Article
Medicine, General & Internal
Ning Li, Yuan Zhu, Lu-Ying Liu, Yan-Ru Feng, Wen-Ling Wang, Jun Wang, Hao Wang, Gao-Feng Li, Yuan Tang, Chen Hu, Wen-Yang Liu, Hua Ren, Shu-Lian Wang, Wei-Hu Wang, Yong-Wen Song, Yue-Ping Liu, Hui Fang, Yu Tang, Ning-Ning Lu, Bo Chen, Shu-Nan Qi, Xin-Fan Liu, Ye-Xiong Li, Jing Jin
Summary: The addition of oxaliplatin to postoperative capecitabine-based chemoradiotherapy did not improve treatment efficacy but increased the risk of severe acute toxic effects. Postoperative capecitabine with radiotherapy plays a fundamental role in the treatment of locally advanced rectal cancer.
Article
Multidisciplinary Sciences
Fuqiang Wang, Boon Fei Tan, Sharon Shuxian Poh, Tian Rui Siow, Faye Lynette Wei Tching Lim, Connie Siew Poh Yip, Michael Lian Chek Wang, Wenlong Nei, Hong Qi Tan
Summary: A feasibility study investigated the role of CT-based radiomics in predicting treatment response and survival rates in rectal cancer patients. By constructing NAR and survival models, radiomics features were found to be more accurate in predicting outcomes. CTV radiomics features were especially important in NAR prediction.
SCIENTIFIC REPORTS
(2022)
Article
Surgery
Patricia Sylla, Dana Sands, Alison Ricardo, Antoinette Bonaccorso, Alexandros Polydorides, Mariana Berho, John Marks, Justin Maykel, Karim Alavi, Karen Zaghiyan, Mark Whiteford, Elisabeth Mclemore, Sami Chadi, Sherief F. Shawki, Scott Steele, Alessio Pigazzi, Matthew Albert, Teresa DeBeche-Adams, Erin Moshier, Steven D. Wexner
Summary: Transanal TME (taTME) is a surgical technique that combines abdominal and transanal dissection to preserve the sphincter in patients with low rectal tumors. This study reports early results of taTME, including surgical complications, oncologic outcomes, and functional outcomes.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Gastroenterology & Hepatology
Youngki Hong, Amandeep Ghuman, Keat Seong Poh, Dimitri Krizzuk, Arun Nagarajan, Sudha Amarnath, Juan J. Nogueras, Steven D. Wexner, Giovanna DaSilva
Summary: The study aimed to evaluate whether changes in CEA levels following chemoradiation in patients with locally advanced rectal cancer can predict prognosis post-surgery. Results indicated that normalized CEA can serve as a prognostic indicator.
COLORECTAL DISEASE
(2021)
Article
Multidisciplinary Sciences
Seung Yeun Chung, Hirotoshi Takiyama, Jae Hyun Kang, Jee Suk Chang, Byung Soh Min, Hiroshi Tsuji, Shigeru Yamada, Woong Sub Koom
Summary: This study compared the effectiveness of carbon ion radiotherapy (CIRT) and X-ray radiotherapy (XRT) for the treatment of locoregional rectal cancer recurrence. The results showed that CIRT had better outcomes in terms of local control, overall survival, and late toxicity rate compared to XRT.
SCIENTIFIC REPORTS
(2022)
Article
Gastroenterology & Hepatology
Qingyang Feng, Weitang Yuan, Taiyuan Li, Bo Tang, Baoqing Jia, Yanbing Zhou, Wei Zhang, Ren Zhao, Cheng Zhang, Longwei Cheng, Xiaoqiao Zhang, Fei Liang, Guodong He, Ye Wei, Jianmin Xu
Summary: Robotic surgery for rectal cancer showed better oncological quality of resection, less surgical trauma, and better postoperative recovery compared to conventional laparoscopic surgery in patients with middle and low rectal cancer.
LANCET GASTROENTEROLOGY & HEPATOLOGY
(2022)
Article
Oncology
Alex Federico, Luigi Pedone Anchora, Valerio Gallotta, Francesco Fanfani, Francesco Cosentino, Luigi Carlo Turco, Nicolo' Bizzarri, Francesco Legge, Elena Teodorico, Gabriella Macchia, Vincenzo Valentini, Giovanni Scambia, Gabriella Ferrandina
Summary: Persistence of pathologic residual tumor on the cervix and lymph nodes after chemoradiation and adjuvant surgery is a reliable predictor of survival for locally advanced cervical cancer patients. Positive pelvic lymph nodes and aortic lymph nodes are also associated with worse survival rates.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Oncology
C. S. Wong, W. Chu, S. Ashamalla, D. Fenech, S. Berry, A. Kiss, M. Koritzinsky
Summary: The study aimed to investigate whether adding metformin to neoadjuvant chemoradiation therapy for rectal cancer could improve pathologic complete response rates in non-diabetic patients. Results revealed that the addition of metformin did not increase toxicities. Future research will refine the design and implementation of a phase 2 trial to assess whether metformin enhances pCR/cCR rates.
