Review
Biochemistry & Molecular Biology
Brandon He, Kyle Sheldrick, Abhirup Das, Ashish Diwan
Summary: Degenerative cervical myelopathy (DCM) is a non-traumatic, chronic, and progressive disease, and current diagnostic and prognostic techniques have limitations. This article presents evidence on novel quantitative MRI (qMRI) techniques for assessing spinal cord integrity in DCM and suggests future research directions.
Article
Computer Science, Artificial Intelligence
Bing Ji, Qihang Dai, Xinyu Ji, Weiming Wu, Qinghua Sun, Hecheng Ma, Menglin Cong, Lei Cheng, Cong Wang, Meng Si, Wei Zeng
Summary: In this study, a dynamic method for the detection of cervical spondylotic myelopathy (CSM) is proposed based on the nonlinear dynamics of the gait system and deterministic learning theory. Discriminant kinematic gait features are extracted using a 3D gait analysis system, and the dynamics of the gait system are modeled and identified using deterministic learning theory. The method achieves high accuracy in classifying and detecting CSM, making it a potential candidate for automatic detection in clinical examination.
ARTIFICIAL INTELLIGENCE REVIEW
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Lifeng Li, Na Li, Jiahui Zhou, Handong Li, Xianping Du, Haibo He, Pengfei Rong, Wei Wang, Yin Liu
Summary: The study found that changes in cervical lordosis after anterior cervical fusion surgery may be related to postoperative adjacent segment pathology. Maintaining good cervical curvature after surgery may reduce the incidence of adjacent segment pathology after anterior cervical fusion.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2022)
Review
Medicine, General & Internal
Ji Tu, Jose Vargas Castillo, Abhirup Das, Ashish D. Diwan
Summary: Degenerative Cervical Myelopathy (DCM) is a common and serious neurological disorder caused by chronic compression or irritation of the spinal cord in the neck, leading to neck pain and impaired motor function. Decompressive surgery is the most effective treatment, but timing for the procedure remains a challenge due to poor prognosis and limited understanding of its molecular mechanisms.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Orthopedics
Yanyan Ma, Zhijun Xin, Weijun Kong, Longsheng Zhang, Qian Du, Wenbo Liao
Summary: This study investigated the clinical application of anterior percutaneous full-endoscopic transcorporeal decompression of the spinal cord (APFETDSC) in patients with single-segment cervical spondylotic myelopathy (CSM). The surgical procedure determined the diameter and direction of the bony passage based on the size and position of the disc-osteophyte complex. The results showed improved pain and function postoperatively, complete decompression of the spinal cord, and no cervical instability.
BMC MUSCULOSKELETAL DISORDERS
(2022)
Review
Clinical Neurology
Chester J. Donnally, Parthik D. Patel, Jose A. Canseco, Alexander R. Vaccaro, Christopher K. Kepler
Summary: Cervical spondylotic myelopathy (CSM) is a spinal cord injury caused by degenerative changes in the cervical spine, commonly seen in older patients with delayed treatment. This article evaluates the etiology, natural history, diagnosis, and treatment of CSM. Patients often do not associate their symptoms with cervical spine disease, and even those with radiographic findings may be asymptomatic clinically. Classic symptoms of CSM include poor hand dexterity, unsteady gait, and difficulty with motor skills. Magnetic resonance imaging is required for diagnosis, but patients with contraindications to MRI can opt for computerized tomography myelography. Asymptomatic patients with incidental findings of cervical cord compression can be managed conservatively, while those with moderate-severe disease impacting daily activities should undergo surgical treatment.
CLINICAL SPINE SURGERY
(2022)
Article
Neurosciences
Kanwaijeet Garg, Roshan Sahu, Mohit Agrawal, Shashwat Mishra, Sachin Borkar, P. S. Chandra, Shashank S. Kale
Summary: This study investigated the awareness and utilization of assessment tools among spine surgeons for patients with cervical spondylotic myelopathy. While most surgeons were aware of these tools, time constraint was a major factor limiting their usage.
