Article
Endocrinology & Metabolism
Jenneke E. van Atteveld, Renee L. Mulder, Marry M. van den Heuvel-Eibrink, Melissa M. Hudson, Leontien C. M. Kremer, Roderick Skinner, W. Hamish Wallace, Louis S. Constine, Claire E. Higham, Sue C. Kaste, Riitta Niinimaki, Sogol Mostoufi-Moab, Nathalie Alos, Danilo Fintini, Kimberly J. Templeton, Leanne M. Ward, Eva Frey, Roberto Franceschi, Vesna Pavasovic, Seth E. Karol, Nadia L. Amin, Lynda M. Vrooman, Arja Harila-Saari, Charlotte Demoor-Goldschmidt, Robert D. Murray, Edit Bardi, Maarten H. Lequin, Maria Felicia Faienza, Olga Zaikova, Claire Berger, Stefano Mora, Kirsten K. Ness, Sebastian J. C. M. M. Neggers, Saskia M. F. Pluijm, Jill H. Simmons, Natascia Di Iorgi
Summary: Childhood, adolescent, and young adult cancer survivors are at increased risk of reduced bone mineral density, and guidelines for bone mineral density surveillance are important for timely diagnosis and treatment. Current discordances in guidelines highlight the need for international harmonisation to provide evidence-based care for survivors.
LANCET DIABETES & ENDOCRINOLOGY
(2021)
Article
Oncology
Hye Young Jin, Jun Ah Lee, Meerim Park, Hyeon Jin Park
Summary: The study aims to evaluate ovarian function and associated health outcomes in female adolescent and young adult survivors of childhood cancer. It found that premature ovarian insufficiency is common in childhood cancer survivors and is associated with certain treatment factors. Regular monitoring of ovarian function is necessary for better health outcomes.
CANCER RESEARCH AND TREATMENT
(2023)
Article
Oncology
Hjelmer Ida, Gustafsson Kylberg Alicia, Fridenborg Anna, Leijonhufvud Irene, Nystrom Anna, Morse Helena, Elfving Maria, Henic Emir, Nenonen Hannah
Summary: The study investigates the health status and well-being of female CCS, finding that those with premature ovarian insufficiency have the lowest level of well-being. This has implications for identifying and providing support for cancer survivors with POI.
JOURNAL OF CANCER SURVIVORSHIP
(2023)
Review
Oncology
MatthewJ Ehrhardt, Jan M. Leerink, Renee L. Mulder, Annelies Mavinkurve-Groothuis, Wouter Kok, Anju Nohria, Paul C. Nathan, Remy Merkx, Esmee de Baat, Ogechukwu A. Asogwa, Roderick Skinner, Hamish Wallace, E. A. M. Lieke Feijen, Maelle de Ville de Goyet, Maya Prasad, Edit Bardi, Vesna Pavasovic, Helena van der Pal, Brice Fresneau, Charlotte Demoor-Goldschmidt, Ulrike Hennewig, Julia Steinberger, Chris Plummer, Ming Hui Chen, ArcoJ Teske, Nadia Haddy, Elvira C. van Dalen, Louis S. Constine, Eric J. Chow, Gill Levitt, Melissa M. Hudson, Leontien C. M. Kremer, Saro H. Armenian
Summary: Survivors of childhood, adolescent, and young adult cancer who were previously treated with anthracycline chemotherapy or radiotherapy that exposed the heart have an increased risk of developing cardiomyopathy. Specialist organizations have endorsed guidelines on cardiac surveillance for these high-risk cancer survivors, as symptomatic cardiomyopathy is typically preceded by asymptomatic changes in heart structure and function. The International Late Effects of Childhood Cancer Guideline Harmonization Group compiled these guidelines into a uniform set of recommendations applicable to different clinical environments. This systematic review and guideline provide updated recommendations based on evidence published up to September 2020.
Review
Oncology
Edit Bardi, Renee L. Mulder, Elvira C. van Dalen, Neel S. Bhatt, Kathy A. Ruble, Jennifer Burgis, Sharon M. Castellino, Louis S. Constine, Caroline M. den Hoed, Daniel M. Green, Bart G. P. Koot, Gill Levitt, Laszlo Szonyi, W. Hamish Wallace, Roderick Skinner, Melissa M. Hudson, Leontien C. M. Kremer, Karen E. Effinger, Dorine Bresters
Summary: This study developed guidelines for the surveillance of treatment-induced chronic liver disease in survivors of childhood, adolescent and young adult cancer. It strongly recommends physical examination and liver enzyme measurement at entry into long-term follow-up for those potentially exposed to radiation therapy.
