Journal
ADVANCES IN COLLOID AND INTERFACE SCIENCE
Volume 305, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.cis.2022.102686
Keywords
Copper; Metal-organic frameworks; Biomedical applications; Anticancer; Antibacterial
Categories
Funding
- National Natural Science Foundation of China [51903172, 51773130, 51873121]
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This article reviews the applications of copper-based metal-organic frameworks (Cu-MOFs) in the field of biomedicine and discusses their future development prospects. The article introduces the synthesis methods and strategies of Cu-MOFs and summarizes their recent advances in cancer treatment, bacterial inhibition, biosensing, biocatalysis, and wound healing.
Metal-organic frameworks (MOFs) are a class of important porous, crystalline materials composed of metal ions (clusters) and organic ligands. Owing to the unique redox chemistry, photochemical and electrical property, and catalytic activity of Cu2+/+, copper-based MOFs (Cu-MOFs) have been recently and extensively explored in various biomedical fields. In this review, we first make a brief introduction to the synthesis of Cu-MOFs and their composites, and highlight the recent synthetic strategies of two most studied representatives, three-dimensional HKUST-1 and two-dimensional Cu-TCPP. The recent advances of Cu-MOFs in the applications of cancer treatment, bacterial inhibition, biosensing, biocatalysis, and wound healing are summarized and discussed. Furthermore, we propose a prospect of the future development of Cu-MOFs in biomedical fields and beyond.
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