Article
Oncology
Brian De, Rituraj Upadhyay, Kaiping Liao, Tiffany Kumala, Christopher Shi, Grace Dodoo, Joseph Abi Jaoude, Kelsey L. Corrigan, Gohar S. Manzar, Kathryn E. Marqueen, Vincent Bernard, Sunyoung S. Lee, Kanwal P. S. Raghav, Jean-Nicolas Vauthey, Ching-Wei Tzeng, Hop Tran S. Cao, Grace Lee, Jennifer Wo, Theodore S. Hong, Christopher H. Crane, Bruce D. Minsky, Grace L. Smith, Emma B. Holliday, Cullen M. Taniguchi, Albert C. Koong, Prajnan Das, Milind Javle, Ethan B. Ludmir, Eugene Koay
Summary: Tumor-related liver failure (TRLF) is the leading cause of death in patients with intrahepatic cholangiocarcinoma (ICC). The role of liver radiotherapy (L-RT) for patients with extrahepatic metastatic disease (M1) remains undefined. This study aimed to compare outcomes for M1 ICC patients treated with and without L-RT.
Article
Gastroenterology & Hepatology
Yeon Seung Chung, Youngsic Jeon, Jeong Eun Yoo, Taek Chung, Hyang Joo Ryu, Hyunki Kim, Hyungjin Rhee, Young Nyun Park
Summary: In this study, a method was developed to differentiate intrahepatic cholangiocarcinomas (iCCAs) from adenocarcinomas originating from extrahepatic organs adjacent to the liver. The combination of albumin mRNA in situ hybridization (ISH) and immunohistochemistry (IHC) staining for filamin-A and cytokeratin 19 (CK19) showed better diagnostic performance than albumin ISH alone. The newly developed iCCA-score consisting of these three markers can accurately differentiate iCCA from extrahepatic adenocarcinomas.
HEPATOLOGY INTERNATIONAL
(2023)
Article
Medicine, General & Internal
Wei-Wen Liu, Jian-Fei Tu, Xi-Hui Ying, Zheng-Ju Chen, Yun-Bing Wang
Summary: The study aimed to clarify the difference between extrahepatic cholangiocarcinoma (ECC) and intrahepatic cholangiocarcinoma (ICC) in postoperative cancer-specific death. The study found that there was no difference in postoperative cancer-specific death between ECC and ICC, both in the natural state and in multiple variable-matched conditions.
Article
Oncology
Kristen Spencer, Leontios Pappas, Islam Baiev, Jordan Maurer, Andrea Grace Bocobo, Karen Zhang, Apurva Jain, Anaemy Danner De Armas, Stephanie Reyes, Tri Minh Le, Osama E. Rahma, Jennifer Stanton, Thomas T. DeLeon, Marc Roth, Mary Linton B. Peters, Andrew X. Zhu, Jochen K. Lennerz, A. John Iafrate, Kylie Boyhen, Christine VanCott, Lewis R. Roberts, Stacie Lindsey, Nora Horick, Laura Williams Goff, Kabir Mody, Mitesh J. Borad, Rachna T. Shroff, Robin Kate Kelley, Milind M. Javle, Lipika Goyal
Summary: This study compares the treatment patterns for intrahepatic cholangiocarcinoma (ICC) and extrahepatic cholangiocarcinoma (ECC) and finds differences between them. Patients with ECC are less likely to undergo molecular profiling and receive targeted therapy and clinical trial enrollment. The prognosis for both subtypes of cholangiocarcinoma remains poor and new effective targeted therapies and broader access to clinical trials are needed.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2023)
Article
Oncology
Bo Wu, Yang Bai, Shi'an Yu
Summary: This study reports a case of synchronous primary malignant tumor of the left hepatic and common bile ducts, which was successfully treated with laparoscopic left hemihepatectomy and pancreaticoduodenectomy. There were no complications post-operation and the pathology confirmed the origin of the tumor. Laparoscopic hepatopancreatoduodenectomy appears to be a safe and feasible treatment for synchronous primary cholangiocarcinoma.
