Article
Dentistry, Oral Surgery & Medicine
Bardia Vadiati Saberi, Farouq Yousefi, Tooba Yousefi, Durdi Qujeq
Summary: This study determined the correlation between mucin and alpha-amylase protein levels in gingival crevicular fluid (GCF) with chronic periodontitis. The results showed that the levels of both markers were higher in patients with chronic periodontitis compared to successfully recovered patients, suggesting that they could be used to determine the activity of periodontal disease.
Article
Biochemistry & Molecular Biology
Javier Fernandez, Constanza Jimenez, Dafna Benadof, Paulina Morales, Jessica Astorga, Felipe Caceres, Marcela Hernandez, Alejandra Fernandez, Fernando Valenzuela
Summary: The study aimed to evaluate the levels of MMP-2 and MMP-9 in gingival crevicular fluid as novel biomarkers for rosacea. The results showed a significant increase in MMP-9 concentration in the GCF of patients with rosacea compared to healthy patients. MMP-9 levels can be used as a diagnostic biomarker for rosacea.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Tauqeer Bibi, Zohaib Khurshid, Ambreen Rehman, Eisha Imran, Kumar Chandan Srivastava, Deepti Shrivastava
Summary: Evaluation methods for periodontal diseases have advanced to provide quick, realistic, and scientifically proven results. The use of biomarkers like Gingival crevicular fluid can help differentiate between periodontal health and disease status accurately and quickly.
Article
Dentistry, Oral Surgery & Medicine
Alejandra Chaparro, Ornella Realini, Marcela Hernandez, Daniela Albers, Laura Weber, Valeria Ramirez, Fernanda Param, Juan Pedro Kusanovic, Timo Sorsa, Gregory Edward Rice, Sebastian E. Illanes
Summary: The study found that concentrations of MMP-8 and -9 in gingival crevicular fluid during early pregnancy are increased in women with severe periodontitis and associated with the development of GDM.
JOURNAL OF PERIODONTOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Luigi Nibali, Abish Stephen, Eleni Hagi-Pavli, Robert Allaker, Antonino Di Pino, Valentina Terranova, Marcella Pisano, Salvatore Di Marca, Viviana Ferrara, Roberto Scicali, Mauro Giordano, Francesco Purrello, Nikolaos Donos, Lorenzo Malatino
Summary: The study suggests that GCF markers in patients with metabolic syndrome may be associated with concomitant periodontitis, particularly the levels of markers such as Aggrecan, IL-6, and IL-8 are correlated with the severity of the disease.
JOURNAL OF DENTISTRY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Vikender S. Yadav, Riyaz A. Mir, Anu Bhatia, Rakhee Yadav, Mahaiwon Shadang, Shyam S. Chauhan, Kunaal Dhingra, Om P. Kharbanda, Renu Yadav, Rahul Garg
Summary: This study found that smoking and chronic periodontitis may increase the synthesis of metallothionein (MT) due to increased oxidative stress and heavy metal intoxication. Further research with larger sample size and interventional arm is needed to confirm the role of MT as a potential biomarker in periodontitis.
JOURNAL OF PERIODONTOLOGY
(2021)
Article
Health Care Sciences & Services
Hammam Ibrahim Fageeh, Hytham N. Fageeh, Shankargouda Patil
Summary: Periodontitis is an inflammatory condition caused by pathogenic bacteria in dental plaque. Macrophages derived from monocytes play a dual role in periodontitis, presenting antigens to lymphocytes while also contributing to periodontal destruction. The study found that GCF samples from periodontitis patients have higher levels of specific cytokines, and that treatment with these samples can induce monocytes to differentiate into destructive macrophages, affecting the phenotype and function of resident cells in the periodontium.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Chemistry, Physical
Elisa Bellei, Carlo Bertoldi, Emanuela Monari, Stefania Bergamini
Summary: Periodontal disease, comprising gingivitis and periodontitis, is a common disorder without fully explained etiopathogenetic models. This study used proteomic analysis to identify potential biomarkers in the gingival crevicular fluid of patients with severe periodontitis. The results revealed several proteins that could be valuable for periodontitis assessment.