Article
Clinical Neurology
Maksim A. Shlykov, Erica M. Giles, Michael P. Kelly, Shiow J. Lin, Vy T. Pham, Nancy L. Saccone, Elizabeth L. Yanik
Summary: This study aimed to evaluate the associations between genetic and nongenetic factors and degenerative cervical myelopathy (DCM). The study identified age, sex, and relative socioeconomic deprivation as independent risk factors for DCM, while Asian race was inversely associated. Additionally, potential SNP markers were found in the GTPBP1 gene on chromosome 22 and an intergenic region on chromosome 18. These findings contribute to understanding the disease processes, guiding prevention and interventions, and potentially influencing surgical outcomes for DCM.
Article
Clinical Neurology
Tonje Okkenhaug Johansen, Vetle Vangen-Lonne, Siril T. Holmberg, Oyvind O. Salvesen, Tore K. Solberg, Agnete M. Gulati, Oystein P. Nygaard, Sasha Gulati
Summary: Decompressive surgery for degenerative cervical myelopathy (DCM) leads to significant improvements in clinical outcomes and quality of life for both younger and elderly patients at 1-year follow-up. Age should not be the sole determinant for denying surgery.
ACTA NEUROCHIRURGICA
(2022)
Article
Medicine, General & Internal
Ryan Wing-Yuk Chan, Yung-Hsiao Chiang, Hsiu-Chen Lin, Chih-Yau Chang, Yi-Syue Tsou
Summary: Although several large-scale studies have investigated the surgical interventions for cervical spondylotic myelopathy (CSM), specifically multilevel anterior cervical discectomy and fusion (ACDF) and laminoplasty (LAMP), the optimal approach remains controversial. This study compared the postoperative complications of these two procedures and found that LAMP resulted in a higher frequency of surgical wound infections, longer hospital stays, and higher rates of unplanned reoperation. However, there were no significant differences in systemic complications and perioperative mortality between the two approaches.
Article
Medicine, General & Internal
Ningbo Fei, Guangsheng Li, Xuxiang Wang, Junpeng Li, Xiaosong Hu, Yong Hu
Summary: In this study, an automatic segmentation method based on ROI was proposed for the diagnosis of Cervical Spondylotic Myelopathy (CSM). The UNet model was trained with the proposed heatmap distance loss to accurately segment the spinal cord images. The ROI-based mean FA values showed strong correlation with the values based on manual drawing, indicating the potential of this method to quantify the detailed status of the cervical spinal cord.
Article
Computer Science, Artificial Intelligence
Bing Ji, Qihang Dai, Xinyu Ji, Meng Si, Hecheng Ma, Menglin Cong, Lei Cheng, Liying Guan, Bo Su, Yuyan Zhang, Wei Zeng
Summary: Cervical spondylotic myelopathy (CSM) is a main cause of spine cord dysfunction in middle-aged and elderly patients, leading to numbness and gait disturbance. The difficulty in screening CSM at an early stage often results in medication delay, emphasizing the need for identification and treatment. This study develops an automated classification method using 54 lower extremity kinematic parameters derived from three-dimensional gait analysis. By employing a deep neural network (DNN) model, informative features are extracted from raw gait kinematic data for CSM screening using multiple shallow classifiers. Experimental results show remarkable accuracy rates of 99.44% using different cross-validation methods, and suggest that the proposed method is efficient in detecting early onset CSM and outperforms other cutting-edge techniques.
APPLIED INTELLIGENCE
(2023)
Article
Orthopedics
Wook-Tae Park, Woo-Kie Min, Ji-Hoon Shin, Sang-Bong Ko, Eun-Seok Son, Jiyoun Kim, Jihoon Jang, Gun Woo Lee
Summary: This study aimed to assess the reliability and accuracy of dynamic magnetic resonance imaging in detecting cervical spondylotic myelopathy (CSM). The results indicated that dynamic MR showed better diagnostic reliability and accuracy compared to conventional MR, with extension MR scans providing a more accurate diagnosis than other images.
