Novel EPR-enhanced strategies for targeted drug delivery in pancreatic cancer: An update

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Fiber-reinforced composites in milling and grinding: machining bottlenecks and advanced strategies

(2022) Teng Gao et al.   Frontiers of Mechanical Engineering

Regulation of tumor microenvironment for pancreatic cancer therapy

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Targeting of claudin-4 by Clostridium perfringens enterotoxin-conjugated polysialic acid nanoparticles for pancreatic cancer therapy

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Nanodrug Delivery Systems Modulate Tumor Vessels to Increase the Enhanced Permeability and Retention Effect

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Anti-Angiogenic Therapy: Current Challenges and Future Perspectives

(2021) Filipa Lopes-Coelho et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Artificial neural networking (ANN) analysis for heat and entropy generation in flow of non‐Newtonian fluid between two rotating disks

(2021) Tie‐Hong Zhao et al.   MATHEMATICAL METHODS IN THE APPLIED SCIENCES

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(2021) Mingming Zhang et al.   Acta Pharmaceutica Sinica B

Nanotechnology and pancreatic cancer management: State of the art and further perspectives

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Multimodal deep learning with feature level fusion for identification of choroidal neovascularization activity in age‐related macular degeneration

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DeepM6ASeq-EL: prediction of human N6-methyladenosine (m6A) sites with LSTM and ensemble learning

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Property-Tuneable Microgels Fabricated by Using Flow-Focusing Microfluidic Geometry for Bioactive Agent Delivery

(2021) Wing-Fu Lai et al.   Pharmaceutics

MXenes for antimicrobial and antiviral applications: recent advances

(2021) Mehrdad Khatami et al.   MATERIALS TECHNOLOGY

Fabrication of a sensitive sensor for determination of xanthine in the presence of uric acid and ascorbic acid by modifying a carbon paste sensor with Fe3O4@Au core–shell and an ionic liquid

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A novel, sensitive and selective nanosensor based on graphene nanoribbon–cobalt ferrite nanocomposite and 1-methyl-3-butylimidazolium bromide for detection of vanillin in real food samples

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Low-temperature synthesis of hetero-structures of magnetically separable iron oxide@Au-rGO nanocomposite for efficient degradation of organic dye under visible light irradiation

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Novel therapeutic strategies and perspectives for metastatic pancreatic cancer: vaccine therapy is more than just a theory

(2020) Wenhao Luo et al.   Cancer Cell International

Endocytosis of ATB0,+(SLC6A14)-targeted liposomes for drug delivery and its therapeutic application for pancreatic cancer

(2020) Longfa Kou et al.   Expert Opinion on Drug Delivery

Targeting the undruggable in pancreatic cancer using nano-based gene silencing drugs

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Sequential delivery of nanoformulated α-mangostin and triptolide overcomes permeation obstacles and improves therapeutic effects in pancreatic cancer

(2020) Jingxian Feng et al.   BIOMATERIALS

Nanoformulated Bioactive Compounds Derived from Different Natural Products Combat Pancreatic Cancer Cell Proliferation

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The tumour microenvironment in pancreatic cancer — clinical challenges and opportunities

(2020) Won Jin Ho et al.   Nature Reviews Clinical Oncology

Exploiting the dynamics of the EPR effect and strategies to improve the therapeutic effects of nanomedicines by using EPR effect enhancers

(2020) Jun Fang et al.   ADVANCED DRUG DELIVERY REVIEWS

Nitric oxide-induced stromal depletion for improved nanoparticle penetration in pancreatic cancer treatment

(2020) Xiaohui Chen et al.   BIOMATERIALS

Pancreatic cancer

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Chiral Protein Supraparticles for Tumor Suppression and Synergistic Immunotherapy: An Enabling Strategy for Bioactive Supramolecular Chirality Construction

(2020) Jin Yan et al.   NANO LETTERS

What Went Wrong with Anticancer Nanomedicine Design and How to Make It Right

(2020) Duxin Sun et al.   ACS Nano

Curcumin-loaded mesoporous silica nanoparticles/nanofiber composites for supporting long-term proliferation and stemness preservation of adipose-derived stem cells