Article
Biotechnology & Applied Microbiology
Zefeng Shen, Jingwei Cai, Liye Tao, Junhao Zheng, Zhengtao Ye, Yang Liu, Haoyu Pan, Yali Wang, Junjie Xu, Xiao Liang
Summary: This study systematically and comprehensively explored cuproptosis in intrahepatic cholangiocarcinoma (ICC) for the first time. The researchers identified diagnostic and treatment strategies for ICC patients prone to cuproptosis and further investigated the intracellular and extracellular mechanisms of ICC cells prone to cuproptosis.
CANCER GENE THERAPY
(2023)
Article
Gastroenterology & Hepatology
Qianyi Lin, Jianjun Chen, Kangde Li, Junxing Yang, Xiaofeng Luo, Qi Cai, Weihong Lin, Guanjing Peng, Dexiong Chen, Chunhong Qin, Tao He, Zhenlong Wang
Summary: The impact of lymphadenectomy (LND) on clinical outcomes in ICC patients aged >= 70 years was investigated in this study. The results showed that LND can prolong overall survival and be beneficial for appropriately selected elderly populations.
JOURNAL OF GASTROINTESTINAL SURGERY
(2023)
Article
Medicine, General & Internal
Peng Liao, Li Cao, Hang Chen, Shui-Zi Pang
Summary: This study is the first to compare metastasis and survival rates between ECCA and ICCA, showing an inverse relationship between age and metastasis, better prognosis for patients with ECCA compared to ICCA, and better survival for ICCA patients in the T1 stage than ECCA patients in the T1 stage.
Article
Medicine, General & Internal
Lipika Goyal, Funda Meric-Bernstam, Antoine Hollebecque, Juan W. Valle, Chigusa Morizane, Thomas B. Karasic, Thomas A. Abrams, Junji Furuse, Robin K. Kelley, Philippe A. Cassier, Heinz-Josef Kluempen, Heung-Moon Chang, Li-Tzong Chen, Josep Tabernero, Do-Youn Oh, Amit Mahipal, Markus Moehler, Edith P. Mitchell, Yoshito Komatsu, Kunihiro Masuda, Daniel Ahn, Robert S. Epstein, Abdel-Baset Halim, Yao Fu, Tehseen Salimi, Volker Wacheck, Yaohua He, Mei Liu, Karim A. Benhadji, John A. Bridgewater
Summary: In this study, 103 patients with FGFR2-altered intrahepatic cholangiocarcinoma were treated with futibatinib for a median duration of 17.1 months. The results showed that futibatinib treatment could effectively inhibit tumor growth, improve survival, and maintain quality of life for patients.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Review
Medicine, General & Internal
Sudha Kodali, Akshay Shetty, Soumya Shekhar, David W. Victor, Rafik M. Ghobrial
Summary: Cholangiocarcinoma, a tumor arising from differentiation of cholangiocytes, can develop anywhere in the biliary tree. Early diagnosis allows for surgical resection, while late-stage intrahepatic cholangiocarcinoma cases may require chemotherapy, locoregional therapies, and radiation as treatment options.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Oncology
Yuki Bekki, Dagny Von Ahrens, Hideo Takahashi, Myron Schwartz, Ganesh Gunasekaran
Summary: Understanding the risk factors, patterns, and treatment options for intrahepatic cholangiocarcinoma recurrence is crucial for tailoring postoperative surveillance and selecting treatment strategies. Re-resection may be considered for selected patients at experienced centers, potentially leading to long-term survival. ICC remains a challenging disease, but advances in understanding its genomic landscape are paving the way for personalized treatment options.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Daisuke Nagashima, Minoru Esaki, Satoshi Nara, Daisuke Ban, Takeshi Takamoto, Takahiro Mizui, Kazuaki Shimada, Nobuyoshi Hiraoka
Summary: In this study, the presence of intraepithelial spread (IES) was evaluated in 382 cases of extrahepatic cholangiocarcinoma (eCCA) and compared with other biliary tract cancers (BTCs). The results showed that IPNB had a higher rate of IES compared to conventional eCCAs, and the presence of IES was associated with a higher survival rate in distal eCCAs. The extension of IES also varied depending on the tumor location and type among BTCs.
FRONTIERS IN ONCOLOGY
(2023)
Review
Oncology
Mackenzie Owen, Mina S. Makary, Eliza W. Beal
Summary: This review examines locoregional therapy approaches for intrahepatic cholangiocarcinoma and summarizes the current literature. Locoregional therapies include thermal ablation, transarterial chemoembolization, transarterial radioembolization, external beam radiotherapy, stereotactic body radiotherapy, hepatic arterial infusion of chemotherapy, irreversible electroporation, and brachytherapy. These therapies are effective in prolonging overall survival and further research is needed to determine their comparative efficacy and optimal treatment strategies.
