Review
Surgery
Jia Chen, Hongyan Liu, Siliang Man, Geng Liu, Quan Li, Qingyao Zuo, Lili Huo, Wei Li, Wei Deng
Summary: This meta-analysis evaluated the efficacy and safety of endoscopic transsphenoidal surgery (ETS) and microscopic transsphenoidal surgery (MTS) for patients with pituitary adenomas. The results showed no significant difference in tumor removal and hormone-excess secretion remission between ETS and MTS. However, ETS was associated with a lower incidence of diabetes insipidus, hypothyroidism, and septal perforation compared to MTS.
FRONTIERS IN SURGERY
(2022)
Article
Medicine, General & Internal
Chao Tao, Gang Cheng, Yunxiang Chen, Peiyuan Gu, Weixing Hu
Summary: This study retrospectively reviewed the tumor characteristics and surgical outcomes of a consecutive series of endoscopic endonasal approach pituitary adenomas resection mainly performed by a single author between March 2018 and June 2019. The results demonstrated that EEA is an effective and safe approach for resecting pituitary adenomas with satisfactory gross total resection rate, near-total resection rate, and endocrinological remission rate, while maintaining minimal nasal injury.
Article
Clinical Neurology
Ryan Delport, James King, Mendel Castle-Kirszbaum, Tony Goldschlager, Carmela Caputo, Yi Yuen Wang
Summary: This study aimed to determine if resection of pituitary adenomas via the endoscopic endo-nasal approach (EEA) improves headaches and investigate factors that may be associated with headaches in patients with pituitary adenoma. The results showed that surgery using this method can significantly improve headaches and patients with cavernous sinus invasion are more likely to experience improvement in headaches.
WORLD NEUROSURGERY
(2023)
Article
Clinical Neurology
Iyan Younus, Mina Gerges, Theodore H. Schwartz, Rohan Ramakrishna
Summary: Patients with Medicaid insurance undergoing endonasal endoscopic transsphenoidal surgery for pituitary adenoma tend to have larger tumor diameter, longer postoperative length of stay, higher rate of complications, and increased likelihood of long-term cranial neuropathy. However, there were no statistically significant differences in baseline comorbidities, apoplexy, endocrine outcome, vision outcome, or 30-day readmission.
JOURNAL OF NEUROSURGERY
(2021)
Article
Oncology
Andrej Pala, Andreas Knoll, Max Schneider, Gwendolin Etzrodt-Walter, Georg Karpel-Massler, Christian Rainer Wirtz, Michal Hlavac
Summary: IMRI-assisted transsphenoidal surgery can improve the surgical treatment of recurrent adenomas by increasing the extent of resection. Tumor volume and microscopic technique are significantly associated with further resection after IMRI.
Article
Oncology
Xiaoyu Ji, Xinyu Zhuang, Siyuan Yang, Kai Zhang, Xiaozhe Li, Kun Yuan, Xiaofeng Zhang, Xuebo Sun
Summary: The purpose of this study was to analyze and predict the likelihood of visual field recovery after endoscopic transsphenoidal surgery (ETSS) in patients with pituitary adenoma. The study investigated factors that affect the improvement of visual field defects (VFD) and built a predictive nomogram model based on these risk factors. The study also identified specific recovery regions of the visual field associated with VFD improvement.
FRONTIERS IN ONCOLOGY
(2023)
Article
Clinical Neurology
Penelope Trimpou, Erika Backlund, Oskar Ragnarsson, Thomas Skoglund, Tobias Hallen, Gunnhildur Gudnadottir, Jeanette Carlqvist, Dan Farahmand
Summary: This study compared the outcomes of endoscopic and microscopic surgical approaches for the treatment of Cushing's disease. It found no difference in remission, recurrence, and complication rates between the two approaches. Additionally, the endoscopic group had a shorter postoperative hospital stay, possibly due to the minimally invasive nature of the endoscopic approach.
WORLD NEUROSURGERY
(2022)
Review
Otorhinolaryngology
Zaid Al-Qurayshi, Douglas M. Bennion, Jeremy D. W. Greenlee, Scott M. Graham
Summary: This study provides a national epidemiological perspective on transsphenoidal approach for pituitary tumors surgery in the United States. The risk of postoperative cerebrospinal fluid (CSF) leak appears to be associated with intrinsic patient factors rather than hospital volume and teaching status.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2022)
Article
Endocrinology & Metabolism
Juan Manuel Canelo Moreno, Elena Dios Fuentes, Eva Venegas Moreno, Pablo Jesus Remon Ruiz, Cristina Munoz Gomez, Ana Pinar Gutierrez, Eugenio Cardenas Valdepenas, Ariel Kaen, Alfonso Soto Moreno
Summary: This study aimed to investigate the prevalence and predictive factors of water and electrolyte disturbances in patients undergoing surgery with an extended endoscopic endonasal approach. The study found a high prevalence of electrolyte disturbances, with most cases being transient hypotonic polyuria and a smaller proportion being transient or permanent diabetes insipidus.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Oncology
Mingjian Lin, Wenbo Wang, Lejian Tang, Yunxiang Zhou, Wencai Li, Jing Xiao, Zhizhu Peng, Xuewei Xia
Summary: The suprasellar extension (SSE) value on sagittal MRI can predict the risk of intracranial infection in patients with suprasellar extended pituitary adenoma after endoscopic endonasal transsphenoidal resection (EETA). Neurosurgeons should pay attention to the imaging characteristics of pituitary adenomas and select appropriate treatment plans based on intraoperative conditions to reduce the incidence of intracranial infection.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2023)
Article
Clinical Neurology
Mendel Castle-Kirszbaum, Yi Yuen Wang, James King, Tony Goldschlager
Summary: Surgery for pituitary adenoma is effective for relieving mass effect and controlling endocrinopathy. Preoperative factors can predict the outcome of endocrine function and visual improvement after surgery, with most patients maintaining normal endocrine function postoperatively if it was normal preoperatively. Surgery is a safe and effective therapy for pituitary adenomas, with nearly all patients experiencing improvement in visual fields.
