Article
Chemistry, Physical
Soheyla Karimi, Hassan Namazi
Summary: This study successfully developed a novel magnetic carrier for targeted delivery of anticancer drugs, utilizing magnetic nanocomposites with antioxidant properties. The synthesized carrier showed controlled release of anticancer drugs, excellent cytotoxicity, and promising antioxidant activity, making it a potential co-drug delivery system for cancer therapy.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2021)
Article
Biochemistry & Molecular Biology
Ashok Bora, Dimpee Sarmah, Muzamil Ahmad Rather, Manabendra Mandal, Niranjan Karak
Summary: In this study, a bio-based hydrogel nanocomposite (HNC) was successfully prepared and used to evaluate pH-sensitive drug release properties. The HNC exhibited sustained drug release and pH responsive behavior. Additionally, it showed antibacterial activity and photocatalytic degradation of dyes.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Polymer Science
Meirong Zhao, Weiwei Jiang, Xinrong Xie, Yogini Jaiswal, Leonard Williams, Mei Wei, Ying Mo, Yifu Guan, Hua Yang
Summary: In this paper, a new drug carrier was synthesized using self-assembled polymeric micelles to load paclitaxel. The drug-loading content of the carrier prepared by the optimized method was 1.97%. The results indicate that the developed carrier has good pH sensitivity and potential for increased solubility and clinical efficacy of paclitaxel.
Article
Chemistry, Multidisciplinary
Yan Zhang, Fanglin Gong, Yue Wu, Siyuan Hou, Lingjing Xue, Zhigui Su, Can Zhang
Summary: The study utilized poly-beta-cyclodextrin and dextran sulfate grafted with benzimidazole to self-assemble into a supramolecular nanoassembly to address cholesterol crystals in lysosomes. The nanoassembly can release cholesterol crystals in lysosomes, promoting cholesterol efflux and aiding in the regression of atherosclerosis.
Article
Chemistry, Applied
Karim Khoshgard, Narges Ahmadi, Mehdi Jaymand
Summary: This study aimed to design and develop a novel theranostic hydrogel-based drug delivery system composed of beta-cyclodextrin, poly(N,N'-dimethylamino)ethyl methacrylate, and Fe3O4 and Bi2O3 nanoparticles. The drug-loaded hydrogels showed pH-dependent and sustained drug release behavior. The hydrogels exhibited good cytocompatibility and higher anti-cancer activities, while the nanoparticles allowed diagnosis by MRI and CT and served as efficient X-ray radiosensitizers.
CARBOHYDRATE POLYMER TECHNOLOGIES AND APPLICATIONS
(2023)
Article
Biotechnology & Applied Microbiology
Mahdieh Darroudi, Seyedeh Elnaz Nazari, Maryam Karimzadeh, Fereshteh Asgharzadeh, Nima Khalili-Tanha, Seyyedeh Zahra Asghari, Sara Ranjbari, Fatemeh Babaei, Majid Rezayi, Majid Khazaei
Summary: Cervical cancer, as a leading cause of cancer-related death in women, requires novel therapeutic approaches for improved effectiveness. Mxene-based nanocarriers, such as Ti3C2-Fe3O4@SiO2-FA, show promise in targeted drug delivery for cervical cancer treatment. The nanocarrier, when magnetically controlled, exhibits significant tumor growth suppression and synergistic therapeutic efficacy with pharmaceuticals.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Chemistry, Physical
Waixiang Yang, Lei Yang, Fanjie Li, Yulin Zhao, Xiali Liao, Chuanzhu Gao, Jing Yang, Bo Yang
Summary: A novel tumor-targeting drug delivery system was designed by encapsulating PPT in CD derivatives, significantly increasing its water solubility. The system showed effective proliferation inhibition on cancer cells while reducing cytotoxicity to normal cells.