CANCER TREATMENT REVIEWS
(2021)
Review
Oncology
Jordan Gilleland Marchak, Salome Christen, Renee L. Mulder, Katja Baust, Johanna M. C. Blom, Tara M. Brinkman, Iris Elens, Erika Harju, Nina S. Kadan-Lottick, Joel W. T. Khor, Jurgen Lemiere, Christopher J. Recklitis, Claire E. Wakefield, Lori Wiener, Louis S. Constine, Melissa M. Hudson, Leontien C. M. Kremer, Roderick Skinner, Janine Vetsch, Jennifer L. Lee, Gisela Michel
Summary: The clinical practice guideline aims to harmonize international recommendations for mental health surveillance in survivors of childhood, adolescent, and young adult cancer. It strongly recommends mental health surveillance for all survivors of these cancers at every follow-up visit and prompt referral to mental health specialists when problems are identified.
Review
Oncology
Elvira C. van Dalen, Renee L. Mulder, Eugene Suh, Matthew J. Ehrhardt, Gregory J. Aune, Edit Bardi, Bradley J. Benson, Jutta Bergler-Klein, Ming H. Chen, Eva Frey, Ulrike Hennewig, Liane Lockwood, Ulla Martinsson, Monica Muraca, Helena van der Pal, Chris Plummer, Katrin Scheinemann, Christina Schindera, Emily S. Tonorezos, W. Hamish Wallace, Louis S. Constine, Roderick Skinner, Melissa M. Hudson, Leontien C. M. Kremer, Gill Levitt, Daniel A. Mulrooney
Summary: This study aimed to harmonize international recommendations for coronary artery disease (CAD) surveillance for survivors of childhood, adolescent and young adult cancers. An extensive systematic literature review was conducted to identify a wide range of CAD surveillance recommendations, highlighting the need to focus on the increased risk of CAD among those treated for cancer.
EUROPEAN JOURNAL OF CANCER
(2021)
Review
Oncology
Jarmila Kruseova, Andrea Zichova, Tomas Eckschlager
Summary: Progress in medicine has increased the survival time of children with cancer, but it has also led to the development of late effects of anticancer therapy. These late effects, such as endocrinopathies, cardiovascular diseases, and subsequent cancers, pose serious health, social, and economic problems. The premature biological aging in cancer survivors is caused by therapy and the mechanisms involved in its development are not fully understood.
Review
Obstetrics & Gynecology
Anne-Lotte Lolkje Femke van der Kooi, Renee L. Mulder, Melissa M. Hudson, Leontien C. M. Kremer, Rod Skinner, Louis S. Constine, Wendy van Dorp, Eline van Dulmen-den Broeder, Jeanette Falck-Winther, W. Hamish Wallace, Jason Waugh, Teresa K. Woodruff, Richard A. Anderson, Saro H. Armenian, Kitty W. M. Bloemenkamp, Hilary O. D. Critchley, Charlotte Demoor-Goldschmidt, Matthew J. Ehrhardt, Daniel M. Green, William A. Grobman, Yuriko Iwahata, Iris Krishna, Joop S. E. Laven, Gill Levitt, Lillian R. Meacham, Emily S. Miller, Annemarie Mulders, Angela Polanco, Cecile M. Ronckers, Amber Samuel, Tom Walwyn, Jennifer M. Levine, Marry M. van den Heuvel-Eibrink
Summary: Female childhood, adolescent, and young adult cancer survivors are at increased risk for adverse pregnancy outcomes related to their cancer treatment. Clinical practice guidelines are essential in identifying and addressing these risks, but national guidelines are currently lacking. The International Late Effects of Childhood Cancer Guideline Harmonization Group offers recommendations for counseling and surveillance to enhance evidence-based obstetrical care for this population.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2021)
Review
Oncology
Marco Torella, Gaetano Riemma, Pasquale De Franciscis, Marco La Verde, Nicola Colacurci
Summary: Innovations in childhood cancer treatment have increased survival rates, but female childhood cancer survivors are at risk for late reproductive aftereffects. AMH is used for ovarian reserve screening in reproductive medicine, but is not the gold standard. This study found that female neuroblastoma survivors have higher risk for reduced AMH levels and POI.
