Review
Immunology
Yong Xi, Lijie Chen, Jian Tang, Bentong Yu, Weiyu Shen, Xing Niu
Summary: Immunogenic cell death (ICD) is a unique mode of cell death that triggers long-term protective antitumor immune responses by releasing immunogenic damage-associated molecular patterns (DAMPs) and tumor-associated antigens. Amplifying the "eat me" signal during the tumor ICD cascade is critical for cancer immunotherapy.
IMMUNOLOGICAL REVIEWS
(2023)
Review
Oncology
Robin Demuynck, Iuliia Efimova, Faye Naessens, Dmitri Krysko
Summary: Ferroptosis is a newly discovered form of regulated cell death distinct from apoptosis and necroptosis, and has potential in anticancer therapy. However, ferroptotic cancer cells may pose a risk of tumor evasion due to decreased phagocytosis and antigen cross-presentation. Factors such as lactate, acidification, and hypoxia in the tumor microenvironment play a role in promoting ferroptosis resistance and affecting its immunogenicity.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Chemistry, Multidisciplinary
Dan Liu, Shuang Liang, Kongshuo Ma, Qian-Fang Meng, Xingang Li, Jian Wei, Mengli Zhou, Kaiqing Yun, Yuanwei Pan, Lang Rao, Xiaoyuan Chen, Zhaohui Wang
Summary: Tumor microenvironment-responsive nanoparticles are utilized to activate the stimulator of interferon genes (STING) and Toll-like receptor 4 (TLR4) pathways, leading to increased secretion of interferons and pro-inflammatory cytokines and creating an immune-supportive microenvironment. Combined with an anti-PD-1 antibody, these nanoparticles show synergistic efficacy and induce systemic antitumor memory.
ADVANCED MATERIALS
(2023)
Article
Multidisciplinary Sciences
Zhusheng Huang, Yuxiang Wang, Dan Yao, Jinhui Wu, Yiqiao Hu, Ahu Yuan
Summary: The study demonstrates a strategy of using gadolinium-based nanoscale coordination polymers to enhance radiation-induced immunogenic cell death, thereby boosting anti-tumor immune responses.
NATURE COMMUNICATIONS
(2021)
Article
Engineering, Biomedical
Shuilin Shen, Zimeng Zhang, Haixiao Huang, Jing Yang, Xinyue Tao, Zhengjie Meng, Hao Ren, Xueming Li
Summary: An injectable hydrogel containing anti-PD-L1 antibody and nitric oxide donor was designed to enhance immunotherapy by inducing immunogenic cell death and regulating cancer-associated fibroblasts. The hydrogel exhibited photothermal and chemodynamic effects to kill cancer cells and increase immune cell infiltration. Furthermore, it reduced the proportion of cancer-associated fibroblasts and M2-type macrophages, improving the immunosuppressive tumor microenvironment and enhancing the efficacy of anti-PD-L1 treatment.
BIOMATERIALS RESEARCH
(2023)
Article
Chemistry, Multidisciplinary
Xingheng Wang, Qian Li, Zhenyang Zhao, Lanlan Yu, Sichun Wang, Hong Pu, Mohsen Adeli, Li Qiu, Peng Gu, Ling Li, Chong Cheng
Summary: This study demonstrates the synthesis of a dual-functional artificial peroxidase with ferriporphyrin networks (FePorNW-DAP) that can serve as a tumor microenvironment (TME)-adaptive and ultrasound (US)-controllable reactive oxygen species (ROS)-generator for amplifying tumor immunotherapies. The FePorNW-DAP shows efficient dual-functional ROS production capabilities to combat tumor cells and amplify tumor immunotherapies. This research provides critical evidence for the induction of a strong antitumor immune response and immune memory by the proposed dual-functional artificial peroxidases, and offers essential guidance for creating high-performance and biocompatible strategies to regulate the immunosuppression TME and enhance the antitumor immune responses of breast cancer.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Review
Biochemistry & Molecular Biology
Liwen Fu, Xiaojun Zhou, Chuanglong He
Summary: Immunotherapy has shown a promising direction for cancer treatment by regulating the anti-cancer immune system through immunogenic cancer cell death (ICD). Polymer nanoparticles play a critical role in delivering antigens or immune inducers for ICD-based immunotherapy with their controllable size and excellent biocompatibility.
MACROMOLECULAR BIOSCIENCE
(2021)
Review
Immunology
Wenhao Xu, Wangrui Liu, Jianfeng Yang, Jiahe Lu, Hailiang Zhang, Dingwei Ye
Summary: Immunogenic cell death (ICD) is a special form of tumor cell death that can stimulate a tumor-specific immune response. Stimuli-responsive nanoparticles have been developed to improve the efficiency of immunotherapy by enhancing the delivery of ICD inducers and reducing toxicity. Further advancements in understanding ICD biomarkers, the immunosuppressive microenvironment, and ICD inducers will accelerate the development of smarter nanodelivery systems.