JOURNAL OF MOLECULAR STRUCTURE
(2021)
Article
Biochemistry & Molecular Biology
Zixue Li, Wei Zhao, Na Liang, Pengfei Yan, Shaoping Sun
Summary: A tumor-targeting and pH-sensitive inclusion complex based on the host-guest recognition between FA-CS-CD and BM-SA was designed for controlled delivery of paclitaxel. The optimized PTX-loaded FA-CS-CD/BM-SA inclusion complex exhibited enhanced antitumor efficiency and minimized systemic toxicity, as demonstrated by in vitro and in vivo evaluations. This system shows promise as a carrier for paclitaxel.
Article
Pharmacology & Pharmacy
Zahra Sobhani, Reza Khalifeh, Mina Banizamani, Maryam Rajabzadeh
Summary: This paper reports a pH-responsive nanocarrier ZnO QD-PG-FA for the delivery of the anticancer drug doxorubicin. The carrier exhibits excellent drug release performance and antitumor activity.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Engineering, Environmental
Ayhan Bergal, Muberra Andac
Summary: In this study, oxidized beta-cyclodextrin (O-beta-CD) nanoparticles were synthesized and Amoxicillin trihydrate (AMOX) model drug was integrated both through a Schiff base reaction (C=N bond) and inclusion into the cavity of O-beta-CD to evaluate pH-responsive drug release behavior. The drug-loaded nanocarrier showed a sustained and prolonged drug release profile, especially in low pH conditions. Mathematical modeling indicated that drug release occurred through both dissolution and diffusion. These findings demonstrate the potential of this nanostructure as a pH-sensitive drug carrier.
JOURNAL OF POLYMERS AND THE ENVIRONMENT
(2023)
Article
Multidisciplinary Sciences
Hossein Hosseinzadeh, Ziba Jahanbakhsh, Bakhshali Masoumi, Vahid Hooshangi
Summary: A novel beta-CD-based magnetic nanocarrier with superparamagnetic and molecular recognition properties was synthesized for controlled drug release. The nanocarrier showed efficient loading and releasing behaviors of doxorubicin, with drug loading efficiency dependent on initial drug concentration, beta-CD content, and temperature. The in vitro release rate of doxorubicin was found to be pH-dependent, and the nanocarrier exhibited high performance in killing cancerous cells.
ARABIAN JOURNAL FOR SCIENCE AND ENGINEERING
(2023)
Article
Polymer Science
Muhammad Suhail, Yu-Fang Shao, Quoc Lam Vu, Pao-Chu Wu
Summary: pH-sensitive hydrogels were prepared for targeted drug delivery to the colon. The hydrogels showed high thermal stability, swelling capacity, and drug release in both acidic and basic environments.
Article
Oncology
Willi Jugel, Stefanie Tietze, Jennifer Daeg, Dietmar Appelhans, Felix Broghammer, Achim Aigner, Michael Karimov, Gabriele Schackert, Achim Temme
Summary: A new hybrid polyplex has been developed for targeted gene therapy, efficiently delivering genes to specific tumor cells. This approach may have significant implications for cancer treatment.
Article
Biochemistry & Molecular Biology
Saman Emami Gerami, Mehrab Pourmadadi, Hooman Fatoorehchi, Fatemeh Yazdian, Hamid Rashedi, Mona Navaei Nigjeh
Summary: In this study, nanocomposites of hematite/chitosan/polyvinylpyrrolidone were synthesized as a drug carrier for doxorubicin, exhibiting pH-sensitive and controlled release properties. The chemical and physical interactions within the nanocomposites were confirmed through analyses, and they demonstrated good cytotoxicity and anticancer effects in cell experiments.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Pharmacology & Pharmacy
Parbeen Singh, Yongli Chen, Deependra Tyagi, Li Wu, Xiaohong Ren, Jinglong Feng, Andrew Carrier, Tiangang Luan, Yongjun Tang, Jiwen Zhang, Xu Zhang
Summary: 13-Cyclodextrin was grafted onto hyaluronic acid in a single step to create a supramolecular biopolymer, HA-13-CD, which showed high loading capacity for drugs doxorubicin and Rhodamine B. The polymer also exhibited targeted drug delivery to cancerous cells with a high level of CD44 receptor expression, potentially making it a promising cancer-cell-targeting drug carrier.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Polymer Science
Mustafa Kalay, Abidin Esidir, Mahmut Ruzi, N. Burak Kiremitler, Mustafa Serdar Onses
Summary: This study proposes stable and addressable polymer PUFs, utilizing a cross-linkable polymer system, which demonstrates high stochastic characteristics and low-cost production. The performance of the polymer features is evaluated through various analyses, and direct image authentication is achieved using feature matching algorithms.
