Article
Oncology
Maria Danieli, Francesco Barretta, Marco Fiore, Stefano Radaelli, Claudia Sangalli, Marta Barisella, Silvia Stacchiotti, Elena Palassini, Rosalba Miceli, Anna Maria Frezza, Dario Callegaro, Paolo Giovanni Casali, Alessandro Gronchi
Summary: The widespread use of preoperative treatments and increased availability of medical agents in recent years have been associated with improved outcomes for extremity and superficial trunk soft tissue sarcoma (ESTSTS) patients.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Review
Oncology
Mai-Kim Gervais, Dario Callegaro, Alessandro Gronchi
Summary: Soft-tissue sarcomas are rare tumors that originate from mesenchymal tissues. They present a heterogeneous group with over 50 types, making clinical trial development challenging. Decisions regarding neoadjuvant or adjuvant chemotherapy and radiation therapy are based on current trial evidence and multidisciplinary clinical judgment.
JOURNAL OF SURGICAL ONCOLOGY
(2022)
Article
Oncology
Maria Danieli, Carol J. Swallow, Alessandro Gronchi
Summary: Almost half of retroperitoneal sarcomas are liposarcomas, and surgery is the only potentially curative treatment. Better understanding of different histology-specific patterns and the development of outcome predictors have improved management of these rare tumors.
Article
Oncology
Monika Scheer, Christian Vokuhl, Sebastian Bauer, Joerg Fuchs, Steffan Loff, Beate Timmermann, Marc Muenter, Anton George Henssen, Bernarda Kazanowska, Felix Niggli, Ruth Ladenstein, Gustaf Ljungman, Ewa Koscielniak, Thomas Klingebiel
Summary: The benefit of adjuvant therapy in synovial sarcoma (SS) treatment is debated. Long-term follow-up data are lacking. Analysis of SS patients showed that tumor size and receiving chemotherapy are associated with event-free survival and overall survival, with tumor size being a significant factor in the risk of developing metastases.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2021)
Review
Oncology
Eelco de Bree, Dimosthenis Michelakis, Ioannis Heretis, Nikolaos Kontopodis, Konstantinos Spanakis, Eleni Lagoudaki, Maria Tolia, Michail Zografakis-Sfakianakis, Christos Ioannou, Dimitrios Mavroudis
Summary: RPS is a rare and heterogeneous disease for which surgery is the cornerstone of treatment. However, the local recurrence rate is much higher than in soft tissue sarcoma of the extremities since wide resection is usually unfeasible in RPS due to its large size, indistinct tumor borders, anatomical constraints and the thinness of the overlying peritoneum. In recent decades, the role of emerging therapeutic strategies, such as more extended surgery and (neo)adjuvant treatments to improve oncological outcome in primary localized RPS, has been extensively investigated. Personalized, histology-tailored multimodality treatment is promising and will likely further evolve as our understanding of the molecular and genetic characteristics within RPS improves.
Article
Oncology
Kenji Nakano, Naoki Fukuda, Yasuyoshi Sato, Tetsuya Urasaki, Akihiro Ohmoto, Xiaofei Wang, Naomi Hayashi, Hirotaka Suto, Shohei Udagawa, Ryosuke Oki, Mayu Yunokawa, Makiko Ono, Junichi Tomomatsu, Yusuke Minami, Keiko Hayakawa, Taisuke Tanizawa, Keisuke Ae, Seiichi Matsumoto, Shunji Takahashi
Summary: This study retrospectively analyzed the characteristics, chemotherapy details, and prognoses of patients with retroperitoneal/intra-abdominal soft tissue sarcoma and extremities/trunk soft tissue sarcoma who received systemic chemotherapy in a recurrent/metastatic setting, revealing similar outcomes in salvage chemotherapy between the two cohorts.
