Article
Biochemistry & Molecular Biology
Helka Kaunisto, Teea Salmi, Katri Lindfors, Esko Kemppainen
Summary: Dermatitis herpetiformis is a skin manifestation of celiac disease characterized by blistering rash on specific body parts. The role of immunocomplexes in the pathogenesis of DH is still unknown. Although gluten intolerance develops similarly in both DH and celiac disease, their manifestations differ widely.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Saykat Das, Jorunn Stamnaes, Esko Kemppainen, Kaisa Hervonen, Knut E. A. Lundin, Naveen Parmar, Frode L. Jahnsen, Jorgen Jahnsen, Katri Lindfors, Teea Salmi, Rasmus Iversen, Ludvig M. Sollid
Summary: Dermatitis herpetiformis (DH) is an inflammatory skin disorder often considered as an extra intestinal manifestation of celiac disease (CeD). Hallmarks of CeD and DH are auto-antibodies to transglutaminase 2 (TG2) and transglutaminase 3 (TG3), respectively. DH patients have auto-antibodies reactive with both transglutaminase enzymes.
Review
Gastroenterology & Hepatology
Giuseppe Losurdo, Milena Di Leo, Edoardo Santamato, Monica Arena, Maria Rendina, Carmelo Luigiano, Enzo Ierardi, Alfredo Di Leo
Summary: The European Society of Pediatric Gastroenterology, Hepatology, and Nutrition has approved new criteria for diagnosing celiac disease in children, allowing for biopsy avoidance in specific antibody value and positivity cases, while adults still require histological biopsy for diagnosis.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Gastroenterology & Hepatology
Hugo A. Penny, Suneil A. Raju, Michelle S. Lau, Lauren J. S. Marks, Elisabeth M. R. Baggus, Julio C. Bai, Gabrio Bassotti, Hetty J. Bontkes, Antonio Carroccio, Mihai Danciu, Mohammad H. Derakhshan, Arzu Ensari, Azita Ganji, Peter H. R. Green, Matt W. Johnson, Sauid Ishaq, Benjamin Lebwohl, Adam Levene, Roxana Maxim, Hamid Mohaghegh Shalmani, Mohammad Rostami-Nejad, David Rowlands, Irene A. Spiridon, Amitabh Srivastava, Umberto Volta, Vincenzo Villanacci, Graeme Wild, Simon S. Cross, Kamran Rostami, David S. Sanders
Summary: The study aimed to determine the predictive capacity and diagnostic yield of a 10-fold increase in serum IgA antitissue transglutaminase (tTG) antibody levels for detecting small intestinal injury diagnostic of coeliac disease (CD) in adult patients. Results showed that IgA tTG levels of >= 10xULN have a strong predictive value at identifying adults with intestinal changes diagnostic of CD, supporting the use of a no-biopsy approach for the diagnosis of adult CD.
Article
Medicine, General & Internal
Justyna Gornowicz-Porowska, Agnieszka Seraszek-Jaros, Magdalena Jalowska, Monika Bowszyc-Dmochowska, Elzbieta Kaczmarek, Marian Dmochowski
Summary: The study compared the utility of ELISA and b-aIB with tTG in the serological diagnoses of dermatitis herpetiformis (DH), finding that b-aIB with tTG showed good sensitivity and specificity, with some agreement with ELISA, but lower agreement with direct immunofluorescence (DIF) results.
Review
Gastroenterology & Hepatology
Jocelyn A. Silvester, Amelie Therrien, Ciaran P. Kelly
Summary: Our understanding of the pathophysiology of celiac disease has greatly improved in the past 25 years, but there are still misconceptions about the clinical characteristics and management. Global epidemiological data now show that celiac disease is widespread, and an elevated body mass index is common at the time of diagnosis. The gluten-free diet is an imperfect treatment for celiac disease, as not all individuals respond to it.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Medicine, General & Internal
Giuseppe Losurdo, Milena Di Leo, Edoardo Santamato, Antonio Giangaspero, Maria Rendina, Carmelo Luigiano, Enzo Ierardi, Alfredo Di Leo
Summary: The study suggests that diagnostic criteria for celiac disease and villous atrophy based solely on serological markers are not reliable in adults. While high TGA levels are linked to villous atrophy, the sensitivity and specificity of this relationship are limited in adult patients.