Review
Oncology
Amram Kupietzky, Arie Ariche
Summary: This paper reviews the surgical management of intrahepatic cholangiocarcinoma (ICC), highlighting surgical resection as the only curative treatment for ICC.
Article
Gastroenterology & Hepatology
Fernando Carapeto, Behnaz Bozorgui, Rachna T. Shroff, Sharmeen Chagani, Luisa Solis Soto, Wai Chin Foo, Ignacio Wistuba, Funda Meric-Bernstam, Ahmed Shalaby, Milind Javle, Anil Korkut, Lawrence N. Kwong
Summary: This study integrated immunohistochemistry with next-generation sequencing to analyze intrahepatic CCA samples and found that T-cell and immune checkpoint markers were enriched at tumor margins compared to the center. High PD-1 or LAG-3 and low CD3/CD4/ICOS in the tumor center were associated with poor survival. Loss-of-function mutations in BRCA1-associated protein-1 were associated with elevated expression of the immunosuppressive checkpoint marker B7-H4.
Article
Gastroenterology & Hepatology
Mathew Vithayathil, Scott Smith, Sergey Goryachev, Jennifer Nayor, Mingyang Song
Summary: This study established a cohort study using natural language processing to analyze a large dataset of over 300,000 colonoscopies, revealing that around one-third of the examinations showed patients with colorectal adenomas or serrated polyps, with a small percentage developing metachronous cancers or high-risk polyps. The cohort provides essential infrastructure for future research to enhance understanding of colorectal cancer's natural history and improve screening and post-polypectomy strategies.
DIGESTIVE DISEASES AND SCIENCES
(2022)
Article
Medicine, General & Internal
Mathew Vithayathil, Paul Carter, Siddhartha Kar, Amy M. Mason, Stephen Burgess, Susanna C. Larsson
Summary: The study showed that BMI is a causal risk factor for some cancers, with body fat potentially playing a role in the development of specific cancers. Public health strategies should focus on reducing obesity as a risk factor for cancer, but the benefits may be limited to certain cancers.
Article
Gastroenterology & Hepatology
Mathew Vithayathil, Ines Modolell, Jacobo Ortiz-Fernandez-Sordo, Dahmane Oukrif, Apostolos Pappas, Wladyslaw Januszewicz, Maria O'Donovan, Andreas Hadjinicolaou, Michele Bianchi, Adrienn Blasko, Jonathan White, Philip Kaye, Marco Novelli, Lorenz Wernisch, Krish Ragunath, Massimiliano di Pietro
Summary: The study compared the diagnostic accuracy of AFI-guided pCLE with molecular biomarkers and HRWLE with Seattle protocol biopsies for inconspicuous dysplasia in Barrett's esophagus. The results showed similar sensitivity between the two methods, but the addition of molecular biomarkers could improve the detection sensitivity for different grades of dysplasia.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Oncology
Shuai Yuan, Amy M. Mason, Paul Carter, Mathew Vithayathil, Siddhartha Kar, Stephen Burgess, Susanna C. Larsson
Summary: The study found that high selenium status may not prevent cancer development, and genetically predicted blood selenium levels showed suggestive associations with the risk of kidney cancer and multiple myeloma. Further studies are needed to verify these associations.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Endocrinology & Metabolism
Susanna C. Larsson, Siddhartha Kar, John R. B. Perry, Paul Carter, Mathew Vithayathil, Amy M. Mason, Douglas F. Easton, Stephen Burgess
Summary: This Mendelian randomization study found that higher levels of endogenous 17 beta-estradiol (E2) were associated with increased risk of estrogen receptor-positive breast cancer and endometrioid subtype of endometrial cancer, but no significant association was found with other cancers.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Gastroenterology & Hepatology
Mathew Vithayathil, John Bridgewater, Shahid A. Khan
JOURNAL OF HEPATOLOGY
(2021)
Article
Nutrition & Dietetics
Susanna C. Larsson, Amy M. Mason, Mathew Vithayathil, Paul Carter, Siddhartha Kar, Ju-Sheng Zheng, Stephen Burgess
Summary: The Mendelian randomization study suggests that vitamin C may play a role in the prevention of small intestine and colorectal cancer.
