Article
Chemistry, Inorganic & Nuclear
Gurdeep Kaur, Iqubal Singh, Runjhun Tandon, Nitin Tandon
Summary: This review presents the recent advancements in coumarin-based chemosensors for sensing cations and anions, including the design, performance, and complexation of probes. The colorimetric and fluorescent approach of the probes is elaborated with pictorial representation, along with their detection limits and stoichiometric ratios. The review highlights the potential for developing efficient chemosensors for harmful ions and challenges researchers for commercial applications.
INORGANIC CHEMISTRY COMMUNICATIONS
(2023)
Article
Spectroscopy
Dhanushkodi Mohanasundaram, R. Bhaskar, Murugesan Sankarganesh, Kasi Nehru, Gujuluva Gangatharan Vinoth Kumar, Jegathalaprathaban Rajesh
Summary: A novel pyridine-based receptor (S) has been reported for selective detection of copper ion, showing drastic color and fluorescence changes under normal light and UV light. The metal sensing ability of the receptor was confirmed through various spectroscopic methods, with a low limit of detection for Cu2+ ions. This receptor also demonstrated effective utilization for measurements of Cu2+ ions in different water tests.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Article
Chemistry, Organic
Sarita Gond, Pranjalee Yadav, Aayoosh Singh, Somenath Garai, Anusmita Shekher, Subash Chandra Gupta, Vinod P. Singh
Summary: The colorimetric and fluorescence responses of a new rhodamine-functionalized probe RMP were studied. RMP was thoroughly characterized using spectroscopic tools and X-ray diffraction. It demonstrated highly sensitive colorimetric and fluorescence responses towards Al3+, Fe(3+) and Cr(3+) metal ions among competing cations. The spectral shifts were visible in the visible region and detectable with the naked eye. The fluorescence quantum yield, stoichiometric ratio, binding constant, and detection limit of RMP towards Al3+, Fe(3+), and Cr(3+) metal ions were calculated. Furthermore, RMP-M3+ complexes were reversible and sensitive to EDTA, mimicking a molecular logic gate. Al3+, Fe(3+), and Cr(3+) metal ions were applied intracellularly in model human cells.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2023)
Article
Chemistry, Inorganic & Nuclear
Sharmin Akther Rupa, William Emmanuel Ghann, Md Abdul Majed Patwary, Jamal Uddin
Summary: In this study, two novel fluorescein hydrazone compounds were synthesized and characterized, and one of them showed selective sensing of Pb2+ ions with visual color change. The chemosensor L2 exhibited considerable sensitivity towards Pb2+ ions, possibly due to the chelation-enhanced fluorescence effect.
INORGANIC CHEMISTRY COMMUNICATIONS
(2022)
Article
Spectroscopy
Brian Musikavanhu, Zeping Huang, Quanhong Ma, Yongdi Liang, Zhaoli Xue, Lei Feng, Long Zhao
Summary: A pyridine modified naphthol hydrazone Schiff base chemosensor, NaPy, was prepared and used to detect aluminum ion. The probe showed a turn-off emission response towards Al3+ at a 1:1 binding stoichiometry, indicating its high sensitivity and selectivity. Application investigations suggested that NaPy can be used as an efficient probe for sensing Al3+ in real environmental samples and biosystems.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2023)
Review
Biochemistry & Molecular Biology
Brian Musikavanhu, Yongdi Liang, Zhaoli Xue, Lei Feng, Long Zhao
Summary: This review investigates the techniques and approaches used to strengthen the sensitivity and selectivity of Schiff base fluorescent chemosensors designed specifically to detect toxic and heavy metal cations. By improving selectivity and achieving heightened sensitivity and detection limits, these strategies contribute to the advancement of accurate and efficient detection methods.
Article
Chemistry, Multidisciplinary
Junzhu Zeng, Xin Xu, Lei Xue, Yang Xu, Xin Wang, Yang Zhang, Haibin Wang
Summary: A chemosensor (L) based on pyridine and julolidine was designed and synthesized for the detection of Al3+ in ethanol solution. The emission intensity of L was enhanced by 85-fold in the presence of Al3+ by emitting bright green fluorescence. The recognition process of L was not significantly affected by other common cations. The detection limit for Al3+ was estimated to be 2.74x10(-8) M.
Article
Chemistry, Inorganic & Nuclear
Brett M. Hakey, Dylan C. Leary, Lauren M. Lopez, Leyla R. Valerio, William W. Brennessel, Carsten Milsmann, Ellen M. Matson
Summary: The first actinide complexes of the pyridine dipyrrolide (PDP) ligand class have been reported, and their chemical properties and structures have been studied. The compounds exhibit rich redox profiles and distorted octahedral geometry.
