AGA Clinical Practice Update: Diagnosis and Management of Nonalcoholic Fatty Liver Disease in Lean Individuals: Expert Review

Caucasian lean subjects with non-alcoholic fatty liver disease share long-term prognosis of non-lean: time for reappraisal of BMI-driven approach?

(2021) Ramy Younes et al.   GUT

Diagnosis and management of secondary causes of steatohepatitis

(2021) Roman Liebe et al.   JOURNAL OF HEPATOLOGY

Therapeutic pipeline in nonalcoholic steatohepatitis

(2021) Raj Vuppalanchi et al.   Nature Reviews Gastroenterology & Hepatology

Weight change and resolution of fatty liver in normal weight individuals with nonalcoholic fatty liver disease

(2021) Dong Hyun Sinn et al.   EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY

Diagnostic accuracy of non-invasive tests for advanced fibrosis in patients with NAFLD: an individual patient data meta-analysis

(2021) Ferenc Emil Mózes et al.   GUT

Nonalcoholic Fatty Liver Disease in Lean Subjects: Associations With Metabolic Dysregulation and Cardiovascular Risk—A Single-Center Cross-Sectional Study

(2021) Georg Semmler et al.   Clinical and Translational Gastroenterology

Glucagon-Like Peptide-1 Receptor Agonists for Non-Alcoholic Fatty Liver Disease in Type 2 Diabetes: A Meta-Analysis

(2021) Chloe Wong et al.   Frontiers in Endocrinology

Natural History of Nonalcoholic Fatty Liver Disease With Normal Body Mass Index: A Population-Based Study

(2021) Omar T. Ahmed et al.   Clinical Gastroenterology and Hepatology

Preparing for the NASH Epidemic: A Call to Action

(2021) Fasiha Kanwal et al.   GASTROENTEROLOGY

Clinical Care Pathway for the Risk Stratification and Management of Patients With Nonalcoholic Fatty Liver Disease

(2021) Fasiha Kanwal et al.   GASTROENTEROLOGY

Cardiovascular Risk Is Elevated in Lean Subjects with Nonalcoholic Fatty Liver Disease

(2021) Yuna Kim et al.   Gut and Liver

Liver-related Mortality is Increased in Lean Subjects with Non- alcoholic Fatty Liver Disease Compared to Overweight and Obese Subjects

(2021) Alexandra Feldman et al.   Journal of Gastrointestinal and Liver Diseases

EASL Clinical Practice Guidelines on non-invasive tests for evaluation of liver disease severity and prognosis – 2021 update

(2021) Annalisa Berzigotti et al.   JOURNAL OF HEPATOLOGY

MRI-based (MAST) score accurately identifies patients with NASH and significant fibrosis

(2021) Mazen Noureddin et al.   JOURNAL OF HEPATOLOGY

Advances in non-invasive assessment of hepatic fibrosis

(2020) Rohit Loomba et al.   GUT

Update on NAFLD genetics: from new variants to the clinic

(2020) Eric Trépo et al.   JOURNAL OF HEPATOLOGY

FibroScan-AST (FAST) score for the non-invasive identification of patients with non-alcoholic steatohepatitis with significant activity and fibrosis: a prospective derivation and global validation study

(2020) Philip N Newsome et al.   Lancet Gastroenterology & Hepatology

Enhanced liver fibrosis test for the non-invasive diagnosis of fibrosis in patients with NAFLD: A systematic review and meta-analysis

(2020) Yasaman Vali et al.   JOURNAL OF HEPATOLOGY

Genome-wide association study of non-alcoholic fatty liver and steatohepatitis in a histologically-characterised cohort

(2020) Quentin M. Anstee et al.   JOURNAL OF HEPATOLOGY

Prevalence, characteristics and mortality outcomes of obese, nonobese and lean NAFLD in the United States, 1999–2016

(2020) B. Zou et al.   JOURNAL OF INTERNAL MEDICINE

Lean Americans With Nonalcoholic Fatty Liver Disease Have Lower Rates of Cirrhosis and Co-morbid Diseases

(2020) Ethan M. Weinberg et al.   Clinical Gastroenterology and Hepatology

Screening for Non-Alcoholic Fatty Liver Disease in Persons with Type 2 Diabetes in the U.S. is Cost Effective: A Comprehensive Cost-Utility Analysis

(2020) Mazen Noureddin et al.   GASTROENTEROLOGY

A blood-based biomarker panel (NIS4) for non-invasive diagnosis of non-alcoholic steatohepatitis and liver fibrosis: a prospective derivation and global validation study

