Journal
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
Volume 174, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.ejps.2022.106191
Keywords
Starch-based biocompatible hydrogel; Light-curable hydrogel; Quercetin; Bioavailability; Biodegradable hydrogel
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Funding
- University of Zanjan
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Researchers prepared a biodegradable starch-based hydrogel using a new technique to improve the release and bioavailability of quercetin. By modifying the molecular structure of starch and using Fe3O4 nanoparticles, they achieved an in vitro drug release rate of 56.62%.
In spite of quercetin advantages, its utilization as a cancer drug is confined due to its very low water solubility and bioavailability. Accordingly, we prepared a biodegradable starch-based hydrogel, using a new technique to control and improve quercetin release and bioavailability. For this purpose, the molecular structure of starch was modified by polyethylene glycol/acrylate and Fe3O4 nanoparticles were used to enhance mechanical properties of hydrogel. In order to prepare the final hydrogel drug carrier, the modified starch was directly mixed with quercetin and other additives in different ratios and cured under blue light. Synthesis confirmation and structural properties of the modified starch, silanized and pure Fe3O4 nanoparticles and final hydrogel were studied using H-1 NMR, FT-IR, SEM, XRD, TGA, VSM and DLS analyses. We improved in vitro drug release to 56.62%, while the maximum release of quercetin from the starch-based hydrogel in our previous study was only 27% (Doosti et al., 2019).
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