Journal
GUT AND LIVER
Volume 16, Issue 6, Pages 840-848Publisher
EDITORIAL OFFICE GUT & LIVER
DOI: 10.5009/gnl210479
Keywords
Inflammatory bowel disease; Crohn disease; Ulcerative colitis
Categories
Ask authors/readers for more resources
There is a well-known association between inflammatory bowel disease and colorectal cancer, with patients with inflammatory bowel disease having an increased risk of colorectal cancer. Control of chronic inflammation and surveillance colonoscopies are important in preventing colorectal cancer in these patients. Current evidence supports the use of chemoprevention therapy with mesalamine to reduce the risk of colorectal cancer in patients with ulcerative colitis.
The association between inflammatory bowel disease and colorectal cancer is well known. Although the overall incidence of inflammatory bowel disease has declined recently, patients with this disease still have a 1.7-fold increased risk of colorectal cancer. The risk factors for developing colorectal cancer include extensive colitis, young age at diagnosis, disease duration, primary sclerosing cholangitis, chronic colonic mucosal inflammation, dysplasia lesion, and post-inflammatory polyps. In patients with inflammatory bowel disease, control of chronic inflammation and surveillance colonoscopies are important for the prevention of colorectal cancer. The 2017 guidelines from the European Crohn's and Colitis Organisation suggest that colonoscopies to screen for colorectal cancer should be performed when inflammatory bowel disease symptoms have lasted for 8 years. Current evidence supports the use of chemoprevention therapy with mesalamine to reduce the risk of colorectal cancer in patients with ulcerative colitis. Other compounds, including thiopurine, folic acid, statin, and tumor necrosis factor-a inhibitor, are controversial. Large surveillance cohort studies with longer follow-up duration are needed to evaluate the impact of drugs on colorectal cancer risks. (Gut Liver 2022;16:840-848)
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available