Article
Chemistry, Multidisciplinary
Weiqiang Lin, Hongxing Liu, Lingwu Chen, Junxing Chen, Dong Zhang, Qingqing Cheng, Fang Yang, Qinsong Zeng, Tianfeng Chen
Summary: This study presents a nanoscale oxygen generator (PLZ4@SeD) for intravesical instillation of bladder tumor, aiming to overcome hypoxia and low target efficiency issues. The results demonstrate that PLZ4@SeD can precisely target the tumor area within the bladder, enhance MRI contrast efficacy, and improve tumor permeability. Furthermore, PLZ4@SeD effectively consumes excess H2O2 inside the tumor, thus relieving hypoxia resistance and inhibiting BCa cell proliferation.
Article
Oncology
Karen M. Doersch, William B. Tabayoyong, Jathin Bandari
Summary: This study compared the occurrence of dose-limiting toxicities and serious adverse events in bladder cancer trials for intravesical therapies to other routes of administration. The results showed no significant difference in the subject-level dose-limiting toxicity rate between intravesical and other routes of administration, while the rate of serious adverse events was lower in the intravesical group.
Article
Urology & Nephrology
Ahmed Elkashef, Nashwa Barakat, Sherry M. Khater, Amira Awadalla, Fathallah Belal, Ahmed M. El-Assmy, Khaled Z. Sheir, Ahmed A. Shokeir
Summary: The combination of intravesical EPI and LESW reduces BCa invasion and dysplasia formation, as LESW enhances urothelial permeability of EPI and its delivery into tumor tissues. This combination therapy also results in lower expression levels of key genes related to BCa progression and better histopathological outcomes. No adverse toxicity was observed in the study.
Article
Chemistry, Multidisciplinary
Fan Huo, Yang Zhang, Yiran Li, Huagang Bu, Yaliang Zhang, Wei Li, Yuna Guo, Lan Wang, Ru Jia, Tengfei Huang, Weiyi Zhang, Pengchao Li, Lin Ding, Chao Yan
Summary: In this study, the abnormal changes in glycosylation in bladder cancer were analyzed, and mannose was identified as the most aberrantly expressed glycan on the surface of bladder cancer cell lines and human bladder tumor tissues. A lectin-drug conjugate was constructed by linking concanavalin A (ConA) - a lectin that specifically binds to mannose, with the chemotherapeutic drug epirubicin (EPI) through a pH-sensitive linker. This conjugate exhibited selective cytotoxicity to cancer cells in vitro and showed better antitumor activity in an orthotopic mouse model of bladder cancer. This research provides a potential strategy for targeted intravesical chemotherapy of bladder cancer.
CHEMISTRY-AN ASIAN JOURNAL
(2022)
Article
Polymer Science
Qing-song Yu, Zhi-hua Gan
Summary: Bladder cancer is a common tumor in the urinary system, with non-muscle invasive bladder cancer (NMIBC) accounting for over 75%. Surgical resection combined with postoperative perfusion therapy is recommended as the standard treatment. However, the limitations of small drugs, such as short bladder retention and high toxicity, hinder their application in intravesical instillation.
ACTA POLYMERICA SINICA
(2023)
Review
Oncology
Na Zeng, Meng-Yao Xu, Jian-Xuan Sun, Chen-Qian Liu, Jin-Zhou Xu, Ye An, Xing-Yu Zhong, Si-Yang Ma, Hao-Dong He, Qi-Dong Xia, Shao-Gang Wang
Summary: Given the shortage of BCG vaccine, it is important to find an alternative treatment for delaying bladder tumor recurrence in NMIBC patients. A network meta-analysis revealed that Hyperthermia Intravesical Chemotherapy (HIVEC) had a similar preventive efficacy compared to BCG instillation, making it a potential standard therapy during the global shortage of BCG.