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Use of graphene-based materials as carriers of bioactive agents

(2020) Wingfu Lai et al.   Asian Journal of Pharmaceutical Sciences

Losartan treatment enhances chemotherapy efficacy and reduces ascites in ovarian cancer models by normalizing the tumor stroma

(2019) Yanxia Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pretreating Mesenchymal Stem Cells with Cancer Conditioned‐Media or Proinflammatory Cytokines Changes the Tumor and Immune Targeting by Nanoghosts Derived from these Cells

(2019) Yael Lupu‐Haber et al.   Advanced Healthcare Materials

Can intracellular drug delivery using hyaluronic acid functionalised pH-sensitive liposomes overcome gemcitabine resistance in pancreatic cancer?

(2019) Mingtan Tang et al.   JOURNAL OF CONTROLLED RELEASE

Tumor-specific delivery of gemcitabine with activatable liposomes

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Enzyme-activatable polymer–drug conjugate augments tumour penetration and treatment efficacy

(2019) Quan Zhou et al.   Nature Nanotechnology

Augmentation of EPR Effect and Efficacy of Anticancer Nanomedicine by Carbon Monoxide Generating Agents

(2019) Jun Fang et al.   Pharmaceutics

Preparation, Characterization, and in Vitro/in Vivo Evaluation of Paclitaxel-Bound Albumin-Encapsulated Liposomes for the Treatment of Pancreatic Cancer

(2019) Yuko Okamoto et al.   ACS Omega

Insights into Active Targeting of Nanoparticles in Drug Delivery: Advances in Clinical Studies and Design Considerations for Cancer Nanomedicine

(2019) Amanda K. Pearce et al.   BIOCONJUGATE CHEMISTRY

Electrochemical Nano-biosensors as Novel Approach for the Detection of Lung Cancer-related MicroRNAs

(2019) Roghayeh Sheervalilou et al.   CURRENT MOLECULAR MEDICINE

Reductions of Circulating Nitric Oxide are Followed by Hypertension during Pregnancy and Increased Activity of Matrix Metalloproteinases-2 and -9 in Rats

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Development of Mesoporous Silica Nanoparticles of Tunable Pore Diameter for Superior Gemcitabine Drug Delivery in Pancreatic Cancer Cells

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Tumor targeting via EPR: Strategies to enhance patient responses

(2018) Susanne K. Golombek et al.   ADVANCED DRUG DELIVERY REVIEWS

Molecular Mechanisms of Nitric Oxide in Cancer Progression, Signal Transduction, and Metabolism

(2018) Veena Somasundaram et al.   ANTIOXIDANTS & REDOX SIGNALING

Therapy-Educated Mesenchymal Stem Cells Enrich for Tumor-Initiating Cells

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Stromal barriers to nanomedicine penetration in the pancreatic tumor microenvironment

(2018) Hiroyoshi Y. Tanaka et al.   CANCER SCIENCE

Experimental assessment of an environmentally friendly grinding process using nanofluid minimum quantity lubrication with cryogenic air

(2018) Jianchao Zhang et al.   JOURNAL OF CLEANER PRODUCTION

Cyclopamine treatment disrupts extracellular matrix and alleviates solid stress to improve nanomedicine delivery for pancreatic cancer

(2018) Bo Zhang et al.   JOURNAL OF DRUG TARGETING

Progress and challenges towards targeted delivery of cancer therapeutics

(2018) Daniel Rosenblum et al.   Nature Communications

UTMD-Promoted Co-Delivery of Gemcitabine and miR-21 Inhibitor by Dendrimer-Entrapped Gold Nanoparticles for Pancreatic Cancer Therapy

(2018) Lizhou Lin et al.   Theranostics

Companion Diagnostic 64Cu-Liposome Positron Emission Tomography Enables Characterization of Drug Delivery to Tumors and Predicts Response to Cancer Nanomedicines

(2018) Helen Lee et al.   Theranostics

Biomimetic nanoparticles delivered hedgehog pathway inhibitor to modify tumour microenvironment and improved chemotherapy for pancreatic carcinoma

