Article
Pharmacology & Pharmacy
Lasse Harkanen, Henriikka Hakomaki, Jukka Huopio, Hannu Kokki, Sanni Korhonen, Marko Lehtonen, Sari Sjovall, Merja Kokki
Summary: This study investigated the concentrations of buprenorphine in plasma and cerebrospinal fluid (CSF) in patients undergoing arthroplasty. The results showed a large between-subject variability in buprenorphine concentrations in both plasma and CSF.
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Trusha J. Purohit, Sara M. Hanning, Satya Amirapu, Zimei Wu
Summary: This study highlighted the advantages of SNA 15 suppositories over PEG suppositories in providing rapid and complete rectal absorption of AS and tissue compatibility.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Pharmacology & Pharmacy
Ali M. Nasr, Fayrouz Moftah, Mohammed A. S. Abourehab, Shadeed Gad
Summary: This study successfully formulated valsartan ethosomes for sustained release transdermal gel dosage form. The optimized VLT-ETHs showed nanometric size, negative surface charge, and high drug encapsulation, resulting in enhanced bioavailability. In vivo studies demonstrated sustained release of VLT from the ethosomal gel in rats.
Article
Chemistry, Multidisciplinary
Qiong Bian, Lingling Huang, Yihua Xu, Ruxuan Wang, Yueting Gu, Anran Yuan, Xiaolu Ma, Jingyi Hu, Yuefeng Rao, Donghang Xu, Hangxiang Wang, Jianqing Gao
Summary: Nanomedicine-based photodynamic therapy for melanoma has great potential, but faces challenges due to complex nanoparticle designs and high doses of photosensitizers. A new carrier-free nanoassembly method using fast-dissolving microneedles showed efficient and accurate drug delivery in melanoma treatment models, with promising therapeutic effects.
Article
Chemistry, Multidisciplinary
Jushan Gao, Shanbo Ma, Xinxin Zhao, Jinpeng Wen, Datao Hu, Xiaoye Zhao, Xiaopeng Shi, Ke Wang
Summary: The study explored the potential mechanisms of a dual-labeled nano drug delivery system for transdermal absorption, revealing that the nanoparticles can impact cell functions through various pathways to promote transdermal absorption. Visual demonstrations confirmed the penetration of the nanoparticle delivery system into the dermis, suggesting a new method for future investigations into transdermal drug delivery mechanisms.
CHINESE CHEMICAL LETTERS
(2021)
Article
Pharmacology & Pharmacy
Henriikka Hakomaki, Hannu Kokki, Marko Lehtonen, Juha Rasanen, Hanna-Marja Voipio, Veli-Pekka Ranta, Merja Kokki
Summary: The study on pregnant sheep using extended-release buprenorphine transdermal patch found low transplacental passage of buprenorphine from the mother to the fetus, supporting buprenorphine as an alternative to methadone in opioid maintenance therapy during pregnancy.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Raquel Costa, Sofia A. Costa Lima, Paula Gameiro, Salette Reis
Summary: Flavonoids are natural polyphenolic compounds found abundantly in plants, with therapeutic properties for skin disorders, but their limited oral bioavailability and rapid degradation in the body hinder their potential. Various cutaneous delivery systems, such as lipid or polymer-based nanoparticles, have been studied to improve the delivery of flavonoids for skin applications.
Article
Pharmacology & Pharmacy
Danish Mazhar, Naveed Ul Haq, Mahira Zeeshan, Qurat Ul Ain, Hussain Ali, Salman Khan, Saeed Ahmad Khan
Summary: In this study, transfersomes were used to improve the oral absorption of Metformin Hydrochloride (MF HCl), an anti-diabetic drug, and increase its bioavailability. The MF-TFs were prepared using a modified thin film hydration technique and embedded in Carbopol gel containing a permeation enhancer. The resulting formulation showed smooth and spherical MF-TFs particles with sustained drug release. Skin permeation studies demonstrated superior permeability of MF-TFs gel compared to the pure drug. Glucose tolerance test and in vivo pharmacokinetic evaluation further confirmed the potential of MF-TFs gel for transdermal application in the management of type 2 diabetes mellitus (DM-II).
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Shivaprasad Gadag, Reema Narayan, Yogendra Nayak, Sanjay Garg, Usha Y. Nayak
Summary: This study developed a transdermal patch of resveratrol (RVT) for site-specific delivery in breast cancer therapy. The patch containing HPMC E15LV, HPMC-K4M, and PVP K30 as release controlling polymers showed the best permeation of RVT. In vivo studies demonstrated higher breast tissue disposition and reduced tumor volume and serum CA 15-3 levels compared to oral administration of RVT.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Biochemistry & Molecular Biology
Mossab K. Alsaedi, Omar Lone, Hojatollah Rezaei Nejad, Riddha Das, Rachel E. Owyeung, Ruben Del-Rio-Ruiz, Sameer Sonkusale
Summary: Transdermal drug delivery is a promising method for painless and localized sustained drug delivery. Soft injectable sutures carrying drugs can remain in place during delivery and serve as microfluidic capillary channels. Experiments have shown successful long-term delivery of varying quantities of drugs using this method.
MACROMOLECULAR BIOSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Ze Qiang Zhao, Ling Liang, Liu Fu Hu, Yu Ting He, Li Yue Jing, Yue Liu, Bo Zhi Chen, Xin Dong Guo
Summary: To address the issue of drug administration in Alzheimer's disease patients, a new drug delivery system using subcutaneously implanted microneedles was developed. The microneedles release the drug over an extended period and offer advantages such as faster onset of effect and longer duration compared to oral administration.
Review
Oncology
Stefano Mastrangelo, Michele Antonio Capozza, Silvia Triarico, Giorgio Attina, Palma Maurizi, Alberto Romano, Antonio Ruggiero
Summary: Transdermal delivery system (TDDS) is a non-invasive and cost-effective method for drug delivery, but limited to a restricted group of drugs. Opioids like fentanyl and buprenorphine are suitable for chronic pain management through TDDS, but not approved for pediatric use yet.
ANNALS OF TRANSLATIONAL MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Haihua Shang, Xiaohan Dai, Mi Li, Yueyi Kai, Zerong Liu, Min Wang, Quansheng Li, Yuan Gu, Changxiao Liu, Duanyun Si
Summary: This study provides the first systematic elucidation of the absorption and distribution characteristics of Rotundic acid (RA) in rats, which can provide valuable information for the further development and evaluation of RA in drug metabolism and pharmacokinetic studies.
JOURNAL OF PHARMACEUTICAL ANALYSIS
(2022)
Article
Pharmacology & Pharmacy
Yun Kuang, Sai-Ying Wang, Meng-Na Wang, Guo-Ping Yang, Can Guo, Shuang Yang, Xing-Fei Zhang, Xiao-Yan Yang, Qi Pei, Chan Zou, Yan-Hong He, Ying-Yong Zhou, Kai-Ming Duan, Jie Huang
Summary: The present study evaluated the safety and pharmacokinetics/pharmacodynamics of Dex nasal spray in healthy adults and its potential use in children. The results showed that the optimized nasal spray method greatly improved the bioavailability of Dex nasal spray.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Agriculture, Dairy & Animal Science
Margherita Galosi, Alessandro Troisi, Pietro Toniolo, Luca Pennasilico, Vincenzo Cicirelli, Angela Palumbo Piccionello, Caterina Di Bella
Summary: This study evaluated the analgesic efficacy of transdermal buprenorphine compared to intravenous buprenorphine in dogs undergoing mastectomy. The results showed that transdermal administration provided comparable analgesic quality to the injectable route, while avoiding repeated injections.