Review
Pharmacology & Pharmacy
Cristina Martin-Sabroso, Ana Isabel Torres-Suarez, Mario Alonso-Gonzalez, Ana Fernandez-Carballido, Ana Isabel Fraguas-Sanchez
Summary: Folate receptors are lowly expressed in normal tissues but overexpressed in certain pathological conditions. Targeting folate receptors can lead to the development of new therapeutic tools for cancer and inflammatory diseases, with nanocarriers playing a crucial role.
Article
Immunology
Aashaq Hussain Bhat
Summary: The increasing number of pet animals in modern society is a result of the commitment of numerous individuals to their care. The close interaction between household pets and humans creates ideal conditions for bacterial transmission. With various bacteria developing resistance to antimicrobial agents used in animal husbandry, there is a need for data on the use of antimicrobials in pet animals.
MICROBIAL PATHOGENESIS
(2021)
Review
Construction & Building Technology
Laura Galuppi, Annalisa Franco, Chiara Bedon
Summary: The evaluation of thermally induced stresses and strains is a critical issue in the design of structural glass elements in buildings. Thermal stresses are one of the main causes of premature failure in glass due to its sensitivity to temperature gradients. Existing standards prescribe different methods for calculating temperature fields and the resulting stress, often based on simplifying assumptions, and lack uniformly defined procedures.
Review
Pharmacology & Pharmacy
Jennifer A. Kricker, Clive P. Page, Fridrik Runar Gardarsson, Olafur Baldursson, Thorarinn Gudjonsson, Michael J. Parnham
Summary: Macrolides, especially azithromycin, are widely prescribed for respiratory infections and exhibit time-dependent immunomodulatory actions that can benefit both infectious and chronic inflammatory diseases. Chronic use of these drugs can lead to bacterial resistance, but they have shown to enhance barrier properties of airway epithelial cells, contributing to therapeutic efficacy. Nonantibacterial macrolides are being studied for their immunomodulatory and barrier-strengthening properties to overcome the issue of resistance, with a focus on their beneficial effects in chronic inflammation and epithelial protection.
PHARMACOLOGICAL REVIEWS
(2021)
Review
Biochemistry & Molecular Biology
Alejandro Rodriguez-Camacho, Jose Guillermo Flores-Vazquez, Julia Moscardini-Martelli, Jorge Alejandro Torres-Rios, Alejandro Olmos-Guzman, Cindy Sharon Ortiz-Arce, Dharely Raquel Cid-Sanchez, Samuel Rosales Perez, Monsserrat Del Sagrario Macias-Gonzalez, Laura Crystell Hernandez-Sanchez, Juan Carlos Heredia-Gutierrez, Gabriel Alejandro Contreras-Palafox, Jose de Jesus Emilio Suarez-Campos, Miguel Angel Celis-Lopez, Guillermo Axayacalt Gutierrez-Aceves, Sergio Moreno-Jimenez
Summary: Glioblastoma is a lethal tumor with limited treatment options. Efforts are being made in various research areas to find new therapies that can improve patient survival and quality of life.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Chemistry, Multidisciplinary
Jia Lv, Yiyun Cheng
Summary: Fluoropolymers possess unique physicochemical properties and have been widely used in biomedical applications, especially in gene delivery, drug delivery, magnetic resonance imaging, etc. They exhibit distinct mechanisms and features in these specific applications, but also face challenges in utilizing their full potential in the biomedical field.
CHEMICAL SOCIETY REVIEWS
(2021)
Review
Medicine, General & Internal
Marina Petkovic, Melad Henis, Oliver Heese, Angela Relogio
Summary: Circadian rhythms play a crucial role in drug metabolism and treatment efficacy. Chronotherapy, based on individual circadian rhythm, maximizes treatment effectiveness and minimizes adverse effects. The application of chronotherapy in the treatment of glioblastoma multiforme (GBM), a highly aggressive brain tumor, offers potential to improve patient survival and quality of life. This article discusses the latest advancements in using chronotherapy regimens and novel treatments targeting the core circadian clock in GBM therapy.
Article
Engineering, Mechanical
Alexander F. Vakakis, Oleg Gendelman, Lawrence A. Bergman, Alireza Mojahed, Majdi Gzal
Summary: This paper provides a brief overview of the current progress in the field of nonlinear targeted energy transfer (TET) and discusses some future directions for research. The authors introduce four emerging research areas, including intermodal targeted energy transfer, implementation of TET in nonlinear acoustic metamaterials, the breakdown of classical reciprocity in elastodynamics in the context of TET, and the impact of TET on the bandwidth of general classes of nonlinear resonators. The aim of the authors is to outline the main ideas, summarize recent developments, suggest possible directions for future work, and encourage further research in both the discussed topics and other TET-related areas.