Article
Oncology
Renee L. Mulder, Anna Font-Gonzalez, Daniel M. Green, Erik A. H. Loeffen, Melissa M. Hudson Jacqueline, Jacqueline Loonen, Richard Yu, Jill P. Ginsberg, Rod T. Mitchell, Julianne Byrne, Roderick Skinner, Antoinette Anazodo, Louis S. Constine, Andrica de Vries, Kirsi Jahnukainen, Armando Lorenzo, Andreas Meissner, Leena Nahata, Marij Dinkelman-Smit, Herman Tournaye, Riccardo Haupt, Marry M. van den Heuvel-Eibrink, Hanneke M. van Santen, Ans M. M. van Pelt, Uta Dirksen, Jaap den Hartogh, Eline van Dulmen-den Broeder, W. Hamish Wallace, Jennifer Levine, Wim J. E. Tissing, Leontien C. M. Kremer, Lisa B. Kenney, Marianne D. van de Wetering
Summary: This clinical practice guideline provides guidance on risk assessment and fertility preservation methods for male patients diagnosed with childhood, adolescent, and young adult cancer at age 25 or younger. By rigorously evaluating existing evidence, transparent and easy-to-use recommendations are developed to facilitate the care of male patients at high risk of fertility impairment.
Article
Oncology
Isabelle M. Dudley, Ceren Sunguc, Emma J. Heymer, David L. Winter, Jop C. Teepen, Fabien N. Belle, Edit Bardi, Francesca Bagnasco, Thorgerdur Gudmundsdottir, Roderick Skinner, Gisela Michel, Julianne Byrne, Hilde Ofstaas, Momcilo Jankovic, Maja Cesen Mazic, Luzius Mader, Jaqueline Loonen, Stanislaw Garwicz, Thomas Wiebe, Daniela Alessi, Rodrigue S. Allodji, Nadia Haddy, Desiree Grabow, Peter Kaatsch, Melanie Kaiser, Milena M. Maule, Zsuzsanna Jakab, Maria Winther Gunnes, Monica Terenziani, Lorna Zadravec Zaletel, Claudia E. Kuehni, Riccardo Haupt, Florent de Vathaire, Leontien C. Kremer, Paivi M. Lahteenmaki, Jeanette F. Winther, Lars Hjorth, Michael M. Hawkins, Raoul C. Reulen
Summary: This study found that survivors of Hodgkin lymphoma (HL) are at an increased risk of developing non-Hodgkin lymphoma (NHL) after treatment. The researchers also identified other types of childhood cancer survivors who are at risk of developing NHL, including survivors of Wilms tumor, leukemia, and bone sarcoma. Treatment with chemotherapy increased the risk of NHL, while treatment with radiotherapy did not.
Article
Oncology
Renee L. Mulder, Anna Font-Gonzalez, Melissa M. Hudson, Hanneke M. van Santen, Erik A. H. Loeffen, Karen C. Burns, Gwendolyn P. Quinn, Eline van Dulmen-den Broeder, Julianne Byrne, Riccardo Haupt, W. Hamish Wallace, Marry M. van den Heuvel-Eibrink, Antoinette Anazodo, Richard A. Anderson, Anke Barnbrock, Joern D. Beck, Annelies M. E. Bos, Isabelle Demeestere, Christian Denzer, Natascia Di Iorgi, Holly R. Hoefgen, Rejin Kebudi, Cornelis Lambalk, Thorsten Langer, Lillian R. Meacham, Kenny Rodriguez-Wallberg, Catharyn Stern, Eveline Stutz-Grunder, Wendy van Dorp, Margreet Veening, Saskia Veldkamp, Eline van der Meulen, Louis S. Constine, Lisa B. Kenney, Marianne D. van de Wetering, Leontien C. M. Kremer, Jennifer Levine, Wim J. E. Tissing
Summary: This study aims to develop clinical practice guidelines for fertility preservation in female patients diagnosed with childhood, adolescent, and young adult cancer at age 25 years or younger. By utilizing the Grading of Recommendations Assessment, Development and Evaluation methodology, transparent recommendations were formed to facilitate the care of high-risk female patients. Collaboration led to a comprehensive review of existing evidence, transparent reporting, and achievement of global interdisciplinary consensus.