MEDICINA-LITHUANIA
(2021)
Article
Multidisciplinary Sciences
Hoda Gad, Ibrahim Mohammed, Saras Saraswathi, Bara Al-Jarrah, Maryam Ferdousi, Ioannis N. Petropoulos, Georgios Ponirakis, Adnan Khan, Parul Singh, Souhaila Al Khodor, Mamoun Elawad, Wesam Almasri, Hatim Abdelrahman, Khalid Hussain, Mohamed A. Hendaus, Fatma Al-Mudahka, Khaled Abouhazima, Anthony K. Akobeng, Rayaz A. Malik
Summary: This study aims to investigate whether quantification of corneal Langerhans cells (LCs) using corneal confocal microscopy (CCM) can serve as a surrogate marker for antigen presenting cell status and disease activity in children with CeD. The results showed no difference in LC density between the CeD group and the control group, but LC density correlated with anti-TtG levels.
SCIENTIFIC REPORTS
(2022)
Article
Gastroenterology & Hepatology
M. Ines Pinto-Sanchez, Jocelyn A. Silvester, Benjamin Lebwohl, Daniel A. Leffler, Robert P. Anderson, Amelie Therrien, Ciaran P. Kelly, Elena F. Verdu
Summary: Coeliac disease is a serious condition with significant research progress, but there are still many gaps in diagnosis and treatment, as the gluten-free diet is not universally effective, and new treatment options are currently being investigated.
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
(2021)
Review
Pharmacology & Pharmacy
Harrison A. Besser, Chaitan Khosla
Summary: This review summarizes the pathogenesis of celiac disease, focusing on the interactions between three molecular families and the potential for pharmacological targeting.
TRENDS IN PHARMACOLOGICAL SCIENCES
(2023)
Review
Immunology
Esko Kemppainen, Teea Salmi, Katri Lindfors
Summary: Dermatitis herpetiformis is a skin manifestation of celiac disease, characterized by itching rash on elbows, knees, and buttocks; triggered by gluten intake and treated with gluten-free diet; the mechanism of interaction between specific cell populations in patients is still unclear.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, General & Internal
Rakel Nurmi, Camilla Pasternack, Teea Salmi, Kaisa Hervonen, Inka Koskinen, Jutta Jarvelin, Heini Huhtala, Pekka Collin, Jukka Mustonen, Katri Kaukinen, Satu Makela
Summary: Patients with celiac disease have an increased risk of kidney diseases, particularly IgA nephropathy. This risk is phenotype-dependent and is not observed in patients with dermatitis herpetiformis.
JOURNAL OF INTERNAL MEDICINE
(2022)
Article
Gastroenterology & Hepatology
Annalisa Schiepatti, Anupam Rej, Stiliano Maimaris, Simon S. Cross, Petra Porta, Imran Aziz, Tim Key, John Goodwin, Amelie Therrien, Shakira Yoosuf, Daniel A. Leffler, Jocelyn A. Silvester, Catherine Klersy, Federico Biagi, David S. Sanders
Summary: The study found that seronegative coeliac disease has a more aggressive phenotype than seropositive coeliac disease, highlighting the importance of strict clinical and histologic follow-up in the management of seronegative coeliac disease.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Gastroenterology & Hepatology
Shubham Mehta, Ankit Agarwal, Aditya Vikram Pachisia, Alka Singh, Sana Dang, Dwarakanathan Vignesh, Anam Ahmed, Bodhisattya Roy Chaudhari, Shubham Prasad, Ritik Mahaveer Goyal, Amitkumar Chavan, Aagamjit Singh, Sanjay Kumar, Divya Sharma, Ashish Chauhan, Mahendra Singh Rajput, Sachin Rajput, Prasenjit Das, Sushil Falodia, Saroj Kant Sinha, Rakesh Kochhar, Vineet Ahuja, Govind K. Makharia
Summary: Delayed diagnosis of celiac disease leads to increased severity of symptoms, highlighting the need for increased sensitivity in diagnosing celiac disease in appropriate clinical settings.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Gianpiero Stefanelli, Sara Navisse, Marco Valvano, Filippo Vernia, Antonio Ciccone, Dina Melideo, Stefano Necozione, Giuseppe Calvisi, Gino Coletti, Angelo Viscido, Giovanni Latella
Summary: The study highlights how histologic evaluation of duodenal biopsies remains the gold standard for both celiac disease diagnosis and the evaluation of mucosal recovery after 18-24 months of a GFD.
EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY
(2021)
Article
Dermatology
Camilla Pasternack, Kaisa Hervonen, Eriika Mansikka, Timo Reunala, Katri Kaukinen, Teea Salmi
Summary: This study found that long-term treated female patients with dermatitis herpetiformis have better adherence to a gluten-free diet, but they also experience more severe clinical symptoms compared with males.
