Histone methyltransferase DOT1L is essential for self-renewal of germline stem cells

Developmental underpinnings of spermatogonial stem cell establishment

(2020) Nathan C. Law et al.   Andrology

Donor-derived spermatogenesis following stem cell transplantation in sterile NANOS2 knockout males

(2020) Michela Ciccarelli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DOT1L-controlled cell-fate determination and transcription elongation are independent of H3K79 methylation

(2020) Kaixiang Cao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Maternal DOT1L is dispensable for mouse development

(2020) Ji Liao et al.   Scientific Reports

CARF promotes spermatogonial self-renewal and proliferation through Wnt signaling pathway

(2020) Wenhao Cui et al.   Cell Discovery

Developmental kinetics and transcriptome dynamics of stem cell specification in the spermatogenic lineage

(2019) Nathan C. Law et al.   Nature Communications

Sertoli cell-only phenotype and scRNA-seq define PRAMEF12 as a factor essential for spermatogenesis in mice

(2019) Zhengpin Wang et al.   Nature Communications

DOT1L: a key target in normal chromatin remodelling and in mixed-lineage leukaemia treatment

(2019) Federica Sarno et al.   Epigenetics

DOT1L promotes progenitor proliferation and primes neuronal layer identity in the developing cerebral cortex

(2018) Henriette Franz et al.   NUCLEIC ACIDS RESEARCH

The upstreams and downstreams of H3K79 methylation by DOT1L

(2016) Hanneke Vlaming et al.   CHROMOSOMA

The regulatory repertoire of PLZF and SALL4 in undifferentiated spermatogonia

(2016) Dawn L. Lovelace et al.   DEVELOPMENT

DMRT1 Is Required for Mouse Spermatogonial Stem Cell Maintenance and Replenishment

(2016) Teng Zhang et al.   PLoS Genetics

Improved Serum- and Feeder-Free Culture of Mouse Germline Stem Cells1

(2014) Mito Kanatsu-Shinohara et al.   BIOLOGY OF REPRODUCTION

AF10 Regulates Progressive H3K79 Methylation and HOX Gene Expression in Diverse AML Subtypes

(2014) Aniruddha J. Deshpande et al.   CANCER CELL

The regulation of Hox gene expression during animal development

(2013) Moisés Mallo et al.   DEVELOPMENT

Regulation of pluripotency in male germline stem cells by Dmrt1

(2013) S. Takashima et al.   GENES & DEVELOPMENT

SALL4 Expression in Gonocytes and Spermatogonial Clones of Postnatal Mouse Testes

(2013) Kathrin Gassei et al.   PLoS One

Tumor suppressor gene Rb is required for self-renewal of spermatogonial stem cells in mice

(2013) Y.-C. Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional Antagonism between Sall4 and Plzf Defines Germline Progenitors

(2012) Robin M. Hobbs et al.   Cell Stem Cell

Human Histone H3K79 Methyltransferase DOT1L Methyltransferase Binds Actively Transcribing RNA Polymerase II to Regulate Gene Expression

(2012) Seung-Kyoon Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chromatin-modifying enzymes as modulators of reprogramming

(2012) Tamer T. Onder et al.   NATURE

Inhibitor of DNA Binding 4 Is Expressed Selectively by Single Spermatogonia in the Male Germline and Regulates the Self-Renewal of Spermatogonial Stem Cells in Mice1

(2011) Melissa J. Oatley et al.   BIOLOGY OF REPRODUCTION

Requirement for Dot1l in murine postnatal hematopoiesis and leukemogenesis by MLL translocation

(2011) S. Y. Jo et al.   BLOOD

MLL-Rearranged Leukemia Is Dependent on Aberrant H3K79 Methylation by DOT1L

(2011) Kathrin M. Bernt et al.   CANCER CELL

Reconstitution of the Mouse Germ Cell Specification Pathway in Culture by Pluripotent Stem Cells

(2011) Katsuhiko Hayashi et al.   CELL

The Specificity and Topology of Chromatin Interaction Pathways in Yeast

(2011) Tineke L. Lenstra et al.   MOLECULAR CELL

Early mammalian erythropoiesis requires the Dot1L methyltransferase

(2010) Y. Feng et al.   BLOOD

Plzf Regulates Germline Progenitor Self-Renewal by Opposing mTORC1

(2010) Robin M. Hobbs et al.   CELL

Identification of Glial Cell Line-Derived Neurotrophic Factor-Regulated Genes Important for Spermatogonial Stem Cell Self-Renewal in the Rat1

(2009) Jonathan A. Schmidt et al.   BIOLOGY OF REPRODUCTION

The pluripotency factor LIN28 marks undifferentiated spermatogonia in mouse

(2009) Ke Zheng et al.   BMC DEVELOPMENTAL BIOLOGY

A role for Lin28 in primordial germ-cell development and germ-cell malignancy

(2009) Jason A. West et al.   NATURE

The RNA-Binding Protein NANOS2 Is Required to Maintain Murine Spermatogonial Stem Cells

(2009) A. Sada et al.   SCIENCE

Foxo3 is a PI3K-dependent molecular switch controlling the initiation of oocyte growth

(2008) George B. John et al.   DEVELOPMENTAL BIOLOGY

Male Germ Cell Transplantation

(2008) I Dobrinski   REPRODUCTION IN DOMESTIC ANIMALS

The Histone H3K79 Methyltransferase Dot1L Is Essential for Mammalian Development and Heterochromatin Structure

(2008) Brendan Jones et al.   PLoS Genetics