(2020) Stephen A Harrison et al.   Lancet Gastroenterology & Hepatology

Characterization of Essential Domains in HSD17B13 for Cellular Localization and Enzymatic Activity

(2020) Yanling Ma et al.   JOURNAL OF LIPID RESEARCH

Role of Noninvasive Tests in Clinical Gastroenterology Practices to Identify Patients With Nonalcoholic Steatohepatitis at High Risk of Adverse Outcomes

(2020) Zobair M. Younossi et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

MRE combined with FIB-4 (MEFIB) index in detection of candidates for pharmacological treatment of NASH-related fibrosis

(2020) Jinho Jung et al.   GUT

NAFLD : Reporting Histologic Findings in Clinical Practice

(2020) Elizabeth M. Brunt et al.   HEPATOLOGY

Non-invasive stratification of hepatocellular carcinoma risk in non-alcoholic fatty liver using polygenic risk scores

(2020) Cristiana Bianco et al.   JOURNAL OF HEPATOLOGY

A Placebo-Controlled Trial of Subcutaneous Semaglutide in Nonalcoholic Steatohepatitis

(2020) Philip N. Newsome et al.   NEW ENGLAND JOURNAL OF MEDICINE

NASH in Lean Individuals

(2019) Ramy Younes et al.   SEMINARS IN LIVER DISEASE

Risks and clinical predictors of cirrhosis and hepatocellular carcinoma diagnoses in adults with diagnosed NAFLD: real-world study of 18 million patients in four European cohorts

(2019) Myriam Alexander et al.   BMC Medicine

Prospective evaluation of a primary care referral pathway for patients with non-alcoholic fatty liver disease

(2019) Ankur Srivastava et al.   JOURNAL OF HEPATOLOGY

Role of Vitamin E for Nonalcoholic Steatohepatitis in Patients With Type 2 Diabetes: A Randomized Controlled Trial

(2019) Fernando Bril et al.   DIABETES CARE

High Risk of Fatty Liver Disease Amplifies the Alanine Transaminase‐Lowering effect of a HSD 17B13 Variant

(2019) Helene Gellert‐Kristensen et al.   HEPATOLOGY

Association Between PNPLA3 rs738409 C>G Variant and Liver-Related Outcomes in Patients with Non-alcoholic Fatty Liver Disease

(2019) Stefania Grimaudo et al.   Clinical Gastroenterology and Hepatology

Performance of simple fibrosis scores in non-obese patients with nonalcoholic fatty liver disease

(2019) Charmaine Fu et al.   Clinical Gastroenterology and Hepatology

Lean NAFLD : A Distinct Entity Shaped by Differential Metabolic Adaptation

(2019) Fei Chen et al.   HEPATOLOGY

Alcohol Use is Associated with Hepatic Steatosis Among Persons with Presumed Non-alcoholic Fatty Liver Disease

(2019) Michelle T. Long et al.   Clinical Gastroenterology and Hepatology

NASH Leading Cause of Liver Transplant in Women: Updated Analysis of Indications For Liver Transplant and Ethnic and Gender Variances

(2018) Mazen Noureddin et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Non-alcoholic Steatohepatitis is the Fastest Growing Cause of Hepatocellular Carcinoma in Liver Transplant Candidates

(2018) Zobair Younossi et al.   Clinical Gastroenterology and Hepatology

Magnetic Resonance vs Transient Elastography Analysis of Patients With Non-alcoholic Fatty Liver Disease: a Systematic Review and Pooled Analysis of Individual Participants

(2018) Cynthia Hsu et al.   Clinical Gastroenterology and Hepatology

Accuracy of the Enhanced Liver Fibrosis Test vs FibroTest, Elastography, and Indirect Markers in Detection of Advanced Fibrosis in Patients With Alcoholic Liver Disease

(2018) Maja Thiele et al.   GASTROENTEROLOGY

Diagnostic modalities for nonalcoholic fatty liver disease, nonalcoholic steatohepatitis, and associated fibrosis

(2018) Zobair M. Younossi et al.   HEPATOLOGY

Global Perspectives on Non-alcoholic Fatty Liver Disease and Non-alcoholic Steatohepatitis

(2018) Zobair Younossi et al.   HEPATOLOGY

Beneficial effects of lifestyle intervention in non-obese patients with non-alcoholic fatty liver disease

