Article
Medicine, Research & Experimental
Yanhao Zhang, Hao Zhang, Ji Wang, Chao Liu, Hanlei Xing, Yuhao Jiang, Xinsong Li
Summary: A reduction-responsive DTX prodrug encapsulated within HSA nanoparticles was developed for improved cancer treatment. The nanoparticles exhibited good stability and high drug-loading efficiency, and showed prolonged circulation time and superior tumor growth inhibition in vivo. Therefore, DTX-SS-COOH/HSA NPs represent a promising nanoformulation for clinical application.
MOLECULAR PHARMACEUTICS
(2023)
Article
Biochemical Research Methods
Wisnu Arfian A. Sudjarwo, Mathias Thomas Dobler, Peter A. Lieberzeit
Summary: Solid-phase synthesis produces small molecularly imprinted polymer nanoparticles that selectively bind to human serum albumin, allowing for competitive QCM-based assays with low detection limits and high recovery rates.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Jimin Park, Mi-Sun Kim, Taeseong Park, Young Hwan Kim, Dong Hae Shin
Summary: Pharmaceutical-grade HSA has altered oxidative and ligand-binding properties compared to native HSA, which provides important insights for the production of p-HSA solutions and HSA-based biomaterials with higher biorelevance.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Chemistry, Physical
Jinjun Tian, Zhenghai Shi, Gongke Wang
Summary: In this study, the binding interaction between silver nanoparticles and human serum albumin was investigated. The results showed that the interaction is driven by entropy, leading to conformational changes in the protein and a decrease in alpha-helix content. Additionally, the binding followed pseudo-second-order kinetics and fit the Freundlich model for multilayer adsorption.
Article
Biotechnology & Applied Microbiology
Jyotsna Thayath, Keechilat Pavithran, Shantikumar Nair, Manzoor Koyakutty
Summary: The study team developed a method to convert total blood serum into chemo drug-loaded nanoparticles and demonstrated its significant antitumor efficacy in vitro and in vivo.
Article
Pharmacology & Pharmacy
Soniya Kumbham, Milan Paul, Asif Itoo, Balaram Ghosh, Swati Biswas
Summary: Combination chemotherapy with self-assembled nanoparticles of human serum albumin and oleanolic acid, entrapping doxorubicin, demonstrated superior therapeutic effects in vitro and in vivo, with increased cellular uptake, apoptosis induction, and tumor regression. It could be a powerful treatment strategy for solid tumors.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Review
Polymer Science
Viktoria Hornok
Summary: This paper summarizes the research results on serum albumin-based nanoparticles for drug delivery purposes, focusing on their preparation techniques, synthesis parameters, and successful clinical applications. Despite promising possibilities, products made from different types of albumin nanoparticles, with the exception of a few, have not been invented yet. The paper also discusses promising applications of serum albumin nanoparticles for various biomedical purposes, such as carriers, delivery systems, and contrast agents.
Article
Chemistry, Multidisciplinary
Chihiro Mochizuki, Junna Nakamura, Michihiro Nakamura
Summary: Researchers successfully prepared adhesive cell-like FBS-copper phosphate hybrid particles, which showed toxicity towards cancer cells under cell culture conditions and have great potential for various applications.
Article
Biochemistry & Molecular Biology
Soniya Kumbham, Adrija Ghosh, Balaram Ghosh, Swati Biswas
Summary: Oral cancer is a prevalent malignancy worldwide. Researchers developed a biocompatible tumor-targeted nanoformulation by conjugating human serum albumin with poly(lactide) for efficient loading of the hydrophobic drug, DTX. The nanoformulation showed stable drug incorporation, improved cell internalization, and long circulation, demonstrating its potential as an effective nanomedicine for oral cancer treatment.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Pharmacology & Pharmacy
Sofia Mickaela Martinez, Ayelen Inda, Alida Marina Garcia, Jose Maria Bermudez, Elio Emilio Gonzo, Rocio Herrero-Vanrell, Jose Domingo Luna, Daniel Alberto Allemandi, Daniela Alejandra Quinteros
Summary: This study successfully obtained nanoparticulate systems loaded with melatonin through an improved desolvation method. The systems exhibited favorable physicochemical and pharmacotechnical parameters and showed stability in drug delivery. Furthermore, the formulation demonstrated good biocompatibility without irritation when administered topically.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Agriculture, Multidisciplinary
Ronggang Liu, Kangjing Liu, Guoxin Cui, Mingqian Tan
Summary: Nanoparticles can form protein coronas with plasma proteins, and the presence of protein coronas mitigates the cytotoxicity of nanoparticles on cells.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Review
Pharmacology & Pharmacy
Milan Paul, Asif Mohd Itoo, Balaram Ghosh, Swati Biswas
Summary: This review highlights the importance of albumin as a drug carrier in nanomedicine, as well as the methods for preparing albumin nanoparticles. Albumin exhibits excellent biocompatibility and tumor targeting, making it a promising carrier for nanomedicine.
