A relic of design: against proper functions in biology

The role of purifying selection in the origin and maintenance of complex function

(2021) Tyler D.P. Brunet et al.   STUDIES IN HISTORY AND PHILOSOPHY OF SCIENCE

Getting clear about the F-word in genomics

(2020) Stefan Linquist et al.   PLoS Genetics

Global reference mapping of human transcription factor footprints

(2020) Jeff Vierstra et al.   NATURE

There Are No Ahistorical Theories of Function

(2019) Justin Garson   PHILOSOPHY OF SCIENCE

Is the cell really a machine?

(2019) Daniel J. Nicholson   JOURNAL OF THEORETICAL BIOLOGY

Pervasive contingency and entrenchment in a billion years of Hsp90 evolution

(2018) Tyler N. Starr et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

How objective are biological functions?

(2017) Marcel Weber   SYNTHESE

Junk or functional DNA? ENCODE and the function controversy

(2014) Pierre-Luc Germain et al.   BIOLOGY & PHILOSOPHY

Distinguishing between "Function" and "Effect" in Genome Biology

(2014) W. F. Doolittle et al.   Genome Biology and Evolution

Defining functional DNA elements in the human genome

(2014) M. Kellis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Getting "function" right

(2014) T. D. P. Brunet et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

What makes biological organisation teleological?

(2014) Matteo Mossio et al.   SYNTHESE

The ENCODE project: Missteps overshadowing a success

(2013) Sean R. Eddy   CURRENT BIOLOGY

On the Immortality of Television Sets: "Function" in the Human Genome According to the Evolution-Free Gospel of ENCODE

(2013) D. Graur et al.   Genome Biology and Evolution

Is junk DNA bunk? A critique of ENCODE

(2013) W. F. Doolittle   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Can ENCODE tell us how much junk DNA we carry in our genome?

(2012) Deng-Ke Niu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Cancer cells and adaptive explanations

(2012) Pierre-Luc Germain   BIOLOGY & PHILOSOPHY

More on how and why: cause and effect in biology revisited

(2012) Kevin N. Laland et al.   BIOLOGY & PHILOSOPHY

The C-value paradox, junk DNA and ENCODE

(2012) Sean R. Eddy   CURRENT BIOLOGY

What does our genome encode?

(2012) J. A. Stamatoyannopoulos   GENOME RESEARCH

Annotation of functional variation in personal genomes using RegulomeDB

(2012) A. P. Boyle et al.   GENOME RESEARCH

Lessons for big-data projects

(2012) Ewan Birney   NATURE

An integrated encyclopedia of DNA elements in the human genome

(2012)   NATURE

ENCODE Project Writes Eulogy for Junk DNA

(2012) E. Pennisi   SCIENCE

The (r)evolution of cancer genetics

(2010) Francesca D Ciccarelli   BMC BIOLOGY

Phylostratigraphic tracking of cancer genes suggests a link to the emergence of multicellularity in metazoa

(2010) Tomislav Domazet-Lošo et al.   BMC BIOLOGY

The virtue of vagueness

(2010) Andrew Robinson   NATURE

An Organizational Account of Biological Functions

(2009) M. Mossio et al.   BRITISH JOURNAL FOR THE PHILOSOPHY OF SCIENCE

Protein promiscuity and its implications for biotechnology

(2009) Irene Nobeli et al.   NATURE BIOTECHNOLOGY

In What Sense Does ‘Nothing Make Sense Except in the Light of Evolution’?

(2008) Paul Edmund Griffiths   ACTA BIOTHEORETICA

Natural Selection on Genes that Underlie Human Disease Susceptibility

(2008) Ran Blekhman et al.   CURRENT BIOLOGY