Article
Oncology
Hisaki Aiba, Costantino Errani, Giovanni Ciani, Marco Gambarotti, Alberto Righi, Margherita Maioli, Paolo Spinnato, Giorgio Frega, Toni Ibrahim, Alessandra Longhi
Summary: This study evaluated the role of surgical margins, radiotherapy, and chemotherapy in myoepithelial carcinoma of soft tissue and bone. The results showed a high incidence of local recurrences and metastases in MC-SB, with poor prognosis for patients with metastatic disease.
EUROPEAN JOURNAL OF CANCER
(2023)
Article
Oncology
Jeanny Kwon, Byoung Hyuck Kim
Summary: This study investigates the role of adjuvant radiotherapy in neuroendocrine tumors treated with primary resection and systemic chemotherapy. A novel scoring system is proposed to guide the recommendation of adjuvant radiotherapy in selected patients.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Oncology
Lili Wu, Yaolin Xu, Yuhong Zhou, Zhaochong Zeng, Yue Fan, Dansong Wang, Wenchuan Wu, Xi Guo, Minzhi Lv, Yuxiu Ouyang, Shisuo Du, Wenhui Lou
Summary: This retrospective study examined the role of adjuvant radiation therapy (RT) after radical resection of pancreatic ductal adenocarcinoma (PDAC) and found that it did not result in an overall survival (OS) benefit for all patients. However, a potential OS benefit was observed in the subgroup of patients with T4N2 disease or R1 resection who survived for more than 1 year after surgery.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Qiying Zhang, Zi Liu, Yali Wang, Jing Zhang, Wen Li, Tao Wang, Juan Wang, Fan Shi, Jin Su
Summary: This study compared the survival outcomes of intermediate- or high-risk cervical cancer patients who received adjuvant chemoradiotherapy after minimally invasive surgery or open surgery. The results showed that there was no significant difference in disease-free survival and overall survival between the two groups. Tumor size and a time interval of more than 7 weeks from surgery to radiotherapy were identified as adverse prognostic factors for disease-free survival.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2022)
Article
Oncology
Claudia Giani, Stefano Radaelli, Rosalba Miceli, Lorenza Gandola, Claudia Sangalli, Anna Maria Frezza, Salvatore Provenzano, Sandro Pasquali, Rossella Bertulli, Marco Fiore, Dario Callegaro, Michela Casanova, Stefano Chiaravalli, Paola Collini, Gian Paolo Dagrada, Carlo Morosi, Nadia Zaffaroni, Paolo G. Casali, Andrea Ferrari, Alessandro Gronchi, Silvia Stacchiotti
Summary: A retrospective study on primary DSRCT was conducted to characterize long-term survivors (LTS). It was found that 13% of patients achieved cure, who had no liver or extra-abdominal metastasis at diagnosis, received complete surgery, and possibly underwent whole abdomino-pelvic radiotherapy (WAP-RT) and maintenance chemotherapy (MC).
Article
Oncology
Bree R. Eaton, Line Claude, Daniel J. Indelicato, Ralph Vatner, Brian Yeh, Rudolf Schwarz, Nadia Laack
Summary: Ewing sarcoma requires complex multidisciplinary management, with standard treatment involving a combination of chemotherapy, surgery, and radiation followed by consolidation local treatment. Data support the efficacy of these treatment modalities.
PEDIATRIC BLOOD & CANCER
(2021)
Review
Oncology
Nicolas A. Devaud, Jean M. Butte, Juan C. de la Maza, Sebastian von Muhlenbrock Hugo, Kenneth Cardona
Summary: Retroperitoneal sarcomas (RPSs) are aggressive tumors that can affect major retroperitoneal vessels. Surgery is the main treatment, and resection may involve major vascular reconstruction. Improved understanding of tumor biology and surgical expertise have allowed for successful multi-visceral resections with vascular reconstructions for RPSs.