EUROPEAN POLYMER JOURNAL
(2024)
Article
Polymer Science
Jingyu Jin, Guoqiang Lu, Jun Nie, Xiaoqun Zhu
Summary: Photopolymerization technology is limited in the fields of food packaging and biomedicine due to the high migration of small molecules from photoinitiators. In this study, a polymerizable 2-vinyl thioxanthone (ETX) was synthesized to improve the migration stability of photoinitiators. Macromolecular photoinitiators (PPI1, PPI2) were also prepared to further reduce migration. The results showed that the ETX/TEOA system had higher initiation performance and PPI2 displayed favorable initiation ability. Additionally, the migration of ETX, PPI1, and PPI2 in photocured film was significantly reduced. These low-migration photoinitiators have potential applications in the fields of food packaging and biological materials.
EUROPEAN POLYMER JOURNAL
(2024)
Article
Polymer Science
Weijie Li, Jun Nie, Yingying Zhao, Xiaoqun Zhu
Summary: This study focuses on the development of high-performance, low-migration photoinitiators. A polymerizable photoinitiator (VBP) was synthesized by introducing an ethylene group into benzophenone, and three different molecular weight single-component photoinitiators (PVBN1-3) were synthesized based on VBP. The results show that these new photoinitiators have stronger absorption ability compared to benzophenone and significantly reduce the migration of initiators and co-initiators, addressing the safety concerns caused by migration.
EUROPEAN POLYMER JOURNAL
(2024)
Article
Polymer Science
Seira Morimune-Moriya, Yuki Iwahashi, Mitsuru Nakamura, Daisuke Ogawa, Keiji Nakamura
Summary: This study investigates the effect of plasma treatment on carbon nanotubes (CNTs) and the structure/properties of polyimide (PI) nanocomposites with ultra-low content of CNTs. The results show that plasma treatment introduces isocyanate groups on the surface of CNTs and enhances the interfacial interaction between PI and treated CNTs. This leads to a significant improvement in the mechanical properties of the nanocomposites, with even a small addition of treated CNTs showing a substantial increase in Young's modulus, tensile strength and toughness.
EUROPEAN POLYMER JOURNAL
(2024)
Article
Polymer Science
Yuanlong Li, Chaojie Chen, Guoqing Cui, Li Liu, Chao Zhou, Guangfeng Wu
Summary: In this study, a novel ion-conducting hydrogel was fabricated using a straightforward approach. The hydrogel showed excellent tensile properties and high toughness due to physical interactions and covalent binding. Additionally, the introduction of hydroxyethyl cellulose and lithium chloride improved the biocompatibility, mechanical properties, electrical conductivity, and frost resistance of the hydrogel, demonstrating its potential for cold climate applications.
EUROPEAN POLYMER JOURNAL
(2024)
Article
Polymer Science
Dengwei Yan, Jinxian Yang, Xuejun Pan, Xiaozheng Duan, Lianwei Li, Mo Zhu
Summary: The influence of backbone length on grafting efficiency during the graft-onto reaction process was investigated. It was found that the polydispersity effect of backbone length does not affect the final grafting efficiency, indicating that the local dynamics of chain segments dominate the graft-onto process.
EUROPEAN POLYMER JOURNAL
(2024)
Article
Polymer Science
Zhaoyi Luo, Xianjie Pan, Fanqi Liu, Quanxi Yi, Yanning Zeng, Yunhua Chen, Chaoyang Wang
Summary: This study provides a method to prepare high-performance epoxy materials with good malleability and thermal stability. The materials have self-healing and welding capabilities, thanks to the addition of specific chemical bonds and network structures. They exhibit mechanical properties comparable to commercial epoxy resins and show great potential for sustainable industrial development.
