Review
Cardiac & Cardiovascular Systems
Jacqueline T. Vuong, Ashley F. Stein-Merlob, Richard K. Cheng, Eric H. Yang
Summary: Anthracyclines are important in the treatment of various cancers, but can have significant implications on cardiovascular health. As the number of cancer survivors increases, it becomes crucial to detect and treat anthracycline-induced cardiotoxicity. Current treatment methods are based on conventional heart failure treatment, but there is a need for specific therapies for anthracycline-induced cardiotoxicity.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Plant Sciences
Tingru Zeng, Zhaodong Meng, Runqing Yue, Shouping Lu, Wenlan Li, Wencai Li, Hong Meng, Qi Sun
Summary: Using a large-scale investigation, this study identified 59 significantly associated genetic loci related to maize yield through genome-wide association analysis. These findings are important for understanding the genetic architecture of maize yield and genetic improvement of maize.
Article
Cardiac & Cardiovascular Systems
Fabian Muehlberg, Markus Kornfeld, Leonora Zange, Saeed Ghani, Annette Reichardt, Peter Reichardt, Jeanette Schulz-Menger
Summary: This study aims to assess the subclinical changes in functional and morphologic myocardial MR parameters early in the course of high-dose anthracycline treatment. The results suggest that an early increase in myocardial T2 times 48 hours after the first anthracycline treatment may predict the subsequent development of anthracycline-induced cardiomyopathy. Additionally, a decrease in native T1 times was observed regardless of the development of cardiomyopathy in high-dose anthracycline therapy.
Article
Physiology
Yunxiao Zheng, Peng Hou, Liying Zhu, Weibin Song, Han Liu, Yaqun Huang, Hong Wang, Jinjie Guo
Summary: This study identified genes and molecular mechanisms controlling vascular bundle-related traits in maize through genome-wide association study. The results demonstrated that these traits are influenced by genetic structure, and several genes related to vascular development, cell wall, and stalk strength were discovered.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Oncology
Xuexia Wang, Purnima Singh, Liting Zhou, Noha Sharafeldin, Wendy Landier, Lindsey Hageman, Paul Burridge, Yutaka Yasui, Yadav Sapkota, Javier G. G. Blanco, Kevin C. C. Oeffinger, Melissa M. M. Hudson, Eric J. J. Chow, Saro H. H. Armenian, Joseph P. P. Neglia, A. Kim Ritchey, Douglas S. S. Hawkins, Jill P. P. Ginsberg, Leslie L. L. Robison, Gregory T. T. Armstrong, Smita Bhatia
Summary: This study identified genetic variants associated with anthracycline-related cardiomyopathy using two independent study cohorts. Two single-nucleotide polymorphisms (SNPs), rs17736312 (ROBO2) and rs113230990 (near a CCCTC-binding factor insulator), showed significant gene-environment interaction effect on anthracycline-related cardiomyopathy in the discovery cohort and rs17736312 was successfully replicated in the replication cohort. The study also identified gene-gene interaction and independent effects of TGF-beta 1 and ROBO2 on heart failure.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Agriculture, Dairy & Animal Science
Qixin Guo, Lan Huang, Yong Jiang, Zhixiu Wang, Yulin Bi, Guohong Chen, Hao Bai, Guobin Chang
Summary: Good feed efficiency is crucial for the economic output of the livestock and poultry industries. This study conducted a genome-wide association study to identify potential variants and genes associated with seven feed efficiency measures in ducks. The findings provide insights into the genetic mechanisms and genes involved in feed efficiency-related traits in ducks. Further investigations are warranted to validate these findings.
Article
Medicine, General & Internal
Keiko Inoue, Noriko Iida, Kazuko Tajiri, Hiroko Bando, Shigeru Chiba, Nobutaka Tasaka, Kenji Nagashio, Rumi Sasamura, Hiroyuki Naito, Momoko Murata, Siqi Li, Tomoko Ishizu, Yoko Nakazawa, Ikuo Sekine, Masaki Ieda
Summary: The study conducted a prospective multicenter registry study on cardiac management in patients treated with anthracyclines. Analysis of 1-year follow-up data of 97 patients showed the feasibility of the AIC registry study in Japanese patients. The study aims to collect echocardiographic and biomarker data on cardiotoxicity in a real-world setting.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Biotechnology & Applied Microbiology
Qi Zhang, Tingting Sun, Jiabao Wang, JianBo Fei, Yufu Liu, Lu Liu, Peiwu Wang
Summary: This study conducted a genome-wide association study (GWAS) on the contents of protein and fat in soybeans grown at the experimental base of Jilin Agricultural University from 2019-2021. Four SNP sites were found to be significantly associated with soybean fat content for three consecutive years, while two SNP sites were significantly associated with soybean protein content. Genes related to soybean protein synthesis and lipid metabolism were selected and their expression levels were validated. The results provide a basis for further studying the molecular mechanisms regulating the accumulation of protein and fat in soybean seeds.