(2018) Ting Jiang et al.   Artificial Cells Nanomedicine and Biotechnology

The role of microRNAs and nanoparticles in ovarian cancer: a review

(2018) Leila Kafshdooz et al.   Artificial Cells Nanomedicine and Biotechnology

Processing Characteristics of Vegetable Oil-based Nanofluid MQL for Grinding Different Workpiece Materials

(2018) Yaogang Wang et al.   International Journal of Precision Engineering and Manufacturing-Green Technology

Targeted Therapies for Pancreatic Cancer

(2018) Idoroenyi Amanam et al.   Cancers

Long noncoding RNA SNHG12 promotes the progression of cervical cancer via modulating miR-125b/STAT3 axis

(2018) Xue-J. Jin et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Nanoparticle Delivery of RIG-I Agonist Enables Effective and Safe Adjuvant Therapy in Pancreatic Cancer

(2018) Manisit Das et al.   MOLECULAR THERAPY

Dispersing mechanism and tribological performance of vegetable oil-based CNT nanofluids with different surfactants

(2018) Teng Gao et al.   TRIBOLOGY INTERNATIONAL

Pancreatic stellate cells derived from human pancreatic cancer demonstrate aberrant SPARC-dependent ECM remodeling in 3D engineered fibrotic tissue of clinically relevant thickness

(2018) Hiroyoshi Y. Tanaka et al.   BIOMATERIALS

Maximum undeformed equivalent chip thickness for ductile-brittle transition of zirconia ceramics under different lubrication conditions

(2017) Min Yang et al.   INTERNATIONAL JOURNAL OF MACHINE TOOLS & MANUFACTURE

Experimental evaluation of the lubrication performance of mixtures of castor oil with other vegetable oils in MQL grinding of nickel-based alloy

(2017) Shuming Guo et al.   JOURNAL OF CLEANER PRODUCTION

Rethinking cancer nanotheranostics

(2017) Hongmin Chen et al.   Nature Reviews Materials

Hypoxic stellate cells of pancreatic cancer stroma regulate extracellular matrix fiber organization and cancer cell motility

(2016) Masafumi Sada et al.   CANCER LETTERS

Grinding temperature and energy ratio coefficient in MQL grinding of high-temperature nickel-base alloy by using different vegetable oils as base oil

(2016) Benkai Li et al.   Chinese Journal of Aeronautics

Tumor angiogenesis—characteristics of tumor endothelial cells

(2016) Kyoko Hida et al.   International Journal of Clinical Oncology

Nanoghosts as a Novel Natural Nonviral Gene Delivery Platform Safely Targeting Multiple Cancers

(2016) Limor Kaneti et al.   NANO LETTERS

Monocyte cell membrane-derived nanoghosts for targeted cancer therapy

(2016) S. Krishnamurthy et al.   Nanoscale

An MRI-based classification scheme to predict passive access of 5 to 50-nm large nanoparticles to tumors

(2016) Anastassia Karageorgis et al.   Scientific Reports

Design and optimization of topical methotrexate loaded niosomes for enhanced management of psoriasis: Application of Box–Behnken design, in-vitro evaluation and in-vivo skin deposition study

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Principles of nanoparticle design for overcoming biological barriers to drug delivery

(2015) Elvin Blanco et al.   NATURE BIOTECHNOLOGY

CO2 bubbling-based 'Nanobomb' System for Targetedly Suppressing Panc-1 Pancreatic Tumor via Low Intensity Ultrasound-activated Inertial Cavitation

(2015) Kun Zhang et al.   Theranostics

Development of next-generation macromolecular drugs based on the EPR effect: challenges and pitfalls

(2014) Hideaki Nakamura et al.   Expert Opinion on Drug Delivery

Characterizing EPR-mediated passive drug targeting using contrast-enhanced functional ultrasound imaging

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Improving Conventional Enhanced Permeability and Retention (EPR) Effects; What Is the Appropriate Target?

