Protective effects of Liensinine, Isoliensinine, and Neferine on PC12 cells injured by amyloid‐β

Silenced lncRNA H19 and up-regulated microRNA-129 accelerates viability and restrains apoptosis of PC12 cells induced by Aβ25-35 in a cellular model of Alzheimer’s disease

(2021) Yan-Yun Zhang et al.   CELL CYCLE

New Tyramine- and Aporphine-Type Alkamides with NO Release Inhibitory Activities from Piper puberulum

(2021) Yuan-kun Zheng et al.   JOURNAL OF NATURAL PRODUCTS

Neferine Protects against Hypoxic-Ischemic Brain Damage in Neonatal Rats by Suppressing NLRP3-Mediated Inflammasome Activation

(2021) Jin-jin Zhu et al.   Oxidative Medicine and Cellular Longevity

Trilobatin Protects Against Aβ25–35-Induced Hippocampal HT22 Cells Apoptosis Through Mediating ROS/p38/Caspase 3-Dependent Pathway

(2020) Nana Chen et al.   Frontiers in Pharmacology

Neferine, a bisbenzylisoquinoline alkaloid of Nelumbo nucifera, inhibits glutamate release in rat cerebrocortical nerve terminals through 5-HT1A receptors

(2020) Kun Chieh Yeh et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Methyl B12 protects PC12 cells against cytotoxicity induced by Aβ25−35

(2019) Mingkai Wang et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Major compounds of red ginseng oil attenuate Aβ25–35-induced neuronal apoptosis and inflammation by modulating MAPK/NF-κB pathway

(2018) Seonah Lee et al.   Food & Function

Mitochondrial protective effect of neferine through the modulation of nuclear factor erythroid 2-related factor 2 signalling in ischaemic stroke

(2018) Chuanhong Wu et al.   BRITISH JOURNAL OF PHARMACOLOGY

Inhibitory effects of three bisbenzylisoquinoline alkaloids on lipopolysaccharide-induced microglial activation

(2017) Xue-Lian Meng et al.   RSC Advances

Human Ether-à-go-go Related Gene (hERG) Channel Blocking Aporphine Alkaloids from Lotus Leaves and Their Quantitative Analysis in Dietary Weight Loss Supplements

(2015) Ulrike Grienke et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

A simple U-HPLC-MS/MS method for the determination of liensinine and isoliensinine in rat plasma

(2015) Li-Sheng Peng et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Simultaneous determination of liensinine, isoliensinine and neferine in rat plasma by UPLC–MS/MS and application of the technique to pharmacokinetic studies

(2015) Guoxin Hu et al.   JOURNAL OF ETHNOPHARMACOLOGY

Serotonergic mechanisms are involved in antidepressant-like effects of bisbenzylisoquinolines liensinine and its analogs isolated from the embryo ofNelumbo nucifera Gaertner seeds in mice

(2015) Yumi Sugimoto et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Ceramides in Alzheimer’s Disease: Key Mediators of Neuronal Apoptosis Induced by Oxidative Stress and AβAccumulation

(2015) Maja Jazvinšćak Jembrek et al.   Oxidative Medicine and Cellular Longevity

Amyloid-β and Tau

(2014) George S. Bloom   JAMA Neurology

The many faces of calmodulin in cell proliferation, programmed cell death, autophagy, and cancer

(2013) Martin W. Berchtold et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Structural studies on the regulation of Ca2+/calmodulin dependent protein kinase II

(2013) Margaret M Stratton et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

The interaction between human breast cancer resistance protein (BCRP) and five bisbenzylisoquinoline alkaloids

(2013) Ye Tian et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Protective Effects of Alkaloid Compounds from Nelumbinis Plumula on tert-Butyl Hydroperoxide-Induced Oxidative Stress

(2013) Yong Xie et al.   MOLECULES

Screening calmodulin-binding ligands using intensity-fading matrix-assisted laser desorption/ionization mass spectrometry

(2013) Lei Ma et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

New cholinesterase inhibiting bisbenzylisoquinoline alkaloids from Abuta grandifolia

(2011) Maria Francesca Cometa et al.   FITOTERAPIA

Anti-amnesic activity of neferine with antioxidant and anti-inflammatory capacities, as well as inhibition of ChEs and BACE1

(2010) Hyun Ah Jung et al.   LIFE SCIENCES

Deregulation of sphingolipid metabolism in Alzheimer's disease

(2008) Xingxuan He et al.   NEUROBIOLOGY OF AGING

The release of calcium from the endoplasmic reticulum induced by amyloid-beta and prion peptides activates the mitochondrial apoptotic pathway

(2008) Elisabete Ferreiro et al.   NEUROBIOLOGY OF DISEASE

Calcium and apoptosis: ER-mitochondria Ca2+ transfer in the control of apoptosis

(2008) P Pinton et al.   ONCOGENE