Article
Plant Sciences
Zhibo Qu, Ying Wu, Die Hu, Ting Li, Hangyu Liang, Fan Ye, Jiquan Xue, Shutu Xu
Summary: This study dissected the genetic basis of maize grain size using genome-wide association analysis and identified 139 loci associated with the trait. Transcriptome data revealed differential expression of 15 candidate genes involved in regulating peroxidase activity, oxidoreductase, and leaf senescence.
FRONTIERS IN PLANT SCIENCE
(2022)
Review
Cell Biology
Carina Mauersberger, Heribert Schunkert, Hendrik B. Sager
Summary: While the importance of inflammation in atherosclerosis is recognized, the exact molecular processes remain unclear. Modern genetics, specifically genome-wide association studies, have revealed many loci related to inflammatory processes in coronary artery disease, but translating these findings into specific molecular mechanisms is still challenging.
Article
Plant Sciences
Zibo Zhao, Daowu Hu, Muhammad Tehseen Azhar, Hongge Li, Chenhui Ma, Shoupu He, Xiaoyang Wang, Gaofei Sun, Tahir Mahmood, Washu Dev, Xiongming Du
Summary: This study identified significant loci and candidate genes related to root color in Gossypium arboreum through GWAS and RNAseq analysis, providing a theoretical basis for cotton breeders to utilize elite genes and SNPs associated with root color and economically important traits.
Article
Multidisciplinary Sciences
Matthew Blades, Jamie Freyer, Jonas Donner, Rebecca Chodroff Foran, Oliver P. Forman
Summary: This study used extensive genetic testing and clinical records to identify a putative variant associated with cryptorchidism in dogs, which was also found to be associated with adult weight.
Article
Hematology
Paola Leon-Mimila, Hugo Villamil-Ramirez, Luis R. Macias-Kauffer, Leonor Jacobo-Albavera, Blanca E. Lopez-Contreras, Rosalinda Posadas-Sanchez, Carlos Posadas-Romero, Sandra Romero-Hidalgo, Sofia Moran-Ramos, Mayra Dominguez-Perez, Marisol Olivares-Arevalo, Priscilla Lopez-Montoya, Roberto Nieto-Guerra, Victor Acuna-Alonzo, Gaston Macin-Perez, Rodrigo Barquera-Lozano, Blanca E. Del-Rio-Navarro, Israel Gonzalez-Gonzalez, Francisco Campos-Perez, Francisco Gomez-Perez, Victor J. Valdes, Alicia Sampieri, Juan G. Reyes-Garcia, Miriam Del C. Carrasco-Portugal, Francisco J. Flores-Murrieta, Carlos A. Aguilar-Salinas, Gilberto Vargas-Alarcon, Diana Shih, Peter J. Meikle, Anna C. Calkin, Brian G. Drew, Luis Vaca, Aldons J. Lusis, Adriana Huertas-Vazquez, Teresa Villarreal-Molina, Samuel Canizales-Quinteros
Summary: The study identified a genetic variant in the SIDT2 gene associated with HDL-C levels and cardiovascular risk in Mexicans, with implications for cholesterol and lipoprotein metabolism. The SIDT2/Val636Ile variant was more common in Native American populations and linked to lower LDL-C and ApoB levels. Further investigation showed that the variant affects cholesterol transport function, highlighting SIDT2 as a new player in human lipid metabolism.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Gastroenterology & Hepatology
Hideto Kawaratani, Hiromi Sawai, Masaya Onishi, Tomomi Kogiso, Noritomo Shimada, Haruki Uojima, Tomoaki Nakajima, Naoki Matsumoto, Kenichi Ikejima, Toru Ishikawa, Shuji Terai, Hiroyuki Motoyama, Atsumasa Komori, Noboru Hirashima, Satoru Saito, Yuichiro Eguchi, Masanori Nojima, Yosuke Kawai, Masakuni Tateyama, Hitoshi Yoshiji, Yasuhito Tanaka
Summary: A genome-wide association study in the Japanese population identified an SNP (rs2991364) within the SVEP1 gene associated with the efficacy of tolvaptan for patients with hepatic ascites, helping to identify non-responders. Multivariate analyses showed significant associations between serum sodium, blood urea nitrogen, SVEP1 SNP, and treatment response.