NEUROSURGICAL REVIEW
(2022)
Editorial Material
Clinical Neurology
Baha'eddin A. Muhsen, Edinson Najera, Zachary Cappello, Hamid Borghei-Razavi, Pablo F. Recions
Summary: This article discusses the surgical challenges and higher surgical complications associated with giant pituitary adenoma compared to non-giant pituitary adenoma. Symptoms arise from compression of neighboring structures as well as hypopituitarism. The endoscopic endonasal approach is an effective method for tumor resection, but the treatment of high-flow cerebrospinal fluid leak should be taken into consideration.
CLINICAL NEUROLOGY AND NEUROSURGERY
(2023)
Article
Clinical Neurology
Penelope Trimpou, Erika Backlund, Oskar Ragnarsson, Thomas Skoglund, Tobias Hallen, Gunnhildur Gudnadottir, Jeanette Carlqvist, Dan Farahmand
Summary: This study compared the outcomes of endoscopic and microscopic surgery for Cushing's disease over a 15-year period, finding no significant differences in remission, recurrence, and complication rates between the two techniques. However, the endoscopic group had a shorter postoperative hospital stay.
WORLD NEUROSURGERY
(2022)
Article
Medicine, Research & Experimental
Bita Naimi, Alexander Duffy, Emily Garvey, Zachary Urdang, Douglas Farquhar, Patrick Kelly, Christopher Farrell, Mindy Rabinowitz, Marc Rosen, Elina Toskala, James Evans, Gurston Nyquist
Summary: This study investigates national trends in transsphenoidal approaches to pituitary tumors and compares the outcomes of microscopic approach (MA) and endoscopic approach (EA) from 2010 to 2021. The results show an increasing adoption of EA since 2013, and overall improved complication rates for EA compared to MA, potentially due to improving surgeon familiarity and experience.
Article
Neurosciences
Chuan Shao, Junwei Wang, Pan Wang, Nan Wu
Summary: Retrospective analysis was conducted on patients with Cushing's disease (CD) who underwent endoscopic transsphenoidal surgery (ETS) with a layered peel strategy. The study found a low rate of surgical complications postoperatively and no recurrence events during follow-up. However, further studies are needed to confirm the effectiveness and safety of this approach due to the limited number of cases.
Article
Oncology
Yang Gao, Liangdong Li, Hui Zheng, Changshuai Zhou, Xin Chen, Bin Hao, Yiqun Cao
JOURNAL OF NEURO-ONCOLOGY
(2020)
Article
Cell Biology
Yang Gao, Hui Zheng, Liangdong Li, Mingtao Feng, Xin Chen, Bin Hao, Zhongwei Lv, Xiaoyan Zhou, Yiqun Cao
Summary: This study found that high expression of PSMA in GBM is associated with poor prognosis, promoting angiogenesis in GBM by enhancing proliferation, invasion, and tube formation ability of HUVECs. PSMA may promote angiogenesis in GBM by interacting with ITGB4 and activating the NF-kappa B signaling pathway.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Yuchen Pei, Chang Liu, Mingtao Feng, Liangdong Li, Changshuai Zhou, Lei Chen, Xin Hu, Shaoli Song, Yiqun Cao, Yang Gao
Summary: Brain metastases (BMs) of lung cancer are intracranial tumors with poor prognosis and severe neurological symptoms. This study investigated the expression of prostate-specific membrane antigen (PSMA) in BMs using 68Ga-PSMA PET/CT and immunohistochemical staining. It was found that PSMA was highly expressed in BMs and might be regulated by ATF3 and NR4A1 factors associated with ER stress.
TRANSLATIONAL ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Wenjing Tu, Hui Zheng, Liangdong Li, Changshuai Zhou, Mingtao Feng, Lei Chen, Deheng Li, Xin Chen, Bin Hao, Huaping Sun, Yiqun Cao, Yang Gao
Summary: This study demonstrates that the GBM-secreted cytokine SPP1 regulates the expression of PSMA in human umbilical vein endothelial cells (HUVECs) through the transcription factor HIF1 alpha, and promotes cell migration and tube formation. SPP1 is abundantly expressed in GBM, associated with poor prognosis, and has high clinical diagnostic value. These findings provide insight into the angiogenic process and promising candidates for targeted GBM therapy.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2023)