EUROPEAN POLYMER JOURNAL
(2024)
Article
Polymer Science
Chaoji Xiong, Hao Wang, Lihua Deng, Kun Liang, Chunhua Wu, Wei Wu, Qian Chen
Summary: In this study, four polyamides were synthesized and their adsorption performances for Hg2+ in aqueous systems were investigated. The polyamides exhibited high adsorption capacities and excellent reusability, with the involvement of sulfur, nitrogen, and oxygen in the chemical adsorption process of Hg2+.
EUROPEAN POLYMER JOURNAL
(2024)
Article
Polymer Science
Siim Laanesoo, Olivier Bonjour, Rauno Sedrik, Iris Tamsalu, Patric Jannasch, Lauri Vares
Summary: The insertion of rigid aliphatic or aromatic building blocks in polymer structures is an effective way to synthesize high -Tg polymer materials. In this study, a series of isosorbide-2-aryl carboxylate-5-methacrylate monomers (ArIMAs) were synthesized by functionalizing isosorbide 5-methacrylate with various aromatic lignin-inspired esters. These monomers were polymerized to obtain high molecular-weight poly(aryl carboxylate isosorbide methacrylates) (PArIMAs). The resulting polymers showed high glass transition temperatures and thermal stability, making them suitable for use as high-performance plastics and coatings.
EUROPEAN POLYMER JOURNAL
(2024)
Article
Polymer Science
Yuqian Wu, Weijie Xu, Jianliang Li, Zhangfeng Zhong, Liqing Huang, Shengke Li, Huaping Tan
Summary: This study investigates the improvement of degradation and drug release characteristics of dynamic Schiff base-mediated natural polysaccharide hydrogels using tannic acid (TA), leading to enhanced stability and functionality.
EUROPEAN POLYMER JOURNAL
(2024)
Article
Polymer Science
Xi Zhang, Xiangli Kong, Xin Zhou, Yiyan Gao, Yibo Sun, Guanghui Gao, Wei Liu, Kai Shi
Summary: Conductive hydrogels have great development prospects in flexible strain sensors, but long-term direct contact with human skin can cause bacterial infection. A hydrogel with antibacterial, biocompatibility, and toughness was designed and manufactured using a freeze-thaw method. The hydrogel maintains tensile properties and fatigue resistance at low temperatures and is resistant to bacteria. Therefore, hydrogel sensors can be used to monitor human movements.
EUROPEAN POLYMER JOURNAL
(2024)
Article
Polymer Science
Wei Zhang, Jiangang Yu, Mingyang Wu, Rui Li, Anqiang Zhang, Yaling Lin
Summary: In this study, polyacrylamide containing quaternary ammonium salts (PAM-X) were synthesized and found to effectively inhibit soil-borne pathogenic fungi while maintaining the balance of microbial population in soil. PAM-X also showed low toxicity to earthworms and fish, providing a new method for the prevention and control of soil-borne fungal diseases.
EUROPEAN POLYMER JOURNAL
(2024)
Article
Polymer Science
Jiawen He, Haojie Yu, Li Wang, Jian Yang, Yanhui Zhang, Wenbing Huang, Chenguang Ouyang
Summary: This review discusses the use of polymeric hydrogels for atmospheric water harvesting (AWH), including the mechanism of water sorption, fabrication methods, and strategies for optimizing the structure of hydrogels. The extended applications of hygroscopic photothermal hydrogels, such as agricultural irrigation and dehumidification, are also explored. The challenges and prospects of using polymeric hydrogels for AWH are summarized.
EUROPEAN POLYMER JOURNAL
(2024)
Article
Polymer Science
Ying Du, Shuaishuai Lu, Yuanna Sun, Qingshan Li, Xinhai He
Summary: This study introduces a method to improve the performance of hydrogels by incorporating proline, resulting in hydrogels with excellent stretchability, high conductivity, and long-term stability. The hydrogel remains flexible and conductive even at ultra-low temperatures.
EUROPEAN POLYMER JOURNAL
(2024)