LIVER INTERNATIONAL
(2021)
Article
Cardiac & Cardiovascular Systems
Jan M. Leerink, Elizabeth A. M. Feijen, Perry D. Moerland, Esmee C. de Baat, Remy Merkx, Helena J. H. van der Pal, Wim J. E. Tissing, Marloes Louwerens, Marry M. van den Heuvel-Eibrink, A. Birgitta Versluys, Folkert W. Asselbergs, Arjan Sammani, Arco J. Teske, Elvira C. van Dalen, Margriet van der Heiden-van der Loo, Eline van Dulmen-den Broeder, Andrica C. H. de Vries, Livia Kapusta, Jacqueline Loonen, Yigal M. Pinto, Leontien C. M. Kremer, Annelies M. C. Mavinkurve-Groothuis, Wouter E. M. Kok
Summary: We identified 3 specific inflammatory proteins as candidate plasma biomarkers for ACMP in long-term childhood cancer survivors and demonstrated protein overlap with dilated cardiomyopathy.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Pediatrics
Wendy Landier, Smita Bhatia, F. Lennie Wong, Jocelyn M. York, Jessica S. Flynn, Harrison M. Henneberg, Purnima Singh, Kandice Adams, Karen Wasilewski-Masker, Brooke Cherven, Rama Jasty-Rao, Marcia Leonard, James A. Connelly, Saro H. Armenian, Leslie L. Robison, Anna R. Giuliano, Melissa M. Hudson, James L. Klosky
Summary: This study aimed to evaluate the immunogenicity and safety of HPV vaccine in young cancer survivors. The results showed that the three-dose series of HPV vaccine had similar immunogenicity and safety in cancer survivors compared to the general population, providing evidence for its use in this vulnerable population.
LANCET CHILD & ADOLESCENT HEALTH
(2022)
Article
Biophysics
Noha Sharafeldin, Jianqing Zhang, Purnima Singh, Alysia Bosworth, Yanjun Chen, Sunita K. Patel, Xuexia Wang, Liton Francisco, Stephen J. Forman, F. Lennie Wong, Akinyemi Ojesina, Smita Bhatia
Summary: The study suggests that genome-wide significant SNPs may be associated with cognitive impairment in BMT recipients. The construction of a weighted genome-wide polygenic risk score allows for the prediction of cognitive impairment risk.
BONE MARROW TRANSPLANTATION
(2022)
Article
Hematology
Lucie M. Turcotte, Jillian A. Whitton, Wendy M. Leisenring, Rebecca M. Howell, Joseph P. Neglia, Rachel Phelan, Kevin C. Oeffinger, Kirsten K. Ness, William G. Woods, E. Anders Kolb, Leslie L. Robison, Gregory T. Armstrong, Eric J. Chow
Summary: The five-year survival rate for childhood acute myeloid leukemia (AML) has increased due to advancements in treatment and supportive care. However, the long-term health outcomes of AML survivors remain unclear. This study examined the incidence of late mortality and chronic health conditions (CHC) among 5-year AML survivors diagnosed between 1970 and 1999. The results showed that hematopoietic cell transplantation (HCT) was associated with higher late mortality, but the incidence of CHC has decreased over time for all treatment groups.
