Dynamic movement and turnover of extracellular matrices during tissue development and maintenance

Extracellular matrices (ECMs) are essential for the architecture and function of animal tissues. ECMs have been thought to be highly stable structures; however, too much stability of ECMs would hamper tissue remodelling required for organ development and maintenance. Regarding this conundrum, this article reviews multiple lines of evidence that ECMs are in fact rapidly moving and replacing components in diverse organisms including hydra, worms, flies, and vertebrates. Also discussed are how cells behave on/in such dynamic ECMs, how ECM dynamics contributes to embryogenesis and adult tissue homoeostasis, and what molecular mechanisms exist behind the dynamics. In addition, it is highlighted how cutting-edge technologies such as genome engineering, live imaging, and mathematical modelling have contributed to reveal the previously invisible dynamics of ECMs. The idea that ECMs are unchanging is to be changed, and ECM dynamics is emerging as a hitherto unrecognized critical factor for tissue development and maintenance.

Automated summary

Extracellular matrices (ECMs) are essential for the architecture and function of animal tissues. This article reveals that ECMs are actually rapidly moving and replacing components in different organisms. It discusses the behavior of cells on/in dynamic ECMs, the contribution of ECM dynamics to embryogenesis and tissue maintenance, and the molecular mechanisms behind the dynamics. Advanced technologies have helped uncover the previously unknown dynamics of ECMs.