INORGANIC CHEMISTRY
(2022)
Article
Chemistry, Physical
Xin Chen, Yifeng Zhou, Guiyang Zhang, Junjun Wang, Chunmei Guo, Yan Wang
Summary: Novel gelators based on isomeric pyridine-hydrazide derivatives, specifically G1, G2, and G3, were successfully synthesized and characterized. Among them, G2 showed superior gelation properties and was able to detect analytes such as F, Cu2+, and Fe3+. The organogel-to-metallogel transformation process of G2 resulted in color changes, making it a promising multi-stimuli-responsive sensor for detecting various substances.
COLLOID AND INTERFACE SCIENCE COMMUNICATIONS
(2021)
Article
Chemistry, Applied
Wheeler R. Lovett, Alaa Al Hamd, Stefanie Casa, Maged Henary
Summary: In this study, four benzothiazole-derived dyes with pyridine moieties were synthesized as prospective pH-responsive probes. These dyes exhibited absorption and emission in the far-red range of the visible spectrum and showed changes in their spectral properties when exposed to hydrochloric acid, indicating their potential as pH probes. Computational studies further confirmed the influence of pyridine on the spectral properties of these dyes.
Article
Chemistry, Multidisciplinary
Dina H. Dawood, Aladdin M. Srour, Dalia O. Saleh, Kelley J. Huff, Francesca Greco, Helen M. Osborn
Summary: A series of new pyridine- and/or chromene- analogues were designed, synthesized and screened for their vasodilatory and cytotoxic properties. The study identified compounds with significant vasodilation efficacy and promising anti-proliferative properties, indicating the potential for development as new therapeutic candidates.
Article
Biochemistry & Molecular Biology
Mohamed G. Abouelenein, Ahmed A. El-Rashedy, Hanem M. Awad, Ahmed F. El Farargy, Ibrahim F. Nassar, Amr Nassrallah
Summary: The present study describes the synthesis of a novel series of polyfunctionalized pyridine congeners and their evaluation for cytotoxic efficacy against cancer cells and normal cells. Some of the compounds showed potential as anticancer candidate drugs. Molecular impact studies revealed the influence of certain compounds on gene expression, promoting apoptosis in cancer cells. Docking studies and molecular dynamic simulations provided insights into the binding modes of the compounds with target proteins. Finally, POM analysis facilitated the identification of promising compounds.
BIOORGANIC CHEMISTRY
(2023)
Review
Biology
Beata Morak-Mlodawska, Malgorzata Jelen, Krystian Pluta
Summary: Azaphenothiazines, the largest and most prospective group of modified phenothiazines, exhibit a variety of biological activities including potential anticancer properties. This review summarizes the current knowledge on the anticancer activity of isomeric pyridobenzothiazines and dipyridothiazines, highlighting the influence of molecular structure and substituents on the strength of anticancer action.
Article
Chemistry, Inorganic & Nuclear
Junmiao Wu, Tongfu Yang, Xiaojun Wang, Wenjuan Li, Min Pang, Hongbin Sun, Hong Liang, Feng Yang
Summary: This study aimed to design effective multi-target anticancer agents based on metal chelation, and found that one of the compounds, C5, exhibited high cytotoxicity against tumors. In addition, C5 not only effectively inhibits tumor growth in vivo, but also suppresses angiogenesis and cancer cell metastasis in vitro.
DALTON TRANSACTIONS
(2021)
Article
Biochemistry & Molecular Biology
Iryna Ivasechko, Ihor Yushyn, Piotr Roszczenko, Julia Senkiv, Nataliya Finiuk, Danylo Lesyk, Serhii Holota, Robert Czarnomysy, Olga Klyuchivska, Dmytro Khyluk, Nataliya Kashchak, Andrzej Gzella, Krzysztof Bielawski, Anna Bielawska, Rostyslav Stoika, Roman Lesyk
Summary: Novel pyridine-thiazole hybrid molecules showed high antiproliferative activity against various cancer cell lines, suggesting their potential as anticancer agents. The selective cytotoxicity of these compounds prompted further investigation into their mechanisms of action, which may be related to inducing genetic instability in tumor cells.
