Article
Chemistry, Applied
Khalil Ahmad, Jawad Manzur, Muhammad Tahir, Rabia Hussain, Mahmood Khan, Abdul Wadood, Egemen Avcu, Muhammad Atiq Ur Rehman
Summary: In this study, zein coatings containing cloves were developed on stainless steel substrates using electrophoretic deposition. The coatings exhibited excellent antibacterial activity, drug release capability, surface properties, corrosion resistance, and adhesion. These zein/cloves coatings have potential applications in orthopedics as they possess antimicrobial effects and can provide targeted drug delivery.
PROGRESS IN ORGANIC COATINGS
(2023)
Article
Chemistry, Physical
Filip Maciag, Tomasz Moskalewicz, Kazimierz Kowalski, Alicja Lukaszczyk, Zoya Hadzhieva, Aldo Roberto Boccaccini
Summary: In this study, zein coatings were successfully obtained on titanium substrates by electrophoretic deposition, with the coating morphology being significantly influenced by the zein content, water to ethanol ratio, process voltage, and time. Chemical treatment of the Ti substrate surface prior to deposition was found to enhance the adhesion of the coatings. Coated titanium substrates exhibited slightly lower electrochemical corrosion resistance in aqueous solution compared to uncoated substrates, and showed well-developed surface topography and hydrophilic nature.
Article
Electrochemistry
F. Maciag, T. Moskalewicz, K. Cholewa-Kowalska, Z. Hadzhieva, M. Dziadek, B. Dubiel, A. Lukaszczyk, A. R. Boccaccini
Summary: Cu- and Mg-doped mesoporous sol-gel bioactive glasses were developed and their microstructure was investigated. The electrophoretic deposition conditions for composite coatings on Ti-13Nb-13Zr substrates were determined. The coated alloy showed enhanced resistance to electrochemical corrosion and improved antibacterial properties compared to pure zein.
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
(2023)
Review
Chemistry, Multidisciplinary
Viswanathan S. Saji
Summary: Electrophoretic deposition is a commonly studied surface coating technique used in various applications, while superhydrophobic surfaces have attracted significant research interest. This comprehensive review provides insights into the electrophoretic-deposited superhydrophobic coatings, covering processes, materials, and specific applications in fields such as anti-corrosion and biomedical applications.
CHEMISTRY-AN ASIAN JOURNAL
(2021)
Article
Chemistry, Applied
Chen Wang, Yang Luo, Zilong Wang, Wenlong Yan, Yanyan Zhao, Ningtao Quan, Haijun Peng, Kaiwen Wu, Yuehua Ma, Chunlei Zhao, Dunbo Yu
Summary: Using electrophoretic deposition (EPD) method, TbF3 powders were deposited on the surface of sintered Nd-Fe-B magnets, and the influence of MgCl2 on electrophoretic deposition and grain boundary diffusion was investigated. The addition of 5 wt% MgCl2 was found to significantly enhance the EPD efficiency and improve the coating's adhesion by relieving local stress through the formation of unique gully morphology. The study examined the effects of suspension concentration, voltage, and time on the EPD amount, and simplified the Biesheuvel equation to calculate the quantitative deposition.
JOURNAL OF RARE EARTHS
(2023)
Article
Materials Science, Multidisciplinary
Ozge Varlik, Yapincak Goncu, A. Y. Nuran
Summary: Titanium diboride-chitosan composite coatings were successfully produced by electrophoretic deposition techniques. The effect of process parameters on the coatings was investigated and the suspension properties and deposition mechanism were discussed. The results showed that the coatings had a uniform and crack-free morphology, and the chitosan content significantly affected the adhesion behavior.
MATERIALS CHEMISTRY AND PHYSICS
(2022)
Article
Materials Science, Multidisciplinary
Arman Molaei, MardAli Yousefpour
Summary: Composite coatings of chitosan-bioglass-hydroxyapatite-halloysite nanotube were successfully produced by electrophoretic deposition, demonstrating good corrosion resistance and apatite-inducing ability in corrected simulated body fluid.
Article
Materials Science, Multidisciplinary
Zoya Hadzhieva, Katarzyna Cholewa-Kowalska, Ivo Dlouhy, Tomasz Moskalewicz, Aldo R. Boccaccini
Summary: Coatings based on zein with the addition of bioactive glass particles doped with fluoride or a combination of fluoride and copper were deposited on titanium by electrophoretic deposition. The coatings showed improved scratch resistance and antibacterial activity, with no impact on bioactivity. These coatings have potential applications in orthopaedic and dental implants.