EXPERT OPINION ON DRUG DELIVERY
(2022)
Article
Cell Biology
Hao Wu, Yijun Chu, Shanshan Sun, Guozheng Li, Shouping Xu, Xianyu Zhang, Yongdong Jiang, Song Gao, Qin Wang, Jian Zhang, Da Pang
Summary: This study found that hypoxia-induced HIF-1 alpha upregulated C1QBP, which when inhibited, notably blocked the metastasis of TNBC cells and increased their sensitivity to PTX under hypoxic conditions. Depletion of C1QBP decreased VCAM-1 expression by reducing the amount of P65 in the nucleus and suppressed the activation of hypoxia-induced PKC-NF-kappa B signaling. Targeting C1QBP along with PTX treatment could be a potential treatment for TNBC patients.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Microbiology
Yu Zhang, Yan-Chao Liu, Si-Min Chen, Hui Zong, Wei-Tong Hou, Xi-Ran Qiu, Shi-Yu Guo, Yu-Fang Sun, Yuan-Ying Jiang, Mao-Mao An, Hui Shen
Summary: This study aimed to develop anidulafungin-loaded Human Serum Albumin nanoparticles to enhance its solubility and antifungal efficacy. The results showed that the nanoparticles improved water solubility of anidulafungin, exhibited stronger antifungal effects in vitro, and prolonged survival time in a murine model of invasive candidiasis compared to the free drug. The developed nanoparticles have the potential to improve drug administration and therapeutic outcomes for fungal diseases.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Food Science & Technology
Kang Ma, Han Chen, Ke Wang, Xue Han, Yue Zhang, Hui Wang, Zhiqiang Hu, Jing Wang
Summary: In this study, it was found that pterostilbene (PTE) can inhibit the metastasis of triple negative breast cancer (TNBC) by reversing the epithelial to mesenchymal transition (EMT) and suppressing stemness. PTE can also inhibit the lung metastasis of TNBC by suppressing the nuclear translocation of beta-catenin.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Biochemistry & Molecular Biology
Milan Paul, Asif Mohd Itoo, Balaram Ghosh, Swati Biswas
Summary: Hypoxia is a key characteristic of the tumor microenvironment and affects various aspects of cancer, including cell proliferation, metastasis, and therapy resistance. A nanomicellar system that generates oxygen through near-infrared light activation was developed for the treatment of oral squamous cell carcinoma. The system showed significant potential in chemo-photodynamic combination therapy, effectively reversing hypoxia in oral cancer models.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
(2023)
Review
Chemistry, Medicinal
Suvankar Banerjee, Sandip Kumar Baidya, Nilanjan Adhikari, Tarun Jha, Balaram Ghosh
Summary: Epigenetic modulations by HDACs are associated with various diseases. Developing specific HDAC inhibitors with high potency and selectivity, such as hydrazide-based compounds, is crucial for the treatment of diverse diseases. This article provides detailed information on the structure-activity relationship of existing hydrazide-based HDAC inhibitors, which can be utilized for the development of promising drug candidates in the future.