Review
Neurosciences
Hayder M. Al-Kuraishy, Ali I. Al-Gareeb, Abdur Rauf, Fahad A. Alhumaydhi, Malgorzata Kujawska, Gaber El-Saber Batiha
Summary: COVID-19 is a respiratory disease caused by SARS-CoV-2 that has a significant impact worldwide. It has been found to present various neurological symptoms, including seizures, due to the virus's neuroinvasive and neurotropic capabilities. The olfactory neurons may serve as a pathway for the virus to invade the central nervous system, leading to neuronal injury and inflammation. While ACE2 has been studied as a receptor for SARS-CoV-2, other receptors in the brain have been proposed to mediate viral-neuronal interactions and subsequent neurological complications. This critical review aims to explore the association and mechanisms between COVID-19 and the risk of seizures.
CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS
(2023)
Review
Food Science & Technology
Chuqi Wang, Minhao Li, Xinyu Duan, Tareq Abu-Izneid, Abdur Rauf, Zidan Khan, Saikat Mitra, Talha Bin Emran, Abdullah S. M. Aljohani, Fahad A. Alhumaydhi, Muthu Thiruvengadam, Hafiz A. R. Suleria
Summary: Tomatoes are widely consumed worldwide and are rich in nutritional and bioactive compounds. However, the processing of tomatoes into various products may affect the bioavailability of these compounds. This review discusses the nutritional and anti-nutritional compounds in tomatoes and their effects on human health, as well as the impact of different food processing techniques on the bioavailability of tomato antioxidants.
FOOD REVIEWS INTERNATIONAL
(2023)
Article
Biochemistry & Molecular Biology
Bader Saud Alotaibi, Jatin Joshi, Mohammad Raghibul Hasan, Mohd Shahnawaz Khan, Salem Hussain Alharethi, Taj Mohammad, Fahad A. Alhumaydhi, Abdelbaset Mohamed Elasbali, Md Imtaiyaz Hassan
Summary: In this study, potential inhibitors of ROCK1 were identified through structure-based virtual screening of natural compounds. Isoononin and Candidissiol showed appreciable binding affinity and selectivity towards ROCK1, and molecular dynamics simulations confirmed their stability.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Biochemistry & Molecular Biology
Moyad Shahwan, Fahad A. Alhumaydhi, Sharaf E. Sharaf, Badrah S. Alghamdi, Saleh Baeesa, Haythum O. Tayeb, Ghulam Md Ashraf, Anas Shamsi
Summary: Neuronal damage in iron-sensitive brain regions is associated with iron dyshomeostasis and neurodegenerative diseases, particularly Alzheimer's disease (AD). Ferritin plays a key role in iron homeostasis. Natural compound bryostatin may have therapeutic implications for AD. This study explores the binding mechanism of bryostatin 1 with ferritin.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Biochemistry & Molecular Biology
Akhtar Atiya, Shivani Batra, Taj Mohammad, Nasser M. Alorfi, Waleed Al Abdulmonem, Fahad A. Alhumaydhi, Ghulam Md Ashraf, Saleh S. Baeesa, Abdelbaset Mohamed Elasbali, Moyad Shahwan
Summary: This study identified two potential CDK5 inhibitors through virtual screening from a herbal library. These compounds showed significant binding to CDK5's ATP-binding pocket. These findings are important for treating complex diseases such as neurodegeneration and tumors.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Biochemistry & Molecular Biology
Said Daoui, Sahin Direkel, Munjed M. Ibrahim, Burak Tuzun, Tarik Chelfi, Mohammed Al-Ghorbani, Mustapha Bouatia, Miloud El Karbane, Anass Doukkali, Noureddine Benchat, Khalid Karrouchi
Summary: A series of pyridazinone derivatives were synthesized and characterized in this study. These compounds were screened for their antibacterial activities against several bacterial strains, and compounds 7 and 13 showed promising activity against multiple strains. Computational studies and ADMET studies were also conducted to explore the properties and potential uses of these compounds.
Article
Chemistry, Analytical
Asmaa A. A. Mandour, Nada Nabil, Hala E. E. Zaazaa, Munjed M. M. Ibrahim, Mohamed A. A. Ibrahim
Summary: A comparative study was conducted on two stability-indicating chromatographic methods for the assay of brinzolamide and timolol maleate in their ophthalmic formulation, especially in the presence of the probable carcinogenic oxidative degradation product of timolol maleate. The first method involved thin-layer chromatography coupled with densitometric determination, while the second method utilized high performance liquid chromatography with photo diode array detection. Both methods showed good separation and linearity for the analyzed components. The HPLC-DAD method demonstrated superior separation and time-saving results, while the TLC method exhibited higher sensitivity.
