Review
Biochemistry & Molecular Biology
Mustapha Benkhalifa, Fabien Joao, Cynthia Duval, Debbie Montjean, Molka Bouricha, Rosalie Cabry, Marie-Claire Belanger, Hatem Bahri, Pierre Miron, Moncef Benkhalifa
Summary: After more than four decades of assisted reproductive technology (ART) practice, the failure of in vitro fertilization (IVF) treatments and recurrent implantation failures (RIFs) and repeated pregnancy loss (RPL) remain significant issues. This article reviews different therapeutic options and suggests that immunomodulation and predictive biomarkers may be promising solutions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Jiaxing Li, Jia Qi, Guangxin Yao, Qinling Zhu, Xinyu Li, Rui Xu, Zhenyi Zhu, Hanting Zhao, Yuan Wang, Ying Ding, Yun Sun
Summary: SIRT1 plays a crucial role in regulating differentiation and maintaining ROS homeostasis of human ESCs during decidualization. Decreased expression of SIRT1 in RIF patients disrupts ROS balance, leading to inhibition of decidualization and reduced expression of decidual markers.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Cell Biology
Nischelle R. Kalakota, Lea C. George, Sara S. Morelli, Nataki C. Douglas, Andy V. Babwah
Summary: This article discusses the impact of elevated progesterone levels on human endometrial receptivity and oocyte/embryo quality, finding that early rise in progesterone levels minimally affects oocyte/embryo quality but does affect endometrial development and implantation window, leading to reduced implantation and pregnancy rates.
Article
Endocrinology & Metabolism
Junyu Zhai, Shang Li, Jingwen Hu, Minzhi Gao, Yun Sun, Zi-Jiang Chen, Linda C. Giudice, Yanzhi Du
Summary: This study assessed the profiling of core circadian clock genes in the human endometrium across the menstrual cycle, with a focus on the role of PER2 in window of implantation (WOI) and recurrent implantation failure (RIF). The research found varied expression of circadian clock genes and confirmed the positive regulation of PER2 to SHTN1, KLF5, and STEAP4 in compromised endometrial receptivity and RIF. Aberrant expression of endometrial PER2 may contribute to impaired endometrial receptivity and development of RIF through the regulation of SHTN1, KLF5, and STEAP4.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Biochemistry & Molecular Biology
Amber Rose Hart, Norhayati Liaqat Ali Khan, Keerthie Dissanayake, Kasun Godakumara, Aneta Andronowska, Saji Eapen, Paul R. Heath, Alireza Fazeli
Summary: Successful embryo implantation and endometrial receptivity require communication between the embryo and the maternal endometrium, which is facilitated by extracellular vehicles (EVs). This study investigated the influence of menstrual cycle hormones (estrogen, progesterone, and estrogen plus progesterone) on endometrial-derived EVs. The results showed that hormonal stimulation affected the size and proteome of EVs, with proteins involved in embryo implantation, endometrial receptivity, and embryo development being enhanced in the EVs from the receptive phase (estrogen plus progesterone). This supports the concept of EV-mediated communication between the embryo and the maternal endometrium.
Editorial Material
Oncology
Cock van Oosterhout, Daniel Marcu, Simone Immler
Summary: This article discusses the significant impact of genetic load on assisted reproductive technology, human reproduction, and fertility. It explores these topics in the context of evolutionary genetic theory, the technological revolution in ART, and the advancements in genomics and bioinformatics.