BMC MUSCULOSKELETAL DISORDERS
(2022)
Article
Clinical Neurology
Catherine Boudreau, Sylvine Carrondo Cottin, Jessica Ruel-Laliberte, David Mercier, Nicholas Gelinas-Phaneuf, Jerome Paquet
Summary: The study showed discrepancies in sagittal alignment between supine MRI and standing radiographs in patients with CSM, indicating that standing radiographs of the cervical spine should always be included in surgical planning for CSM patients.
EUROPEAN SPINE JOURNAL
(2021)
Article
Surgery
Yan Sun, Haoning Ma, Zhihai Zhang, Mingsheng Tan
Summary: This study introduced a hybrid surgery for treating atlantoaxial dislocation (AAD) coexisting with multilevel cervical spondylotic myelopathy (CSM). The results showed that the hybrid surgery was effective in improving the clinical outcomes and maintaining cervical alignment, proving its value and safety as an alternative technique.
FRONTIERS IN SURGERY
(2023)
Article
Rehabilitation
Shauna Dudley-Javoroski, Jinhyun Lee, Richard K. Shields
Summary: This study aims to investigate the correlations between aging, cognitive impairment, and quality of life (QOL) in individuals with and without spinal cord injury (SCI). The results showed that individuals with SCI had lower global QOL, particularly in domains related to physical function and symptoms, but higher QOL in positive affect/well-being and resilience. There were no significant differences in cognitive function between SCI and non-SCI individuals, but strong correlations between age and cognition were absent in SCI. Significant correlations between cognition and QOL were prevalent for non-SCI individuals but not for those with SCI.
PHYSIOTHERAPY THEORY AND PRACTICE
(2022)
Article
Neurosciences
Shojiro Nozu, Kristin A. Johnson, Masahiro Takemura, Richard K. Shields
Summary: By disrupting somatosensory information with a foam pad, participants demonstrated different postural control strategies with and without disruption during a posteromedial reach test. Strategies for ankle and trunk movement may influence the posteromedial reach distance.
Article
Orthopedics
Michael A. Petrie, Eric B. Taylor, Manish Suneja, Richard K. Shields
Summary: Physical therapists develop patient-centered exercise prescriptions to address the various stressors in individuals' health. This report summarizes factors specific to spinal cord injury that need to be considered in precision prescription of muscle activity. It also presents a genomic and epigenomic analysis of muscle signaling pathways during different types of electrically induced exercise.
Editorial Material
Orthopedics
Richard K. Shields
Article
Orthopedics
Richard K. Shields, Shauna Dudley-Javoroski
Summary: Epigenetic processes regulate gene expression by tagging DNA, affecting individual health and disease. New research shows that non-biological factors such as social stress and poverty can trigger epigenetic adaptations in gene pathways, impacting chronic diseases. Epigenetic processes thus connect the genome with social determinants of health.
Article
Neurosciences
Colleen L. Bringman, Richard K. Shields, Stacey L. DeJong
Summary: The study aimed to investigate the modulation of corticospinal pathway on spinal reflex excitability. The results showed that subthreshold TMS pulses could partially restore the H-reflex when it was almost completely suppressed by lower extremity vibration. This suggests that the disinhibition of the H-reflex by corticospinal signals may play a role in the control of voluntary movement.
EXPERIMENTAL BRAIN RESEARCH
(2022)
Article
Orthopedics
Shauna Dudley-Javoroski, Richard K. Shields
Summary: The Benchmarking in Academic Physical Therapy study develops performance benchmarks for physical therapist education using a survey. The study reveals strengths and challenges in physical therapist education, such as emphasis on problem solving/critical thinking and clinical reasoning, and issues with diversity and student debt.
