Journal
JOURNAL OF COLLOID AND INTERFACE SCIENCE
Volume 472, Issue -, Pages 229-236Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.jcis.2016.03.040
Keywords
Superparamagnetic iron oxide nanoparticles; Physico-chemical properties; Protein adsorption; Contrast agent; Magnetic resonance imaging; T-1-T-2 contrast
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Funding
- POCTEP (Operational Programme for Cross border Cooperation Spain-Portugal)
- ERDF (European Regional Development Fund) under grant InveNNta Project
- European Union [600375]
- ERDF (European Regional Development Fund) under P.O Norte CCDR-N/ON.2 programme
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Ultrasmall superparamagnetic iron oxide nanoparticles (USPIOs) coated with polyacrylic acid (PAA) were synthesized by a hydrothermal method in gram-scale quantity and extensively characterized. Only the nanoparticles subjected to an additional centrifugation step showed narrow size distribution, high polymeric coverage, and ideal superparamagnetism. In addition to improved physico-chemical properties, these nanoparticles feature high stability in vitro as well as dual T-1-T-2 performance as contrast agents (CAs) for magnetic resonance imaging (MRI), highlighting the importance of the additional separation step in obtaining material with the desired properties. (C) 2016 Elsevier Inc. All rights reserved.
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