FRONTIERS IN ONCOLOGY
(2023)
Review
Medicine, General & Internal
Mi Ah Han, Philipp Maisch, Jae Hung Jung, Jun Eul Hwang, Vikram Narayan, Anne Cleves, Eu Chang Hwang, Philipp Dahm
Summary: This study assessed the comparative effectiveness and toxicity of intravesical gemcitabine for NMIBC and found that gemcitabine may have a more favorable impact on recurrence and progression-free survival compared to mitomycin and BCG, but uncertainty remains regarding major adverse events. Therefore, better quality studies are needed to confirm these results.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2021)
Article
Multidisciplinary Sciences
Weijian Zhou, Jianping Liu, Dongdong Mao, Changying Hu, Dianjun Gao
Summary: This review and meta-analysis evaluated the clinical efficacy and safety of equipment-assisted intravesical instillation of mitomycin C (MMC) in patients with nonmuscular invasive bladder cancer (NMIBC). The results showed that device-assisted MMC instillation significantly reduced tumor recurrence and progression in NMIBC patients, without significant differences in safety or side effects.
Article
Urology & Nephrology
Jennifer Dunsmore, Eilidh Duncan, Paramananthan Mariappan, Marijn de Bruin, Sara MacLennan, Konstantinos Dimitropoulos, Veeru Kasivisvanathan, Hugh Mostafid, Alberto Briganti, James N'Dow, Steven MacLennan
Summary: The study identified barriers and facilitators to the use of single instillation of intravesical chemotherapy (SI-IVC) after resection of non-muscle-invasive bladder cancer in Scotland and England. Barriers included policies in some hospitals against instilling SI-IVC in theatre, delays in ordering and storing chemotherapy, and lack of training and skills. Facilitators included modern instilling devices and reminders in operation proforma. Improving adherence to SI-IVC requires modifications in policies, delivery and storage of chemotherapy, staff training, and documentation.
Article
Chemistry, Multidisciplinary
Weiqiang Jing, Chen Chen, Ganyu Wang, Maosen Han, Shouzhen Chen, Xin Jiang, Chongdeng Shi, Peng Sun, Zhenmei Yang, Benkang Shi, Xinyi Jiang
Summary: In this study, a perfusable nanoporter-encased hydrogel system was developed for combating ammonia toxicity in bladder cancer. The system involved the synthesis of a biomimetic fusogenic liposomalized nanoporter (FLNP) decorated with urea transporter-B (UT-B) for targeted delivery of urease and siRNA targeting CPS1 (siCPS1) to bladder tumor cells. A mussel-inspired hydrogel was fabricated for the immobilization of FLNP. The study showed that this hybrid system effectively induced urea transportation into tumor cells and boosted ammonia accumulation, leading to tumor cell apoptosis. Combined with a high-protein diet, the system enhanced tumor inhibition by increasing ammonia deposition in bladder cancer cells.
Review
Oncology
Yilei Lu, Siqi Wang, Yuhang Wang, Mingshan Li, Yili Liu, Dongwei Xue
Summary: Bladder cancer is a common malignant tumor in the urinary system. Nano-drug delivery system is a novel way in the treatment of bladder cancer, which can increase drug absorption rate, prolong drug duration, and sustain drug action.
FRONTIERS IN ONCOLOGY
(2022)
Article
Environmental Sciences
Chung-Hsin Yeh, Bo-He Chen, Xiao-Wen Tseng, Chun-Hou Liao, Wei-Kung Tsai, Han-Sun Chiang, Yi-No Wu
Summary: This study found that intravesical administration of ketamine and norketamine can induce different types of cystitis, with norketamine treatment causing more severe bladder dysfunction than ketamine treatment. Detailed studies of cellular mechanisms are needed to determine the pathogenesis of ketamine cystitis.
