Journal
JOURNAL OF CLINICAL NEUROSCIENCE
Volume 26, Issue -, Pages 75-78Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.jocn.2015.10.008
Keywords
Amyotrophic lateral sclerosis; Astrocytes; Biomarker; GFAP; Motor neuron disease
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Glial fibrillary acidic protein (GFAP) has been shown to be increased in the cerebrospinal fluid (CSF) of patients suffering from neurological diseases involving the activation of astrocytes, but has not been studied in amyotrophic lateral sclerosis (ALS) patients to our knowledge. CSF samples of patients with definite ALS and of those with other neurological diseases were evaluated for their GFAP concentrations. CSF-GFAP concentrations of patients with ALS were significantly elevated by 53% compared to patients with other neurologic diseases. GFAP might serve as a biomarker in ALS. Our findings support the concept that astrocytes play a role in ALS pathogenesis. (C) 2015 Elsevier Ltd. All rights reserved.
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