Article
Engineering, Chemical
Chenning Zhang, Tetsuo Uchikoshi
Summary: A completely transparent alumino-silicate geopolymer with a crystal structure similar to zeolite was successfully synthesized via hydrolysis and polymerization. It was found to be suitable for the electrophoretic deposition process, significantly improving the adhesion of the coatings.
ADVANCED POWDER TECHNOLOGY
(2023)
Article
Materials Science, Ceramics
Chia Ching Kee, Kelvin Ng, Bee Chin Ang, Hendrik Simon Cornelis Metselaar
Summary: Europium (Eu) doped calcium silicate (CS) coatings were successfully formed on titanium substrates via electrophoretic deposition. A low amount of Eu (2.5 mol%) improved coating adhesion strength and provided good apatite forming ability with lower degradation rate. Human fetal osteoblast (hFOB) cells attached and proliferated on all Eu-CS coatings, suggesting their biocompatible nature. Eu2.5CS coatings not only showed comparable cell proliferation with CS, but also enhanced the osteogenic activity of the CS coating, making them promising materials for biomedical implants.
JOURNAL OF THE EUROPEAN CERAMIC SOCIETY
(2023)
Article
Materials Science, Multidisciplinary
Elisa Zanchi, Antonio Gianfranco Sabato, Mari Carmen Monterde, Lucile Bernadet, Marc Torrell, Jose Antonio Calero, Albert Tarancon, Federico Smeacetto
Summary: Developing cost-effective and durable interconnects is crucial for commercializing solid oxide cells. This study reviews and discusses the microstructural and electrical characteristics of MnCo2O4 spinel coatings on ferritic stainless steel using electrophoretic deposition. The results show improved performance and durability with a low cost, making it a promising approach for complex-shaped interconnects.
MATERIALS & DESIGN
(2023)
Article
Materials Science, Ceramics
Esma Yilmaz, Ping Xiao
Summary: This study investigates the electrophoretic deposition of Yb2Si2O7 particles on SiC substrates to produce Environmental Barrier Coatings, focusing on the effects of solvent, dispersant concentration, and pH. Ethanol was found to provide a well-dispersed suspension and crack-free coating, while dispersant concentration above 0.5g/L resulted in higher ionic strength and cracked coatings. The study also revealed that the deposition rate and coating integrity were influenced by suspension properties and sintering processes.
JOURNAL OF THE EUROPEAN CERAMIC SOCIETY
(2022)
Review
Chemistry, Physical
Marija Djosic, Ana Jankovic, Vesna Miskovic-Stankovic
Summary: Current trends in biomaterials science focus on designing multifunctional implant coatings that can inhibit bacterial growth while promoting osseointegration to ensure prolonged implant functionality.
Article
Materials Science, Coatings & Films
Sandeep Singh, Gurpreet Singh, Niraj Bala
Summary: The study fabricated a composite coating of CS-HA-BG-Fe3O4 with bioactivity, high corrosion resistance, and excellent cell proliferation, suitable for biomedical applications.
SURFACE & COATINGS TECHNOLOGY
(2021)
Article
Materials Science, Multidisciplinary
Jun Zhang, Shaojun Chu, Weiliang Jin, Fei Cai, Hongmin Zhu, Saijun Xiao
Summary: This paper presents a novel process for preparing TiB2 coatings by synthesizing TiB2 nanoparticles and subsequent electrophoretic deposition. The thickness of the coatings increased with the rise of cell voltages, and the hardness and elastic modulus values also increased with elevated electrophoretic voltages.
JOURNAL OF MATERIALS RESEARCH AND TECHNOLOGY-JMR&T
(2022)
Review
Materials Science, Multidisciplinary
Farnaz Ghorbani, Theresa Reiter, Liliana Liverani, Dirk W. Schubert, Aldo R. Boccaccini, Judith A. Roether
Summary: Electrospinning is a promising method for designing fibrous tissue engineering scaffolds for hard and soft tissues. Incorporating bioactive cues, such as bioactive glass (BG), into electrospun biopolymer fibers has shown potential in improving fiber properties and enhancing biological performance. This article provides a comprehensive overview of BG-containing electrospun polymer composite fibers and discusses their effects on mechanical properties, biological response, and applications in bone regeneration, wound healing, and drug delivery. The study highlights essential aspects for future translational research in tissue engineering using BG-polymer composite fibers.
ADVANCED ENGINEERING MATERIALS
(2023)
Article
Materials Science, Multidisciplinary
Giovanni Falcone, Sonja Kuth, Aldo R. Boccaccini, Rita P. Aquino, Tiziana Esposito, Paola Russo
Summary: To fully utilize the potential of 3D printing, particularly in the case of semisolid extrusion (SSE), the technological challenges need to be addressed. This study focuses on investigating the physicochemical properties of natural polymers, specifically alginate hydrogel, for 3D printing tablets that are easy to swallow. By adding sorbitol as a plasticizer, the aim is to improve the swallowability of the tablets. Different concentrations of sorbitol solution are evaluated to determine the best composition in terms of printing and technological properties. The results highlight a predictable relationship between the amount of sorbitol loaded and the residual mass of the final platforms.
