Journal
DRUGS
Volume 82, Issue 10, Pages 1127-1135Publisher
ADIS INT LTD
DOI: 10.1007/s40265-022-01739-7
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Mavacamten, an oral small-molecule cardiac myosin inhibitor, has been approved for the treatment of obstructive HCM, which is important for improving patients' functional capacity and symptoms.
Mavacamten (Camzyos (TM)) is an oral small-molecule cardiac myosin inhibitor developed by MyoKardia, Inc., a wholly owned subsidiary of Bristol Myers Squibb, for the treatment of hypertrophic cardiomyopathy (HCM) and diseases of diastolic dysfunction. In April 2022, mavacamten was approved for use in the USA in the treatment of adults with symptomatic New York Heart Association (NYHA) class II-III obstructive HCM to improve functional capacity and symptoms. This article summarizes the milestones in the development of mavacamten leading to this first approval for the treatment of adults with symptomatic NYHA class II-III obstructive HCM.
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