ACTA DERMATO-VENEREOLOGICA
(2022)
Article
Gastroenterology & Hepatology
Inka Koskinen, Kaisa Hervonen, Heini Huhtala, Camilla Pasternack, Teea Salmi, Timo Reunala, Pekka Collin, Katri Kaukinen
Summary: This study aimed to determine the long-term mortality of celiac disease. The results showed that overall mortality was not increased in any celiac disease phenotype during a very long-term follow-up, but mortality from certain diseases was increased and the risk of alcohol-related diseases was decreased.
DIGESTIVE AND LIVER DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Helka Kaunisto, Teea Salmi, Katri Lindfors, Esko Kemppainen
Summary: Dermatitis herpetiformis is a skin manifestation of celiac disease characterized by blistering rash on specific body parts. The role of immunocomplexes in the pathogenesis of DH is still unknown. Although gluten intolerance develops similarly in both DH and celiac disease, their manifestations differ widely.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Rakel Nurmi, Camilla Pasternack, Teea Salmi, Kaisa Hervonen, Inka Koskinen, Jutta Jarvelin, Heini Huhtala, Pekka Collin, Jukka Mustonen, Katri Kaukinen, Satu Makela
Summary: Patients with celiac disease have an increased risk of kidney diseases, particularly IgA nephropathy. This risk is phenotype-dependent and is not observed in patients with dermatitis herpetiformis.
JOURNAL OF INTERNAL MEDICINE
(2022)
Letter
Dermatology
Louise F. Risnes, Marketa Chulbnova, Elio Magistrelli, Esko Kemppainen, Kaisa Hervonen, Eriika Mansikka, Katri Lindfors, Teea Salmi, Shiva Dahal-Koirala, Ludvig M. Solid
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Letter
Medicine, General & Internal
Rakel Nurmi, Camilla Pasternack, Teea Salmi, Kaisa Hervonen, Inka Koskinen, Jutta Jarvelin, Heini Huhtala, Pekka Collin, Jukka Mustonen, Katri Kaukinen, Satu Makela
JOURNAL OF INTERNAL MEDICINE
(2022)
Article
Dermatology
Anna Poyry, Teija Kimpimaeki, Ilkka Kaartinen, Teea T. Salmi
Summary: This study evaluated the completeness, accuracy, timeliness, and case coverage of the Tampere Wound Registry (TWR). The results showed that the TWR is a reliable tool for health care documentation and a more reliable data source than patient medical records.
INTERNATIONAL WOUND JOURNAL
(2023)
Article
Medicine, General & Internal
Noora Nilsson, Joonas Leivo, Pekka Collin, Inka Koskinen, Katri Kaukinen, Heini Huhtala, Johanna Palmio, Timo Reunala, Kaisa Hervonen, Teea Salmi, Camilla Pasternack
Summary: This cohort study investigated the risk for vascular diseases in dermatitis herpetiformis (DH) and coeliac disease patients. The results showed that compared to coeliac disease patients, DH patients had a decreased risk for cerebrovascular diseases, while coeliac disease patients had an increased risk for cerebrovascular and cardiovascular diseases. Coeliac disease, but not DH, was associated with an increased risk for venous thrombosis.
ANNALS OF MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Elli Turjanmaa, Kaisa Hervonen, Heini Huhtala, Sanna Arnala, Timo Reunala, Katri Kaukinen, Teea Salmi
Summary: This study aimed to investigate the frequency, severity, and quality of life effects of skin disorders in coeliac disease patients compared to controls, as well as the impacts of a gluten-free diet on these skin diseases. The results showed that coeliac disease patients were not at an increased risk for certain skin diseases, but they still experienced a burden on their quality of life due to skin symptoms.
SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Chemistry, Multidisciplinary
Saykat Das, Jorunn Stamnaes, Esko Kemppainen, Kaisa Hervonen, Knut E. A. Lundin, Naveen Parmar, Frode L. Jahnsen, Jorgen Jahnsen, Katri Lindfors, Teea Salmi, Rasmus Iversen, Ludvig M. Sollid
Summary: Dermatitis herpetiformis (DH) is an inflammatory skin disorder often considered as an extra intestinal manifestation of celiac disease (CeD). Hallmarks of CeD and DH are auto-antibodies to transglutaminase 2 (TG2) and transglutaminase 3 (TG3), respectively. DH patients have auto-antibodies reactive with both transglutaminase enzymes.
Meeting Abstract
Transplantation
Rakel Nurmi, Camilla Pasternack, Teea Salmi, Kaisa Hervonen, Inka Koskinen, Jutta Jarvelin, Heini Huhtala, Pekka Collin, Jukka Mustonen, Katri Kaukinen, Satu Makela
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2022)