ADVANCED ENGINEERING MATERIALS
(2023)
Article
Materials Science, Multidisciplinary
F. Maciag, T. Moskalewicz, K. Cholewa-Kowalska, Z. Hadzhieva, M. Dziadek, A. Lukaszczyk, A. R. Boccaccini
Summary: The objective of this study was to develop cathodic electrophoretic deposition (EPD) to obtain composite coatings of mesoporous sol-gel glass (MSGG) particles embedded in a zein matrix on Ti-13Nb-13Zr substrates. The EPD process successfully produced uniform coatings with open porosity and good adhesion to the substrates. The coated substrates exhibited improved resistance to electrochemical corrosion, as well as moderate hydrophilicity and roughness. The composite coatings also showed enhanced antibacterial properties and the ability to form hydroxyapatite.
METALLURGICAL AND MATERIALS TRANSACTIONS A-PHYSICAL METALLURGY AND MATERIALS SCIENCE
(2023)
Review
Materials Science, Multidisciplinary
Annabel Braem, Nur Hidayatul Nazirah Kamarudin, Nitu Bhaskar, Zoya Hadzhieva, Andrea Mele, Jeremy Soulie, Denver P. Linklater, Linda Bonilla-Gameros, Aldo R. Boccaccini, Ipsita Roy, Christophe Drouet, Elena P. Ivanova, Diego Mantovani, Bikramjit Basu
Summary: Peri-implant infection is a significant challenge in the clinical field. Researchers are developing biomaterial and bioengineering-based antimicrobial strategies to tackle this issue. However, the development of these approaches is hindered by challenges like biocompatibility concerns, reduced antimicrobial effectiveness, long-term stability issues, and antibiotic resistance development. This review provides insights into current state-of-the-art biomaterial-based antimicrobial approaches and highlights the importance of translational research strategies and regulatory frameworks for clinical implementation. The integration of computational tools and experimental databases using artificial intelligence (AI) is proposed as a vision to accelerate the development of next-generation biomaterial-based antimicrobial strategies.
INTERNATIONAL MATERIALS REVIEWS
(2023)
Article
Materials Science, Biomaterials
Irem Unalan, Stefan Schruefer, Dirk W. Schubert, Aldo R. Boccaccini
Summary: This study aimed to develop 3D-printed hydrogels as multifunctional wound dressings containing phytotherapeutic agents. Results showed that blending xanthan gum (XAN) overcame the challenges associated with sodium alginate (ALG) in terms of printability and shape fidelity. Clove essential oil (CLV) was successfully incorporated into the 3D-printed hydrogels, exhibiting long-term release and enhanced antioxidant and antibacterial activity. Additionally, CLV showed potential anti-inflammatory effects and had no toxic effect on NHDF cells. Overall, this study highlights the potential benefits of incorporating natural phytotherapeutics into 3D-printed hydrogels for wound healing.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2023)
Article
Oncology
Joerg Fellenberg, Sarina Losch, Max R. Marinescu, Birgit Frey, Burkhard Lehner, Marcela Arango-Ospina, Zoya Hadzhieva, Aldo R. Boccaccini, Fabian Westhauser
Summary: The cytotoxic effects of bioactive glasses (BGs) on giant cell tumor (GCTB) cell lines were observed in vitro, and a significant reduction in tumor formation and growth was seen in the chicken chorioallantoic membrane (CAM) assay. These findings suggest that BGs could be potential candidates for the treatment of GCTBs.
Article
Pharmacology & Pharmacy
Mirna L. Sanchez, Hugo Valdez, Micaela Conde, Pamela Viana-Mendieta, Aldo R. Boccaccini
Summary: This article discusses the development of biomaterial platforms using functional hydrogels for delivering reagents of interest in the field of biomedicine. In situ dosing of therapeutic components for dermatological injuries, such as diabetic foot ulcers, is a novel strategy to improve wound healing. Hydrogels have shown advantages over other therapies in terms of comfort and their compatibility with tissues. The paper also proposes a new approach to wound care by modulating macrophage polarization using advanced biomaterials.
