A review of study designs and data analyses in metabolomics studies in myopia

Metabolomics analyzes the entire range of small molecule metabolites in biological systems to reveal the response signals that are transmitted from genetics and environment, which could help us understand complex phenotypes of diseases. Metabolomics has been successfully applied to the study of eye diseases including age -related macular degeneration, glaucoma, and diabetic retinopathy. In this review, we summarize the findings of myopic metabolomics and discuss them from a design and analysis perspective. Finally, we provide new ideas for the future development of myopia metabolomics research based on the broader ocular metabolomics study.

Automated summary

Metabolomics is an approach to analyzing small molecule metabolites in biological systems, which helps understand complex phenotypes of diseases by revealing response signals transmitted from genetics and environment. This review summarizes the findings of myopic metabolomics and discusses them from a design and analysis perspective. Additionally, the review provides new ideas for the future development of myopia metabolomics research based on broader ocular metabolomics studies.