Article
Chemistry, Multidisciplinary
Alina-Ramona Dimofte, Dorin Nicolae Gheorghe, Dora Maria Popescu, Ioana Mitrut, Petre Costin Marasescu, Horia Octavian Manolea, Mihail Virgil Boldeanu, Petra Surlin
Summary: This study evaluated the influence of metal-ceramic crowns on periodontal parameters and inflammatory marker levels. The results showed that metal-ceramic crowns can cause changes in periodontal clinical parameters and are associated with inflammatory marker levels.
APPLIED SCIENCES-BASEL
(2023)
Article
Microbiology
Simran Preet Bhalla, Ann Maria Shaju, Carlos Marcelo da Silva Figueredo, Leticia Algarves Miranda
Summary: C5a levels were significantly increased in both gingival crevicular fluid and saliva of patients with periodontal disease, indicating a potential role of this molecule in the pathogenesis of the disease.
Article
Dentistry, Oral Surgery & Medicine
Zeliha Guney, Sivge Kurgan, Canan Onder, Cavid Mammadov, Muhittin A. Serdar, Meral Gunhan
Summary: This study aimed to evaluate the levels of ADMA, SDMA, and IL-1 beta in GCF from periodontitis patients. The results showed that the levels of IL-1 beta, ADMA, and SDMA in GCF were significantly higher in periodontitis patients compared to the control group, and they were positively correlated with clinical periodontal parameters. It suggests that ADMA and SDMA may be involved in the pathogenesis of periodontal disease.
JOURNAL OF PERIODONTAL RESEARCH
(2023)
Article
Biology
Hytham N. Fageeh, Hammam Ibrahim Fageeh, Samar Saeed Khan, Prabhadevi C. Maganur, Nishant Vyas, Vikrant R. Patil, A. Thirumal Raj, Hosam Ali Baeshen, Shankargouda Patil
Summary: This study aimed to characterize monocytes isolated from the gingival crevicular fluid (GCF) in patients with periodontitis, evaluating cytokine levels, gene expression, and secreted cytokines and chemokines. CD14+ monocytes from GCF secreted higher levels of CCL2 and expressed genes responsible for monocyte migration, indicating their role in the inflammatory microenvironment of periodontitis.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Dentistry, Oral Surgery & Medicine
Hyun-Duck Kim, Sandeep Karna, YooJin Shin, Huong Vu, Hyun-Jae Cho, Sungtae Kim
Summary: This study compared the association and screening ability of S100A8 and S100A9 in saliva, blood, and gingival crevicular fluid for periodontitis status. Salivary S100A8 was significantly higher in established periodontitis, while GCF S100A8 and S100A9 were higher in no or initial periodontitis. Salivary S100A8 could be a potential diagnostic marker for established periodontitis.
Article
Dentistry, Oral Surgery & Medicine
Beral Afacan, Harika Atmaca Ilhan, Timur Kose, Gulnur Emingil
Summary: This study aims to evaluate the levels of GCF Galectin-3 and IL-1 beta in different grades of stage 3 periodontitis and investigate their efficiency in discriminating periodontal diseases. ELISA was used to measure the total amounts of GCF Galectin-3 and IL-1 beta in 80 individuals. The results showed that GCF Galectin-3 is associated with the pathogenesis of periodontal diseases and has high diagnostic performance.
CLINICAL ORAL INVESTIGATIONS
(2023)
Article
Biochemistry & Molecular Biology
Federica Romano, Giovanni Iaderosa, Matteo Corana, Stefano Perotto, Giacomo Baima, Federica Di Scipio, Giuliana Abbadessa, Giulia Maria Mariani, Mario Aimetti, Giovanni Nicolao Berta
Summary: This study analyzed the elemental composition of gingival crevicular fluid (GCF) and saliva and found differences in their content that could be used to diagnose periodontitis and periodontal health. GCF showed higher clustering potential than saliva.
Article
Dentistry, Oral Surgery & Medicine
Jung-Seok Lee, Jin-Young Park, Hye-Min Chung, Young Woo Song, Franz-Josef Strauss
Summary: The study suggests that vertical ridge augmentation (VRA) can be achieved through guided bone regeneration (GBR) without additional stabilization, using only resorbable collagen membranes and particulate bone substitutes.