Editorial Material
Biotechnology & Applied Microbiology
Farnaz Ghorbani, Behafarid Ghalandari, Aldo R. Boccaccini, Derek H. Rosenzweig
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Thomas Gruhn, Camilo Ortiz Monsalve, Claudia Mueller, Susanne Heid, Aldo R. Boccaccini, Sahar Salehi
Summary: In this study, the dynamics of anisotropic fillers in fibrous structures with hydrogel-based matrices were analyzed using computational simulations. Microfabricated rods were used as anisotropic fillers in the fabrication of composite filaments and their orientation in the fibers was evaluated experimentally. The results showed that the fillers were not well aligned during the extrusion process, leading to a random distribution in the fibers.
BIOENGINEERING-BASEL
(2023)
Article
Electrochemistry
F. Maciag, T. Moskalewicz, K. Cholewa-Kowalska, Z. Hadzhieva, M. Dziadek, B. Dubiel, A. Lukaszczyk, A. R. Boccaccini
Summary: Cu- and Mg-doped mesoporous sol-gel bioactive glasses were developed and their microstructure was investigated. The electrophoretic deposition conditions for composite coatings on Ti-13Nb-13Zr substrates were determined. The coated alloy showed enhanced resistance to electrochemical corrosion and improved antibacterial properties compared to pure zein.
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
(2023)
Article
Biochemistry & Molecular Biology
Irem Unalan, Ilenia Occhipinti, Marta Miola, Enrica Verne, Aldo R. Boccaccini
Summary: This study used polycaprolactone (PCL) and melt electrowriting (MEW) technique to fabricate scaffolds coated with superparamagnetic iron oxide nanoparticles (SPIONs) and silica-coated-SPIONs (Si-SPIONs). The hydrophilicity of the scaffolds was improved by alkaline treatment. The scaffolds showed good biocompatibility. The alkaline-treated scaffolds and SPIONs/Si-SPIONs-coated scaffolds exhibited higher pre-osteoblastic cell adhesion and proliferation efficiency. All samples were able to generate heat when subjected to an alternating magnetic field, useful for hyperthermia treatment.
MACROMOLECULAR BIOSCIENCE
(2023)
Article
Materials Science, Multidisciplinary
Jonas Hazur, Jonas Roeder, Jonas Czwalinna, Dirk W. W. Schubert, Aldo R. R. Boccaccini
Summary: The main challenge in extrusion-based bioprinting is to develop inks with multiple characteristics before, during, and after printing. Hydrogel microparticles (HMPs) are proposed to produce internally pre-crosslinked inks, which effectively improve printability. Rheological measurements reveal the increase in yield stress and viscosity, as well as the reduction in loss angle, after HMP pre-crosslinking. Additionally, pre-crosslinking significantly alters the hydrogel's internal microstructure and NIH/3T3 cells proliferate in HMP pre-crosslinked bioinks.
MACROMOLECULAR MATERIALS AND ENGINEERING
(2023)
Article
Chemistry, Multidisciplinary
Catalina Adler, Mahshid Monavari, Gustavo A. Abraham, Aldo R. Boccaccini, Farnaz Ghorbani
Summary: This study synthesized electroconductive silane-modified gelatin-poly(3,4-ethylenedioxythiophene) polystyrene sulfonate (PEDOT:PSS) scaffolds to simulate the chemistry and piezoelectricity of bone. The scaffolds were functionalized with polydopamine (PDA) inspired by mussels to enhance hydrophilicity, cell interaction, and biomineralization. Analysis showed that the PDA-coated scaffolds had improved electrical resistance, hydrophilicity, compressive strength, modulus, and biomineralization capability. The scaffolds also promoted the viability, adhesion, proliferation, alkaline phosphatase expression, and HA deposition of MG-63 cells, indicating their potential for bone regeneration.
Article
Engineering, Biomedical
Hazel O. Simila, Ana M. Beltran, Aldo R. Boccaccini
Summary: This study investigated the antimicrobial and mechanical properties of dental floss coated with chitosan or chitosan + mesoporous bioactive glass nanoparticles. The coatings showed significant ability to inhibit bacterial growth after 24 hours, although the impact was minimal at 3 hours. Furthermore, the addition of these layers improved the tensile strength of the floss, making it more effective for cleaning between teeth. Enhanced investigations of these composites are therefore proposed due to their potential in promoting oral health.
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
(2023)
Article
Chemistry, Physical
Soledad Stagnoli, Cintia Garro, Ozlem Ertekin, Susanne Heid, Stefan Seyferth, Gaston Soria, N. Mariano Correa, Aldo Leal-Egana, Aldo R. Boccaccini
Summary: This study developed a system for delivering water-insoluble drugs, which can efficiently load drugs and increase the likelihood of drug uptake by cancer cells instead of healthy cells. The system also demonstrates high efficiency and stability during topical application, and it is less invasive compared to alternative methods.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
