Journal
CELL
Volume 185, Issue 15, Pages 2725-2738Publisher
CELL PRESS
DOI: 10.1016/j.cell.2022.06.040
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Funding
- KU Leuven-LISCO (Leuven Institute for Single Cell Omics)
- Rega institute
- VIB
- FWO senior postdoctoral fellowship [12V9421N]
- VIB Tech Watch Program
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Microbial culturing and meta-omic profiling technologies have advanced our understanding of the human microbiome. Single-cell techniques provide unique insights into the biology and behavior of human microbiomes, allowing us to study low-abundant and less-prevalent bacteria as well as individual cell behaviors.
Microbial culturing and meta-omic profiling technologies have significantly advanced our understanding of the taxonomic and functional variation of the human microbiome and its impact on host processes. The next increase in resolution will come by understanding the role of low-abundant and less-prevalent bacteria and the study of individual cell behaviors that underlie the complexity of microbial ecosystems. To this aim, single-cell techniques are being rapidly developed to isolate, culture, and characterize the genomes and transcriptomes of individual microbes in complex communities. Here, we discuss how these single-cell technologies are providing unique insights into the biology and behavior of human microbiomes.
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