Article
Oncology
Georges F. Hatoum, H. Thomas Temple, Silvio A. Garcia, Yi Zheng, Fouad Kfoury, Jill Kinley, Xiaodong Wu
Summary: This study reported a successful case of a large extremity soft tissue sarcoma (2933 cc) treated with a novel approach of interdigitating high-dose LATTICE radiation therapy (LRT) with standard radiation therapy as a neoadjuvant treatment to surgery. The patient tolerated the radiation therapy regimen well and achieved a negative surgical margin and over 95% necrosis of the total tumor volume. The study demonstrated the feasibility of interdigitating multiple sessions of high-dose LATTICE radiation treatments with standard neoadjuvant radiation therapy for soft tissue sarcoma.
CANCER MANAGEMENT AND RESEARCH
(2023)
Article
Oncology
Monika Scheer, Erika Hallmen, Christian Vokuhl, Joerg Fuchs, Per-Ulf Tunn, Marc Muenter, Beate Timmermann, Sebastian Bauer, Anton George Henssen, Bernarda Kazanowska, Felix Niggli, Ruth Ladenstein, Gustaf Ljungman, Angelika Eggert, Thomas Klingebiel, Ewa Koscielniak
Summary: This study evaluated the effects of neoadjuvant or adjuvant radiation therapy and surgery only on long-term outcomes in patients with synovial sarcoma. The results showed that the best local control was achieved when tumors were irradiated pre-operatively and underwent R0 or R1 resection thereafter.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Review
Oncology
Paolo Gallo, Marianna Silletta, Antonio De Vincentis, Federica Lo Prinzi, Francesca Terracciani, Giuseppina Di Fazio, Valentina Flagiello, Umberto Vespasiani Gentilucci, Raffaele Antonelli Incalzi, Antonio Picardi
Summary: This article highlights the occurrence of sarcopenia in patients with cirrhosis and hepatocellular carcinoma, emphasizing the need to consider all factors involved in the pathogenesis for appropriate management. There is currently a lack of properly designed intervention studies and effective strategies, making the optimization of liver disease treatment crucial.
Article
Oncology
Bruno Vincenzi, Andrea Napolitano, Marta Fiocco, Olivier Mir, Piotr Rutkowski, Jean-Yves Blay, Peter Reichardt, Heikki Joensuu, Elena Fumagalli, Spyridon Gennatas, Nadia Hindi, Margherita Nannini, Mariella Spalato Ceruso, Antoine Italiano, Giovanni Grignani, Antonella Brunello, Silvia Gasperoni, Tommaso De Pas, Giuseppe Badalamenti, Maria A. Pantaleo, Winan J. van Houdt, Nikki S. IJzerman, Neeltje Steeghs, Hans Gelderblom, Ingrid M. E. Desar, Johanna Falkenhorst, Marianna Silletta, Marta Sbaraglia, Giuseppe Tonini, Javier Martin-Broto, Peter Hohenberger, Axel Le Cesne, Robin L. Jones, Angelo P. Dei Tos, Alessandro Gronchi, Sebastian Bauer, Paolo G. Casali
Summary: This study evaluated the effect of high-dose imatinib on the survival of patients with KIT exon 9-mutated gastrointestinal stromal tumors. The results showed that increasing the dose from 400 mg/day to 800 mg/day did not lead to better survival outcomes.
CLINICAL CANCER RESEARCH
(2022)
Article
Oncology
Ambreen Muhammed, Claudia Angela Maria Fulgenzi, Sirish Dharmapuri, Matthias Pinter, Lorenz Balcar, Bernhard Scheiner, Thomas U. Marron, Tomi Jun, Anwaar Saeed, Hannah Hildebrand, Mahvish Muzaffar, Musharraf Navaid, Abdul Rafeh Naqash, Anuhya Gampa, Umut Ozbek, Junk-Yi Lin, Ylenia Perone, Bruno Vincenzi, Marianna Silletta, Anjana Pillai, Yinghong Wang, Uqba Khan, Yi-Hsiang Huang, Dominik Bettinger, Yehia I. Abugabal, Ahmed Kaseb, Tiziana Pressiani, Nicola Personeni, Lorenza Rimassa, Naoshi Nishida, Luca Di Tommaso, Masatoshi Kudo, Arndt Vogel, Francesco A. Mauri, Alessio Cortellini, Rohini Sharma, Antonio D'Alessio, Celina Ang, David J. Pinato
Summary: The study found that blood inflammatory markers can predict the survival and response of patients with advanced hepatocellular carcinoma treated with immunotherapy. Neutrophile to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) were identified as independent prognostic factors.
