL OF CRITICAL CARE
(2024)
Article
Critical Care Medicine
Katsura Hayakawa, Shigehiko Uchino, Hideki Endo, Kazuki Hasegawa, Kazuya Kiyota
Summary: This study assessed the performance of the APACHE III and JROD models under different conditions of missing variables and found that a higher number of missing physiological variables led to underestimated predicted mortality rates and higher standardized mortality ratios.
JOURNAL OF CRITICAL CARE
(2024)