CLINICAL NUTRITION
(2022)
Article
Nutrition & Dietetics
Paul Carter, Shuai Yuan, Siddhartha Kar, Mathew Vithayathil, Amy M. Mason, Stephen Burgess, Susanna C. Larsson
Summary: This Mendelian randomisation study investigated the causal associations of coffee consumption with various cancers. The results showed that coffee consumption was associated with an increased risk of oesophageal cancer, but not with the majority of other cancer types. However, coffee consumption was associated with an increased risk of multiple myeloma and a reduced risk of ovarian cancer.
CLINICAL NUTRITION
(2022)
Article
Oncology
Shuai Yuan, Amy M. Mason, Olga E. Titova, Mathew Vithayathil, Siddhartha Kar, Jie Chen, Xue Li, Stephen Burgess, Susanna C. Larsson
Summary: Morning chronotype is associated with a reduced risk of digestive tract cancer, particularly stomach and colorectal cancers. This Mendelian randomization study provides evidence of the association between morning chronotype and digestive tract cancer.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Oncology
Mathew Vithayathil, Scott Smith, Mingyang Song
Summary: This study analyzed a large cohort of colonoscopy patients to characterize the epidemiological profiles of serrated polyps (SPs) and compare them to conventional adenomas. The study found differences in subsite distribution and prevalence of polyps among different age groups, which has implications for improving colonoscopy screening and surveillance, as well as understanding the etiological heterogeneity of colorectal cancer.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Gastroenterology & Hepatology
Mathew Vithayathil, Antonio D'Alessio, Claudia A. M. Fulgenzi, Naoshi Nishida, Martin Schoenlein, Johann von Felden, Kornelius Schulze, Henning Wege, Anwaar Saeed, Brooke Wietharn, Hannah Hildebrand, Linda Wu, Celina Ang, Thomas U. Marron, Arndt Weinmann, Peter R. Galle, Dominik Bettinger, Bertram Bengsch, Arndt Vogel, Lorenz Balcar, Bernhard Scheiner, Pei-Chang Lee, Yi-Hsiang Huang, Suneetha Amara, Mahvish Muzaffar, Abdul Rafeh Naqash, Antonella Cammarota, Nicola Personeni, Tiziana Pressiani, Matthias Pinter, Alessio Cortellini, Masatoshi Kudo, Lorenza Rimassa, David J. Pinato, Rohini Sharma
Summary: This study investigated the efficacy and safety of combination therapy with atezolizumab and bevacizumab in older patients with hepatocellular carcinoma. The results showed that there were no significant differences in treatment outcomes and safety between older and younger patients.
LIVER INTERNATIONAL
(2022)
Article
Rheumatology
Shuai Yuan, Jie Chen, Xixian Ruan, Mathew Vithayathil, Siddhartha Kar, Xue Li, Amy M. Mason, Stephen Burgess, Susanna C. Larsson
Summary: This study suggests that rheumatoid arthritis may play a role in the development of several site-specific cancers.
ARTHRITIS RESEARCH & THERAPY
(2022)
Meeting Abstract
Gastroenterology & Hepatology
Claudia Moore-Gillon, Alex Cole, Maria Bashyam, Mathew Vithayathil, Rooshi Nathwani, David Koeckerling, Sujit Mukherjee, Benjamin H. Mullish, Maud Lemoine, Lucia Possamai, Heather Lewis, Nowlan Selvapatt, Ameet Dhar
JOURNAL OF HEPATOLOGY
(2022)
Meeting Abstract
Gastroenterology & Hepatology
Mathew Vithayathil, Antonio D'Alessio, Arndt Weinmann, Peter Galle, Claudia Angela Maria Fulgenzi, Petros Fessas, Dominik Bettinger, Bertram Bengsch, Arndt Vogel, Lorenz Balcar, Bernhard Scheiner, Mahvish Muzaffar, Suneetha Amara, Ambreen Muhammed, Abdul Rafeh Naqash, Nicola Personeni, Tiziana Pressiani, Antonella Cammarota, Matthias Pinter, Alessio Cortellini, Lorenza Rimassa, David J. Pinato, Rohini Sharma
JOURNAL OF HEPATOLOGY
(2022)