CURRENT TOPICS IN MEDICINAL CHEMISTRY
(2023)
Article
Polymer Science
Tarun Patel, Asif Mohd Itoo, Milan Paul, Likhitha Purna Kondapaneni, Balaram Ghosh, Swati Biswas
Summary: A pH-sensitive nanoaggregate was developed by covalently linking a methoxy(polyethylene glycol)(hydrazone)block(hydroxypropyl methacrylamide) to gemcitabine. The nanoaggregate formed spherical structures in an aqueous environment. The nanoaggregate exhibited a lower IC50 and induced DNA damage, cell-growth arrest, and apoptosis in breast cancer cells, suggesting its potential as a safe and effective treatment option.
EUROPEAN POLYMER JOURNAL
(2023)
Review
Chemistry, Medicinal
Srinidhi Rajaraman, Ranjani Balakrishnan, Dhruv Deshmukh, Abhiram Ganorkar, Swati Biswas, Sravani Pulya, Balaram Ghosh
Summary: HDAC8 is responsible for removing acetyl groups from both histones and nonhistone proteins. Abnormal expression of HDAC8 is associated with various diseases, including cancer, myopathies, Cornelia de Lange syndrome, renal fibrosis, and viral and parasitic infections. HDAC8 substrates play important roles in cancer-related processes such as cell proliferation, invasion, metastasis, and drug resistance. This article focuses on the importance, recent advancements, and the structural and functional aspects of HDAC8, with a special emphasis on the medicinal chemistry of HDAC8 inhibitors for the development of novel epigenetic therapeutics.
FUTURE MEDICINAL CHEMISTRY
(2023)
Article
Chemistry, Physical
Suvankar Banerjee, Sandip Kumar Baidya, Nilanjan Adhikari, Balaram Ghosh, Tarun Jha
Summary: COVID-19 is a devastating global disease with high transmissibility and mutations, and the lack of potential therapeutics has made it a crisis. Natural molecules, such as glycyrrhizin and its derivatives, show promise as a therapeutic strategy against COVID-19. This review discusses the therapeutic implications of glycyrrhizin and its derivatives, as well as their potential role in traditional Chinese medicine. Derivatization of glycyrrhizin and combination therapy with other anti-SARS-CoV-2 agents could lead to the development of novel treatments for COVID-19.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Chemistry, Multidisciplinary
S. Banerjee, S. K. Baidya, B. Ghosh, T. Jha, N. Adhikari
Summary: This study explored the structural and sub-structural fingerprints responsible for modulating MMP-9 inhibition through classification-dependent analysis. Based on these findings, new lead compounds were designed and validated, potentially serving as novel MMP-9 inhibitors in the future.
SAR AND QSAR IN ENVIRONMENTAL RESEARCH
(2023)
Article
Chemistry, Applied
Sanjay Ch, Sri Ganga Padaga, Balaram Ghosh, Sanhita Roy, Swati Biswas
Summary: A mucoadhesive self-assembling polymeric system carrying moxifloxacin was developed for bacterial keratitis treatment. Moxifloxacin-encapsulated mixed micelles (M@CF68/127(5/10)Ms) were prepared using chitosan-PLGA conjugate and poloxamers. The system demonstrated high corneal penetration, mucoadhesiveness, and antibacterial efficacy, with M@CF127(10)Ms showing superior therapeutic effects in P. aeruginosa and S. aureus-infected BK mouse model.
CARBOHYDRATE POLYMERS
(2023)
Article
Biology
Goverdhan Lanka, Darakhshan Begum, Suvankar Banerjee, Nilanjan Adhikari, P. Yogeeswari, Balaram Ghosh
Summary: This study utilized pharmacophore modeling and molecular docking methods to screen compounds with potential HDAC3 inhibitory properties. After lead optimization, four potential HDAC3 inhibitors were identified. These findings provide theoretical basis for the discovery of new potential HDAC3 inhibitors.