CLINICAL IMPLANT DENTISTRY AND RELATED RESEARCH
(2022)
Article
Dentistry, Oral Surgery & Medicine
Franz J. Strauss, Marina Siegenthaler, Christoph H. F. Hammerle, Irena Sailer, Ronald E. Jung, Daniel S. Thoma
Summary: This study assessed the outcomes and patient satisfaction of directly veneered zirconia restorations cemented on non-original titanium bases over a 5-year period. The results showed that the restorative angle may influence initial marginal bone loss but does not affect long-term clinical performance.
CLINICAL ORAL IMPLANTS RESEARCH
(2022)
Article
Dentistry, Oral Surgery & Medicine
Daniel S. Thoma, Thomas J. W. Gasser, Christoph H. F. Haemmerle, Franz J. Strauss, Ronald E. Jung
Summary: This randomized controlled trial aimed to assess the long-term clinical and radiographic outcomes of soft tissue augmentation using volume-stable collagen matrix (VCMX) or subepithelial connective tissue grafts (SCTGs) at implant sites. The study found that both VCMX and SCTG resulted in stable peri-implant tissues, favorable esthetics, and clinically negligible contour changes at 5 years post loading.
JOURNAL OF PERIODONTOLOGY
(2023)
Review
Dentistry, Oral Surgery & Medicine
Daniel S. Thoma, Franz J. Strauss, Leonardo Mancini, Thomas J. W. Gasser, Ronald E. Jung
Summary: The aim of this study was to compare patient-reported outcome measures of soft tissue substitutes versus autogenous grafts for soft tissue augmentation procedures at implant sites. The results showed that soft tissue substitutes significantly improved pain perception, reduced painkiller usage, and shortened surgery time compared to autogenous grafts.
PERIODONTOLOGY 2000
(2023)
Article
Biochemistry & Molecular Biology
Pablo Veloso, Alejandra Fernandez, Jessica Astorga, David Gonzalez-Quintanilla, Alfredo Castro, Alejandro Escobar, Anilei Hoare, Marcela Hernandez
Summary: The study found that Pg LPS can induce a macrophage M1 phenotype (pro-inflammatory) while Pe LPS does not elicit a significant response. Additionally, the expressions of TLR2 and TLR4 were not modified by Pg or Pe LPS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Dentistry, Oral Surgery & Medicine
Anina-Nives Zuercher, Leonardo Mancini, Nadja Naenni, Daniel-Stefan Thoma, Franz-Josef Strauss, Ronald-Ernst Jung
Summary: This study describes the L-shape technique in guided bone regeneration (GBR) with simultaneous implant placement and reports on its clinical, esthetic, and patient satisfaction outcomes up to 14 years of follow-up. The results show that the L-shape augmentation procedure is a reliable technique for GBR and simultaneous implant placement in the esthetic zone, with stable clinical and esthetic results and high levels of patient satisfaction.
JOURNAL OF ESTHETIC AND RESTORATIVE DENTISTRY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Jin-Young Park, Hye-Min Chung, Franz-Josef Strauss, Jung-Seok Lee
Summary: This study evaluated the dimensional changes after horizontal and vertical guided bone regeneration (GBR) without membrane fixation using the retentive flap technique. The results showed that using the retentive flap technique for GBR can preserve the vertical bone dimensions, but may not be as effective in preserving the width of augmented tissue.
CLINICAL IMPLANT DENTISTRY AND RELATED RESEARCH
(2023)
Article
Dentistry, Oral Surgery & Medicine
Gustavo Saenz-Ravello, Johanna Contreras, Mauricio Baeza, Ana Beatriz Silva, Karen Danke, Sebastian Gonzalez, Gisela Jara, Jorge Gamonal
Summary: There is an association between functional dentition and cognitive health, social participation, and quality of life. Daily fruit and vegetable consumption mediates the association between functional dentition and cognitive health, while functional dentition has a direct impact on social participation. The association between functional dentition and quality of life is mediated by cognitive health and oral health-related quality of life.