Article
Oncology
F. Lennie Wong, Janie M. Lee, Wendy M. Leisenring, Joseph P. Neglia, Rebecca M. Howell, Susan A. Smith, Kevin C. Oeffinger, Chaya S. Moskowitz, Tara O. Henderson, Ann Mertens, Paul C. Nathan, Yutaka Yasui, Wendy Landier, Gregory T. Armstrong, Leslie L. Robison, Smita Bhatia
Summary: This study evaluated the outcomes and cost-effectiveness of breast cancer screening using mammography and breast magnetic resonance imaging (MRI) in female chest-irradiated childhood Hodgkin lymphoma survivors. The results showed that annual mammography screening at age 30-74 years is effective and cost-effective in this population.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Oncology
Xuexia Wang, Purnima Singh, Liting Zhou, Noha Sharafeldin, Wendy Landier, Lindsey Hageman, Paul Burridge, Yutaka Yasui, Yadav Sapkota, Javier G. G. Blanco, Kevin C. C. Oeffinger, Melissa M. M. Hudson, Eric J. J. Chow, Saro H. H. Armenian, Joseph P. P. Neglia, A. Kim Ritchey, Douglas S. S. Hawkins, Jill P. P. Ginsberg, Leslie L. L. Robison, Gregory T. T. Armstrong, Smita Bhatia
Summary: This study identified genetic variants associated with anthracycline-related cardiomyopathy using two independent study cohorts. Two single-nucleotide polymorphisms (SNPs), rs17736312 (ROBO2) and rs113230990 (near a CCCTC-binding factor insulator), showed significant gene-environment interaction effect on anthracycline-related cardiomyopathy in the discovery cohort and rs17736312 was successfully replicated in the replication cohort. The study also identified gene-gene interaction and independent effects of TGF-beta 1 and ROBO2 on heart failure.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Oncology
Danielle Novetsky Friedman, Pamela J. Goodman, Wendy M. Leisenring, Lisa R. Diller, Susan L. Cohn, Rebecca M. Howell, Susan A. Smith, Emily S. Tonorezos, Suzanne L. Wolden, Joseph P. Neglia, Kirsten K. Ness, Todd M. Gibson, Paul C. Nathan, Brent R. Weil, Leslie L. Robison, Kevin C. Oeffinger, Gregory T. Armstrong, Charles A. Sklar, Tara O. Henderson
Summary: This study examines the risk of late mortality, subsequent malignant neoplasms, and chronic health conditions in survivors of neuroblastoma diagnosed in infancy. The results show that the overall risk is relatively low, and there has been a decline in chronic health conditions with reduced exposure to radiation therapy in recent treatment eras.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Oncology
Brent R. Weil, Andrew J. Murphy, Qi Liu, Rebecca M. Howell, Susan A. Smith, Christopher B. Weldon, Elizabeth A. Mullen, Arin L. Madenci, Wendy M. Leisenring, Joseph P. Neglia, Lucie M. Turcotte, Kevin C. Oeffinger, Amanda M. Termuhlen, Sogol Mostoufi-Moab, Jennifer M. Levine, Kevin R. Krull, Yutaka Yasui, Leslie L. Robison, Gregory T. Armstrong, Eric J. Chow, Saro H. Armenian
Summary: This study evaluated long-term morbidity and mortality rates among unilateral, nonsyndromic Wilms tumor (WT) survivors based on conventional treatment regimens. The results showed that survivors in different treatment groups were at risk for late mortality and chronic health conditions, especially an elevated risk for intestinal obstruction and kidney failure. The intensity of treatment was associated with an increased risk for severe chronic health conditions.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Review
Oncology
Madeline R. Horan, Jin-ah Sim, Kevin R. Krull, Kirsten K. Ness, Yutaka Yasui, Leslie L. Robison, Melissa M. Hudson, Justin N. Baker, I-Chan Huang
Summary: Patient-reported outcome measures (PROMs) are useful in assessing the subjective experiences of childhood cancer survivors and can be used to monitor health status and inform medical decision making. This article provides 10 important considerations for clinicians when assessing PROMs for childhood cancer survivors, addressing practical barriers and solutions. An example framework for integrating PROMs into clinical workflow using cutting-edge technologies is also discussed.