IMMUNOLOGICAL REVIEWS
(2023)
Article
Materials Science, Biomaterials
Yukun Wang, Wenjing Li, Bi Lin, Ying Yuan, Pengbo Ning, Xiaofeng Tao, Ruichan Lv
Summary: Photothermal therapy effectively destroys tumors by photothermal ablation and promotes immunogenic cell death. However, inhibiting the tumor immune microenvironment can hinder the anti-tumor immune response stimulated by photothermal therapy. In this study, we developed a GdOF@PDA-HA-R837-hydrogel complex for NIR-II imaging-guided photothermal ablation and enhanced immune response. The synthesized nanoparticles with Yb and Er elements, as well as a polydopamine coating, allow for NIR-II and photoacoustic imaging of tumor tissues. The combination of photothermal therapy with immune adjuvants in the hydrogel resulted in increased specific anti-tumor immunity and improved efficacy.
BIOMATERIALS SCIENCE
(2023)
Article
Engineering, Biomedical
Yun Huang, Dengshuai Wei, Bin Wang, Dongsheng Tang, Ailan Cheng, Shengjun Xiao, Yingjie Yu, Weiguo Huang
Summary: This article proposes a strategy to maximize the immunogenic cell death (ICD) effect of oxaliplatin (OXA) by combining it with nanoparticles containing a platinum (IV) prodrug (Pt(IV)-C16) and a near-infrared II (NIR-II) photothermal agent (IR1061). Under NIR-II light irradiation, these nanoparticles significantly improve the anti-cancer efficacy against triple-negative breast cancer 4T1 tumor, compared to OXA or IR1061 alone.
ACTA BIOMATERIALIA
(2023)
Article
Oncology
Veronica Olivo Pimentel, Damienne Marcus, Alexander M. A. van der Wiel, Natasja G. Lieuwes, Rianne Biemans, Relinde I. Y. Lieverse, Dario Neri, Jan Theys, Ala Yaromina, Ludwig J. Dubois, Philippe Lambin
Summary: This study aimed to trigger curative therapeutic responses in poorly immunogenic tumors by combining L19-IL2 and/or immune checkpoint blockade (ICB) with radiotherapy. The results showed that combining RT, anti-PD-L1, and L19-IL2 cured 38% of LLC tumors, which was dependent on both CD8(+) T and NK cells. Triple combinations were not superior to RT+L19-IL2 in the tumor models tested.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Review
Immunology
Ming-Zhu Jin, Xi-Peng Wang
Summary: Cancer immunotherapy has made significant progress, but is limited in immunologically cold tumors. Inducing immunogenic cell deaths (ICDs) is seen as an attractive approach to activate antitumor immunity. ICD-based cancer vaccines mimic the effect of cancer vaccines but face challenges.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Songxin Zhu, Yuming Wang, Jun Tang, Min Cao
Summary: This review investigates the impact of radiotherapy on the tumor immune microenvironment (TIME) and the potential of remodeling TIME to enhance the effectiveness of immunotherapy. Understanding the causes of immune escape in tumor cells is crucial for the treatment of drug-resistant tumors.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Fengguang Guo, Jugal K. Das, Koichi S. Kobayashi, Qing-Ming Qin, Thomas A. Ficht, Robert C. Alaniz, Jianxun Song, Paul De Figueiredo
Summary: This study demonstrates that live attenuated bacterial treatment can improve antitumor immunity by remodeling the tumor microenvironment, overcoming cancer resistance to chimeric antigen receptor T-cell therapy.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Engineering, Multidisciplinary
BeiBei Chen, KangLi Guo, HaoRan Wang, Fu-Jian Xu, JuLin Wang, NaNa Zhao
Summary: This study demonstrates the use of Janus nanoparticles for enhanced cancer immunotherapy by optimizing their composition and morphology. The findings show that these nanoparticles can induce immunogenic cell death of tumor cells and activate antitumor immune responses through a combination therapy approach involving starvation therapy, chemodynamic therapy, and immunoadjuvant properties.
SCIENCE CHINA-TECHNOLOGICAL SCIENCES
(2023)
Article
Chemistry, Medicinal
Jing Liu, Fei Ji, Zhuolu Xia, Chunhua Zhang, Changshun Zhao, Yanfei Li, Xiang Zhou, Dechun Huang, Wei Chen, Feng Jiang
Summary: Tightly wrapped CPUL1 and TPP derivative self-assembled into stable nanoparticles with positive surface charge, facilitating easier cellular uptake and accumulation in mitochondria to induce cell apoptosis. Compared to free CPUL1, the multifunctional nanoaggregates showed better antitumor efficacy on HUH7 hepatoma cells in vitro.