Article
Oncology
Claudia Angela Maria Fulgenzi, Andrea Napolitano, Eliodoro Faiella, Laura Messina, Gennaro Castiello, Flavia Paternostro, Marianna Silletta, Francesco Pantano, Giuseppe Tonini, Daniele Santini, Bruno Vincenzi
Summary: This study retrospectively evaluated the effect of Imatinib on bone mineral density and muscle composition in GIST patients. The results showed an increase in bone mineral density in patients receiving Imatinib treatment, while no changes were observed in the control group. Additionally, patients with lower lean body mass and lower body mass index experienced more treatment-related toxicities.
JOURNAL OF BONE ONCOLOGY
(2022)
Article
Oncology
Carlo Greco, Oriol Pares, Nuno Pimentel, Vasco Louro, Beatriz Nunes, Justyna Kociolek, Joao Marques, Zvi Fuks
Summary: Prostate motion mitigation using rectal distension-mediated technique is safe and effective in salvage treatment of intraprostatic cancer recurrences following initial radiotherapy. This technique allows for effective organ at risk sparing and has low toxicity.
FRONTIERS IN ONCOLOGY
(2022)
Review
Health Care Sciences & Services
Valerio Nardone, Emma D'Ippolito, Roberta Grassi, Angelo Sangiovanni, Federico Gagliardi, Giuseppina De Marco, Vittorio Salvatore Menditti, Luca D'Ambrosio, Fabrizio Cioce, Luca Boldrini, Viola Salvestrini, Carlo Greco, Isacco Desideri, Francesca De Felice, Ida D'Onofrio, Roberto Grassi, Alfonso Reginelli, Salvatore Cappabianca
Summary: Despite being mainly used in oncological patients, radiotherapy can also be an effective treatment for non-malignant disorders. Recent interest has shed light on this approach, and further investigation and clinical application are needed.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Oncology
Giovanni Antonio Marrocco, Marianna Silletta, Vincenzo Bianco, Francesco Mondera, Carolina Sciortino, Laura Pappalardo, Valentina Viglialoro, Enrico Cortesi, Giuseppe Tonini, Salvatore Caponnetto
Summary: This retrospective study analyzed the results of the REFLECT study, which demonstrated the non-inferiority of Lenvatinib to Sorafenib. A total of 21 patients with advanced hepatocellular carcinoma were included and divided into two treatment groups. The overall survival and progression-free survival were higher in the Lenvatinib group, and the albumin bilirubin index was identified as a key prognostic factor. Sorafenib had more adverse events compared to Lenvatinib.