Article
Neurosciences
Kristin A. Johnson, Michael A. Petrie, Richard K. Shields
Summary: This study aimed to understand if females have an innate ability to rapidly increase the H-reflex, which could predict future performance-based injury. The findings showed that females can acutely upregulate the H-reflex with training, and electro-physiological and hormonal factors may be associated with this improvement.
JOURNAL OF NEUROPHYSIOLOGY
(2023)
Article
Clinical Neurology
Timothy R. Koscik, Ellen van der Plas, Jeffrey D. Long, Stephen Cross, Laurie Gutmann, Sarah A. Cumming, Darren G. Monckton, Richard K. Shields, Vincent Magnotta, Peggy C. Nopoulos
Summary: This study compared the changes in white matter microstructure, functional measures, and clinical symptoms in patients with myotonic dystrophy type 1. The results showed that indices of white matter health were associated with functional performance and could accurately reflect disease progression. These findings are crucial for the design of clinical trials.
NEUROMUSCULAR DISORDERS
(2023)
Article
Education & Educational Research
Richard K. Shields, Manish Suneja, Bridget E. Shields, Josef N. Tofte, Shauna Dudley-Javoroski
Summary: This study examines whether the average educational debt for healthcare graduates in the United States can be supported by entry-level salaries, and explores whether trainees from minoritized backgrounds have higher educational debt than their peers in physical therapy.
BMC MEDICAL EDUCATION
(2023)
Article
Sport Sciences
Michael A. Petrie, Kristin A. Johnson, Olga Dubey, Richard K. Shields
Summary: Exercise is an effective medication for managing glucose control issues, but healthcare providers' recommendation timing does not align with best practice suggestions.
JOURNAL OF FUNCTIONAL MORPHOLOGY AND KINESIOLOGY
(2023)
Article
Sport Sciences
Amy L. Kimball, Michael A. Petrie, Patrick M. Mccue, Kristin A. Johnson, Richard K. Shields
Summary: After spinal cord injury (SCI), prolonged sitting and inactivity can lead to changes in body composition, such as increased visceral adipose tissue (VAT) thickness, which is associated with impaired glucose tolerance. This study suggests that VAT may serve as an important indicator of leanness and that mobility methods may influence glucose tolerance for individuals with SCI.
JOURNAL OF FUNCTIONAL MORPHOLOGY AND KINESIOLOGY
(2023)
Review
Clinical Neurology
Oday Atallah, Amr Badary, Yasser F. Almealawy, Vivek Sanker, Wireko Andrew Awuah, Toufik Abdul-Rahman, Sura N. Alrubaye, Bipin Chaurasia
Summary: This study investigates unexpected deaths resulting from primary brain tumors and analyzes the contributing variables. The findings reveal that unexpected deaths are a complex phenomenon, with headache being the most common initial symptom and meningiomas and astrocytomas being the most common lesions.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Alexandra E. Quimby, Mandy K. Salmon, Christopher H. Zhao, John Y. K. Lee, Douglas C. Bigelow, Michael J. Ruckenstein, Jason A. Brant
Summary: The study found that socioeconomic factors including race, health insurance, and income have an impact on the quality of life at the time of vestibular schwannoma diagnosis. Black/African American and uninsured/self-pay patients had lower quality of life, while patients with higher income had higher quality of life.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Review
Clinical Neurology
Arosha S. Dissanayake, Kwok M. Ho, Timothy J. Phillips, Stephen Honeybul, Graeme J. Hankey
Summary: This study systematically reviews models that aim to provide patient-specific predictions of pre-treatment rebleeding risk in patients with aneurysmal subarachnoid hemorrhage. The reported discriminative performance of the models varied, and no model showed consistently low bias risk and clinical applicability in all domains. Only one model was formulated using a patient cohort that underwent contemporary, evidence-based aneurysm treatment practices, but this model lacked calibration or clinical utility.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Colin Kok Ann Teo, Yilong Zheng, Jeremy Bingyuan Lin, Hock Luen Teoh, Bernard Poon Lap Chan, Vijay Kumar Sharma, Kejia Teo, Vincent Diong Weng Nga, Tseng Tsai Yeo
