Article
Cell Biology
Warren B. Nothnick
Summary: Endometriosis is a significant disease characterized by infertility and pelvic pain. Altered responsiveness to progesterone, potentially regulated by miRNAs, may contribute to the pathophysiology of the disease.
Review
Biochemistry & Molecular Biology
Ping Zhang, Guoyun Wang
Summary: Endometriosis is a disease where endometrial-like tissue grows outside the uterus. Progestins are the most commonly used treatment, but some patients show resistance to these drugs. The mechanisms of this progesterone resistance include abnormal PGR signaling, chronic inflammation, aberrant gene expression, epigenetic alterations, and environmental toxins. Understanding these mechanisms may help develop new therapeutic regimens to reverse progesterone resistance in endometriosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biology
Brett D. McKinnon, Samuel W. Lukowski, Sally Mortlock, Joanna Crawford, Sharat Atluri, Sugarniya Subramaniam, Rebecca L. Johnston, Konstantinos Nirgianakis, Keisuke Tanaka, Akwasi Amoako, Michael D. Mueller, Grant W. Montgomery
Summary: The study reveals inherent differences in endometrial cells of women with endometriosis and highlights the potential role of cellular differentiation in disease susceptibility.
COMMUNICATIONS BIOLOGY
(2022)
Article
Obstetrics & Gynecology
Serdar E. Bulun, Sule Yildiz, Mazhar Adli, Debabrata Chakravarti, James Brandon Parker, Magdy Milad, Linda Yang, Angela Chaudhari, Susan Tsai, Jian Jun Wei, Ping Yin
Summary: Endometriosis and adenomyosis are closely related disorders with similar pathophysiologies. They both originate from eutopically located intracavitary endometrium and involve somatic mutations and epigenetic abnormalities in the endometrial glandular epithelial cells and stromal cells. KRAS mutations are commonly found in endometriotic epithelial cells, while adenomyotic epithelial cells almost exclusively bear KRAS mutations. Both disorders exhibit similar epigenetic defects involving abnormal expression of nuclear receptors and resulting in excessive estrogen biosynthesis and abnormal estrogen action. Deficient progesterone receptor expression leads to progesterone resistance in both endometriosis and adenomyosis.
FERTILITY AND STERILITY
(2023)
Article
Biochemistry & Molecular Biology
Yanyu Wei, Wei Lu, Yehua Yu, Yuanmei Zhai, Hezhou Guo, Shaoxin Yang, Chong Zhao, Yanjie Zhang, Jiali Liu, Yuhui Liu, Jian Fei, Jun Shi
Summary: Increased expression of miR-29c&b2 in AML patients is associated with poor overall survival, while wildtype mice with high miR-29c&b2 expression show shorter survival and heavier leukemia infiltration in extramedullary organs. MiR-29c&b2 inside leukemia cells promote EMI by targeting Hbp1 and reducing its binding to Myh10, leading to increased migration of leukemia cells.
Article
Obstetrics & Gynecology
Shih-Chieh Lin, Wan-Ning Li, Shin-Chih Lin, Haun-Tzu Hou, Ya-Chuan Tsai, Tin-Chien Lin, Meng-Hsing Wu, Shaw-Jenq Tsai
Summary: YAP1 inhibition can alleviate progesterone resistance in endometriosis. Through in vitro and in vivo experiments, it has been found that YAP1 inhibition can reduce progesterone resistance. It is known that progesterone resistance not only causes treatment failure for endometriosis but also inhibits eutopic endometrial cell proliferation, dysregulates decidualization, and reduces the success rates of pregnancy.
HUMAN REPRODUCTION
(2023)
Article
Obstetrics & Gynecology
Kashmira Bane, Junita Desouza, Diksha Shetty, Prakash Choudhary, Shalaka Kadam, R. R. Katkam, Gwendolyn Fernandes, Raj Sawant, Uddhavraj Dudhedia, Neeta Warty, Anahita Chauhan, Uddhav Chaudhari, Rahul Gajbhiye, Geetanjali Sachdeva
Summary: The study indicates that the DNA damage response is dysregulated in the eutopic endometrium of women with endometriosis, with higher expression of DDR genes compared to those without the disease. Additionally, DNA repair genes are also up-regulated in the eutopic endometrium of women with endometriosis.
