Review
Cell Biology
Aatiqa Nawaz, Temirlan Shilikbay, Geena Skariah, Stephanie Ceman
Summary: MOV10, an RNA helicase, plays a key role in cellular response to viral infection, suppression of retrotransposition, and development. It associates with various proteins, undergoes posttranslational modifications, and exhibits cell type-specific localization. Studies on MOV10 have primarily focused on germline cells and neurons.
WILEY INTERDISCIPLINARY REVIEWS-RNA
(2022)
Editorial Material
Biochemistry & Molecular Biology
Nicholas T. Ingolia
Summary: In Cell Chemical Biology, Naineni et al. (2021) describe the structure of a synthetic analog binding to initiation factor eIF4A and RNA, providing insight into a potential druggable site and highlighting novel interactions.
Article
Biochemistry & Molecular Biology
Litong Yao, Qian Hao, Mozhi Wang, Yuhai Chen, Hongyi Cao, Qiang Zhang, Keda Yu, Yizhou Jiang, Zhiming Shao, Xiang Zhou, Yingying Xu
Summary: In this study, researchers identified KLHL29 as a crucial tumor suppressor that regulates chemosensitivity in triple-negative breast cancer (TNBC). Low levels of KLHL29 were associated with unfavorable prognoses. Mechanistically, KLHL29 suppressed TNBC growth by degrading DDX3X and inhibiting cell cycle progression. The combination of DDX3X inhibitor RK33 and platinum-based chemotherapy showed promising results in suppressing TNBC.
Article
Biochemical Research Methods
Marco Caterino, Katrin Paeschke
Summary: The nucleic acid structure known as G-quadruplex (G4) plays a significant role in nucleic acid-based mechanisms that impact cellular processes. DNA G4 is well-studied, while RNA G4 is gaining attention for its role in cellular homeostasis. Proper regulation of G4 structures within cells is crucial, and helicases are important in resolving them. However, only a few rG4 unwinding helicases have been identified and characterized so far.
Article
Biochemistry & Molecular Biology
Katherine E. Bohnsack, Anthony K. Henras, Henrik Nielsen, Markus T. Bohnsack
Summary: This article discusses the diverse mechanisms employed in different organisms to establish connections between the 5' and 3' ends of the large subunit (LSU) ribosomal RNA (rRNA) for rRNA domain compaction and subunit assembly.
TRENDS IN BIOCHEMICAL SCIENCES
(2023)
Article
Chemistry, Medicinal
Christopher J. Zerio, Tyler A. Cunningham, Allison S. Tulino, Erin A. Alimusa, Thomas M. Buckley, Kohlson T. Moore, Matthew Dodson, Nathan C. Wilson, Andrew J. Ambrose, Taoda Shi, Jared Sivinski, Derek J. Essegian, Donna D. Zhang, Stephan C. Schurer, Jonathan H. Schatz, Eli Chapman
Summary: This study focused on a novel eIF4A inhibitor that is RNA-competitive and ATP-uncompetitive, engaging a new pocket in the RNA groove of eIF4A to interfere with proper RNA binding and suppress ATP hydrolysis, thereby inhibiting unwinding activity. This unique mechanism may offer new strategies for targeting promising intersection points of multiple oncogenic pathways.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Plant Sciences
Anzhela Migur, Florian Heyl, Janina Fuss, Afshan Srikumar, Bruno Huettel, Claudia Steglich, Jogadhenu S. S. Prakash, Richard Reinhardt, Rolf Backofen, George W. Owttrim, Wolfgang R. Hess
Summary: RNA helicases play crucial roles in plants, particularly in response to abiotic stress, development, post-transcriptional gene regulation, and housekeeping functions. These RNA helicases, influenced by cyanobacteria, have diverse molecular targets, with CrhR specifically involved in responding to redox balance in the photosynthetic electron transport chain. The identified interactome of CrhR explains its physiological role and highlights its importance in regulating gene expression in plants.
JOURNAL OF EXPERIMENTAL BOTANY
(2021)
Article
Multidisciplinary Sciences
Yujie Zhu, Mingchao Zhang, Weiran Wang, Shuang Qu, Minghui Liu, Weiwei Rong, Wenwen Yang, Hongwei Liang, Caihong Zeng, Xiaodong Zhu, Limin Li, Zhihong Liu, Ke Zen
Summary: Reduction of renal tubular cell PNPT1 causes renal tubular translation arrest and atrophy, which leads to tubular injury. Increasing PNPT1 expression can alleviate tubular injury.
NATURE COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Olga Sergeeva, Tatiana Abakumova, Ilia Kurochkin, Renata Ialchina, Anna Kosyreva, Tatiana Prikazchikova, Varvara Varlamova, Evgeniya Shcherbinina, Timofei Zatsepin
Summary: The study showed that a strong reduction of DDX3 protein leads to similar changes in vitro and in vivo, including cell cycle deregulation and pathway alterations, while a more moderate downregulation resulted in discordant results between in vitro and in vivo, indicating the significant impact of DDX3 protein levels on cell phenotype.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Mara Doimo, Namrata Chaudhari, Sanna Abrahamsson, Valentin L'Hote, Tran V. H. Nguyen, Andreas Berner, Mama Ndi, Alva Abrahamsson, Rabindra Nath Das, Koit Aasumets, Steffi Goffart, Jaakko L. O. Pohjoismaki, Marcela Davila Lopez, Erik Chorell, Sjoerd Wanrooij
Summary: Mitochondrial DNA (mtDNA) replication stalling is a crucial step in the formation of mtDNA deletions, which are associated with genetic disorders and aging. The mechanisms underlying how replication forks stalling leads to the accumulation of mtDNA deletions are unclear. This study investigates the formation of G-quadruplexes (G4s) in mtDNA and their impact on mtDNA instability. The results demonstrate the transient formation of mtDNA G4s, especially in the major arc, and suggest that replication stalling increases G4 occurrence and unresolved G4s negatively affect mtDNA integrity.