Summary: This study retrospectively reviewed the clinical characteristics and outcomes after surgical revascularization for adult Moyamoya disease (MMD) in a Southeast Asian cohort. The incidence of postoperative transient ischemic attack (TIA)/stroke was 25.9%, with most cases occurring within 7 days postoperatively. Risk factors for 30-day postoperative TIA/stroke included a higher number of preoperative TIAs/strokes and indirect revascularization.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Cheng-Chi Lee, Abel Po-Hao Huang, Ching-Chang Chen, Zhuo-Hao Liu, Mun-Chun Yeap, Ko-Ting Chen, Peng-Wei Hsu, Kuo-Chen Wei, Chun-Ting Chen, Yu-Chi Wang, Ting-Wei Chang, Chi-Cheng Chuang
Summary: Using a novel portable neuroendoscopic system for minimally invasive evacuation of intracerebral hemorrhage (ICH) has shown positive outcomes in reducing hematoma volume and improving neurological function without any death or rebleeding incidents.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Michael M. Haglund, Bruce M. McCormack, Daniel M. Williams, Alexander C. Lemons, Erik M. Summerside
Summary: This study evaluated the long-term radiographic outcomes of patients receiving tissue-sparing posterior cervical fusion (PCF) for the treatment of pseudarthrosis. The results showed that patients achieved rates of arthrodesis similar to open PCF, with fewer postoperative complications and long-term soft tissue pain.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Dong-Dong Meng, Zhe Ruan, Yong-Lan Tang, Zhao-Hua Ji, Yue Su, Tuo Xu, Bo-Zhou Cui, Da-Lin Ren, Ting Chang, Qian Yang
Summary: Depression symptom level, MG severity classification and family's monthly per capita income are independent factors related to the caregivers' disease family burden for MG patients. The daily activity burden of the family and the economic burden of the family were the heaviest among the six dimensions of the caregivers' family disease burdens.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Tugba Ozudogru Celik, Umit Gorgulu, Safiye Gul Kenar, Nadide Koca, Elif Yalcin, Ipek Koymen, Evren Yasar
Summary: This study investigated the forward head posture (FHP), thoracic kyphosis, and their relationship in individuals with migraine compared to healthy controls. The results showed that patients with migraine had a greater FHP and thoracic kyphosis. This suggests that a 3-dimensional objective measurement could be a reliable tool for evaluating posture analysis in clinical practice.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Jason A. Chen, Ari D. Kappel, Erickson F. Torio, David I. Bass, Abdullah Feroze, Nirav J. Patel
Summary: This report presents a case of a 63-year-old woman with a ruptured giant ICA terminus aneurysm, who underwent coil embolization followed by parent vessel sacrifice and high-flow bypass.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Sandeep Kandregula, Sneha Sai Mannam, Shahbaz Saad, Saarang Patel, Visish M. Srinivasan
Summary: A 39-year-old female with a history of smoking and a family predisposition to unruptured aneurysms presented with clinical symptoms of intermittent right-sided headaches, flashes of light, and pulsatile tinnitus. Diagnostic evaluations identified a right occipital arteriovenous malformation (AVM). Treatment involved partial embolization of primary arterial feeders followed by surgical resection, resulting in a successful outcome.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Ari D. Kappel, Jason A. Chen, Joshua I. Chalif, David I. Bass, Erickson F. Torio, Abdullah H. Feroze, Nirav J. Patel
Summary: A 48-year-old male with progressive congestive myelopathy underwent surgical clipping to treat a craniocervical DAVF. Intraoperatively, ICG was used to confirm the solitary inflow.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Aryeh Zolin, Cenai Zhang, Hwai Ooi, Harini Sarva, Hooman Kamel, Neal S. Parikh
Summary: In people with Parkinson's disease, comorbid liver fibrosis is associated with more rapid cognitive decline across multiple domains.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