HUMAN REPRODUCTION
(2021)
Review
Biochemistry & Molecular Biology
Marie-Madeleine Dolmans, Jacques Donnez
Summary: Endometriosis is a chronic inflammatory disease that requires lifelong management. This review evaluates the pathways involved in endometriosis and explores new therapies. Inflammation and inflammatory molecules play a crucial role in the disease, and targeting inflammation, nuclear factor kappa B and cytokines, as well as pathways related to apoptosis and autophagy, may offer new perspectives for non-hormonal treatment.
Article
Multidisciplinary Sciences
Shin Hashizume, Masako Nakano, Kenta Kubota, Seiichi Sato, Nobuaki Himuro, Eiji Kobayashi, Akinori Takaoka, Mineko Fujimiya
Summary: This study demonstrates that MBSR can enhance cognitive function by upregulating miR-29c expression and downregulating DNMT3A and DNMT3B expression in NDEVs. Additionally, intracerebroventricular injection of miR-29c mimic in 5xFAD mice shows potential in preventing cognitive decline and neuronal loss in the hippocampus.
SCIENTIFIC REPORTS
(2021)
Article
Reproductive Biology
Cecilia Constantino Rocha, Thiago Martins, Felipe Alves Correa Carvalho Silva, Mariana Sponchiado, Ky Garrett Pohler, Mario Binelli
Summary: The expression of interferon stimulated genes (ISGs) in lymphocytes can be used for pregnancy diagnosis in cattle. However, the variability between cows has resulted in sub-optimal predictive accuracy. The expression of ISGs in early pregnancy varies according to the proportion of Bos indicus genetics on females.
Article
Biochemistry & Molecular Biology
Xiao-Qian Ma, Yu-Yin Liu, Zhi-Qi Zhong, Si-Man Chen, Wen-Ting Hu, Yan-Ran Sheng, Yu-Kai Liu, Chun-Yan Wei, Ming-Qing Li, Xiao-Yong Zhu
Summary: Endometriosis is an estrogen-dependent, progesterone-resistant gynecological disease. In this study, the dysregulated expression of heme-trafficking proteins and heme-degrading enzymes was investigated, revealing that heme mediates progesterone resistance and induces endometriosis via the mitochondrial oxidative phosphorylation pathway.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2023)
Review
Chemistry, Medicinal
Jacques Donnez, Luciana Cacciottola, Jean-Luc Squifflet, Marie-Madeleine Dolmans
Summary: Estrogens play a critical role in the pathogenesis of endometriosis, and lowering estradiol levels with oral GnRH antagonists, such as linzagolix, can be an effective option for managing symptomatic endometriosis in premenopausal women. Linzagolix is an orally administered GnRH receptor antagonist that reduces LH and FSH production, leading to a dose-dependent decline in estrogen. Phase 2 and 3 trials have shown promising results for the use of linzagolix in the treatment of endometriosis.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2023)
Article
Biochemistry & Molecular Biology
Lijuan Ma, Thomas Andrieu, Brett McKinnon, Lea Duempelmann, Ren-Wang Peng, Carlos Wotzkow, Christoph Mueller, Michael D. Mueller
Summary: This study found a negative correlation between low expression of progesterone receptors (PR) and epithelial-to-mesenchymal transition (EMT) in endometriosis lesions. In both in vitro and in vivo experiments, EMT leads to downregulation of PR gene expression by upregulating EMT transcription factors like SNAI1 and SNAI2, potentially resulting in progesterone resistance.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Andreas Zietzer, Eva Steffen, Sven Niepmann, Philip Duesing, Mohammed Rabiul Hosen, Weiyi Liu, Paul Jamme, Baravan Al-Kassou, Philipp Roger Goody, Sebastian Zimmer, Katrin S. Reiners, Alexander Pfeifer, Michael Boehm, Nikos Werner, Georg Nickenig, Felix Jansen
Summary: The combination of coronary artery disease (CAD) and chronic kidney disease (CKD) affects endothelial function through the intercellular transfer of microRNAs (miRs) via extracellular vesicles (EVs). This study found that CAD + CKD patients had lower levels of vasculo-protective miR-130a-3p and miR-126-3p in their EVs compared to CAD patients and controls. The EVs from CAD + CKD patients impaired endothelial cell proliferation and regeneration, promoting CKD-induced endothelial dysfunction.
