Synthesis and anticancer evaluations of novel 1H-imidazole [4,5-f][1,10] phenanthroline derivative for the treatment of colorectal cancer

Synthesis and biological activity of 1H-imidazo[4,5-f][1,10]phenanthroline as a potential antitumor agent with PI3K/AKT/mTOR signaling

(2021) Shujian Hu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

IPM712, a vanillin derivative as potential antitumor agents, displays better antitumor activity in colorectal cancers cell lines

(2020) Wantong Ma et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

A vanillin derivative suppresses the growth of HT29 cells through the Wnt/β-catenin signaling pathway

(2019) Wantong Ma et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Colorectal cancer cells respond differentially to autophagy inhibition in vivo

(2019) Annie Lauzier et al.   Scientific Reports

Heterogeneity in cancer cells: variation in drug response in different primary and secondary colorectal cancer cell lines in vitro

(2017) Melanie Arul et al.   IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL

Therapeutic Potential of Targeting PI3K/AKT Pathway in Treatment of Colorectal Cancer: Rational and Progress

(2017) Afsane Bahrami et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Monitoring ZEO apoptotic potential in 2D and 3D cell cultures and associated spectroscopic evidence on mode of interaction with DNA

(2017) Fahimeh Salehi et al.   Scientific Reports

Inhibition of the PI3K/AKT/mTOR Pathway in Solid Tumors

(2016) Patricia Mucci LoRusso   JOURNAL OF CLINICAL ONCOLOGY

A novelly synthesized phenanthroline derivative is a promising DNA-damaging anticancer agent inhibiting G1/S checkpoint transition and inducing cell apoptosis in cancer cells

(2015) Ni Zhen et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Microwave-assisted synthesis of phenanthroimidazole derivatives as stabilizer of c-myc G-quadruplex DNA

(2014) Siyan Liao et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Agonist Ligands Mediate the Transcriptional Response of Nuclear Receptor Heterodimers through Distinct Stoichiometric Assemblies with Coactivators

(2014) Mark Remec Pavlin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Picking the Point of Inhibition: A Comparative Review of PI3K/AKT/mTOR Pathway Inhibitors

(2014) R. Dienstmann et al.   MOLECULAR CANCER THERAPEUTICS

4-(1H-Imidazo[4,5-f]-1,10-phenanthrolin-2-yl)phenol-based G-quadruplex DNA binding agents: Telomerase inhibition, cytotoxicity and DNA-binding studies

(2012) Chun-Ying Wei et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Bortezomib interferes with C-KIT processing and transforms the t(8;21)-generated fusion proteins into tumor-suppressing fragments in leukemia cells

(2012) H.-T. Fang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Imidazo [4,5f][1,10] phenanthroline derivatives as inhibitor of c-myc gene expression in A549 cells via NF-κB pathway

(2011) Dong-dong Sun et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The PI3K Pathway As Drug Target in Human Cancer

(2010) Kevin D. Courtney et al.   JOURNAL OF CLINICAL ONCOLOGY

Endogenous Interleukin-4 Promotes Tumor Development by Increasing Tumor Cell Resistance to Apoptosis

(2008) Zhiguang Li et al.   CANCER RESEARCH