Review
Oncology
Daniel C. Bowers, Lisanne C. Verbruggen, Leontien C. M. Kremer, Melissa M. Hudson, Roderick Skinner, Louis S. Constine, Noah D. Sabin, Ranjeev Bhangoo, Riccardo Haupt, Mike M. Hawkins, Helen Jenkinson, Raja B. Khan, Paul Klimo Jr, Pieter Pretorius, Antony Ng, Raoul C. Reulen, Cecile M. Ronckers, Zsila Sadighi, Katrin Scheinemann, Netteke Schouten-van Meeteren, Elaine Sugden, Jop C. Teepen, Nicole J. Ullrich, Andrew Walter, W. Hamish Wallace, Kevin C. Oeffinger, Gregory TArmstrong, Helena J. H. van der Pal, Renee L. Mulder
Summary: Exposure to cranial radiotherapy is associated with an increased risk of subsequent CNS neoplasms among childhood, adolescent, and young adult (CAYA) cancer survivors. Surveillance for subsequent neoplasms is important, but there is currently insufficient evidence to establish whether early detection reduces morbidity and mortality. More research is needed to inform survivorship care.
Review
Obstetrics & Gynecology
Katja C. E. Drechsel, Maxime C. F. Pilon, Francis Stoutjesdijk, Salena Meivis, Linda J. Schoonmade, William Hamish B. Wallace, Eline van Dulmen-den Broeder, Auke Beishuizen, Gertjan J. L. Kaspers, Simone L. Broer, Margreet A. Veening
Summary: This narrative review summarized existing literature on reproductive function in young Hodgkin lymphoma survivors. The results showed that female survivors had a high incidence of premature ovarian insufficiency, while male survivors often experienced post-treatment azoospermia. Higher doses of chemotherapeutic agents and pelvic radiotherapy were associated with impaired reproductive ability.
HUMAN REPRODUCTION UPDATE
(2023)
Article
Endocrinology & Metabolism
Hanneke M. van Santen, Jiska van Schaik, Ichelle M. A. A. van Roessel, Julia Beckhaus, Svenja Boekhoff, Hermann L. Mueller
Summary: Hypothalamic syndrome (HS) in childhood is a rare condition with limited epidemiological knowledge. Diagnostic criteria and a scoring system for presence of HS were developed and validated in a retrospective cohort study of 120 patients at risk for hypothalamic dysfunction. The criteria and scoring system can aid in early recognition and provide care purposes and research benefits.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2023)
Article
Oncology
Elizabeth A. M. Feijen, Jop C. Teepen, Eline van Dulmen-den Broeder, Marry M. van den Heuvel-Eibrink, Margriet van der Heiden-van der Loo, Helena J. H. van der Pal, Andrica C. H. de Vries, Marloes Louwerens, Dorine Bresters, Birgitta Versluys, Hanneke de Ridder, Margreet Veening, Flora E. van Leeuwen, Martha Grootenhuis, Heleen Maurice-Stam, Hanneke M. van Santen, Sebastian J. C. M. M. Neggers, Saskia Pluijm, Jaap den Hartogh, Cecile M. Ronckers, Wim J. E. Tissing, Jacqueline J. Loonen, Leontien C. M. Kremer
Summary: The Dutch Childhood Cancer Survivor Study (DCCSS) conducted a cross-sectional clinical study (LATER 2 study) to investigate the health risks of childhood cancer survivors. Physical and psychosocial health outcomes were assessed through various measurements and questionnaires, and DNA samples were extracted. The study results will fill important gaps in knowledge and contribute to improving the quality of life and care for childhood cancer survivors.
PEDIATRIC BLOOD & CANCER
(2023)
Article
Oncology
Jop C. Teepen, Judith L. Kok, Elizabeth A. M. Feijen, Jacqueline J. Loonen, Marry M. van den Heuvel-Eibrink, Helena J. van der Pal, Wim J. E. Tissing, Dorine Bresters, Birgitta Versluys, Martha A. Grootenhuis, Marloes Louwerens, Sebastian J. C. M. M. Neggers, Hanneke M. van Santen, Andrica de Vries, Geert O. Janssens, Jaap G. den Hartogh, Flora E. van Leeuwen, Nynke Hollema, Nina Streefkerk, Ellen Kilsdonk, Margriet van der Heiden-van der Loo, Eline van Dulmen-den Broeder, Cecile M. Ronckers, Leontien C. M. Kremer
Summary: This study describes the design, methodology, characteristics, and data availability of the Dutch Childhood Cancer Survivor Study LATER cohort. The aim of the study is to identify the risk of and risk factors for specific health outcomes in childhood cancer survivors. The data collected from the LATER cohort will provide new insights into risk stratification for survivors and inform the development of interventions to prevent long term adverse health outcomes.
