Neoantigen-Specific T Cells in Adoptive Cell Therapy

Breast Cancers Are Immunogenic: Immunologic Analyses and a Phase II Pilot Clinical Trial Using Mutation-Reactive Autologous Lymphocytes

(2022) Nikolaos Zacharakis et al.   JOURNAL OF CLINICAL ONCOLOGY

Rapid manufacturing of non-activated potent CAR T cells

(2022) Saba Ghassemi et al.   Nature Biomedical Engineering

Neoantigen T-Cell Receptor Gene Therapy in Pancreatic Cancer

(2022) Rom Leidner et al.   NEW ENGLAND JOURNAL OF MEDICINE

Tissue-resident memory T cells in tumor immunity and immunotherapy

(2021) Karolina Okła et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Identification and Validation of T-cell Receptors Targeting RAS Hotspot Mutations in Human Cancers for Use in Cell-based Immunotherapy

(2021) Noam Levin et al.   CLINICAL CANCER RESEARCH

Tumor-infiltrating lymphocyte treatment for anti-PD-1-resistant metastatic lung cancer: a phase 1 trial

(2021) Benjamin C. Creelan et al.   NATURE MEDICINE

Biochemical and functional characterization of mutant KRAS epitopes validates this oncoprotein for immunological targeting

(2021) Adham S. Bear et al.   Nature Communications

Antigen Experienced T Cells from Peripheral Blood Recognize p53 Neoantigens

(2020) Parisa Malekzadeh et al.   CLINICAL CANCER RESEARCH

Reactive Myelopoiesis Triggered by Lymphodepleting Chemotherapy Limits the Efficacy of Adoptive T Cell Therapy

(2020) Patrick Innamarato et al.   MOLECULAR THERAPY

Tumor infiltrating lymphocytes (TIL) therapy in metastatic melanoma: boosting of neoantigen-specific T cell reactivity and long-term follow-up

(2020) Joost H van den Berg et al.   Journal for ImmunoTherapy of Cancer

A Phase Ib Trial of Personalized Neoantigen Therapy Plus Anti-PD-1 in Patients with Advanced Melanoma, Non-small Cell Lung Cancer, or Bladder Cancer

(2020) Patrick A. Ott et al.   CELL

Stem-like CD8 T cells mediate response of adoptive cell immunotherapy against human cancer

(2020) Sri Krishna et al.   SCIENCE

Persistent mutant oncogene specific T cells in two patients benefitting from anti-PD-1

(2019) Kellie N. Smith et al.   Journal for ImmunoTherapy of Cancer

Immunologic Recognition of a Shared p53 Mutated Neoantigen in a Patient with Metastatic Colorectal Cancer

(2019) Winifred Lo et al.   Cancer Immunology Research

Memory T cells targeting oncogenic mutations detected in peripheral blood of epithelial cancer patients

(2019) Gal Cafri et al.   Nature Communications

Neoantigen screening identifies broad TP53 mutant immunogenicity in patients with epithelial cancers

(2019) Parisa Malekzadeh et al.   JOURNAL OF CLINICAL INVESTIGATION

Endogenous CD4+ T Cells Recognize Neoantigens in Lung Cancer Patients, Including Recurrent Oncogenic KRAS and ERBB2 (Her2) Driver Mutations

(2019) Joshua R. Veatch et al.   Cancer Immunology Research

T cell receptor‐based cancer immunotherapy: Emerging efficacy and pathways of resistance

(2019) Smita S. Chandran et al.   IMMUNOLOGICAL REVIEWS

Unique Neoantigens Arise from Somatic Mutations in Patients with Gastrointestinal Cancers

(2019) Maria R. Parkhurst et al.   Cancer Discovery

Determinants for Neoantigen Identification

(2019) Andrea Garcia-Garijo et al.   Frontiers in Immunology

Efficient identification of neoantigen-specific T-cell responses in advanced human ovarian cancer

(2019) Song Liu et al.   Journal for ImmunoTherapy of Cancer

Sensitive Detection and Analysis of Neoantigen-Specific T Cell Populations from Tumors and Blood

(2019) Songming Peng et al.   Cell Reports

Late-differentiated effector neoantigen-specific CD8+ T cells are enriched in peripheral blood of non-small cell lung carcinoma patients responding to atezolizumab treatment

(2019) Michael Fehlings et al.   Journal for ImmunoTherapy of Cancer

Recognition of human gastrointestinal cancer neoantigens by circulating PD-1+ lymphocytes

(2019) Alena Gros et al.   JOURNAL OF CLINICAL INVESTIGATION

T-cell responses toTP53"hotspot" mutations and unique neoantigens expressed by human ovarian cancers

