Recent advances in oxazolidinones as antituberculosis agents

Simultaneous Determination of a Novel Oxazolidinone Anti-tuberculosis OTB-658 and Its Metabolites in Monkey Blood by LC-MS/MS

(2021) Jianwei Jiang et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Identification of Novel Tricyclic Benzo[1,3]oxazinyloxazolidinones as Potent Antibacterial Agents with Excellent Pharmacokinetic Profiles against Drug-Resistant Pathogens

(2021) Yongqi Wu et al.   JOURNAL OF MEDICINAL CHEMISTRY

In vitro and in vivo activity of oxazolidinone candidate OTB-658 against Mycobacterium tuberculosis

(2021) Shaochen Guo et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Development of Delpazolid for the Treatment of Tuberculosis

(2020) Young Lag Cho et al.   Applied Sciences-Basel

Discovery of a Conformationally Constrained Oxazolidinone with Improved Safety and Efficacy Profiles for the Treatment of Multidrug-Resistant Tuberculosis

(2020) Hongyi Zhao et al.   JOURNAL OF MEDICINAL CHEMISTRY

In Vitro Activity of Tedizolid against Mycobacterium tuberculosis

(2019) Pilar Ruiz et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Breakthrough in the treatment of drug-resistant tuberculosis

(2019) Ammara Mushtaq   Lancet Respiratory Medicine

In vitro and in vivo activity of contezolid (MRX-I) against Mycobacterium tuberculosis

(2018) Carolyn Shoen et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Comparison of in vitro activity and MIC distributions between the novel oxazolidinone delpazolid and linezolid against multidrug-resistant and extensively drug-resistant Mycobacterium tuberculosis in China

(2018) Zhaojing Zong et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Tuberculosis: progress and advances in development of new drugs, treatment regimens, and host-directed therapies

(2018) Simon Tiberi et al.   LANCET INFECTIOUS DISEASES

Effect of food on the pharmacokinetic characteristics of a single oral dose of LCB01-0371, a novel oxazolidinone antibiotic

(2018) Jung Sunwoo et al.   Drug Design Development and Therapy

Synthesis and antibacterial activity evaluation of novel biaryloxazolidinone analogues containing a hydrazone moiety as promising antibacterial agents

(2018) Yachuang Wu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Treatment correlates of successful outcomes in pulmonary multidrug-resistant tuberculosis: an individual patient data meta-analysis

(2018) Nafees Ahmad et al.   LANCET

Design and synthesis of biaryloxazolidinone derivatives containing a rhodanine or thiohydantoin moiety as novel antibacterial agents against Gram-positive bacteria

(2018) Yachuang Wu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Safety, tolerability and pharmacokinetics of 21 day multiple oral administration of a new oxazolidinone antibiotic, LCB01-0371, in healthy male subjects

(2017) Yewon Choi et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Discovery of Fluorine-Containing Benzoxazinyl-oxazolidinones for the Treatment of Multidrug Resistant Tuberculosis

(2017) Hongyi Zhao et al.   ACS Medicinal Chemistry Letters

Role of the Cys154Arg Substitution in Ribosomal Protein L3 in Oxazolidinone Resistance in Mycobacterium tuberculosis

(2016) Gaëlle Guiewi Makafe et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Mycobacterium tuberculosis Mutations Associated with Reduced Susceptibility to Linezolid

(2016) Shuo Zhang et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

An evolved oxazolidinone with selective potency against Mycobacterium tuberculosis and gram positive bacteria

(2016) Amit Kaushik et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Linezolid in the treatment of drug-resistant tuberculosis: the challenge of its narrow therapeutic index

(2016) Sean Wasserman et al.   Expert Review of Anti-Infective Therapy

To be or not to be exclusive: the sutezolid story

(2016) Jane Andrews   Lancet Global Health

Oxazolidinones as Anti-tubercular Agents: Discovery, Development and Future Perspectives

(2015) Pradeep Jadhavar et al.   CURRENT MEDICINAL CHEMISTRY

The structure of the human mitochondrial ribosome

(2015) A. Amunts et al.   SCIENCE

Population Pharmacokinetic/Pharmacodynamic Analysis of the Bactericidal Activities of Sutezolid (PNU-100480) and Its Major Metabolite against Intracellular Mycobacterium tuberculosis inEx VivoWhole-Blood Cultures of Patients with Pulmonary Tuberculosis

(2014) Tong Zhu et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

In VitroandIn VivoActivities of Three Oxazolidinones against Nonreplicating Mycobacterium tuberculosis

(2014) Ming Zhang et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Discovery of novel bis-oxazolidinone compounds as potential potent and selective antitubercular agents