Article
Endocrinology & Metabolism
Jenneke E. van Atteveld, Demi T. C. de Winter, Vincent G. Pluimakers, Marta Fiocco, Rutger A. J. Nievelstein, Monique G. G. Hobbelink, Andrica C. H. de Vries, Jacqueline J. Loonen, Eline van Dulmen-den Broeder, Helena J. van der Pal, Saskia M. F. Pluijm, Leontien C. M. Kremer, Cecile M. Ronckers, Margriet van der Heiden-van der Loo, A. Birgitta Versluijs, Marloes Louwerens, Dorine Bresters, Hanneke M. van Santen, Daniel S. Olsson, Imo Hoefer, Sjoerd A. A. van den Berg, Jaap den Hartogh, Wim J. E. Tissing, Sebastian J. C. M. M. Neggers, Marry M. van den Heuvel-Eibrink, Dutch LATER Study Grp
Summary: This study examined the risk factors for low bone mineral density (BMD), fractures, and vertebral fractures in adult childhood cancer survivors in the Netherlands. The results showed that childhood cancer survivors have an increased risk of fractures, and factors associated with low BMD and fractures include gender, underweight, radiotherapy dose, hormone disorders, lack of physical activity, and vitamin D deficiency. The findings highlight the importance of monitoring bone health and providing interventions for endocrine disorders and vitamin deficiencies in childhood cancer survivors.
LANCET DIABETES & ENDOCRINOLOGY
(2023)
Review
Endocrinology & Metabolism
Ichelle Maa Van Roessel, Boudewijn Bakker, Hanneke M. Van Santen, Wassim Chemaitilly
Summary: Childhood cancer survivors are prone to developing endocrine disorders such as growth hormone, thyroid hormone, and sex hormone deficiencies. The safety of using these hormones as treatments in survivors of childhood cancer and brain tumors is a concern due to their impact on cell growth and metabolism. This article provides an overview of current knowledge, controversies, and areas for future research in this field.
ENDOCRINE CONNECTIONS
(2023)
Review
Oncology
Madeline R. Horan, Jin-ah Sim, Kevin R. Krull, Kirsten K. Ness, Yutaka Yasui, Leslie L. Robison, Melissa M. Hudson, Justin N. Baker, I-Chan Huang
Summary: Patient-reported outcome measures (PROMs) are useful in assessing the subjective experiences of childhood cancer survivors and can be used to monitor health status and inform medical decision making. This article provides 10 important considerations for clinicians when assessing PROMs for childhood cancer survivors, addressing practical barriers and solutions. An example framework for integrating PROMs into clinical workflow using cutting-edge technologies is also discussed.
Article
Nutrition & Dietetics
Amanda Casirati, Alberto Somaschini, Monica Muraca, Emanuele Cereda, Vera Morsellino, Natascia Di Iorgi, Riccardo Caccialanza, Riccardo Haupt
Summary: This study aimed to evaluate the association between fat-to-lean mass ratio (FLR) and dysmetabolic profile in childhood cancer survivors (CCS). The results showed that CCS with FLR ≥0.6 were more likely to be overweight and obese and had higher levels of triglycerides, insulin resistance, and liver function, while having lower levels of insulin-like growth factor 1 and lean mass. Waist circumference, insulin-like growth factor 1, and trunk fat were independent predictors of FLR ≥0.6. It is important to maintain long-term nutritional status through diet and physical activity.
Review
Nutrition & Dietetics
Rossella Attini, Maria Elena Laudani, Elisabetta Versino, Alessio Massaro, Arianna Pagano, Francesca Petey, Alberto Revelli, Bianca Masturzo
Summary: Based on research findings, being pregnant does not increase the risk of COVID-19 infection, but it may lead to more severe complications for both the mother and the fetus. This study found that obesity is associated with a higher risk of severe infection, maternal death, and hospital admission for pregnant women with COVID-19. The level of micronutrients, especially Vitamin D, appears to be lower in COVID-19-positive pregnant women.