Article
Dentistry, Oral Surgery & Medicine
Leonardo Mancini, Daniel S. S. Thoma, Enrico Marchetti, Jung Ronald Ernst, Franz J. J. Strauss
Summary: This study describes a novel 3D method for estimating the emergence profile and restorative angles of single implant-supported crowns, including the buccal sites. The crowns were scanned using an intraoral scanner and analyzed using 3D software. The results show that this 3D analysis method is reliable and applicable in daily practice.
JOURNAL OF ESTHETIC AND RESTORATIVE DENTISTRY
(2023)
Article
Dentistry, Oral Surgery & Medicine
A. N. Zuercher, F. J. Strauss, P. N. Paque, S. P. Bienz, R. E. Jung, D. S. Thoma
Summary: This study compared the effectiveness of subepithelial connective tissue grafts (SCTG) and guided bone regeneration (GBR) in treating small peri-implant dehiscence defects. The results showed that SCTG may be a viable alternative to GBR, as it resulted in more stable profilometric outcomes and comparable clinical outcomes.
CLINICAL ORAL IMPLANTS RESEARCH
(2023)
Article
Dentistry, Oral Surgery & Medicine
Alejandra Fernandez, Daniela Herrera, Anilei Hoare, Marcela Hernandez, Vicente A. A. Torres
Summary: This study aimed to evaluate the angiogenesis-related effects induced by lipopolysaccharide (LPS) from Porphyromonas endodontalis and Porphyromonas gingivalis in vitro via TLR2 and TLR4. The results showed that P. endodontalis LPS stimulated endothelial cell migration and tube formation through TLR2 and TLR4 activation, while P. gingivalis LPS did not have these effects. Moreover, both LPS induced IL-6 and VEGF-A synthesis in endothelial cells.
INTERNATIONAL ENDODONTIC JOURNAL
(2023)
Article
Dentistry, Oral Surgery & Medicine
Franz Josef Strauss, Crystal Marruganti, Mario Romandini, Franco Cavalla, Patricio Neira, Francisco J. J. Jimenez, Ronald E. E. Jung, Mariano Sanz, Jorge Gamonal Aravena
Summary: The aim of this investigation was to estimate the prevalence, severity, and extent of mid-buccal gingival recessions (GRs) in the South American population and identify their risk indicators. The prevalence of mid-buccal GRs in South American adolescents was 14.1%, while it was over 90% in Chilean adults. Different recession types were observed, with RT2 and RT3 being the most common in Chilean adults.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2023)
Review
Dentistry, Oral Surgery & Medicine
Gustavo Saenz-Ravello, Benjamin Ossandon-Zuniga, Vicente Munoz-Meza, Dante Mora-Ferraro, Mauricio Baeza, Shengchi Fan, Keyvan Sagheb, Eik Schiegnitz, Leonardo Diaz
Summary: This study assesses the effects of short implants versus regular implants after bone augmentation in the atrophic posterior mandible. The results suggest that using short implants may decrease the risk of implant failure, marginal bone loss, and biological complications, while increasing patient satisfaction.
INTERNATIONAL JOURNAL OF IMPLANT DENTISTRY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Gustavo Saenz-Ravello, Loreto Matamala, Patricia Cisternas, Jorge Gamonal, Patricia Hernandez, Nidia Castro dos Santos, Ke Deng, Mauricio Baeza
Summary: This study aimed to determine the association between adherence to the Mediterranean Diet Index (MDI) and self-reported gingival health status in Chilean adults, and found a positive correlation between adherence to the Mediterranean diet and gingival health status. This evidence could contribute to the design of low-cost surveillance programs to reduce the burden of periodontal disease and related common risk factors.
JOURNAL OF APPLIED ORAL SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Constanza Jimenez, Javier Fernandez, Marcela Aroca, Maria Jose Bordagaray, Elizabeth Pellegrini, Javier Contador, Marcela Hernandez, Fernando Valenzuela, Alejandra Fernandez
Summary: This case-control study found a link between atopic dermatitis (AD) and periodontitis, with Th2-derived cytokines playing a key role in the development of both diseases. The study also found higher levels of IL-31 and TSLP in AD subjects, while severe periodontitis was associated with lower levels of IL-31.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)