(2014) Wei Ang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and in Vitro Evaluation of the Antitubercular and Antibacterial Activity of Novel Oxazolidinones Bearing Octahydrocyclopenta[c]pyrrol-2-yl Moieties

(2014) Deepak Bhattarai et al.   CHEMICAL & PHARMACEUTICAL BULLETIN

Beijing genotype of Mycobacterium tuberculosis is significantly associated with linezolid resistance in multidrug-resistant and extensively drug-resistant tuberculosis in China

(2014) Zhijian Zhang et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

In vitro and intracellular activity of 4-substituted piperazinyl phenyl oxazolidinone analogues against Mycobacterium tuberculosis

(2014) D. Wang et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

New Potent Antibacterial Oxazolidinone (MRX-I) with an Improved Class Safety Profile

(2014) Mikhail F. Gordeev et al.   JOURNAL OF MEDICINAL CHEMISTRY

Mycobactericidal Activity of Sutezolid (PNU-100480) in Sputum (EBA) and Blood (WBA) of Patients with Pulmonary Tuberculosis

(2014) Robert S. Wallis et al.   PLoS One

Anti-tubercular agents. Part 7: A new class of diarylpyrrole–oxazolidinone conjugates as antimycobacterial agents

(2013) Ahmed Kamal et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

In vitro activities of PNU-100480 and linezolid against drug-susceptible and drug-resistant Mycobacterium tuberculosis isolates

(2013) Peter C.W. Yip et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Tuberculosis

(2013) Alimuddin Zumla et al.   NEW ENGLAND JOURNAL OF MEDICINE

rplCT460C Identified as a Dominant Mutation in Linezolid-Resistant Mycobacterium tuberculosis Strains

(2012) Patrick Beckert et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Syntheses and biological studies of novel spiropiperazinyl oxazolidinone antibacterial agents using a spirocyclic diene derived acylnitroso Diels−Alder reaction

(2012) Cheng Ji et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis and In Vitro Antibacterial Activity of Novel 3-Azabicyclo[3.3.0]octanyl Oxazolidinones

(2012) Deepak Bhattarai et al.   Chemical Biology & Drug Design

Genome-Wide Expression Profiling of the Response to Linezolid in Mycobacterium tuberculosis

(2012) Junchao Liang et al.   CURRENT MICROBIOLOGY

Tedizolid (TR-701): a new oxazolidinone with enhanced potency

(2012) Zeina A. Kanafani et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Linezolid, the first oxazolidinone antibacterial agent

(2011) Karen L. Leach et al.   Annals of the New York Academy of Sciences

Anti-tubercular agents. Part 6: Synthesis and antimycobacterial activity of novel arylsulfonamido conjugated oxazolidinones

(2011) Ahmed Kamal et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design, synthesis and docking studies of quinoline-oxazolidinone hybrid molecules and their antitubercular properties

(2011) K.D. Thomas et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design, Synthesis, and Structure–Activity Relationship Studies of Highly Potent Novel Benzoxazinyl-Oxazolidinone Antibacterial Agents

(2011) Qisheng Xin et al.   JOURNAL OF MEDICINAL CHEMISTRY

In Vitro and In Vivo Activities of LCB01-0371, a New Oxazolidinone

(2010) J.-W. Jeong et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Biomarker-Assisted Dose Selection for Safety and Efficacy in Early Development of PNU-100480 for Tuberculosis

(2010) Robert S. Wallis et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Pharmacokinetics and Whole‐Blood Bactericidal Activity againstMycobacterium tuberculosisof Single Doses of PNU‐100480 in Healthy Volunteers

(2010) Robert S. Wallis et al.   JOURNAL OF INFECTIOUS DISEASES

Addition of PNU-100480 to First-Line Drugs Shortens the Time Needed to Cure Murine Tuberculosis

(2009) Kathy N. Williams et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Linezolid: a review of safety and tolerability

(2009) Donald C. Vinh et al.   JOURNAL OF INFECTION

Promising Antituberculosis Activity of the Oxazolidinone PNU-100480 Relative to That of Linezolid in a Murine Model

(2008) K. N. Williams et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Natural Products, Small Molecules, and Genetics in Tuberculosis Drug Development

(2008) Maria-Teresa Gutierrez-Lugo et al.   JOURNAL OF MEDICINAL CHEMISTRY

Crystal Structure of the Oxazolidinone Antibiotic Linezolid Bound to the 50S Ribosomal Subunit∥

(2008) Joseph A. Ippolito et al.   JOURNAL OF MEDICINAL CHEMISTRY

The oxazolidinone antibiotics perturb the ribosomal peptidyl-transferase center and effect tRNA positioning

(2008) D. N. Wilson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synthesis of novel oxazolidinone antimicrobial agents

(2007) David C. Ebner et al.   BIOORGANIC & MEDICINAL CHEMISTRY