Article
Medicine, General & Internal
Alice Ronco, Sofia Roero, Silvana Arduino, Arianna Arese, Isabella Ferrando, Gabriella Scaltrito, Viola Casula, Teresa Fea, Mattia Mazza, Carlotta Bossotti, Roberto Zizzo, Alberto Revelli
Summary: This study analyzed the specific effects of gestational diabetes mellitus (GDM) on twin pregnancy outcomes. The results showed that compared to GDM singleton pregnancies, GDM twins had higher rates of preeclampsia, cesarean section, and neonatal hypoglycemia. Compared to twin pregnancies without GDM, women with GDM twins were older, had higher BMI, had a higher incidence of large-for-gestational-age (LGA) newborns, and a lower incidence of low APGAR scores. Overall, GDM does not worsen outcomes of twin pregnancy.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Oncology
Lars Tramsen, Konrad Bochennek, Monika Sparber-Sauer, Emilia Salzmann-Manrique, Monika Scheer, Tobias Dantonello, Arndt Borkhardt, Uta Dirksen, Anne Thorwarth, Jeanette Greiner, Martin Ebinger, Jadwiga Weclawek-Tompol, Ruth Ladenstein, Gustaf Ljungman, Erika Hallmen, Thomas Lehrnbecher, Ewa Koscielniak, Thomas Klingebiel
Summary: Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma (STS) in childhood. The HD CWS-96 trial showed improved outcomes for patients receiving maintenance therapy after intensive chemotherapy. In a study comparing different maintenance options for metastatic RMS, long-term maintenance therapy (LTMT) was found to have a significantly better event-free survival (EFS) and overall survival (OS) compared to alloHSCT, with similar outcomes to HDCT but with a lower therapeutic burden.
Article
Oncology
Chantal A. Lebbink, Cor van den Bos, Miranda P. Dierselhuis, Marta Fiocco, Annemarie Verrijn A. Stuart, Eef G. W. M. Lentjes, Sabine L. A. Plasschaert, Wim J. E. Tissing, Hanneke M. van Santen
Summary: A prospective study was conducted on children with cancer, revealing a low risk of developing subclinical hypothyroidism or hyperthyroidism in the first three months of treatment, but a significant decline in free thyroid hormone concentration.
Article
Biotechnology & Applied Microbiology
Maximilian Kerkhoff, Susanne Grunewald, Christiane Schaefer, Stefan K. Zoellner, Pauline Plaumann, Maike Busch, Nicole Duenker, Julia Ketzer, Josephine Kersting, Sebastian Bauer, Jendrik Hardes, Arne Streitbuerger, Uta Dirksen, Wolfgang Hartmann, Wiebke K. Guder
Summary: Resection margin adequacy is crucial for the local control of sarcomas. Fluorescence-guided surgery has shown promise in improving complete resection rates and local recurrence-free survival. This study demonstrates the potential of 5-aminolevulinic acid (5-ALA) mediated photodynamic diagnosis (PDD) and photodynamic therapy (PDT) as tools for defining sarcoma resection margins and adjuvant treatment of the tumor bed.
BIOENGINEERING-BASEL
(2023)
Article
Oncology
Davide Chicco, Riccardo Haupt, Alberto Garaventa, Paolo Uva, Roberto Luksch, Davide Cangelosi
Summary: In this multicentre and retrospective study, Random Forests coupled with recursive feature elimination techniques were applied to electronic records of 3034 neuroblastoma patients to seek new prognostic markers for outcome, relapse or progression. Results showed that maximum response to first-line treatment and time to maximum response to first-line treatment are relevant predictors. The study demonstrates the prognostic value of maximum response to first-line treatment in different risk groups and highlights the importance of time in predicting outcomes and relapse/progression.
EUROPEAN JOURNAL OF CANCER
(2023)
Article
Oncology
Cindy Im, Noha Sharafeldin, Yan Yuan, Zhaoming Wang, Yadav Sapkota, Zhanni Lu, Logan G. Spector, Rebecca M. Howell, Michael A. Arnold, Melissa M. Hudson, Kirsten K. Ness, Leslie L. Robison, Smita Bhatia, Gregory T. Armstrong, Joseph P. Neglia, Yutaka Yasui, Lucie M. Turcotte
Summary: This study evaluated SMNs among long-term childhood cancer survivors of European and African genetic ancestry, finding that a polygenic risk score (PRS) could significantly impact SMN risk in survivors who did not receive radiation therapy and were treated with specific chemotherapies.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Review
Oncology
Pragya G. Poudel, Madeline R. Horan, Tara M. Brinkman, Zhaoming Wang, Leslie L. Robison, Melissa M. Hudson, I-Chan Huang
Summary: This article presents a systematic review of intervention studies addressing social integration or social connectedness issues among young- and middle-aged cancer patients/survivors. The findings suggest that utilizing technology- and non-technology-based platforms can improve social outcomes and enhance the quality of life for patients/survivors.