CARDIOVASCULAR RESEARCH
(2022)
Article
Clinical Neurology
Shaoqiang Han, Ruiping Zheng, Shuying Li, Bingqian Zhou, Yu Jiang, Keke Fang, Yarui Wei, Baohong Wen, Jianyue Pang, Hengfen Li, Yong Zhang, Yuan Chen, Jingliang Cheng
Summary: This study aimed to investigate the altered structural covariance of nucleus accumbens (NAcc) in never-treated first-episode patients with depression and how it was modulated by illness duration and severity of symptom. The results revealed that patients with depression exhibited abnormal structural covariance of NAcc connected to key brain regions in the reward system, and this abnormality was distinctly modulated by illness duration and the severity of symptom.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Obstetrics & Gynecology
Jenny Y. Mei, Divya Mallampati, Ilina D. Pluym, Christina S. Han, Yalda Afshar
Summary: This study evaluated the cost-effectiveness of twin vaginal deliveries in the labor and delivery room (LDR) compared to deliveries in the operating room (OR). The analysis showed that delivering twins in the LDR was the most cost-effective strategy, taking into account factors such as success rate of vaginal delivery, neonatal morbidity, and cost.
AMERICAN JOURNAL OF PERINATOLOGY
(2023)
Article
Acoustics
Greggory R. DeVore, Yalda Afshar, Danielle Harake, Gary Satou, Mark Sklansky
Summary: This study examines fetuses with TOF and evaluates the ventricular contractility and function using speckle-tracking analysis. The results show that LV contractility and function are significantly abnormal in fetuses with TOF, while RV contractility is mostly normal.
JOURNAL OF ULTRASOUND IN MEDICINE
(2022)
Article
Immunology
Alison McCallion, Yasmin Nasirzadeh, Harshavardhan Lingegowda, Jessica E. Miller, Kasra Khalaj, SooHyun Ahn, Stephany P. Monsanto, Mallikarjun Bidarimath, Danielle J. Sisnett, Andrew W. Craig, Steven L. Young, Bruce A. Lessey, Madhuri Koti, Chandrakant Tayade
Summary: This study found that mast cell numbers significantly increase in endometriotic lesions, and the microenvironment within these lesions promotes the recruitment and differentiation of mast cells. There is cross-talk between mast cells and endocrine and immune factors, which may contribute to the pathophysiology of endometriosis.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Marie Altendahl, Thalia Mok, Christine Jang, Seungjun Yeo, Austin Quach, Yalda Afshar
Summary: This study investigated the pathophysiology of COVID-19 in pregnant patients with different clinical trajectories. Severe COVID-19 was associated with distinct proteomic and lipidomic signatures related to complement and antibody activity. Mild/moderate COVID-19 did not show significant alterations compared to controls in serum protein, metabolite, or lipid metabolite levels.
Article
Psychiatry
Tory A. Eisenlohr-Moul, Savannah M. Bowers, Mitchell J. Prinstein, Katja M. Schmalenberger, Erin C. Walsh, Steven L. Young, David R. Rubinow, Susan S. Girdler
Summary: Female suicide attempts peak peri-menstrually, potentially due to withdrawal of estradiol and progesterone. Experimental administration of these hormones can reduce perimenstrual exacerbation of suicidal ideation and related symptoms, while delayed withdrawal leads to symptom relapse.
TRANSLATIONAL PSYCHIATRY
(2022)
Article
Cardiac & Cardiovascular Systems
Justin Hanson, Michael Richley, Jeffrey J. Hsu, Jeannette Lin, Yalda Afshar
Summary: This report presents a case of PASC in a pregnant woman who experienced severe orthostatic symptoms after recovering from COVID-19. Evaluation with the NASA Lean Test revealed orthostatic tachycardia and delayed orthostatic hypotension, leading to the diagnosis of PASC involving autonomic dysfunction. Careful evaluation with dedicated active stand tests and understanding of normal pregnancy physiology are needed when assessing PASC patients with orthostatic symptoms.