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Article
Endocrinology & Metabolism
Xiaowei Zhou, Yi Cao, Mingjuan Zhou, Mi Han, Mengyu Liu, Yanqin Hu, Bufang Xu, Aijun Zhang
Summary: Reduced expression of CD44v3 suppresses the proliferation and decidualization of HESCs, which may play a pivotal role in poor endometrial receptivity in women with RIF.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2022)
Review
Cell Biology
Sepide Goharitaban, Ali Abedelahi, Kobra Hamdi, Mozafar Khazaei, Masoumeh Esmaeilivand, Behrooz Niknafs
Summary: This review discusses the potential use of endometrial miRNAs as noninvasive biomarkers to predict the implantation and reproductive ability of the endometrium during in vitro fertilization (IVF) cycles. Previous studies have shown that certain miRNA levels in the endometrium are associated with implantation potential and pregnancy outcomes. This review introduces the possibility of using endometrial miRNAs as noninvasive biomarkers in assisted reproductive technology (ART) cycles to determine the optimal time for implantation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Endocrinology & Metabolism
Jing Yang, Linlin Wang, Jingwen Ma, Lianghui Diao, Jiao Chen, Yanxiang Cheng, Longfei Li
Summary: This study identified four potential biomarkers (TPPP3, S100A13, HSD17B2, and AZGP1) associated with non-receptive endometrium using iTRAQ-based proteomics analysis. It was found that TPPP3 and HSD17B2 were downregulated in the endometrium of patients with poor endometrial receptivity. These findings provide new evidence for the diagnosis and treatment of non-receptive endometrium and recurrent implantation failure (RIF).
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Oncology
Levent Mutlu, Diego D. Manavella, Giuseppe Gullo, Blair McNamara, Alessandro D. Santin, Pasquale Patrizio
Summary: Young women diagnosed with endometrial cancer face unique challenges, but preserving fertility is possible in early and low-grade cases. Data suggest that conservative approaches with close monitoring do not compromise oncologic outcomes. For patients unable to preserve fertility, assisted reproductive technologies can help achieve fertility goals.
Article
Obstetrics & Gynecology
R. Silva Martins, A. Helio Oliani, D. Vaz Oliani, J. Martinez de Oliveira
Summary: A prospective case control study of 169 subjects undergoing assisted reproductive technologies found that continuous serum estradiol and 3D endometrial volume may serve as useful real time tools for predicting endometrial receptivity during ART procedures.
BMC PREGNANCY AND CHILDBIRTH
(2021)
Review
Biochemistry & Molecular Biology
Manizha Shekibi, Sophea Heng, Guiying Nie
Summary: The development of endometrial receptivity is crucial for successful embryo implantation and pregnancy initiation. Recent studies have focused on the role of microRNAs (miRNAs) in the regulation of endometrial receptivity. This review provides an up-to-date knowledge of the miRNAs identified in humans and mice that may play a functional role in the establishment of receptivity. The findings suggest that miRNAs could be potential biomarkers and therapeutic targets for improving endometrial receptivity in human fertility treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Agriculture, Dairy & Animal Science
Egon Andoni, Giulio Curone, Stella Agradi, Olimpia Barbato, Laura Menchetti, Daniele Vigo, Riccardo Zelli, Elisa Cotozzolo, Maria Rachele Ceccarini, Massimo Faustini, Alda Quattrone, Marta Castrica, Gabriele Brecchia
Summary: Infectious diseases pose significant challenges for livestock reproductive performance, affecting animal welfare and farm profitability. The European Community advocates for reducing antibiotic and hormone use in animal breeding. This study demonstrated that goji berry supplementation can enhance reproductive and productive performance in rabbits by modulating hormonal patterns and milk production. Further research is necessary to validate these findings.
Article
Biotechnology & Applied Microbiology
Hon Yeung Chan, Ha M. Tran, James Breen, John E. Schjenken, Sarah A. Robertson
Summary: This study provides a comprehensive profile of the endometrial transcriptome in the peri-ovulatory and peri-implantation states, identifying genes, regulatory pathways, and upstream drivers involved in the transition to uterine receptivity that were not previously associated with implantation. Several upstream regulators, including cytokines, ovarian steroid hormones, prostaglandin E2, and vascular endothelial growth factor A, were found to be activated during this transition. The findings of this study will contribute to further research on the molecular mechanisms of uterine receptivity.
Article
Anatomy & Morphology
Laura Governini, Francesca P. Luongo, Alesandro Haxhiu, Paola Piomboni, Alice Luddi
Summary: Embryo implantation occurs during a specific period in the mid-secretory phase of the menstrual cycle, and interaction between the endometrium and blastocyst is crucial for successful implantation. While no single molecule or receptor has been identified as essential for implantation, a variety of mediators support pregnancy establishment. Understanding these complex mechanisms can help address issues of implantation failure and infertility.