Article
Chemistry, Multidisciplinary
Yanfei Li, Hongliang Qian, Xin Huang, Xiang Zhou, Bingbing Zhao, Lifen Yang, Jiaxin Chen, Haishi Qiao, Dechun Huang, Yinan Zhong, Wei Chen
Summary: A NIR-triggered NO-releasing nano-gasholder has been developed to combine with ICB therapy for reprogramming ITME and enhancing immune therapeutic effects.
Review
Chemistry, Multidisciplinary
Jiatian Li, Sitong Li, Jiayi Huang, Abdul Qadeer Khan, Baigang An, Xiang Zhou, Zunfeng Liu, Meifang Zhu
Summary: Spider silk is a natural polymeric fiber with remarkable mechanical properties attributed to its hierarchical structure. Researchers have been motivated to develop artificial functional fibers mimicking spider silk, and this review provides insights into the biomimetic preparation of such fibers with interesting properties. Biomimetic studies have yielded noteworthy findings in artificial fibers aiming to exceed the properties of natural spider silk.
Article
Chemistry, Applied
Rui Cui, Xiandie Zhang, Huiqing Mao, Chun Zhang, Jie Ji, Xiang Zhou
Summary: In this study, core-shell structured Al@CuO energetic microspheres were prepared and their reaction characteristics were compared with physically mixed Al/CuO counterparts. The Al@CuO microspheres showed enhanced reaction properties, including lower reaction onset temperature, higher heat release, and faster combustion rate.
PROPELLANTS EXPLOSIVES PYROTECHNICS
(2023)
Article
Multidisciplinary Sciences
Xiaoyu Hu, Jiatian Li, Sitong Li, Guanghao Zhang, Run Wang, Zhongsheng Liu, Mengmeng Chen, Wenqian He, Kaiqing Yu, Wenzhong Zhai, Weiqiang Zhao, Abdul Qadeer Khan, Shaoli Fang, Ray H. Baughman, Xiang Zhou, Zunfeng Liu
Summary: This paper reports an artificial muscle controlled by thermodynamic-twist coupling, which can be used in different actuation modes, such as elongation, contraction, and torsional rotation. It provides a new design strategy for intelligent materials.
NATIONAL SCIENCE REVIEW
(2023)
Review
Biochemistry & Molecular Biology
Xiaowei Zang, Xiang Zhou, Haitao Bian, Weiping Jin, Xuhai Pan, Juncheng Jiang, M. Yu. Koroleva, Ruiqi Shen
Summary: This paper reviews the critical process of machine learning methods in discovering and predicting energetic materials, including data preparation, feature extraction, model construction, and model performance evaluation. The main ideas and basic steps of applying machine learning methods are analyzed and outlined. The state-of-the-art research on machine learning applications in property prediction and inverse material design of energetic materials is further summarized. Finally, the existing challenges and strategies for coping with challenges in the further applications of machine learning methods are proposed.
Article
Thermodynamics
Huiqing Mao, Xiandie Zhang, Rui Cui, Chun Zhang, Xiang Zhou
Summary: Si@PVDF composite microspheres with Si nanopowder uniformly distributed were prepared by electrostatic spraying method. The improved interfacial contact quality in Si@PVDF led to enhanced chemical reactivity, as evidenced by reduced reaction onset temperature, peak temperature, and apparent activation energy compared to physically mixed Si/PVDF counterpart. Si/PVDF could not be ignited by Joule heating, while self-sustained combustion propagation was observed for Si@PVDF pellets. The combustion process of Si@PVDF pellets was influenced by equivalence ratio, pellet porosity, and O2 accessibility in the environment.
COMBUSTION AND FLAME
(2023)
Article
Biochemistry & Molecular Biology
Xinwen Ma, Weiduo Fei, Xiandie Zhang, Jie Ji, Xiang Zhou
Summary: In this study, mesoporous silicon nanoparticles (M-Si) were successfully prepared from mesoporous silica nanoparticles through magnesiothermic reduction. The resulting M-Si exhibited uniform size distribution with average diameter of 160 nm. It possessed a large internal surface area of 93.0 m(2) g(-1) and an average pore size of 16 nm, enabling rich reaction sites and reduced mass diffusion limitations. The M-Si also showed higher reactivity compared to non-porous Si nanopowder, indicating its potential as fuel for metastable intermolecular composites.
