Journal
ADVANCED MATERIALS
Volume 34, Issue 34, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.202203820
Keywords
NIR-II fluorescence imaging; photoactivated chemotherapy; photodynamic therapy; pseudo-conjugated-polymers
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Funding
- Natural Science Foundation of Beijing of China [2202071]
- National Natural Science Foundation of China [52073015]
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This study reports a self-sacrificially degradable pseudo-semiconducting polymer (PSP) for NIR-II fluorescence bioimaging, photodynamic immunotherapy, and photoactivated chemotherapy (PACT). The PSP can co-assemble with a doxorubicin-containing polyester and release the drug at tumor sites, offering potential applications in cancer therapy.
Semiconducting polymers (SP) hold great promise for cancer phototherapy due to their excellent optical properties; however, their clinical application is still hampered by their poor biodegradability. Herein, a self-sacrificially biodegradable pseudo-semiconducting polymer (PSP) for NIR-II fluorescence bioimaging, photodynamic immunotherapy, and photoactivated chemotherapy (PACT) is reported. The PSP can further co-assemble with an amphiphilic polyester with pendant doxorubicin (DOX) in its side chains via reactive oxygen species (ROS)-responsive thioketal linkages (PEDOX), which are denoted as NP@PEDOX/PSP. The NP@PEDOX/PSP can accumulate at tumor sites and generate ROS for photodynamic immunotherapy as well as near-infrared-II fluorescence (NIR-II) for bioimaging upon irradition at 808 nm. The ROS could break up thioketal linkages in PEDOX, resulting in rapid doxorubicin (DOX) release for PACT. Finally, both PEDOX and PSP are degraded sacrificially by intracellular glutathione (GSH), resulting in the dissociation of NP@PEDOX/PSP. This work highlights the application of self-sacrificially degradable PSP for NIR-II fluorescence bioimaging, photodynamic immunotherapy, and PACT in cancer therapy.
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