NUCLEIC ACIDS RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Qian Liu, Dongrong Yi, Jiwei Ding, Yang Mao, Shujie Wang, Ling Ma, Quanjie Li, Jing Wang, Yongxin Zhang, Jianyuan Zhao, Saisai Guo, Zhenlong Liu, Fei Guo, Dongbing Zhao, Chen Liang, Xiaoyu Li, Xiaozhong Peng, Shan Cen
Summary: In this study, researchers found that MOV10 recruits DCP2 to LINE-1 RNA and forms a complex, exhibiting liquid-liquid phase separation properties. DCP2 cooperates with MOV10 to decap LINE-1 RNA, resulting in its degradation and reduced retrotransposition activity.
Article
Biochemistry & Molecular Biology
Sarah Venus, Kaba Tandjigora, Eckhard Jankowsky
Summary: The protein K7 from vaccinia virus is shown to inhibit the biochemical activities and cellular functions of DDX3X by binding to its N-terminus, restraining its association with stress granules.
JOURNAL OF MOLECULAR BIOLOGY
(2023)
Article
Virology
Andrey G. G. Solovyev, Sergey Y. Y. Morozov
Summary: This paper presents a novel perspective on the diversity and taxonomy of beny-like viruses infecting hosts of the plant kingdom. By analyzing open-source data, the study expands the known host range of the family Benyviridae to include red algae and suggests cross-kingdom host changes and gene recombination/exchanges in the evolution of this virus family. Furthermore, the identification of gene blocks encoding known movement proteins in beny-like RNA viruses infecting non-vascular plants provides evidence of the acquisition of movement proteins before the evolutionary emergence of the plant vascular system. The study also highlights the molecular evolution of land-plant-infecting viruses, which gave rise to numerous provisional species encoding no known potential movement genetic systems.
Article
Oncology
Zhi Hao Kwok, Bin Zhang, Xiao Hong Chew, Jia Jia Chan, Velda Teh, Henry Yang, Dennis Kappei, Yvonne Tay
Summary: This study reveals that in colon cancer, some miRNAs transcribed with their host genes cooperate to promote cancer growth, with noncoding RNA FTX regulating A-to-I RNA editing and intronic miRNAs inhibiting tumor suppressors. These findings highlight the complex interplay between intronic miRNAs and host transcripts in driving disease progression and expanding the functional landscape of multigenic loci.
Article
Cell Biology
Yang Cao, Jiacheng Wu, Ye Hu, Yangyang Chai, Jiaying Song, Jiaqi Duan, Song Zhang, Xiaoqing Xu
Summary: A recently identified lncRNA, lncRNA-BTX, is found to promote viral replication and immune escape by enhancing the interactions between specific RBPs. This discovery unveils a strategy developed by viruses to evade host innate immunity, and provides a potential target for antiviral therapeutics.
Article
Fisheries
Qingyun Yang, Peng Wang, Shuaiqi Yang, Xianpeng Li, Xiangmin Zhang, Guangdong Ji, Shicui Zhang, Su Wang, Hongyan Li
FISH & SHELLFISH IMMUNOLOGY
(2020)
Article
Fisheries
Huimin Duan, Shousheng Ni, Shuaiqi Yang, Yang Zhou, Yu Zhang, Shicui Zhang
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Huimin Duan, Shuaiqi Yang, Shousheng Ni, Zengyu Ma, Jianrui Yuan, Shicui Zhang
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Huimin Duan, Shuaiqi Yang, Xiangmin Zhang, Guangdong Ji
Summary: This study demonstrates the crucial role of receptor interacting protein kinase-1 in immune response regulation, including its direct interaction with bacteria, which plays a key role in anti-infectious responses.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2022)
Article
Immunology
Xianpeng Li, Ruitong Guo, Shuaiqi Yang, Xiangmin Zhang, Xiu Yin, Lei Teng, Shicui Zhang, Guangdong Ji, Hongyan Li
Summary: CD248a and CD248b have been identified as orthologs of human CD248 in zebrafish. They are involved in immune response and induce the expression of pro-inflammatory cytokines.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Shuaiqi Yang, Xinyi Xu, Ailong Zhang, Yunchao Wang, Guangdong Ji, Chen Sun, Hongyan Li
Summary: This study investigates the evolution of the Zc3h12 family in zebrafish and their immunomodulatory role. The findings reveal that the number of Zc3h12 family members is more complex and diverse in zebrafish. They can recognize the 3'-UTR regions of inflammatory cytokines through binding to specific RNA secondary structures and negatively regulate their expression.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)