COMPUTERS IN BIOLOGY AND MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Jigme Sangay Dorjay Tamang, Suvankar Banerjee, Sandip Kumar Baidya, Balaram Ghosh, Nilanjan Adhikari, Tarun Jha
Summary: In this study, the crucial structural contributions of dibenzofuran and dibenzothiophene derivatives towards MMP-12 inhibitory activity were determined using 2D and 3D-QSAR techniques. The study identified that the carboxylic group enhances binding with catalytic Zn2+ ion, i-propyl sulfonamido carboxylic acid contributes positively towards MMP-12 inhibition, and the dibenzofuran moiety confers stable binding at the S1 & PRIME; pocket. Molecular docking and MD simulation studies revealed the stable and compact binding between these compounds at the MMP-12 active site. These findings can aid in the development of selective and potent lead molecules for MMP-12-associated diseases.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Chemistry, Medicinal
Sravani Pulya, Ambati Himaja, Milan Paul, Nilanjan Adhikari, Suvankar Banerjee, Ganesh Routholla, Swati Biswas, Tarun Jha, Balaram Ghosh
Summary: HDAC3 modulation shows promise for breast cancer treatment, particularly for triple-negative cases. Novel pyrazino-hydrazide-based HDAC3 inhibitors have been designed and synthesized, with lead compound 4i demonstrating potent HDAC3 inhibition and strong cytotoxicity against triple-negative breast cancer cells. Compound 4i also exhibits favorable pharmacokinetic properties and shows therapeutic efficacy in a tumor-bearing mouse model.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Review
Medicine, Research & Experimental
Aparajita Ghosh, Ambati Himaja, Swati Biswas, Onkar Kulkarni, Balaram Ghosh
Summary: Epigenetic modifications can alter gene expression at the transcriptional level, and dysregulation of these processes can lead to diseases such as cancer and metabolic disorders. Finding medications that target these modifications is of promising therapeutic interest, but very few have been approved for clinical use. This article provides a comprehensive review of recent advances in epigenetic therapeutics for cancer, with a focus on emerging delivery and development strategies.
MOLECULAR PHARMACEUTICS
(2023)
Article
Chemistry, Multidisciplinary
S. K. Baidya, S. Banerjee, B. Ghosh, T. Jha, N. Adhikari
Summary: In this study, the impact of various structures and spatial attributes on MMP-2 inhibition was investigated through computational modeling methods. The study found that favorable steric, electrostatic, and hydrophobic substituents at the terminal phenyl ring play a crucial role in MMP-2 inhibition. Additionally, key amino acid residues and their stable binding interactions with the molecules were identified.
SAR AND QSAR IN ENVIRONMENTAL RESEARCH
(2023)
Article
Nanoscience & Nanotechnology
Sneha Das, Milan Paul, Balaram Ghosh, Swati Biswas
Summary: In this study, a nanoparticle-based combination therapy was developed to inhibit the growth of triple-negative breast cancer cells and induce apoptosis through the synergistic effect of the two drugs. The nanoparticle system exhibited better therapeutic effects compared to the free drugs. In vivo experiments showed that the nanoparticles effectively inhibited tumor growth and induced apoptosis.
ACS APPLIED NANO MATERIALS
(2023)
Article
Nanoscience & Nanotechnology
Milan Paul, Himanshu Bhatt, Soniya Kumbham, Balaram Ghosh, Swati Biswas
Summary: In this study, PLGA nanoparticles modified with human serum albumin (HSA) were developed to co-deliver the photosensitizer Ce6 and chemotherapy drug PTX for combination chemo- and photodynamic therapeutic effects. The nanoparticles were characterized for size, morphology, drug loading, release, stability, and protein integrity. The ability of Ce6 to generate reactive oxygen species (ROS) was monitored biochemically. Cell studies and in vivo experiments were conducted to evaluate cellular uptake, cytotoxicity, combination drug effect, and therapeutic efficacy. The Ce6/PTX-H/P nanoparticles exhibited sustained drug release, enhanced cytotoxicity, and induced a synergistic therapeutic response.
ACS APPLIED NANO MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Suvankar Banerjee, Sandip Kumar Baidya, Balaram Ghosh, Suvendu Nandi, Mahitosh Mandal, Tarun Jha, Nilanjan Adhikari
Summary: In this study, a quantitative structural assessment of meprin beta inhibitors was performed using non-linear pattern recognition techniques and binding mode analysis. The study identified various structural attributes and designed highly effective inhibitors for meprin beta. Molecular dynamics simulation also confirmed the stability of these inhibitors at the active site. Therefore, this study provides valuable tools for identifying and designing potent inhibitors for meprin beta-related pathophysiological conditions.
NEW JOURNAL OF CHEMISTRY
(2023)