CLINICAL AND TRANSLATIONAL RADIATION ONCOLOGY
(2021)
Article
Surgery
J. A. G. van der Heijden, A. J. Kalkdijk-Dijkstra, J. P. E. N. Pierie, H. L. van Westreenen, P. M. A. Broens, B. R. Klarenbeek
Summary: This study aimed to investigate the effects of PFR after LAR compared to usual care. The results showed that while PFR did not lead to significant improvements in all patients, it was beneficial for certain subgroups, such as those with urgency or at least moderate incontinence without near-complete incontinence. It is suggested that a selective referral policy be implemented to improve postoperative functional outcomes for patients after LAR for rectal cancer.
Article
Oncology
Sharlyn Kang, Kate J. Wilkinson, Daniel Brungs, Wei Chua, Weng Ng, James Chen, Elias Nasser, Mark Lee, Karen Wong, Les Bokey, Robert Winn, Soni Putnis, Cheok Soon Lee, Stephanie Hui-Su Lim
Summary: The study compared clinicopathological variables, treatment modalities, and survival outcomes in 736 elderly and young patients with non-metastatic rectal cancer. Elderly patients were less likely to receive trimodality therapy, had higher mortality rates associated with surgery, lower cancer-specific survival rates, but had similar survival outcomes to younger patients when treated with trimodality therapy.
MOLECULAR AND CLINICAL ONCOLOGY
(2021)
Article
Medicine, General & Internal
Yaron Rudnicki, Nir Horesh, Assaf Harbi, Barak Lubianiker, Eraan Green, Guy Raveh, Moran Slavin, Lior Segev, Haim Gilshtein, Muhammad Khalifa, Alexander Barenboim, Nir Wasserberg, Marat Khaikin, Hagit Tulchinsky, Nidal Issa, Daniel Duek, Shmuel Avital, Ian White
Summary: This study aims to assess the rectal cancer rate following local excision of low-grade dysplasia rectal lesions. The study found that approximately 11% of patients with low-grade dysplasia experienced local recurrence and developed rectal cancer within an average of 19.3 months after the initial surgery, with 78% of patients diagnosed within two years. Therefore, closer surveillance is recommended for these patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Oncology
Francesco Caputo, Chiara Santini, Andrea Casadei-Gardini, Krisida Cerma, Camilla Bardasi, Ingrid Garajova, Elisabetta Lattanzi, Alessandro Passardi, Ilario Giovanni Rapposelli, Andrea Spallanzani, Massimiliano Salati, Luca Reggiani Bonetti, Roberta Gelmini, Bruno Meduri, Micaela Piccoli, Annarita Pecchi, Stefania Benatti, Federico Piacentini, Massimo Dominici, Gabriele Luppi, Fabio Gelsomino
Summary: The study found that concurrent use of statins in patients with locally advanced rectal cancer undergoing neoadjuvant chemoradiation was associated with better tumor regression, despite increased chemoradiation-related toxicity.
Article
Surgery
Huashan Liu, Ziwei Zeng, Hong Zhang, Miao Wu, Dan Ma, Quan Wang, Ming Xie, Qing Xu, Jun Ouyang, Yi Xiao, Yongchun Song, Bo Feng, Qingwen Xu, Yanan Wang, Yi Zhang, Yuantao Hao, Shuangling Luo, Xingwei Zhang, Zuli Yang, Junsheng Peng, Xiaojian Wu, Donglin Ren, Meijin Huang, Ping Lan, Weidong Tong, Mingyang Ren, Jianping Wang, Liang Kang
Summary: This study aimed to compare the morbidity, mortality, and pathologic outcomes of transanal total mesorectal resection (taTME) and laparoscopic total mesorectal excision (laTME) in patients with rectal cancer. The results showed that there were no significant differences in intraoperative complications, postoperative morbidity, or mortality between the taTME and laTME groups, indicating that experienced surgeons can safely perform taTME in selected patients with rectal cancer.
Article
Surgery
Shinichiro Takahashi, Izumi Ohno, Masafumi Ikeda, Masaru Konishi, Tatsushi Kobayashi, Tetsuo Akimoto, Motohiro Kojima, Soichiro Morinaga, Hirochika Toyama, Yasuhiro Shimizu, Atsushi Miyamoto, Moriaki Tomikawa, Norihisa Takakura, Wataru Takayama, Satoshi Hirano, Takehito Otsubo, Masato Nagino, Wataru Kimura, Keishi Sugimachi, Katsuhiko Uesaka
Summary: This study evaluated the effectiveness of neoadjuvant chemoradiotherapy (CRT) with S-1 in patients with locally advanced pancreatic cancer (BRPC). The results showed that S-1 and concurrent radiotherapy can effectively increase the R0 resection rate and improve survival in BRPC patients.
Review
Oncology
Paolo Goffredo, Felipe F. Quezada-Diaz, Julio Garcia-Aguilar, J. Joshua Smith
Summary: The management of rectal cancer has become more complex, with chemotherapy and radiation before surgery being accepted as a new standard. Watch and wait and non-operative management are potential treatment options, but identifying suitable candidates remains challenging.