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Cancer nanotechnology: The impact of passive and active targeting in the era of modern cancer biology

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Micro-CT Imaging of Tumor Angiogenesis

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Reconstructed Stem Cell Nanoghosts: A Natural Tumor Targeting Platform

(2013) Naama E. Toledano Furman et al.   NANO LETTERS

Minimal "Self" Peptides That Inhibit Phagocytic Clearance and Enhance Delivery of Nanoparticles

(2013) P. L. Rodriguez et al.   SCIENCE

Response of Human Pancreatic Cancer Cell Xenografts to Tetraiodothyroacetic Acid Nanoparticles

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Overcoming immunosuppression as a new immunotherapeutic approach against pancreatic cancer

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The EPR effect for macromolecular drug delivery to solid tumors: Improvement of tumor uptake, lowering of systemic toxicity, and distinct tumor imaging in vivo

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Personalized Nanomedicine

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Targeted near-IR hybrid magnetic nanoparticles for in vivo cancer therapy and imaging

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The role of stroma in pancreatic cancer: diagnostic and therapeutic implications

(2012) Mert Erkan et al.   Nature Reviews Gastroenterology & Hepatology

Theranostic Nanomedicine

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Cancer stromal targeting (CAST) therapy

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Liposome based delivery systems in pancreatic cancer treatment: From bench to bedside

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Tumour necrosis factor-alpha increases extravasation of virus particles into tumour tissue by activating the Rho A/Rho kinase pathway

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Accumulation of sub-100 nm polymeric micelles in poorly permeable tumours depends on size

(2011) H. Cabral et al.   Nature Nanotechnology

Pancreatic Cancer: The Role of Pancreatic Stellate Cells in Tumor Progression

(2011) Siri Dunér et al.   PANCREATOLOGY

The EPR effect: Unique features of tumor blood vessels for drug delivery, factors involved, and limitations and augmentation of the effect

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Nanoparticles as contrast agents for in-vivo bioimaging: current status and future perspectives

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The unique characteristics of tumor vasculature and preclinical evidence for its selective disruption by Tumor-Vascular Disrupting Agents

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Dynamics of endothelial cell behavior in sprouting angiogenesis

(2010) Hanna M Eilken et al.   CURRENT OPINION IN CELL BIOLOGY

A functional epidermal growth factor (EGF) polymorphism, EGF serum levels and renal cell carcinoma risk in a Chinese population

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(2010) Rakesh K. Jain et al.   Nature Reviews Clinical Oncology

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(2009) Bonnie J. Nieves et al.   BIOFACTORS

In vivo activity of gemcitabine-loaded PEGylated small unilamellar liposomes against pancreatic cancer

(2009) Donato Cosco et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Endothelial Nitric Oxide Synthase Mediates Lymphangiogenesis and Lymphatic Metastasis

(2009) J. Lahdenranta et al.   CANCER RESEARCH

MAKING UP OR BREAKING UP: THE TORTUOUS ROLE OF PLATELET-DERIVED GROWTH FACTOR IN VASCULAR AGEING

(2009) Xiao-Ping Yang et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

The FGF family: biology, pathophysiology and therapy

(2009) Andrew Beenken et al.   NATURE REVIEWS DRUG DISCOVERY

PDX-1 Acts as a Potential Molecular Target for Treatment of Human Pancreatic Cancer

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IL-12 Can Target Human Lung Adenocarcinoma Cells and Normal Bronchial Epithelial Cells Surrounding Tumor Lesions

(2009) Irma Airoldi et al.   PLoS One

Atu027, a Liposomal Small Interfering RNA Formulation Targeting Protein Kinase N3, Inhibits Cancer Progression

(2008) M. Aleku et al.   CANCER RESEARCH

Targeted Delivery of Gemcitabine to Pancreatic Adenocarcinoma Using Cetuximab as a Targeting Agent

(2008) C. R. Patra et al.   CANCER RESEARCH

Comparison of the effects of the kinase inhibitors imatinib, sorafenib, and transforming growth factor-β receptor inhibitor on extravasation of nanoparticles from neovasculature

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MRCPvsERCP in the evaluation of biliary pathologies: Review of current literature

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KAI1 is a potential target for anti-metastasis in pancreatic cancer cells

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