Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 87, Issue 14, Pages 9270-9281Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.2c01005
Keywords
-
Categories
Funding
- Guangdong Basic and Applied Basic Research Foundation [2021A1515010012]
- Guangzhou Scienti fi c Planning Program [202102020805]
Ask authors/readers for more resources
A copper-mediated tandem decarboxylative coupling/annulation protocol was developed for the synthesis of 3-indolmethyl-chromones, with up to 97% yield. A one-pot method from o-hydroxy acetophenones, N, N-dimethylformamide dimethyl acetal, and 3-indoleacetic acids was also achieved. Derivatization of the products yielded various indolmethyl-substituted pyrimidines, some of which exhibited anti-influenza viral activities.
Here, we describe a copper-mediated tandem decarboxylative coupling/annulation protocol of o-hydroxyaryl enaminones with 3-indoleacetic acids. A series of 3-indolmethyl-chromones were afforded in up to 97% yield. A one-pot method for 3-indolmethyl-chromones from o-hydroxy acetophenones, N, N-dimethylformamide dimethyl acetal, and 3-indoleacetic acids was also developed. Derivatization of the products was conducted to provide various indolmethyl-substituted pyrimidines. Moreover, a biological evaluation revealed that some compounds had anti-influenza viral activities.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available