☆ 4.8 Article

Hormesis-Like Effects of Tetrabromobisphenol A on Anaerobic Digestion: Responses of Metabolic Activity and Microbial Community

ENVIRONMENTAL SCIENCE & TECHNOLOGY (2022)

Journal

ENVIRONMENTAL SCIENCE & TECHNOLOGY

Volume 56, Issue 16, Pages 11277-11287

Publisher

AMER CHEMICAL SOC

DOI: 10.1021/acs.est.2c00062

Keywords

tetrabromobisphenol A; anaerobic digestion; hormesis-like effect; environmental risks; bisphenol A; brominated flame retardants

Funding

National Natural Science Foundation of China [52000063]
Natural Science Foundation of Hunan Province of China [2021JJ40080]
Science and Technology Innovation Program of Hunan Province [2021RC4024]

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Abstract

TBBPA exhibits hormesis-like effects on anaerobic digestion, affecting methane production. It binds with proteins in the extracellular polymeric substances of anaerobes and induces an increase in reactive oxygen species. Different anaerobes show varied tolerance to TBBPA.

Tetrabromobisphenol A (TBBPA) has extensive applications in various fields; its release into ecosystems and the potential toxic effects on organisms are becoming major concerns. Here, we investigated the effects of TBBPA on anaerobic digestion, whose process is closely related to the carbon cycles under anaerobic conditions. The results revealed that TBBPA exhibited dose-dependent hormesis-like effects on methane production from glucose, i.e., the presence of 0.1 mg/L TBBPA increased the methane production rate by 8.79%, but 1.0-4.0 mg/L TBBPA caused 3.45-28.98% of decrement. We found that TBBPA was bound by the tyrosine-like proteins of the extracellular polymeric substances of anaerobes and induced the increase of reactive oxygen species, whose slight accumulation stimulated the metabolism activities but high accumulation increased the apoptosis of anaerobes. Owing to the differences between individual anaerobes in tolerance, TBBPA at 0.1 mg/L stimulated the acidogenesis and hydrogenotrophic methanogenesis, whereas higher levels (i.e., 1.0-4.0 mg/L) severely restrained all of the processes of acidogenesis, acetogenesis, and methanogenesis. Along with the accumulation of bisphenol A (BPA) produced from TBBPA by Longilinea sp. and Pseudomonas sp., the methanogenic pathway was partly shifted from acetate-dependent to hydrogen-dependent direction, and the activities of carbon monoxide dehydrogenase and acetyl-CoA decarbonylase/synthase were inhibited, while acetate kinase and F420 were hormetically affected. These findings elucidated the mechanism of anaerobic syntrophic consortium responses to TBBPA, supplementing the potential environmental risks of brominated flame retardants.

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Binding of Tetrabromobisphenol A and S to Human Serum Albumin Is Weakened by Coexisting Nanoplastics and Environmental Kosmotropes

Zongshan Zhao, Haimei Li, Jiaqiang Yao, Jing Lan, Yan Bao, Lining Zhao, Wansong Zong, Qing Zhang, Henner Hollert, Xingchen Zhao

Summary: This study investigated the effects of brominated flame retardant (BFR) binding and corona formation on polystyrene nanoplastics (PNs) using human serum albumin (HSA) as a model protein. HSA helped disperse PNs under physiological conditions but promoted aggregate formation in the presence of tetrabromobisphenol A (TBBPA) and S (TBBPS). The aggregates became larger and had fewer electrostatic repulsion effects at pH 4. The effects of HSA and BFR binding varied due to structural differences of TBBPA and TBBPS.

ENVIRONMENTAL SCIENCE & TECHNOLOGY (2023)