Journal
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
Volume 214, Issue -, Pages 100-110Publisher
ELSEVIER
DOI: 10.1016/j.ijbiomac.2022.06.062
Keywords
Starch nanoparticle; 13-Carotene; Encapsulation; Nanoprecipitation; Stability; Controlled release
Funding
- Ministry of Trade, Industry and Energy, Korea , under the Regional Innovation Cluster Development Program [S3086263]
- Korea Technology & Information Promotion Agency for SMEs (TIPA) [S3086263] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Stable and small-sized composite particles can be prepared by mixing starch nanoparticles with a solution of 13-carotene. These composite particles have good stability under high temperature, acidic, ultraviolet, and oxidation conditions, and the release rate of 13-carotene can be controlled.
To apply starch nanoparticles (SNP) as host materials for 13-carotene encapsulation, aqueous SNP dispersions (10, 25, 50, and 100 mg/10 mL) and 13-carotene in acetone (10, 50, 100, 150, and 200 mu g/mL) were mixed. The acetone in the mixture was evaporated to prepare SNP and 13-carotene composites, which were homogeneously dispersed in aqueous media with over 90 % solubility. When SNP content was higher than 50 mg, over 80 % of 13-carotene was encapsulated in the composite matrix. X-ray diffraction, nuclear magnetic resonance spectroscopy, and transmission electron microscopic analyses confirmed the micellar-shaped composite particles with diameters <120 nm and an amorphous structure. High SNP content in the composites enhanced 13-carotene stability under extremely hot and acidic conditions as well as against ultraviolet rays and oxidation reactions. The encapsulated 13-carotene was not readily released in simulated gastric fluid, but was gradually released in simulated intestinal fluid via SNP digestion in the composites.
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