NONLINEAR DYNAMICS
(2022)
Article
Computer Science, Artificial Intelligence
Zhongliang Jiang, Septimiu E. Salcudean, Nassir Navab
Summary: Ultrasound (US) is widely used in clinical intervention and diagnosis due to its non-invasive and real-time imaging capabilities. However, free-hand US examinations are dependent on the operator's skills. Robotic US Systems (RUSS) aim to overcome this limitation by offering reproducibility and intelligent imaging. This paper categorizes RUSS as teleoperated or autonomous and reviews recent developments in both categories. Machine learning and artificial intelligence play a key role in enabling motion and deformation-aware robotic image acquisition. The recovery of the language of sonography through artificial intelligence research is valuable. The article provides a comprehensive understanding of RUSS and presents challenges in developing intelligent robotic sonographer colleagues.
MEDICAL IMAGE ANALYSIS
(2023)
Article
Green & Sustainable Science & Technology
Sumol Gopinadh, Peddinti V. R. L. Phanendra, Bibin John, T. D. Mercy
Summary: The increasing demand for efficient energy storage devices has led researchers to explore alternative systems that can outperform Li-ion batteries in terms of energy density. Recent studies have shown that fluoride ion batteries have the potential to provide energy densities more than eight times that of current Li-ion batteries. However, further advancements are needed in the performance of the electrode and electrolyte for fluoride ion batteries to reach their full potential.
SUSTAINABLE MATERIALS AND TECHNOLOGIES
(2022)
Review
Biochemistry & Molecular Biology
Veronica Cocetta, Vincenzo Quagliariello, Francesco Fiorica, Massimiliano Berretta, Monica Montopoli
Summary: Resistance to chemotherapy remains a challenge in cancer treatment, but resveratrol has shown promise as a chemosensitizer by modulating cancer-related molecular mechanisms. Despite its low bioavailability, efforts are being made to improve drug delivery strategies for more effective use in therapy-refractory cancer patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Giulia Di Donato, Debora Mariarita d'Angelo, Luciana Breda, Francesco Chiarelli
Summary: Systemic autoinflammatory diseases are a diverse group of disorders with strong genetic backgrounds, involving dysregulation at multiple levels, and advances in genetic sequencing have led to the discovery of over 50 monogenic autoinflammatory diseases. This has provided better understanding of the underlying immune pathways and pathogenesis, offering new perspectives for targeted therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Physical
Debashis Majee, Stanislav Presolski
Summary: This paper discusses the potential applications of dithienylethenes (DTEs) in the field of catalysis, as well as key strategies and development milestones for photo-switchable control. It also outlines potential directions for future development in this relatively young field.
Review
Biochemistry & Molecular Biology
Lei Zhong, Yueshan Li, Liang Xiong, Wenjing Wang, Ming Wu, Ting Yuan, Wei Yang, Chenyu Tian, Zhuang Miao, Tianqi Wang, Shengyong Yang
Summary: Targeted therapeutic drugs have become mainstream cancer treatments due to their advantages in efficacy and safety, but still face challenges such as low response rate and drug resistance. A comprehensive review was conducted on small-molecule targeted anti-cancer drugs to promote their development, discussing current challenges and providing insights and perspectives for future research and development.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2021)
Review
Pharmacology & Pharmacy
Diana Costa, Daniela Santo, Catia Domingues, Francisco Veiga, Henrique Faneca, Ana Figueiras
Summary: The decoding of the human genome has led to a better understanding of how genetics affect health and disease. The development of therapies based on exogenous nucleic acids has grown rapidly to address genetic-associated diseases. Non-viral systems, such as micelleplexes, show promise as gene delivery options, but their performance is often hindered by in vivo barriers.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Pathology
Teruaki Hirota, Kayoko Yonemaru, Mitsunobu Hattori, Mami Murakami, Hiroki Sakai, Akihiro Hirata
Summary: An 11-year-old female Persian cat underwent ovariohysterectomy due to dilation of the uterine cavity with irregular thickening of the wall. The pathological examination revealed multiple nodules originating from the endometrium, invading the myometrium and subserosa, and immunohistochemical staining confirmed the diagnosis of endometrial stromal sarcoma.
JOURNAL OF COMPARATIVE PATHOLOGY
(2024)