(2018) Drew C Deniger et al.   CLINICAL CANCER RESEARCH

Tumor-infiltrating BRAFV600E-specific CD4+ T cells correlated with complete clinical response in melanoma

(2018) Joshua R. Veatch et al.   JOURNAL OF CLINICAL INVESTIGATION

Immune recognition of somatic mutations leading to complete durable regression in metastatic breast cancer

(2018) Nikolaos Zacharakis et al.   NATURE MEDICINE

Neoadjuvant PD-1 Blockade in Resectable Lung Cancer

(2018) Patrick M. Forde et al.   NEW ENGLAND JOURNAL OF MEDICINE

Sensitive and frequent identification of high avidity neo-epitope specific CD8+ T cells in immunotherapy-naive ovarian cancer

(2018) Sara Bobisse et al.   Nature Communications

Reducing Ex Vivo Culture Improves the Anti-leukemic Activity of Chimeric Antigen Receptor (CAR)-T Cells

(2018) Saba Ghassemi et al.   Cancer Immunology Research

Resident memory T cells, critical components in tumor immunology

(2018) Fathia Mami-Chouaib et al.   Journal for ImmunoTherapy of Cancer

Novel and shared neoantigen derived from histone 3 variant H3.3K27M mutation for glioma T cell therapy

(2017) Zinal S. Chheda et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Tumor Mutational Burden and Response Rate to PD-1 Inhibition

(2017) Mark Yarchoan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Landscape of immunogenic tumor antigens in successful immunotherapy of virally induced epithelial cancer

(2017) Sanja Stevanović et al.   SCIENCE

Mismatch repair deficiency predicts response of solid tumors to PD-1 blockade

(2017) Dung T. Le et al.   SCIENCE

Randomized, Prospective Evaluation Comparing Intensity of Lymphodepletion Before Adoptive Transfer of Tumor-Infiltrating Lymphocytes for Patients With Metastatic Melanoma

(2016) Stephanie L. Goff et al.   JOURNAL OF CLINICAL ONCOLOGY

Neoantigen landscape dynamics during human melanoma–T cell interactions

(2016) Els M. E. Verdegaal et al.   NATURE

T-Cell Transfer Therapy Targeting Mutant KRAS in Cancer

(2016) Eric Tran et al.   NEW ENGLAND JOURNAL OF MEDICINE

Evolution of Neoantigen Landscape during Immune Checkpoint Blockade in Non–Small Cell Lung Cancer

(2016) Valsamo Anagnostou et al.   Cancer Discovery

Durable Complete Response from Metastatic Melanoma after Transfer of Autologous T Cells Recognizing 10 Mutated Tumor Antigens

(2016) T. D. Prickett et al.   Cancer Immunology Research

Gapped sequence alignment using artificial neural networks: application to the MHC class I system

(2015) Massimo Andreatta et al.   BIOINFORMATICS

Complete Regression of Metastatic Cervical Cancer After Treatment With Human Papillomavirus–Targeted Tumor-Infiltrating T Cells

(2015) Sanja Stevanović et al.   JOURNAL OF CLINICAL ONCOLOGY

Immunogenicity of somatic mutations in human gastrointestinal cancers

(2015) E. Tran et al.   SCIENCE

Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer

(2015) N. A. Rizvi et al.   SCIENCE

Efficient Identification of Mutated Cancer Antigens Recognized by T Cells Associated with Durable Tumor Regressions

(2014) Y.-C. Lu et al.   CLINICAL CANCER RESEARCH

High-throughput epitope discovery reveals frequent recognition of neo-antigens by CD4+ T cells in human melanoma

(2014) Carsten Linnemann et al.   NATURE MEDICINE

Cancer Immunotherapy Based on Mutation-Specific CD4+ T Cells in a Patient with Epithelial Cancer

(2014) E. Tran et al.   SCIENCE

Mutated PPP1R3B Is Recognized by T Cells Used To Treat a Melanoma Patient Who Experienced a Durable Complete Tumor Regression

(2013) Y.-C. Lu et al.   JOURNAL OF IMMUNOLOGY

Mining exomic sequencing data to identify mutated antigens recognized by adoptively transferred tumor-reactive T cells

(2013) Paul F Robbins et al.   NATURE MEDICINE

TIL therapy broadens the tumor-reactive CD8+T cell compartment in melanoma patients

(2012) Pia Kvistborg et al.   OncoImmunology

Durable Complete Responses in Heavily Pretreated Patients with Metastatic Melanoma Using T-Cell Transfer Immunotherapy

(2011) S. A. Rosenberg et al.   CLINICAL CANCER RESEARCH