EUROPEAN HEART JOURNAL-CASE REPORTS
(2022)
Article
Obstetrics & Gynecology
Kathleen Chung, Ophelia Yin, Aneesh Kallapur, Lauren Bass, Lisa Coscia, Serban Constantinescu, Michael Moritz, Yalda Afshar
Summary: This study aimed to characterize the risk factors and outcomes of emergency prelabor cesarean delivery in kidney and liver transplant recipients. It found that this type of cesarean delivery is associated with increased risks of preterm birth, low birthweight, and neonatal mortality. Therefore, pregnancies after transplantation should involve multidisciplinary transplant-obstetrics collaboration to ensure optimal antepartum disease management, especially for preexisting hypertension.
AMERICAN JOURNAL OF OBSTETRICS & GYNECOLOGY MFM
(2023)
Article
Biology
Yalda Afshar, Feyiang Ma, Austin Quach, Anhyo Jeong, Hannah L. Sunshine, Vanessa Freitas, Yasaman Jami-Alahmadi, Raphael Helaers, Xinmin Li, Matteo Pellegrini, James A. Wohlschlegel, Casey E. Romanoski, Miikka Vikkula, M. Luisa Iruela-Arispe
Summary: Environmental cues play a critical role in cell function, and this study reveals that the in vitro environment significantly affects gene expression in human endothelial cells. Long-term shear stress and heterotypic cell interactions can partially rescue the transcriptional changes caused by the in vitro environment.
Article
Cardiac & Cardiovascular Systems
Ayesha P. Ng, Arjun Verma, Yas Sanaiha, Catherine G. Williamson, Yalda Afshar, Peyman Benharash
Summary: The guidelines for selecting prosthetic heart valves in reproductive-age individuals are not well established. This study aimed to examine the association between prosthetic valve type and maternal and fetal outcomes in pregnant patients. The findings suggest that women with prior valve replacement surgery are at a substantial risk of adverse maternal and fetal events, regardless of the type of valve used.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Obstetrics & Gynecology
Eduardo Hariton, Ruben Alvero, Micah J. Hill, Jennifer E. Mersereau, Shana Perman, David Sable, Fiona Wang, Geoffrey David Adamson, Christos Coutifaris, LaTasha B. Craig, Pardis Hosseinzadeh, Anthony N. Imudia, Erica B. Johnstone, Ruth B. Lathi, Paul C. Lin, Erica E. Marsh, Michele Munch, Gloria Richard-Davis, Lauren W. Roth, Amy K. Schutt, Kim Thornton, Lauren Verrilli, Rachel S. Weinerman, Steven L. Young, Kate Devine
Summary: The field of reproductive endocrinology and infertility faces a mismatch between demand and availability of care. It is recommended to increase the number of qualified physicians and non-REI providers to address the physician shortage problem and improve clinical efficiency through technological improvements.
FERTILITY AND STERILITY
(2023)
Meeting Abstract
Obstetrics & Gynecology
Anthony Bui, Audrey Garneau, Steven L. Young, Genevieve S. Neal-Perry
FERTILITY AND STERILITY
(2022)
Meeting Abstract
Obstetrics & Gynecology
Audrey Garneau, Anthony Bui, Steven L. Young, Melissa Paczkowski, Caitlin Boylan
FERTILITY AND STERILITY
(2022)
Meeting Abstract
Obstetrics & Gynecology
Audrey Oarneau, Anthony Bui, Steven L. Young, Genevieve S. Neal-Perry
FERTILITY AND STERILITY
(2022)
Meeting Abstract
Obstetrics & Gynecology
Rachel Catharine Wilson, Heather M. Sidener, Lauren Drew Martin, Jeanne Link, Steven L. Young, Ov D. Slayden
FERTILITY AND STERILITY
(2022)
Meeting Abstract
Obstetrics & Gynecology
Anthony Bui, Audrey Garneau, Steven L. Young
FERTILITY AND STERILITY
(2022)