Article
Biochemistry & Molecular Biology
Mohammed Alrouji, Debarati DasGupta, Ghulam Md. Ashraf, Anwar L. Bilgrami, Fahad A. Alhumaydhi, Waleed Al Abdulmonem, Moyad Shahwan, Abdulrhman Alsayari, Akhtar Atiya, Anas Shamsi
Summary: This study evaluates the inhibitory potential of Huperzine A (HpA), an acetylcholinesterase inhibitor (AChEI), on MARK4. Molecular docking and molecular dynamics simulation show that the complex formed by HpA and MARK4 is structurally stable, and HpA effectively inhibits the kinase activity of MARK4.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biology
Suvro Biswas, Mohasana Akter Mita, Shamima Afrose, Md. Robiul Hasan, Md. Tarikul Islam, Md. Ashiqur Rahman, Mst. Jasmin Ara, Md. Bakhtiar Abid Chowdhury, Habibatun Naher Meem, Md. Mamunuzzaman, Tanvir Ahammad, Istiaq Uddin Ashik, Munjed M. Ibrahim, Mohammad Tarique Imam, Mohammad Akbar Hossain, Md. Abu Saleh
Summary: Male infertility is influenced by SHBG, which reduces testosterone bioavailability. This study identified 345 phytochemicals that potentially inhibit SARS-CoV-2 and found three phytochemicals with higher binding affinities as potential SHBG inhibitors. These phytochemicals showed no adverse effects and exhibited better stability in simulations compared to the control drug. They could be developed as potential drugs to treat male infertility.
Review
Pharmacology & Pharmacy
Saima Akhter, Farhin Montaha Tasnin, Mohammad Nazmul Islam, Abdur Rauf, Saikat Mitra, Talha Bin Emran, Fahad A. Alhumaydhi, Anees Ahmed Khalil, Abdullah S. M. Aljohani, Waleed Al Abdulmonem, Muthu Thiruvengadam
Summary: The IL-17 cytokine family plays a critical role in inflammatory and autoimmune diseases, and dysregulation may lead to the development of various conditions. Understanding the role of IL-17 in these diseases is crucial for developing targeted therapeutic strategies.
CURRENT PHARMACEUTICAL DESIGN
(2023)
Article
Biochemistry & Molecular Biology
Mohammed Alrouji, Fahad A. Alhumaydhi, Waleed Al Abdulmonem, Sharaf E. Sharaf, Moyad Shahwan, Taghreed Majarisi, Akhtar Atiya, Anas Shamsi
Summary: The natural compounds Peiminine and 27-Deoxywithaferin A show strong potential as scaffolds in drug development efforts targeting BACE1 for the treatment of Alzheimer's disease. Virtual screening identifies these compounds as having a strong affinity and specific interactions with the active site of BACE1, and they also display drug-like properties.
MOLECULAR DIVERSITY
(2023)
Correction
Multidisciplinary Sciences
Saikat Mitra, Arka Jyoti Chakraborty, Abu Montakim Tareq, Talha Bin Emran, Firzan Nainu, Ameer Khusro, Abubakr M. Idris, Mayeen Uddin Khandaker, Hamid Osman, Fahad A. Alhumaydhi, Jesus Simal-Gandara
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2023)
Article
Pharmacology & Pharmacy
A. A. H. Abdellatif, F. A. Alhumaydhi, O. Al Rugaie, N. S. Tolba, A. M. Mousa
Summary: The study aimed to enhance the healing of skin wounds by using natural and safe G-AgNPs. The prepared G-AgNPs-EC showed nano-sized rounded particles, which effectively improved wound healing and tissue proliferation. This demonstrates the potential of G-AgNPs-EC as a new skin wound healer.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2023)
Article
Medicine, General & Internal
Taghreed M. Alamri, Fahad A. Alhumaydhi, Afshan Z. Wasti
Summary: Osteocalcin is a key protein in bone metabolism, existing in carboxylated and uncarboxylated forms. Carboxylated osteocalcin is found in the bone matrix, while uncarboxylated osteocalcin plays a crucial role in glucose metabolism. Assessment of uncarboxylated osteocalcin levels in type 2 diabetes mellitus is important due to its association with obesity, diabetes, and cardiovascular disease.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Akhtar Atiya, Abdullatif Bin Muhsinah, Mohammed Alrouji, Fahad A. Alhumaydhi, Waleed Al Abdulmonem, Mohammad A. Aljasir, Sharaf E. Sharaf, Mohammad Furkan, Rizwan Hasan Khan, Moyad Shahwan, Anas Shamsi
Summary: In this study, compounds with structural similarity to LCS-1 were screened and analyzed for their interaction with SOD1. Two potential SOD1 inhibitors were identified for further exploration.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