Article
Oncology
Lingxiang Jiang, Yingchun Liu, Xiaolin Su, Jiangwei Wang, Ye Zhao, Soumya Tumbath, Jessica A. Kilgore, Noelle S. Williams, Yaomin Chen, Xiaolei Wang, Marc S. Mendonca, Tao Lu, Yang-Xin Fu, Xiumei Huang
Summary: The study identified KP372-1 as a potential anticancer agent targeting NQO1 to induce ROS generation and DNA damage in cancer cells. Combination therapy of KP372-1 and PARPi rucaparib enhanced lethality in NQO1 over-expressing cancers by inhibiting DNA repair and overcoming PARPi resistance. PARP inhibition reversed KP372-1-induced PARP1 hyperactivation, promoted Ca2+-dependent autophagy and apoptosis, and synergistically suppressed tumor growth in mouse models.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Bin Huang, Gaowei Huang, Wenji Li, Lingwu Chen, Xiaopeng Mao, Junxing Chen
Summary: This study found that there was no significant difference in recurrence and progression rates between the IAC + IVC group and the BCG group. The use of IAC combined with IVC can reduce the risk of recurrence and progression in high-risk NMIBC patients, with lower adverse events compared to BCG instillation.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2021)
Review
Oncology
Zhongbao Zhou, Yuanshan Cui, Shuangfeng Huang, Zhipeng Chen, Yong Zhang
Summary: This meta-analysis suggests that high-risk bladder cancer patients treated with intra-arterial chemotherapy combined with intravesical chemotherapy after bladder-sparing surgery have improved overall survival, recurrence-free survival, lower tumor recurrence and progression rates compared to those treated with intravesical chemotherapy alone. Patients appeared to tolerate the toxicities related with intra-arterial chemotherapy well.
FRONTIERS IN ONCOLOGY
(2021)
Review
Chemistry, Multidisciplinary
Zhiyuan Shi, Yong Hu, Xin Li
Summary: Controlled drug delivery systems that can respond to mechanical force offer a unique solution for on-demand drug activation and release. Among various mechanical stimuli, ultrasound (US) has advantages in achieving spatiotemporally controlled drug release. Traditional US-triggered drug release relies on heat-induced phase transitions or chemical transformations, while the cutting-edge approach of Sonopharmacology leverages polymer mechanochemistry. The remaining challenges and potential future directions in this field are also discussed.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Lijie Zheng, Yuanzheng Chen, Xun Gu, Yingying Li, Hanqing Zhao, Wenjun Shao, Tao Ma, Chuanbin Wu, Qingqing Wang
Summary: In this study, a novel dosage form consisting of dissolving microneedles and an adhesive transdermal patch was developed for the treatment of rheumatoid arthritis. In vitro and in vivo experiments demonstrated that the combination of drugs delivered by this dosage form effectively reduced joint inflammation and damage.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Kyungjik Yang, Hwa Seung Han, Seung Hwan An, Kyung Hoon Park, Keonwook Nam, Shinha Hwang, Yuyeon Lee, Sung Yeon Cho, Taehyung Kim, Deokyeong Choe, Sang Won Kim, Wonkyu Yu, Hyunah Lee, Jiyong Park, Sangguan You, Dong- Gyu Jo, Ki Young Choi, Young Hoon Roh, Jae Hyung Park
Summary: This study developed CP-loaded CS microcapsules to enhance the oral bioavailability of CP through controlled gastrointestinal delivery. The optimized microcapsules exhibited desirable physicochemical properties, showed anti-photoaging effects via antioxidant activity, and achieved controlled release in the gastrointestinal tract. This research provides a simple and economical approach for enhancing the oral bioavailability of CP for customized bioactive compound administration.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Huiyang Li, Shuo Liu, Wenjin Dai, Bingmei Yao, Yong Zhou, Sujia Si, Hairong Yu, Riguang Zhao, Fang Jin, Liqun Jiang
Summary: Changes in bodily fluid pressures are crucial in diseases like high-altitude pulmonary edema (HAPE). Researchers have developed hydrostatic pressure-sensitive multivesicular liposomes (PSMVLs) that can release drugs in response to pressure changes, with potential applications in HAPE treatment. Animal experiments showed that this system provides better protection for lung tissues and respiratory function, reducing the occurrence of pulmonary edema.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Qian Hu, Hongbing Lan, Yinmei Tian, Xiaonan Li, Mengmeng Wang, Jiao Zhang, Yulin Yu, Wei Chen, Li Kong, Yuanyuan Guo, Zhiping Zhang