ANTICANCER RESEARCH
(2023)
Article
Oncology
Andrea Casadei-Gardini, Margherita Rimini, Toshifumi Tada, Goki Suda, Shigeo Shimose, Masatoshi Kudo, Jaekyung Cheon, Fabian Finkelmeier, Ho Yeong Lim, Lorenza Rimassa, Jose Presa, Gianluca Masi, Changhoon Yoo, Sara Lonardi, Francesco Tovoli, Takashi Kumada, Naoya Sakamoto, Hideki Iwamoto, Tomoko Aoki, Hong Jae Chon, Vera Himmelsbach, Tiziana Pressiani, Margarida Montes, Caterina Vivaldi, Caterina Solda, Fabio Piscaglia, Atsushi Hiraoka, Takuya Sho, Takashi Niizeki, Naoshi Nishida, Christoph Steup, Massimo Iavarone, Giovanni Di Costanzo, Fabio Marra, Mario Scartozzi, Emiliano Tamburini, Giuseppe Cabibbo, Francesco Giuseppe Foschi, Marianna Silletta, Masashi Hirooka, Kazuya Kariyama, Joji Tani, Masanori Atsukawa, Koichi Takaguchi, Ei Itobayashi, Shinya Fukunishi, Kunihiko Tsuji, Toru Ishikawa, Kazuto Tajiri, Hironori Ochi, Satoshi Yasuda, Hidenori Toyoda, Chikara Ogawa, Takashi Nishimura, Takeshi Hatanaka, Satoru Kakizaki, Noritomo Shimada, Kazuhito Kawata, Fujimasa Tada, Hideko Ohama, Kazuhiro Nouso, Asahiro Morishita, Akemi Tsutsui, Takuya Nagano, Norio Itokawa, Tomomi Okubo, Taeang Arai, Michitaka Imai, Hisashi Kosaka, Atsushi Naganuma, Yohei Koizumi, Shinichiro Nakamura, Masaki Kaibori, Hiroko Iijima, Yoichi Hiasa, Valentina Burgio, Mara Persano, Angelo Della Corte, Francesca Ratti, Francesco De Cobelli, Luca Aldrighetti, Stefano Cascinu, Alessandro Cucchetti
Summary: This retrospective multi-center study compared the clinical efficacy and safety of lenvatinib and atezolizumab plus bevacizumab as a first-line treatment for unresectable HCC. The results showed that atezolizumab plus bevacizumab did not have a significant survival advantage over lenvatinib overall. However, lenvatinib had a higher overall survival rate in patients with non-alcoholic steatohepatitis/non-alcoholic fatty liver disease, while atezolizumab plus bevacizumab had a higher overall survival rate in patients with viral hepatitis. After adjusting for population, atezolizumab plus bevacizumab provided better safety profile for most adverse events.
EUROPEAN JOURNAL OF CANCER
(2023)
Article
Oncology
Mara Persano, Margherita Rimini, Toshifumi Tada, Goki Suda, Shigeo Shimose, Masatoshi Kudo, Jaekyung Cheon, Fabian Finkelmeier, Ho Yeong Lim, Lorenza Rimassa, Jose Presa, Gianluca Masi, Changhoon Yoo, Sara Lonardi, Francesco Tovoli, Takashi Kumada, Naoya Sakamoto, Hideki Iwamoto, Tomoko Aoki, Hong Jae Chon, Vera Himmelsbach, Tiziana Pressiani, Takumi Kawaguchi, Margarida Montes, Caterina Vivaldi, Caterina Solda, Fabio Piscaglia, Atsushi Hiraoka, Takuya Sho, Takashi Niizeki, Naoshi Nishida, Christoph Steup, Massimo Iavarone, Giovanni Di Costanzo, Fabio Marra, Mario Scartozzi, Emiliano Tamburini, Giuseppe Cabibbo, Francesco Giuseppe Foschi, Marianna Silletta, Masashi Hirooka, Kazuya Kariyama, Joji Tani, Masanori Atsukawa, Koichi Takaguchi, Ei Itobayashi, Shinya Fukunishi, Kunihiko Tsuji, Toru Ishikawa, Kazuto Tajiri, Hironori Ochi, Satoshi Yasuda, Hidenori Toyoda, Chikara Ogawa, Takashi Nishimura, Takeshi Hatanaka, Satoru Kakizaki, Noritomo Shimada, Kazuhito Kawata, Fujimasa Tada, Hideko Ohama, Kazuhiro Nouso, Asahiro Morishita, Akemi Tsutsui, Takuya Nagano, Norio Itokawa, Tomomi Okubo, Taeang Arai, Michitaka Imai, Hisashi Kosaka, Atsushi Naganuma, Yohei Koizumi, Shinichiro Nakamura, Masaki Kaibori, Hiroko Iijima, Yoichi Hiasa, Antonella Cammarota, Valentina Burgio, Stefano Cascinu, Andrea Casadei-Gardini