(2018) Vincent Wai-Sun Wong et al.   JOURNAL OF HEPATOLOGY

The epidemiology of obesity

(2018) Yu Chung Chooi et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Risk of Hepatocellular Cancer in Patients With Non-Alcoholic Fatty Liver Disease

(2018) Fasiha Kanwal et al.   GASTROENTEROLOGY

Interferon lambda 4 rs368234815 TT>δG variant is associated with liver damage in patients with nonalcoholic fatty liver disease

(2017) Salvatore Petta et al.   HEPATOLOGY

The diagnosis and management of nonalcoholic fatty liver disease: Practice guidance from the American Association for the Study of Liver Diseases

(2017) Naga Chalasani et al.   HEPATOLOGY

Global burden of NAFLD and NASH: trends, predictions, risk factors and prevention

(2017) Zobair Younossi et al.   Nature Reviews Gastroenterology & Hepatology

Economic evaluation of a community-based diagnostic pathway to stratify adults for non-alcoholic fatty liver disease: a Markov model informed by a feasibility study

(2017) Lukasz Tanajewski et al.   BMJ Open

ACG Clinical Guideline: Evaluation of Abnormal Liver Chemistries

(2016) Paul Y Kwo et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Long-Term Pioglitazone Treatment for Patients With Nonalcoholic Steatohepatitis and Prediabetes or Type 2 Diabetes Mellitus

(2016) Kenneth Cusi et al.   ANNALS OF INTERNAL MEDICINE

Screening for Nonalcoholic Steatohepatitis in Individuals with Type 2 Diabetes: A Cost-Effectiveness Analysis

(2016) Kathleen E. Corey et al.   DIGESTIVE DISEASES AND SCIENCES

Histological severity and clinical outcomes of nonalcoholic fatty liver disease in nonobese patients

(2016) Jonathan Chung-Fai Leung et al.   HEPATOLOGY

EASL–EASD–EASO Clinical Practice Guidelines for the management of non-alcoholic fatty liver disease

(2016)   JOURNAL OF HEPATOLOGY

Liraglutide safety and efficacy in patients with non-alcoholic steatohepatitis (LEAN): a multicentre, double-blind, randomised, placebo-controlled phase 2 study

(2016) Matthew James Armstrong et al.   LANCET

Liraglutide and Cardiovascular Outcomes in Type 2 Diabetes

(2016) Steven P. Marso et al.   NEW ENGLAND JOURNAL OF MEDICINE

Prevalence and Severity of Nonalcoholic Fatty Liver Disease in Non-Obese Patients: A Population Study Using Proton-Magnetic Resonance Spectroscopy

(2015) Jeremy Lok Wei et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

The Impact of PNPLA3 rs738409 Genetic Polymorphism and Weight Gain ≥10 kg after Age 20 on Non-Alcoholic Fatty Liver Disease in Non-Obese Japanese Individuals

(2015) Kenichi Nishioji et al.   PLoS One

Carriage of the PNPLA3 rs738409 C >G polymorphism confers an increased risk of non-alcoholic fatty liver disease associated hepatocellular carcinoma

(2014) Y.-L. Liu et al.   JOURNAL OF HEPATOLOGY

Role of physical activity in nonalcoholic fatty liver disease in terms of visceral obesity and insulin resistance

(2014) Min-Sun Kwak et al.   LIVER INTERNATIONAL

Community-based lifestyle modification programme for non-alcoholic fatty liver disease: A randomized controlled trial

(2013) Vincent Wai-Sun Wong et al.   JOURNAL OF HEPATOLOGY

Regular Exercise Is Associated with a Reduction in the Risk of NAFLD and Decreased Liver Enzymes in Individuals with NAFLD Independent of Obesity in Korean Adults

(2012) Ji Cheol Bae et al.   PLoS One

Resistance exercise reduces liver fat and its mediators in non-alcoholic fatty liver disease independent of weight loss

(2011) K. Hallsworth et al.   GUT

Pioglitazone, Vitamin E, or Placebo for Nonalcoholic Steatohepatitis

(2010) Arun J. Sanyal et al.   NEW ENGLAND JOURNAL OF MEDICINE

Soft drink consumption is associated with fatty liver disease independent of metabolic syndrome

(2009) Ali Abid et al.   JOURNAL OF HEPATOLOGY

Liver biopsy

(2008) Don C. Rockey et al.   HEPATOLOGY

Heritability in the genomics era — concepts and misconceptions

(2008) Peter M. Visscher et al.   NATURE REVIEWS GENETICS