Article
Nutrition & Dietetics
Donghui Yang, Yan Liu, Yafeng Wang, Yudiyang Ma, Jianjun Bai, Chuanhua Yu
Summary: The study found that participants with higher levels of vitamin B6 had a lower risk for all-cause mortality. Maintaining a sufficient level of serum vitamin B6 may lower the all-cause mortality risk in the general population.
Article
Cardiac & Cardiovascular Systems
Qianwei Cui, Xu Zhu, Gongchang Guan, Rutai Hui, Ling Zhu, Junkui Wang, Jingsha Zhao
Summary: This study assessed the association between vitamin B6 turnover rate and mortality in hypertensive adults. Higher vitamin B6 turnover rate was associated with an increased risk of cardiovascular and all-cause mortality in hypertensive adults.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2023)
Article
Nutrition & Dietetics
Paula Schorgg, Till Baernighausen, Sabine Rohrmann, Aedin Cassidy, Nena Karavasiloglou, Tilman Kuehn
Summary: The study found that there were no significant differences in vitamin B6 levels between vegetarians and non-vegetarians, and the use of vitamin B6 supplements was the most important factor in maintaining vitamin B6 levels.
Article
Immunology
Akram A. Da'dara, Manal Elzoheiry, Samar N. El-Beshbishi, Patrick J. Skelly
Summary: The research shows that schistosomes are able to cleave exogenous vitamin B6 and produce pyridoxal, which helps the parasites participate in essential, vitamin B6-driven metabolism. When the surface enzyme SmAP in schistosomes is suppressed, their ability to cleave exogenous vitamin B6 significantly decreases, indicating the important role of SmAP in parasite's vitamin B6 metabolism.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Shaotong Zhou, Xiaotang Chen, Xianpu Ni, Yu Liu, Hui Zhang, Min Dong, Huanzhang Xia
Summary: The study reveals the roles of GenP and GenB3 in the gentamicin biosynthesis pathway which solves a long-standing puzzle and enriches the knowledge of PLP-dependent enzymes chemistry.
MICROBIAL CELL FACTORIES
(2021)
Article
Nutrition & Dietetics
Hyojung Kim, Evelyn B. Enrione, Vijaya Narayanan, Tan Li, Adriana Campa
Summary: This study found gender differences in the relationships between plasma PLP and plasma EPA, DHA, EPA + DHA, EPA/AA, and (EPA + DHA)/AA among US young/middle-aged adults, with significant direct associations in men only.
Article
Biochemical Research Methods
Anthony Maus, Adam Girtman, Jessa Kiesling, Jennifer Faber, Stefan K. G. Grebe
Summary: Pyridoxal-5'-phosphate (PLP), the active form of vitamin B6, plays a crucial role in enzymatic reactions. Accurate measurement of PLP is essential for diagnoses and monitoring, but traditional assays are prone to interferences. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) can overcome these issues, and adding an ion pairing reagent like 1-octanesulfonic acid (OSA) after extraction greatly improves the signal-to-noise ratio and precision of measurements without harming the instrument hardware commonly associated with traditional ion pairing reagent techniques.
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
(2023)
Review
Nutrition & Dietetics
Kamilla Stach, Wojciech Stach, Katarzyna Augoff
Summary: Vitamin B6 is a crucial coenzyme involved in over 150 biochemical reactions in the human body, playing a role in metabolism and cellular signaling. It acts as an antioxidant and is capable of reducing advanced glycation end products. Deficiency in Vitamin B6 may be associated with diseases such as diabetes, heart disease, cancer, and the prognosis of COVID-19.
Article
Biochemistry & Molecular Biology
Eleonora Gnocchini, Eleonora Pilesi, Ludovica Schiano, Fiammetta Verni
Summary: This study investigates whether depletion of the active form of vitamin B6, pyridoxal 5'-phosphate (PLP), can cause loss of heterozygosity (LOH) in the tumor suppressor gene warts (wts) in Drosophila. The researchers found that PLP depletion, induced by PLP inhibitors, promotes LOH of wts locus and results in a significant frequency of wts tumors. Additionally, they identified mitotic recombination as a possible mechanism for PLP deficiency-induced LOH. Importantly, LOH of wts locus induced by PLP inhibitors was rescued by PLP supplementation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nutrition & Dietetics
Paula Schorgg, Nena Karavasiloglou, Anika Beyer, Marie Cantwell, Ina Danquah, Jan Gojda, Sabine Rohrmann, Aedin Cassidy, Till Barnighausen, Monika Cahova, Tilman Kuhn
Summary: This study evaluated the association between biomarkers of vitamin B6 status and mortality risk. The results showed that a higher 4-PA/PLP ratio was associated with increased all-cause and cancer mortality, especially among participants older than 65 years.
CLINICAL NUTRITION
(2022)
Article
Nutrition & Dietetics
Hyojung Kim, Evelyn B. Enrione, Vijaya Narayanan, Tan Li, Adriana Campa
Summary: This study investigated the relationships between vitamin B6, PUFA, and gender in older adults. The results showed that higher plasma levels of vitamin B6 were associated with higher concentrations of EPA, DHA, EPA + DHA, EPA/AA, and (EPA + DHA)/AA. Adequate B6 status was associated with high levels of EPA and EPA/AA.
Article
Biochemistry & Molecular Biology
Shanru He, Yuanyuan Chen, Lulu Wang, Xue Bai, Tingting Bu, Jie Zhang, Ming Lu, Nam-Chul Ha, Chunshan Quan, Ki Hyun Nam, Yongbin Xu
Summary: YggS is a protein that binds to PLP and regulates its balance in bacteria and humans. This study analyzed the function and structure of YggS from Fusobacterium nucleatum and found that its overall structure and PLP-binding site are highly conserved, playing a key role in PLP binding.
Article
Microbiology
Huong N. Vu, Diana M. Downs
Summary: This study reveals the metabolic perturbations caused by a vitamin B-6 antagonist in Salmonella enterica serovar Typhimurium LT2. The results indicate that the antagonist inhibits PLP-dependent enzymes, leading to decreased synthesis of CoA and thiamine. This study highlights the integration of biochemical pathways in microbes.
JOURNAL OF BACTERIOLOGY
(2022)
Article
Chemistry, Physical
Jennifer L. L. Cordoza, Percival Yang-Ting Chen, Linnea R. R. Blaustein, Stella T. T. Lima, Marli F. F. Fiore, Jonathan R. R. Chekan, Bradley S. S. Moore, Shaun M. K. McKinnie
Summary: Researchers have discovered and characterized the biosynthetic pathway of guanitoxin, a neurotoxin containing a cyclic arginine derivative. By comparing the structures and activities, they have identified the amino acid residues that contribute to the catalytic mechanism. This study provides a better understanding of how nature produces cyclic arginine noncanonical amino acids and offers tools for their biocatalytic production and biological applications.
Article
Biochemistry & Molecular Biology
Chengfeng Xue, I-Son Ng
Summary: For the first time, Pyridoxal 5'-phosphate (PLP) was used as a protein decoy to enhance enzyme expression and activity. By introducing new substrates and altering metabolic pathways, the growth and protein yield of the strain were further improved.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)