Summary: This study compares the response rates of lenvatinib and atezolizumab plus bevacizumab in the first-line treatment of hepatocellular carcinoma (HCC) patients. The results show that lenvatinib achieves higher response rates in all patient subgroups. Patients who achieve complete response with atezolizumab plus bevacizumab can achieve a better overall survival compared to other treatments.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Oncology
Rodolfo Sacco, Daryl Ramai, Raffaella Tortora, Giovan Giuseppe di Costanzo, Michela Emma Burlone, Mario Pirisi, Piera Federico, Bruno Daniele, Marianna Silletta, Paolo Gallo, Caterina Cocuzza, Maurizio Russello, Giuseppe Cabibbo, Gabriele Rancatore, Silvia Cesario, Gianluca Masi, Luca Marzi, Andrea Mega, Alessandro Granito, Giulia Pieri, Edoardo G. G. Giannini, Rosa Paolillo, Gennaro Gadaleta-Caldarola, Vincenzo Dadduzio, Guido Giordano, Luca Giacomelli, Simonetta Papa, Matteo Renzulli, Marcello Maida, Michele Ghidini, Mauro Borzio, Antonio Facciorusso
Summary: Hepatocellular carcinoma is the fifth most common cancer worldwide. Lenvatinib has proven to be an effective option for treating advanced diseases. Our study showed that patients with nonviral etiologies have longer survival than those with viral etiology, which is important for clinical decision-making.
Editorial Material
Oncology
Luca Improta, Sandro Pasquali, Sergio Valeri, Alessandro Gronchi
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Luca Improta, Sandro Pasquali, Sara Iadecola, Marta Barisella, Marco Fiore, Stefano Radaelli, Chiara Colombo, Rossana Alloni, Dario Callegaro, Sergio Valeri, Rosalba Miceli, Alessandro Gronchi
Summary: This study investigated the impact of histological organ involvement (HOI) on the prognosis of primary retroperitoneal liposarcoma. Initial and advanced HOIs were frequently detected in both well-differentiated and de-differentiated liposarcomas, suggesting the need for multivisceral resection. HOI stratifies the risk of patients with primary retroperitoneal liposarcoma.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Gastroenterology & Hepatology
Claudia Angela Maria Fulgenzi, Bernhard Scheiner, James Korolewicz, Charalampos-Vlasios Stikas, Alessandra Gennari, Bruno Vincenzi, Mark R. Openshaw, Marianna Silletta, Matthias Pinter, Alessio Cortellini, Lorenza Scotti, Antonio D'Alessio, David J. Pinato
Summary: Direct comparisons across first-line regimens for advanced hepatocellular carcinoma are lacking. This network metanalysis compared first-line systemic treatments for hepatocellular carcinoma and found that ICI + anti-vascular endothelial growth factor combinations, as well as double ICIs, showed the greatest overall survival benefit. However, ICI + kinase inhibitor regimens were associated with greater progression-free survival benefit at the cost of higher toxicity rates.
Article
Radiology, Nuclear Medicine & Medical Imaging
Valerio Nardone, Luca Boldrini, Viola Salvestrini, Carlo Greco, Gian Marco Petrianni, Isacco Desideri, Francesca De Felice
Summary: The Young Section of the Italian Association of Radiotherapy and Clinical Oncology conducted an online survey among Italian radiotherapy residents to investigate their profiles, motivations, knowledge of the discipline, and organizations. The results showed that most residents felt that radiotherapy was not adequately studied during medical school and that an internship in radiotherapy was not mandatory. Only a minority of residents were aware of the Italian Association of Radiotherapy and Clinical Oncology and the European Society for Radiotherapy and Oncology during medical school.