Article
Oncology
Adam J. Esbenshade, Lu Lu, Debra L. Friedman, Kevin C. Oeffinger, Gregory T. Armstrong, Kevin R. Krull, Joseph P. Neglia, Wendy M. Leisenring, Rebecca Howell, Robyn Partin, Amy Sketch, Leslie L. Robison, Kirsten K. Ness
Summary: Using a geriatric rating scale, researchers found that childhood cancer survivors accumulate diseases at a faster rate compared to their siblings and the general population.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Oncology
Purnima Singh, David K. Crossman, Liting Zhou, Xuexia Wang, Noha Sharafeldin, Lindsey Hageman, Javier G. Blanco, Paul W. Burridge, Saro H. Armenian, Frank M. Balis, Douglas S. Hawkins, Frank G. Keller, Melissa M. Hudson, Joseph P. Neglia, A. Kim Ritchey, Jill P. Ginsberg, Wendy Landier, Smita Bhatia
Summary: A novel association between the haptoglobin 2 (HP2) allele and cardiomyopathy was discovered. Higher expression of the HP gene is associated with an increased risk of developing cardiomyopathy. The binding of HP to free hemoglobin prevents oxidative damage, providing a mechanistic basis for this observation.
JACC: CARDIOONCOLOGY
(2023)
Article
Oncology
Cindy Im, Noha Sharafeldin, Yan Yuan, Zhaoming Wang, Yadav Sapkota, Zhanni Lu, Logan G. Spector, Rebecca M. Howell, Michael A. Arnold, Melissa M. Hudson, Kirsten K. Ness, Leslie L. Robison, Smita Bhatia, Gregory T. Armstrong, Joseph P. Neglia, Yutaka Yasui, Lucie M. Turcotte
Summary: This study evaluated SMNs among long-term childhood cancer survivors of European and African genetic ancestry, finding that a polygenic risk score (PRS) could significantly impact SMN risk in survivors who did not receive radiation therapy and were treated with specific chemotherapies.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Multidisciplinary Sciences
Purnima Singh, Liting Zhou, Disheet A. Shah, Romina B. Cejas, David K. Crossman, Mariam Jouni, Tarek Magdy, Xuexia Wang, Noha Sharafeldin, Lindsey Hageman, Donald E. McKenna, Steve Horvath, Saro H. Armenian, Frank M. Balis, Douglas S. Hawkins, Frank G. Keller, Melissa M. Hudson, Joseph P. Neglia, A. Kim Ritchey, Jill P. Ginsberg, Wendy Landier, Paul W. Burridge, Smita Bhatia
Summary: Investigation found an association between genome-wide differential methylation at CpG sites in peripheral blood DNA and anthracycline-induced cardiomyopathy. Several genes associated with cardiac dysfunction were also identified. This suggests that differential DNA methylation of certain genes could play a role in the pathogenesis of anthracycline-induced cardiomyopathy.
SCIENTIFIC REPORTS
(2023)
Article
Cardiac & Cardiovascular Systems
Purnima Singh, Disheet A. Shah, Mariam Jouni, Romina B. Cejas, David K. Crossman, Tarek Magdy, Shaowei Qiu, Xuexia Wang, Liting Zhou, Noha Sharafeldin, Lindsey Hageman, Donald E. McKenna, Saro H. Armenian, Frank M. Balis, Douglas S. Hawkins, Frank G. Keller, Melissa M. Hudson, Joseph P. Neglia, A. Kim Ritchey, Jill P. Ginsberg, Wendy Landier, Ravi Bhatia, Paul W. Burridge, Smita Bhatia
Summary: This study examined the differential blood-based mRNA expression profiles in anthracycline-exposed childhood cancer survivors with and without cardiomyopathy. The results revealed dysregulation of several genes, including LDHA, CD36, IL1R1, IL1R2, MMP8, and MMP9, that are associated with metabolic perturbations, structural remodeling, and symptomatic cardiotoxicity in these survivors.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Review
Oncology
Pragya G. Poudel, Madeline R. Horan, Tara M. Brinkman, Zhaoming Wang, Leslie L. Robison, Melissa M. Hudson, I-Chan Huang
Summary: This article presents a systematic review of intervention studies addressing social integration or social connectedness issues among young- and middle-aged cancer patients/survivors. The findings suggest that utilizing technology- and non-technology-based platforms can improve social outcomes and enhance the quality of life for patients/survivors.
Article
Biochemistry & Molecular Biology
Diren Beyoglu, Eun-Jung Park, Adolfo Quinones-Lombrana, Asim Dave, Falguni Parande, John M. Pezzuto, Jeffrey R. Idle
Summary: This study found that grape powder has significant effects on gut microbiota metabolism and hepatic oxidative stress, while enhancing the utilization of glucose by the liver.