Summary: Coacervate droplets formed through liquid-liquid phase separation have potential as delivery vesicles for therapeutics. However, their lack of physiological stability and membranes are challenges. In this study, polylysine-polynucleotide complex coacervate droplets with favorable stability were formulated to concentrate molecules and nanoparticles. Phospholipid membranes were further coated on the droplets to create coacervate-based artificial protocells (ArtPC) with membrane-like structures. These biofunctional ArtPC effectively reduced blood uric acid levels and prevented renal injuries.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Xiaowei Wang, Hongwei Lu, Fang Luo, Dan Wang, Apeng Wang, Xuelei Wang, Wenkai Feng, Xiaobo Wang, Jiayi Su, Mingliang Liu, Guimin Xia
Summary: Four novel lipid-like GEM diesters were synthesized and encapsulated into liposomes to improve the antitumor efficacy of Gemcitabine. The liposomes loaded with dimyristoyl GEM (LipodmGEM) showed enhanced cellular uptake, improved inhibition of cell migration, and a greatly extended half-life compared to free Gemcitabine. LipodmGEM successfully enriched the drug in the tumor and exhibited excellent anticancer efficacy in vivo with negligible systemic toxicity.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Pengyu Li, Jieyi Pan, Yating Dong, Yingying Sun, Yalong Wang, Kang Liao, Yili Chen, Xin Deng, Shihui Yu, Haiyan Hu
Summary: Chronic pulmonary infection caused by Pseudomonas aeruginosa is a serious public health problem with high mortality rates. In this study, infection-microenvironment responsive nanoparticles were developed to eradicate biofilms and inhibit virulence. These nanoparticles showed promising results in treating chronic pulmonary infections.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Yajing Sun, Ze Lu, John A. Taylor, Jessie L. S. Au
Summary: A recent development in cancer chemotherapy is the use of cytotoxics to induce tumor-specific immune response through immunogenic cell death (ICD). This study describes a method that utilizes immunostaining and machine-learning to identify cells with ecto-CRT in intact 3-dimensional tissues. The method was successfully applied to study drug-induced ICD in human bladder cancer.
JOURNAL OF CONTROLLED RELEASE
(2024)
Review
Chemistry, Multidisciplinary
Rafat Ali, Shantanu Sen, Rohil Hameed, Aamir Nazir, Sandeep Verma
Summary: This review provides a focused overview of emerging strategies for delivering gasotransmitters in a controlled and sustained manner to reestablish neurophysiological homeostasis.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Jing Chen, Xinyi Zhang, Jinshen Zhang, Zhaoxia Wang, Guilan Zhu, Ming Geng, Jinmiao Zhu, Yajun Chen, Wei Wang, Youcui Xu
Summary: In this study, a multifunctional responsive hydrogel system was developed for synergistic reoxygenation and chemo/photothermal therapy. The hydrogel system showed both therapeutic effects against metastatic breast cancer and wound infection, making it a promising strategy for treating and preventing tumor recurrence and associated wound infection.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Baoshan Huang, Na Zhang, Xinying Qiu, Rui Zeng, Shuimiao Wang, Mengxia Hua, Qing Li, Kaihui Nan, Sen Lin
Summary: This study revealed that robust ROS can oxidize mitochondrial DNA (ox-mtDNA) and cause its release into the cytosol, resulting in the activation of NLRP3 inflammasome. By using the mitochondria-targeted antioxidant SkQ1 and a novel mitochondria-targeted nanoparticle (SkQ1 NP), it was found that mitochondrial ROS scavenging could in situ inhibit DED-induced mtDNA oxidation and suppress NLRP3-mediated inflammation.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Wenqi Liu, Cheng Hu, Linyu Long, Shuyi He, Wen Zhang, Zhicun Wang, Li Yang, Yunbing Wang
Summary: Myocardial infarction is the leading cause of cardiovascular mortality, and current treatment methods have limitations. This study developed a smart carrier that can release different therapeutic substances for different pathological processes, effectively improving cardiac function, promoting cardiac repair, and preventing ventricular remodeling.
JOURNAL OF CONTROLLED RELEASE
(2024)