Article
Nanoscience & Nanotechnology
Jie Ji, Rui Cui, Li Liang, Heng Xu, Haozhe Li, Xiang Ke, Xiang Zhou, Xiaode Guo
Summary: In order to improve the pressure output ability of nano-thermites for various applications, this paper proposes a new scheme of nanothermites (Al/CuF2) using the volatile advantage of metal fluoride products. The energy release process of Al/CuF2 at different equivalent ratios was studied under slow and fast heating rates. It was found that the increase of Al powder contributed to the enhancement of the alloy reaction, and the Al/CuF2 composite particles showed excellent gas release ability and ignition performances compared to Al/CuO. Therefore, they are expected to be widely used in military and civilian fields.
ACS APPLIED NANO MATERIALS
(2023)
Article
Nanoscience & Nanotechnology
Bingbing Zhao, Yuqing Wan, Xiang Zhou, Junmei Zhang, Jiaxin Chen, Jiachen Yang, Yunzhu Liu, Wei Chen, Yinan Zhong, Hongliang Qian
Summary: By incorporating a bombesin (BBN)-decorated two-in-one prodrug (T-NO/E-2-PMs) into the body, the expression of androgen receptor (AR) can be inhibited, the tumor microenvironment of castration-resistant prostate cancer (CRPC) can be reprogrammed, and the therapeutic effect of estradiol on hypoxic CRPC can be enhanced.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Review
Chemistry, Multidisciplinary
Xueqi Leng, Guangkai Mei, Guanghao Zhang, Zunfeng Liu, Xiang Zhou
Summary: Twisted-fiber artificial muscles, as a new type of soft actuator, have great potential for lightweight smart devices and soft robotics. They generate internal torque and exhibit rotation, contraction, or elongation through fiber twisting. Preserving the torque during actuation is crucial for reversible and stable artificial muscle performance, but this issue has not been systematically discussed. This review summarizes the mechanisms for preserving torque in twisted fibers and discusses potential applications, challenges, and future directions for research.
CHEMICAL SOCIETY REVIEWS
(2023)
Review
Chemistry, Multidisciplinary
Abdul Qadeer Khan, Muhammad Shafiq, Jiatian Li, Kaiqing Yu, Zunfeng Liu, Xiang Zhou, Meifang Zhu
Summary: It is desirable to develop fiber materials with high strength and toughness, but increasing fiber strength often leads to a decrease in toughness. Spider silk, with its excellent combination of high strength and toughness, has inspired the development of artificial fibers mimicking its material and spinning process. This review summarizes the preparation methods of artificial spider silk from different materials, including nonrecombinant proteins, recombinant proteins, polypeptides, synthetic polymers, and polymer nanocomposites. It also discusses various spinning approaches and novel applications of artificial spider silk, such as artificial muscles, sensing, and smart fibers.
Article
Chemistry, Physical
Jingjing Li, Meilin Wang, Zhanpeng Cui, Shiyong Liu, Danyang Feng, Guangkai Mei, Rui Zhang, Baigang An, Dong Qian, Xiang Zhou, Zunfeng Liu
Summary: This research develops a synergistic actuator for a miniaturized soft robot by mimicking the makeup application process. The actuator consists of a photothermal expansion layer, an interfacial adhesion layer, and a moisture-responsive layer, enabling jumping actuation under near-infrared light or moisture. The actuator achieves exceptionally high bending angle and bending speed when normalized to the thickness and temperature change. Direction-controlled jumping is also realized by an asymmetric structural design. This work provides a new design strategy for miniaturized soft robots, sensors, and intelligent equipment.
JOURNAL OF MATERIALS CHEMISTRY A
(2022)
Article
Materials Science, Multidisciplinary
Abdul Qadeer Khan, Kaiqing Yu, Jiatian Li, Xueqi Leng, Meilin Wang, Xuesong Zhang, Baigang An, Bin Fei, Wei Wei, Huichuan Zhuang, Muhammad Shafiq, Lili Bao, Zunfeng Liu, Xiang Zhou
Summary: Smart textiles have the ability to adapt to irregular surfaces and can contract and expand based on the structure of twisted fibers. This technology can be used to create intelligent textiles that can conform to irregular surfaces.
ADVANCED FIBER MATERIALS
(2022)
Article
Pharmacology & Pharmacy
Xiaobei Cheng, Pei Yu, Xiang Zhou, Jiale Zhu, Yubao Han, Chao Zhang, Lingyi Kong
Summary: This study successfully developed mycoplasma membrane (MM)-fused liposomes (LPs) for nanoparticle transport using inflammatory cytokine-guided autonomous tumor localization. By enhancing neutrophil infiltration in the inflammatory tumor microenvironment, more nanoparticles were delivered into solid tumors, demonstrating superior tumor suppression efficacy. Overall, this strategy of pathogen-mimicking nanoparticles hijacking neutrophils in situ elevates the potential of chemotherapeutics for tumor targeting therapy.
ACTA PHARMACEUTICA SINICA B
(2022)
