pH-responsive and enzymatically-responsive hydrogel microparticles for the oral delivery of therapeutic proteins: Effects of protein size, crosslinking density, and hydrogel degradation on protein delivery

Published 2016 View Full Article

Authors

Keywords

Oral drug delivery, pH-responsive hydrogels, Protein therapeutics, Itaconic acid, Isoelectric point, Enzyme-responsive, Crosslinking density, Salmon calcitonin, Rituxan, Urokinase

Journal

JOURNAL OF CONTROLLED RELEASE

Volume 221, Issue -, Pages 18-25

Publisher

Elsevier BV

Online

2015-12-02

DOI

10.1016/j.jconrel.2015.11.023

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